Monthly Archives: October 2022

SIMATS organizes Induction Ceremony – Afternoonnews – Afternoon News

Posted: October 4, 2022 at 2:14 am

Saveetha Institute of Medical and Technical Sciences (SIMATS) organized the induction ceremony to welcome the Second batch of students who have joined the M.Tech/M.Sc programme in Molecular Medicine for the session 2022-24 was held recently.

Prof. (Dr) Suresh Kumar Rayala, Chairman of GATE/JAM and Professor Department of Biotechnology, IIT Madras, Chennai was the chief guest on the occasion. The Induction ceremony was felicitated by Dr. Sheeja Varghese, Registrar, SIMATS and Dr Aravind Kumar, Dean, Saveetha Dental College and Hospitals, Chennai.

SIMATS started this programme in 2021 for the first time in the state of Tamil Nadu. This course in Molecular Medicine is an interdisciplinary programme with an emphasis on 12 months of dissertation/research work. The programme expands upon the scientific and medical knowledge acquired in bachelor programmes and explores in-depth molecular aspects of medicine.

It should enable students to engage in independent and creative research at the crossroads of medicine and basic science. This year students from diverse fields including graduates and postgraduates in Medicine, Dentistry, Life sciences and Allied Health Sciences joined the programme.

Read this article:
SIMATS organizes Induction Ceremony - Afternoonnews - Afternoon News

Posted in Molecular Medicine | Comments Off on SIMATS organizes Induction Ceremony – Afternoonnews – Afternoon News

The Global Testosterone Replacement Therapy Market is

Posted: October 4, 2022 at 2:13 am

New York, Sept. 13, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Testosterone Replacement Therapy Market 2022-2026" - https://www.reportlinker.com/p04046949/?utm_source=GNW 1% during the forecast period. Our report on the testosterone replacement therapy market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.The report offers an up-to-date analysis of the current global market scenario, the latest trends and drivers, and the overall market environment. The market is driven by initiatives to increase awareness about hypogonadism among population, rise in chronic diseases, and untapped potential in developing countries.The testosterone replacement therapy market analysis includes the product segment and geographic landscape.

The testosterone replacement therapy market is segmented as below:By Product Injectables Topicals Others

By Geographic North America Europe Asia Rest of World (ROW)

This study identifies the rise in novel therapeutic approaches as one of the prime reasons driving the testosterone replacement therapy market growth during the next few years. Also, patient assistance programs and the development of new therapies will lead to sizable demand in the market.

The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters. Our report on the testosterone replacement therapy market covers the following areas: Testosterone replacement therapy market sizing Testosterone replacement therapy market forecast Testosterone replacement therapy market industry analysis

This robust vendor analysis is designed to help clients improve their market position, and in line with this, this report provides a detailed analysis of several leading testosterone replacement therapy market vendors that include AbbVie Inc., Acerus Pharmaceuticals Corp., Acrux Ltd., Actiza Pharmaceutical Pvt. Ltd., Antares Pharma Inc., Aytu BioPharma Inc., Bausch Health Co. Inc., Bayer AG, BIOTE MEDICAL LLC, Cipla Ltd., Clarus Therapeutics Inc., Eli Lilly and Co., Endo International Plc, Novartis AG, Pfizer Inc., Sun Pharmaceutical Industries Ltd., Teva Pharmaceutical Industries Ltd., The Simple Pharma Co. UK Ltd., Upsher Smith Laboratories LLC, and Viatris Inc. Also, the testosterone replacement therapy market analysis report includes information on upcoming trends and challenges that will influence market growth. This is to help companies strategize and leverage all forthcoming growth opportunities.The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.

The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters such as profit, pricing, competition, and promotions. It presents various market facets by identifying the key industry influencers. The data presented is comprehensive, reliable, and a result of extensive research - both primary and secondary. Technavios market research reports provide a complete competitive landscape and an in-depth vendor selection methodology and analysis using qualitative and quantitative research to forecast accurate market growth.Read the full report: https://www.reportlinker.com/p04046949/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

__________________________

Here is the original post:
The Global Testosterone Replacement Therapy Market is

Posted in Testosterone Replacement Therapy | Comments Off on The Global Testosterone Replacement Therapy Market is

Hypogonadism in Men | Endocrine Society

Posted: October 4, 2022 at 2:13 am

Hypogonadism is a common condition in the male population, with a higher prevalence in older men, obese men, and men with type 2 diabetes. It is estimated that approximately 35% of men older than 45 years of age and 30-50% of men with obesity or type 2 diabetes have hypogonadism.

