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Regenerative Medicine | NC Ortho

Posted: September 14, 2018 at 6:40 pm

Regenerative Medicine what is it?

Regenerative medicine is a field of medicine at the intersection of molecular biology and tissue engineering and is a viable non-surgical option for many patients. Its goal is to heal or replace tissues that were possibly previously determined beyond repair through trauma, disease, or congenital issues. Certain cells (such as stem cells) in the body rejuvenate, or possess a natural ability to heal. They have the ability to become other types of cells, such as fat cells (adipocytes), cartilage cells (chondrocytes), bone cells (osteoblasts), and muscle cells (myocytes). By regenerating these cells or their growth factors, we are able to encourage healing in damaged areas that otherwise have lost these characteristics. These cells can be used for issues such as tendonitis and arthritis. Stem cell therapies and tissue engineering/biomaterials are just two exciting areas of regenerative medicine that the surgeons at the North Carolina Orthopaedic Clinic (NCOC) utilizes.

Stem cells are harvested from your own bone marrow or fat and are a natural, safe option to accelerate healing and repair damage. The harvested stem cells are then processed in the operating room or in-office to remove unnecessary products in preparation to be reinjected into the patient. The overall procedures take about 45-60 minutes, but the portion of active time involving the patient (harvesting and re-injecting) is much shorter, about 15 minutes. The rest of the time is spent processing the cells.

There is typically minimal pain associated with these procedures as sites are numbed in office before harvesting begins. After the procedure, the healing process begins. Some patients notice that initially the pain is the same as before the procedure, or perhaps a little worse for a few days following the procedure due to being sore, with improvement starting 2-4 weeks after the procedure and continuing from there. Depending on the location of the injection, you may be placed in a boot for a few days to allow the injection site to calm down. Physical therapy is often used in conjunction with stem cell therapies for the best results.

Regenerative medicine is an important aspect of managing both acute and chronic orthopaedic problems. NCOC is on the forefront of innovation in using both traditional and regenerative medicine to treat numerous knee, shoulder, elbow, hand, and foot and ankle concerns. NCOC offers both in-office procedures to help prevent or delay surgery and intra-operative techniques to help expedite and reinforce healing.

In the office, NCOC performs Lipogems to help stimulate healing in chronically painful areas. This procedure utilizes a patients own harvested abdominal adipose (fat) tissue that is then spun down into stem cells and injected back into the patient to stimulate healing. This procedure is done as a same-day, sterile, in-office environment without need for sedation. Lipogems is similar to PRP injections, but different in that PRP uses plasma (blood products) while Lipogems uses a patients own stem cells. Dr. Parekh has used this technique to successfully treat problems ranging from knee arthritis, to plantar fasciitis to osteoarthritis, delaying or eliminating the need for surgery. You can watch such a procedure being performed at: https://youtu.be/vZbk5rb8eIc

In the operating room, NCOC has multiple techniques to promote successful healing post-operatively. One such technique is bone marrow harvest concentrate (BMAC), where a patients bone marrow is aspirated from the calcaneus (heel), tibia (shin), or iliac crest (pelvis) bone, and then spun down into a stem cell concentrate. Again, as this is the patients own tissue, this is considered an autograft. This concentrate is often mixed with other materials and then reinjected into the body to promote healing in procedures such as spine fusions, midfoot and ankle fusions and enhance fracture healing.

Finally, at times, the surgeons at NCOC may use engineered tissues in the operating room to close a difficult wound, thereby eliminating or lessening the chance of a skin graft or infection.

The goal of regenerative medicine as a technique in orthopedics is to promote tissue regeneration resulting in quality patient outcomes. NCOC is committed to using every technique available to us to successfully alleviate patients concerns. Contact our office at 919-471-9622 to schedule an appointment to discuss your options.

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Epigenetics Research | Icahn School of Medicine

Posted: September 9, 2018 at 4:44 pm

Epigenetics is the study of external or environmental factors that turn genes 'on' and 'off' and affect how cells 'read' genes.