Testosterone is an important sex hormone in men. It is secreted by the testes and is responsible for the typical male characteristics, such as facial, pubic, and body hair as well as muscle. This hormone also helps maintain sex drive, sperm production, and bone health. The brain and pituitary gland (a small gland at the base of the brain) control the production of testosterone by the testes.

Be open with your doctor about your medical history, all prescription and nonprescription drugs you are now taking, sexual problems, and any major changes in your life. Your doctor will take a thorough history of your symptoms and then complete a physical exam, including your body hair, breast tissue, and the size and consistency of the testes and scrotum.

Your doctor will also use blood tests to see if your total testosterone level is low. The normal range depends on the lab that conducts the test. To get a diagnosis of hypogonadism, you need at least two early morning (710 AM) blood tests that reveal low testosterone in addition to signs and symptoms typical of low testosterone. The cause of hypogonadism can be investigated further by your doctor. This might include additional blood tests, and sometimes imaging such as a pituitary MRI.

Male hypogonadism is a combination of low testosterone levels and the presence of any of these symptoms:

Over time, low testosterone may cause a man to lose body hair, muscle bulk, cause weak bones (osteoporosis), low red blood cells and smaller testes. Signs and symptoms (what you see and feel) vary from person to person.

There are many causes of hypogonadism. They may involve a problem with the testes or with the signal from the brain that controls testosterone secretion. Low testosterone can result from:

Improvement of testosterone levels can improve sexual concerns, bone health, muscle and anemia (low red cells in the blood). Hypogonadism can be treated with the use of doctor-prescribed testosterone replacement therapy. This treatment is safe and can be effective for men who are diagnosed with consistently abnormal low testosterone production and symptoms that are associated with this type of androgen (hormone) deficiency.

Although testosterone replacement therapy is the primary treatment option, some conditions that cause hypogonadism, such as obesity, can be reversible without testosterone therapy. These should be addressed before testosterone therapy is contemplated. If testosterone therapy is needed, goals of treatment are to improve symptoms associated with testosterone deficiency and maintain sex characteristics.

There are many different types of testosterone therapy. Method of treatment depends on the cause of low testosterone, the patients preferences, cost, tolerance, and concern about fertility. You should discuss the different options with your physician "your partner in care" to find out which therapy is right for you.

Injections: Self or doctor administered in a muscle every 12 weeks; administered at a clinic every 10 weeks for longer-acting. Side effects: uncomfortable, fluctuating symptoms.

Gels/Solutions: Applied to upper arm, shoulder, inner thigh, armpit. Side effects: may transfer to others via skin contact must wait to absorb completely into skin.

Patches: Adhere to skin every day to back, abdomen, upper arm, thigh; rotate locations to lessen skin reaction. Side effects: skin redness and rashes.

Buccal Tablets: Sticky pill applied to gums twice a day, absorbs quickly into bloodstream through gums. Side effects: gum irritation.

Pellets: Implanted under skin surgically every 36 months for consistent and long-term dosages. Side effects: pellet coming out through skin, site infection/ bleeding (rare), dose decreasing over time and hypogonadism symptoms possibly returning towards the end of dose period.

Nasal Gel: Applied by pump into each nostril 3x a day. Side effects: nasal irritation or congestion.

Sometimes a medication called clomiphene citrate is used to treat hypogonadism, but this is not FDA approved for this indication. A thorough discussion is needed with your doctor.

You should discuss with your physician how to monitor for prostate cancer and other risks to your prostate. Men with known or suspected prostate or breast cancer should not receive testosterone therapy. You should also talk to your doctor about the risks of testosterone therapy if you have, or are at risk for, heart disease or stroke. In addition, if you are planning fertility, you should not use testosterone therapy.

You should not receive testosterone therapy if you have:

Possible risks of testosterone treatment include:

If you are treated with testosterone, your doctor will need to see you regularly, along with blood tests.Testosterone therapy is only recommended for hypogonadism patients. Boosting testosterone is NOT approved by the US Food and Drug Administration (FDA) to help improve your strength, athletic performance, physical appearance, or to treat or prevent problems associated with aging. Using testosterone for these purposes may be harmful to your health.

There is no firm scientific evidence that long-term testosterone replacement is associated with either prostate cancer or cardiovascular events. The FDA requires that you are made aware that the possibility of cardiovascular events may exist during treatment. Prostate cells are stimulated by testosterone, so be extra vigilant about cancer screenings. African American men over age 45 especially those with family history of cancer are already at risk for prostate cancer.

See the rest here:
Hypogonadism in Men | Endocrine Society

Posted in Testosterone Replacement Therapy | Comments Off on Hypogonadism in Men | Endocrine Society

Dr. Roach: Testosterone injections most likely led to severe stroke – Detroit News

Posted: October 4, 2022 at 2:13 am

Dear Dr. Roach: My 75-year-old husband was frustrated with not being able to retain an erection. He talked to his doctor about it, and she prescribed 200 mg of testosterone cypionate, which he would inject into his bottom once a week. He did this for four months, and then had a severe bilateral stroke (as in, he does not know where he is, what happened to him, cannot read or write, cannot walk, etc.).