Very little is known about the role of non-coding and regulatory DNA sequences for normal human brain development, or about their role in changes in the young or old brain, in diseases ranging from autism to Alzheimer's disease. Gaining first insights into these mechanisms is one of the major goals of our team of scientists focused on the neuro-epigenome.

The human genome is comprised of approximately six billion base pairs, the basic building blocks of genetic coding, amounting to a vast amount of genetic information. We are unlikely to gain a deeper understanding of uniquely human brain functions, including cognitive abilities and psychiatric and neurological diseases, merely by studying DNA sequences on a linear genome. This is because less than 1.5% of the genome is directly associated with protein encoding genes, and the majority of genetic polymorphisms and DNA variants conferring risk for neurological and psychiatric disease are positioned outside the portions of DNA encoding amino acids. Much of the remaining 98.5% of the genome is believed to play an important role in coordinating the regulation of gene expression networks. But gaining deeper insights into these mechanisms has been a challenge.

Our research in epigenetics is focused on a number of different areas.

We are developing novel epigenetic therapies for mood and psychosis spectrum disorders, such as depression and schizophrenia. This is the major focus of theDivision of Psychiatric Epigenomics,led bySchahram Akbarian, MD, PhD. Researchers are studying novel types of drugs that could alter the chemistry of brain nucleosomes in animal models of psychiatric disease. One family of molecules of particular interest are the enzymes that add or remove methyl-groups from lysine and arginine residues of the histone proteins. There are an estimated 100 lysine and arginine residue-specific histone methyltransferase and demethylase enzymes encoded in the human genome, many of which are assumed to play a critical role in maintaining neuronal health and function. These families of molecules are expected to provide plenty of targets for drug discovery and ultimately lead to better treatment options for neurological and psychiatric disease.

The Division of Psychiatric Epigenomics is studying nucleosomal organization and molecular composition in the nuclei of human brain nerve cell specimens collected postmortem in an effort to understand epigenetic changes during the course of normal development and aging across the lifespan, as well as epigenetic changes occurring in chronic psychiatric disease. While it is known that the overwhelming majority of nerve cells in the human brain stop multiplying via cell divisionduring prenatal development, extremely little is known about changes inside the nuclei of nerve cells during the subsequent periods of development, maturation, and aging. It remains a mystery how the genome in nerve cells is maintained as we grow, mature, and age, and how the molecular machinery inside our nerve cells is able to adapt to the myriad of environmental influences we are exposed to during our lives. Understanding how epigenetics is important for brain function in healthy brains, as well as those affected by disease, is a central research focus for us.

Scientists involved:Schahram Akbarian,Emily Bernstein,Patrizia Casaccia, Fatemah Haghighi,Yasmin Hurd,Paul Kenny,Javier Gonzalez-Maeso,Eric J. Nestler,Scott J. Russo,Anne Schaefer,Li Shen

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Atlanta, Georgia Stem Cell Transplant, Marietta, Berkeley …

Posted: September 7, 2018 at 5:43 am

Stem cell therapy offers hope to millions of people suffering from inflammatory and degenerative diseases for which there are few treatment options. Globally, stem cell research has advanced at a much more rapid rate than in the United States, with a large number of new studies published each year in a broad range of diseases. Unfortunately, although many legal studies are showing great promise in their results, the FDA has not approved many of them for use in Georgia or the United States.

Fortunately, The Stem Cells Transplant Institute in Costa Rica believes in the potential of stem cell therapy and it can be legally applied here. Under the direction of Dr. Leslie Mesen, the Stem Cells Transplant Institute provides government approved stem cell therapy for the treatment of diseases such as; Alzheimers disease, Parkinsons disease, osteoarthritis, multiple sclerosis, diabetes, cardiovascular disease, and many more.

Georgia patients from Atlanta, Columbus, Savannah, Sandy Springs, and Roswell can experience the benefits of stem cell therapy by scheduling an evaluation at the Stem Cells Transplant Institute. Stem cells offer great hope for treating disease by providing an unlimited source of cells for repairing or replacing damaged tissue. The treatment is a safe, non-invasive, same-day procedure that takes only a few hours. Many patients take the opportunity to make their trip an extended vacation and enjoy the beauty and rich culture of Costa Rica.

There are daily nonstop flights from the Atlanta airport to San Jose, making it easy to escape the hot summer temperatures of Hotlanta or the occasional freezing temperatures of winter, and enjoy the fabulous year-round temperatures of Costa Rica. Stem cell therapy can help you regain your ability to; attend an Atlanta Braves or Atlanta Falcons game, work on your golf swing at Candler Park, or spend the day shopping at Lenox Square. The experts at the Stem Cells Transplant Institute want to help you stay active and live your best life. Contact us today to see if stem cell therapy is right for you.

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Stem Cell Therapy New York | NYC Stem Cells | (212) 262-2412

Posted: September 5, 2018 at 7:45 pm

Welcome to the New York Stem Cell Treatment Center. I am David Borenstein, MD, founder of the center, which is part of my practice, Manhattan Integrative Medicine.

Whether we are treating patients from New York City, Montreal or Toronto, we are dedicated to the advancement of quality care in the area of adult stem cell regenerative medicine. Our mission is to use advanced stem cell technology in order to improve the bodys ability to regenerate, heal and overcome a variety of inflammatory and degenerative conditions.

Therapies are provided at our stem cell clinic for patientsfrom all over the U.S. and around the world. Locations we serve includethe surrounding areas of Manhattan, Brooklyn, Queens, the Bronx, Staten Island, Nassau County, Suffolk County, Long Island, Westchester, New Jersey, Connecticut and Pennsylvania. We treat patientswho visit us from Canada as well, from cities such as Montreal and Toronto.

Feel free to learn more about our stem cell treatments and our stem cell clinic. If you have further questions please go ahead andcontact us, and if you would like to schedule an initial consultation, please fill out acandidate application.

Dr. David Borenstein obtained his medical degree from the Technion Faculty of Medicine in Haifa, Israel and completed his internship at Staten Island University Hospital. He has completed residencies at: University Hospital at Stony Brook; Westchester County Medical Center; and St. Charles Hospital and Rehabilitation Center.

During the course of his career he has attended numerous specialized training courses in order to expand the scope of his medical expertise that he uses every day at his stem cell treatment center. He is board certified in Physical Medicine and Rehabilitation, certified in Medical Acupuncture, and is a member of numerous professional societies.

Dr. Borenstein has held many prestigious clinical appointments and positions in leading medical facilities. He has been published in the European Journal of Ultrasound and has been the Chief Investigator on a research project on Spinal Cord Injuries. He has conducted medical missions in North Korea, Ghana, Cuba, and other countries.

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Genesis and Genetics | We look at Genetics in Genesis

Posted: September 5, 2018 at 7:43 pm

This blog presents several additional points to support the notion that Neanderthal is antediluvian man, i.e. those who lived before the Biblical flood. In 2012, we presented evidence, based on partial mitochondrial DNA sequences, that Neanderthal is indeed our direct, antediluvian ancestor 1. We now have more evidence that solidifies our position. When Neanderthal fossils were discovered in the mid-1800s, Neanderthals were portrayed as ignorant ape-men, but now with the advent of DNA sequencing, they are being portrayed quite differently. More and more they are being portrayed as fully human like us. They are seizing their rightful position in the history of man: our direct line ancestors: the sons and daughters of Adam who lived before the global flood. The following points should be considered in defense of our stance:

Human Speech

It has been found that the human variation of the FOXP2 gene is present in Neanderthal.2 This FOXP2 gene found in Neanderthal is identical to that of humans living today; this is significant in that FOXP2 plays a major role in human speech 3, separating us from the animal kingdom. This finding coupled with the fact that Neanderthals had brains larger than present-day humans4 could suggest that they were more articulate than we.

Genetic Similarity The present-day human and Neanderthal genomes appear to be at least 99.5% identical 5. This difference is statistically the same as some of the latest estimates of genetic differences within the present-day human genome (99.5%) 6. Clearly Neanderthal is fully human; however, since his DNA markers do not exactly align with any present-day family groups or any post-flood family groups, he must be placed as antediluvian man, our pre-flood ancestor. Note: these DNA markers (single nucleotide polymorphism-SNPs) constitute only 0.3% of the human genome 7 and are useful in determining parentage.

Y-chromosome and mitochondrial sequences

To better understand how the mitochondrial and Y-chromosomal DNA supports our position, consider our version of the human family tree:

Figure 1. Human Family Tree

The family tree above shows that the roots of the tree represent the Neanderthals; the stump represents Noah and his family; and the branches and leaves represent us, the present day nations and family groups. The trunk of the tree represents the genetic reset performed by God during or just after the flood; this reset set in motion human DNA compatible with the new ecosystem and lifespan 11. Neanderthal fossils have been found in France, Germany, Spain, Italy, Croatia, Russia, Siberia, Iraq, Israel, Belgium, and Uzbekistan. These Neanderthals are all offspring of Adam and Eve. The Neanderthals died in the flood with the exception of Noah and his family. Since the post-flood ecosystem and human lifespan were much different than the original ecosystem and lifespan, God performed a genetic reset preparing humanity for the new environment and lifespan. One would expect that human DNA sequences prior to Noah and his family would be very similar, but not align exactly with any post-flood nation or family group. And they dont.

A portion of Y-chromosome data has been extracted from Neanderthal fossils. As expected, these sequences do not align exactly with any modern man Y-chromosome nation or family group 8. If they did, one would conclude that Neanderthal was post-flood. But they do not, and, therefore, must be the root. This is a very significant finding for which we have been anxiously waiting. Now, we know that, like the mitochondrial DNA, Y-chromosomal DNA shows that Neanderthals are fully human but are the roots of the tree, not the branches and leaves.

Also, now that we have the full mitochondrial sequences, we find that they, like the Y-chromosome sequences, support our original conclusions: Neanderthal is antediluvian man.

Ruddy/Rosy Complexion

We, at Genesis and Genetics, have concluded that Adam and Eve had red hair and rosy complexions. This conclusion was reached due to the fact that God gave Adam his name which means red. The accompanying rosy complexion is compatible with the pre-flood atmosphere. Just lately, using advanced sequencing tools, scientists have found that two Neanderthal fossils had genes for red hair and ruddy complexions 9. It is difficult to find Neanderthal DNA with these genes intact, so, as far as I know, these are the only two tested for red hair and rosy complexions. It is also, noteworthy that these Neanderthals came from two different locations: one from Spain and the other from Italy. Our model predicts that Neanderthal would, like Adam and Eve, require complexions compatible with the pre-flood atmosphere.

Cannibalism

A recent excavation of a site in Belgium has added evidence to the existing view that Neanderthals were sometimes cannibals 10. There are accounts of modern human acts of cannibalism; however, they overwhelmingly occur when humans are forced to choose between cannibalism and starvation. During the flood, the Bible implies that all humanity didnt die at once, and some could have survived for many months in the water (Genesis 7:19-24). The Neanderthal, being very intelligent, would be in boats, on rafts, or clinging to the large floating mats of debris; but faced with starvation they may very well have resorted to cannibalism. The caves, being the flood drainage pipes, would and do harbor the evidence of this cannibalism.

Summary

Evidence continues to accumulate that Neanderthals were the offspring of Adam and Eve, and our pre-Noah ancestors. Our version of the human family tree is presented above; had it not been for Adams sin, it would look quite different; but Adam did sin and Noah found grace in the eyes of the Creator, thereby forming the bottleneck (family tree stump). Then God chose to make changes in human physiology, including reduced lifespan, all of which required a genetic reset (the trunk of the family tree). Here is a summary of the additional evidence for our version of the family tree:

(1) Neanderthal has the FOXP2 gene identical to present-day humans indicating that they had human speech capabilities.

(2) Neanderthal DNA signature is incongruous with any modern nation or family group. This is true for both Mitochondrial DNA (inherited from the mother) and Y-Chromosome DNA (inherited from the father). The only place available for Neanderthal on the family tree is the roots, our roots.

(3) Neanderthal fossils show evidence of cannibalism. Human cannibalism has a history of occurring primarily when there is some catastrophic event which deprives them of food.

(4) The Neanderthal DNA, so far tested, show evidence of red hair and ruddy complexions which would be compatible with the pre-flood atmosphere and the name God gave Adam.

(5) The similarities of the present-day human and Neanderthal DNA coupled with the fact that they each have unique DNA markers, positions Neanderthal correctly in Biblical history as antediluvian man.

Note: Our former work and evidence can be found here for the blog http://www.genesisandgenetics.org/2013/11/08/177/ and here for the technical paper http://www.genesisandgenetics.org/Neanderthal_Identity.pdf

We will keep you posted as we find more evidence for our position. We do have more compelling evidence for our model which concerns Neanderthal and carbon dating. This will be published soon. You may subscribe here if you would like to be on our mailing list.

Keywords: antediluvian, pre-flood man, Neanderthal, Neanderthals place in human history, Biblical Neanderthal, Neanderthal Bible, Bible Neanderthal, Neanderthal in the Bible

References:

(1) http://www.genesisandgenetics.org/Neanderthal_Identity.pdf

(2) http://www.nature.com/news/2007/071018/full/news.2007.177.html

(3) https://www.ncbi.nlm.nih.gov/gene/93986

(4) http://www.pnas.org/content/105/37/13764.abstract

(5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583069/

(6) journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0050254

(7) https://ghr.nlm.nih.gov/primer/genomicresearch/snp

(8) https://www.ncbi.nlm.nih.gov/pubmed/27058445

(9) https://www.ncbi.nlm.nih.gov/pubmed/17962522

(10) https://www.nature.com/articles/srep29005

(11) http://www.genesisandgenetics.org/2016/11/03/divine-genetic-resets/

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Peer Reviewed Genetics and Molecular Biology Journals …

Posted: September 5, 2018 at 7:41 pm

List of Genetics & Molecular Biology Conferences 2nd Annual summit on Cell Signaling and Cancer Therapy September 19 - 20, 2018 Philadelphia, USA5th World Congress on Synthetic Biology and Advanced Biomaterials September 19-20, 2018 Tokyo, Japan2nd Annual summit on Cell Metabolism and Cytopathology September 19 - 20, 2018 Philadelphia, USA5th International Conference on Human Genetics and Genetic Diseases September 21-22, 2018 Philadelphia, USA11th International Conference on Genomics and Pharmacogenomics September 21-22, 2018 Philadelphia, USA10th Annual Conference on Stem Cell and Regenerative Medicine October 08-09, 2018 Zurich, Switzerland21st European Biotechnology Congress October 11-12, 2018 Moscow, Russia11th Annual Conference on Stem Cell and Regenerative Medicine October 15-16, 2018 Helsinki, FinlandAnnual Congress on Cellular Therapies, Cancer, Stem Cells and Bio Medical Engineering October 17-18, 2018 New York, USA11th International Conference on Tissue Engineering & Regenerative Medicine October 18-20, 2018 Rome, Italy4th International Conference on Synthetic Biology and Tissue Engineering October 18-19, 2018 Rome, Italy24th Biotechnology Congress: Research & Innovations October 24-25, 2018 Boston, USAAnnual congress on CRISPR-Cas9 Technology and Genetic Engineering October 24-25, 2018 Boston, USA2nd Annual Summit on Cell Therapy, Tissue Science and Regenerative Medicine November 9-10, 2018 Atlanta, USA2nd Annual Summit on Stem Cell Research, Cell and Gene Therapy November 9-10, 2018 Atlanta, USA12th International Conference & Exhibition on Tissue Preservation, Life care and Biobanking (B2B & Networking) November 9-10, 2018 Philadelphia, USA9th International conference on Tissue Science and Regenerative Medicine November 12-13, 2018 Singapore City, Singapore4th International Conference on Advances in Biotechnology and Bioscience November 15-17, 2018 Berlin, Germany5th World Congress on Epigenetics and Chromosome November 15-16, 2018 Istanbul, Turkey22nd World Congress on Biotechnology November 19-20, 2018 Bangkok, ThailandInternational Epigenetics and Epitranscriptomics Conference November 26-27, 2018 Helsinki, Finland8th International Conference on Cell & Gene Therapy November 27-28, 2018 Athens, Greece3rd World Biotechnology Congress Dec 03-04, 2018 Sao Paulo, BrazilInternational Conference on Biotechnology and Health Care December 06-07, 2018 Hanoi, Japan11th World Congress on Cell Science, Stem Cell Research & Regenerative Medicine December 07-08, 2018 Chicago, USA13th Annual Conference on Stem Cell & Regenerative Medicine March 07-09, 2019 Nice, France12th World Congress on Cell & Tissue Science March 11-12, 2019 Singapore City, Singapore14th International Conference on Metabolomics and Enzymology March 18-19, 2019 New York, USA2nd World Congress on Cell and Structural Biology March 20-21, 2019 Sydney, Australia 9th International Conference and Exhibition on Advanced Cell and Gene Therapy March 21-22, 2019 Rome, Italy11th World Congress and Expo on Cell & Stem Cell Research March 25-26, 2019 Orlando, USA6th World Congress on Human Genetics and Genetic Diseases April 08-10, 2019 Abu Dhabi, UAE9th World Congress on Plant Genomics and Plant Sciences April 11-12, 2019 Wellington, Newzealand12th International Conference on Genomics and Molecular Biology April 15-17, 2019 Berlin, Germany7th International Conference on Integrative Biology April 15-16, 2019 Berlin, Germany14th International Conference on Tissue Science , Engineering & Regenerative Medicine April 22-23, 2019 Vancouver, CanadaInternational Conference on Cord Blood Banking and Stem cell April 22-23, 2019 Vancouver, Canada12th World Conference on Human Genomics and Genomic Medicine April 22-23, 2019 Abu Dhabi, UAE14th International Conference on Tissue Engineering & Regenerative Medicine April 29-30, 2019 Amsterdam, Netherlands25th Asia Pacific Biotechnology Congress May 01-02, 2019 Kyoto, Japan7th Asia Pacific Plant Biology and Plant Science Congress May 01-02, 2019 Seoul, South Korea10 th Tissue Repair and Regeneration Congress June 10-12, 2019 Helsinki, Finland6th Annual Congress on Biology and Medicine of Molecules June 10-12, 2019 Helsinki, Finland2nd Annual Biotechnology Congress July 29-30, 2019 Chicago, USAMolecular Medicine 2019 Dubai, UAEGenetics Stemcell 2019 Tokyo, JapanInternational Cystic Fibrosis Conference: A cure for all September 20-21, 2018 Dubai, UAE

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Stem Cells and Sports Injuries – Honolulu Hawaii

Posted: September 5, 2018 at 3:44 am

Stem cell research can almost seem too good to be true. The ability to regenerate entire organs or cure blindness may be years or decades away from practical application but orthopedics stem cell research for sports injury are a reality today. The promise of avoiding expensive, painful orthopedic procedures with extended recovery times lies in stem cell therapy. Pro athletes have been looking to stem cell therapy regularly for years now with extremely positive results Pro Athletes and Stem Cells. Most of our stem cell patients have had an almost immediate marked decrease in inflammation, pain and freedom of movement. Many of our chronic joint pain patients have experienced incredible progress and dramatic improvement in quality of life in their ability to increase activity.

To determine if your a good candidate for stem cell therapy, call or contact us to schedule a consultation with our stem cell specialist.

All of our stem cell treatments follow the same sterile closed surgical protocol set forth by our international stem cell network CSN. The process generally entails removing a small amount of fat from the patients abdominal region through a tiny incision. We then isolate the undifferentiated cells from the adipose fat cells. The stem cells are then injected into the damaged areas of the body to initiate healing. The treatment is an out patient procedure done under local anesthetic.

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STEM CELL THERAPY – Orthopedic and Wellness Maryland

Posted: September 5, 2018 at 3:44 am

Orthopedic and Wellnessis proud to introduce a new Regenerative Medicine Therapy offering: Autologous Stem Cell Treatment.

Regenerative Medicine is an exciting and revolutionary field of orthopedics and sports medicine. It involves the application of biological therapies that enhance the bodys ability to heal itself.

What is Stem Cell Therapy?

Stem Cell Therapy involves the therapeutic use of special cells derived from the adult patients own tissues. These stem cells, more specifically referred to as Mesenchymal Stem Cells (MSCs), have the capacity to differentiate into a variety of cell types, including bone, cartilage and muscle. MSCs are therefore responsible for the regeneration (replacement) and healing of the old injured tissue.

How Are Stem Cells Obtained?

We harvest MSCs for injection therapy in our state-of-the-art surgical center. MSCs are usually obtained from the bone marrow or fat tissue.

We stringently follow FDA guidelines for the clinical use of stem cells. We do not expand, reproduce, or grow stem cells in a culture.

What Conditions Are Indicated for Stem Cell Treatment?

What is the Protocol of Stem Cell Treatment?

The treatment plan is tailored to meet the needs of each individual patient. Orthopedic and Wellness offers Stem Cell Treatment in conjunction with PRP Therapy Treatment. PRP provides cell signals and nourishment to help the stem cells flourish and to develop into new cartilage, ligaments and tendons. The relationship is akin to fertilizer and seeds used in gardening.The injection of stem cells may need to be repeated between 1-5 years in order to maintain and improve the result from the first treatment.

We provide a free consultation for new patients who are considering these treatments.The individual patients protocol will be formulated during the consultation.

When Can I expect to See Improvement?

On average, most patients start to see signs of improvement approximately 6-8 weeks after treatment. The most striking results can present in the form of less overall pain, an increased ability to do more activity, or a faster than normal recovery from pain.

Are There Risks Related to Stem Cell Treatment?

Because the Stem Cells are obtained from the patient undergoing treatment (ie the patient is both the stem cell donor and the recipient), there is no risk of tissue rejection or infection from other donors. No report of significant risk related to Stem Cell Treatment has been found. The potential complications associated with Stem Cell Treatment are similar to that from regular joint injections.

Is Stem Cell Treatment Covered by Insurance?

Currently, Stem Cell Treatment is still considered experimental. Most insurance plans, including Medicare, do not pay for this treatment.

What is the cost of Stem Cell Treatment?

We are offering an introductory price to make this regenerative treatment affordable to most patients. The price may be subject to change in the future. Please call our offices to request additional information regarding pricing for this revolutionary therapy.

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Patient Resources | University of Maryland School of Medicine

Posted: September 5, 2018 at 3:44 am

There are many online sources that provide information on stem cells. Each question below has a few links with the most relevant information. The sources are from government agencies, the University of Maryland, and the International Society for Stem Cell Research.

Stem Cells: The Future of Medicine

Stem cell research is transforming the future of medicine. Indeed, as we all begin life as a stem cell, it is through a highly complex series of events that those few stem cells, which are capable of self-renewal and differentiation, develop into all of the specialized cells found in our adult bodies. By studying these events we gain rare insights into how the human body is made. Stem cell research also holds amazing potential for restructuring the way we practice medicine: One day, stem cells may be used to replace or repair damaged tissues and organs and to dramatically alter how we treat diseases like cancer.

There are many areas in medicine in which stem cell research could have a significant impact. For example, there are a variety of diseases and injuries in which a patient's cells or tissues are destroyed and must be replaced by tissue or organ transplants. Stem cells may be able to generate brand new tissue in these cases, and even cure diseases for which there currently is no adequate therapy. Diseases that could see revolutionary advances include Alzheimer's and Parkinson's disease, diabetes, spinal cord injury, heart disease, stroke, arthritis, cancer, and burns.

Stem cells could also be used to gain a better understanding of how genetics work in the early stages of cell development. This can help scientists understand why some cells develop abnormally and lead to medical problems such as birth defects and cancer. By understanding the genetic basis for cell development, scientists may learn how to prevent some of these diseases.

Finally, stem cells may be useful in the testing and development of drugs. Because stem cells can be used to create unlimited amounts of specialized tissue, such as heart tissue, it may be possible to test how drugs react on these specialized tissues before trying the drugs on animals and human subjects. Drugs could be tested for effectiveness and side effects more rapidly.

The University of Maryland School of Medicine is at the forefront of research and development of stem cells for these purposes. Through its University of Maryland Center for Stem Cell Biology and Regenerative Medicine, led by Dr. Curt Civin, the School is exploring how to manipulate stem cells to allow for much better transplantation and transfusion therapies. Its scientists are also working to understand how stem cells contribute to diseases in order to develop ways to improve conventional treatment and prevention of these disorders.

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Combination of traditional chemotherapy, new drug kills …

Posted: September 4, 2018 at 10:46 am

ANN ARBORAn experimental drug combined with the traditional chemotherapy drug cisplatin, when used in mice, destroyed a rare form of salivary gland tumor and prevented a recurrence within 300 days, a University of Michigan study found.

Called adenoid cystic carcinoma, or ACC, this rare cancer affects 3,000-4,000 people annually, and typically arises in the salivary glands. Its usually diagnosed at an advanced stage, is very resistant to therapy, and theres no cure. People may have read about ACC in the news lately, because elite professional runner Gabe Grunewald is currently undergoing her fourth round of treatment since her 2009 ACC diagnosis.

Typically, oncologists treat ACC tumors with surgery and radiation. They rarely use chemotherapy because ACC is extremely slow-growing, and chemotherapy works best on cancers where cells divide rapidly and tumors grow quickly, said Jacques Nr, a U-M professor of dentistry, otolaryngology and biomedical engineering, and principal investigator on the study.

The Nr lab treated ACC tumors with a novel drug called MI-773, and then combined MI-773 with traditional chemotherapy cisplatin. MI-773 prevents a molecular interaction that causes tumor cells to thrive by disarming the critical cancer fighting protein, p53.

Study co-author Shaomeng Wang, U-M professor of medicine, pharmacology and medicinal chemistry, discovered MI-773, which is currently licensed to Sanofi.

Researchers believe that blocking that interaction sensitized ACC cancer cells to cisplatina drug that under normal conditions, wouldnt work. When administered to the mice with ACC tumors, the cisplatin targeted and killed the bulk cells that form the tumor mass, while MI-773 killed the more resistant cancer stem cells that cause tumor recurrence and metastasis.

This drug MI-773 prevents that interaction, so p53 can induce cell death, Nr said. In this study, when researchers activated p53 in mice with salivary gland cancer, the cancer stem cells died.

The key is that in many other types of cancer, p53 is mutated so it cant kill cancer cells, and this mutation renders the MI-773 largely ineffective. However, in most ACC tumors p53 is normal, and Nr said researchers believe this makes these tumors good candidates for this combined therapy.

Researchers performed two different types of experiments to test ACC tumor reduction and recurrence. First, they treated tumors in mice with a combination of MI-773 and cisplatin, and tumors shrank from about the size of an acorn to nearly zero.

In the second experiment, the acorn-sized tumors were surgically removed, and for one month the mice were treated with MI-773 only, with the hope of eliminating the cancer stem cells that fuel recurrence and metastasis.

We did not observe any recurrence in the mice that were treated with this drug after 300 days (about half of mouse life expectancy), and we observed about 62 percent recurrence in the control group that had only the surgery, Nr said. Its our belief that by combining conventional chemotherapy with MI-773, a drug that kills more cancer stem cells, we can have a more effective surgery or ablation.

One limitation of the study is that its known that about half of all ACC tumors recur only after about 10 years, and this observational period was only 300 days.

In a typical metastasis, the cancer cells spread through the blood to other parts of the body. But ACC cancer cells like to move by crawling along nerves, and its common for ACC tumor cells to follow the prominent facial nerves to the brainpicture a mountain climber ascending a ropewhere its often fatal.

Research is still too early-stage to know how humans will respond, and the drug will work primarily in tumors where p53 is normal. If p53 is mutated, which is fairly common in other tumor types, this drug wont work as well, Nr said.

The work was funded by the Adenoid Cystic Carcinoma Research Foundation, U-M and the National Institutes of Health.

The study, Therapeutic Inhibition of the MDM2-p53 interaction prevents recurrence of adenoid cystic carcinomas, appeared earlier this year in the journal Clinical Cancer Research.

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