After spending two weeks in the ICU, he went to a rehabilitation hospital for three weeks. The hematologist there told me his hemoglobin level was up to 20, and there was no reason a 75-year-old should have been prescribed testosterone when it can elevate his hemoglobin so much.

What are the normal protocols for testosterone with older men? Could his testosterone injections have led to his stroke?

D.H.

Dear D.H.: Testosterone replacement therapy is commonly prescribed to men in their 70s and 80s. Elevations of the hemoglobin levels are certainly well-described, but levels above normal only happen about 1% of the time. Experts recommend checking a blood count to look for these elevations three to six months after starting treatment. Testosterone should be stopped if the hemoglobin level is above normal.

Sometimes, there are other causes for the hemoglobin to go up, but a rise that high, when he had never had it before, makes it seem very likely to me that the testosterone was the cause. A hemoglobin level that high, from any cause, is a risk for stroke and heart attack. It is very possible the testosterone prescription led directly to the stroke.

I am publishing this in the column so that men who are taking testosterone know they should be periodically tested for this unusual complication.

Dear Dr. Roach: I had carpal tunnel surgery two years ago. I now have trigger fingers in my index and ring fingers. I had cortisone injections but that didnt cure it. I, at one point, was not able to open my fingers. Now, my fingers are really stiff, and I cant bend them. Surgery was suggested. Im hesitant, because Im wondering if this will get better on its own with exercises.

J.T.

Dear J.T.: Trigger finger is caused by the tendon getting stuck inside one of the pulleys of the hand. To the best of my knowledge, carpal tunnel surgery doesnt predispose to trigger finger, but there are some conditions that put people at risk for both conditions. Initial treatment of trigger finger is conservative, with splinting and anti-inflammatory drugs.

If that doesnt work, injection of cortisone by a hand surgeon is usually successful.

Most of the hand surgeons I know will try injection three times before recommending surgery. Unfortunately, postponing surgery too long can lead to the finger getting a contracture, where it will not straighten at all.

Readers may email questions to ToYourGoodHealth@med.cornell.edu.

Go here to read the rest:
Dr. Roach: Testosterone injections most likely led to severe stroke - Detroit News

Posted in Testosterone Replacement Therapy | Comments Off on Dr. Roach: Testosterone injections most likely led to severe stroke – Detroit News

Foods That Boost Testosterone: 7 Options and How They Work – Healthgrades

Posted: October 4, 2022 at 2:13 am

Testosterone is essential for your reproductive and general health. Certain foods and lifestyle changes may encourage your body to produce more of this hormone.As you age, your bodys testosterone production naturally decreases, according to 2022 research. Some medications and health conditions can also cause low levels of testosterone.

Low testosterone, also known as hypogonadism, can affect your bone health, sex drive, and mood.

Regardless of what causes the decrease, it is important to work with a medical professional to return your levels to a healthy range for you. In some cases, you may need testosterone replacement therapy, but you can also try to increase this hormone naturally.

Keep reading to learn which foods to eat and which to avoid to increase your bodys testosterone production.

Research suggests that honey enhances serum testosterone levels in males. Serum testosterone refers to testosterone found in the blood.

In a peer review of studies from 2019, researchers found that honey may enhance the bodys luteinizing hormone production. The luteinizing hormone stimulates testosterone production.

Other factors, like honeys antioxidant properties, may enhance the performance of Leydig cells. These cells are responsible for testosterone production.

Consuming eggs may increase your testosterone levels, but make sure you consume the yolk. The yolk of one medium egg contains about 225 milligrams (mg) of cholesterol. Your body uses cholesterol to make testosterone.

One 2021 study examined the effect of consuming just egg whites versus whole eggs. In the study, the group who consumed whole eggs experienced an increase in testosterone levels.

A 2021 study indicates that diets low in beans and legumes may have links to low testosterone levels.

Researchers in 2020 also linked low zinc levels to hypogonadism in males. Separately, researchers in 2018 linked low protein intake to hypogonadism in a study on rats.

Beans and legumes are high in protein and zinc.

In fact, 100 grams (g) of dried black beans contain 24.4 g of protein and 3.37 mg of zinc. For reference, the National Institutes of Health (NIH) recommends 11 mg of zinc for males and 8 mg for females daily.

The amount of protein you need varies based on your activity level and body weight, per 2016 research.

Research suggests that magnesium increases free and total testosterone values in males. Free testosterone refers to testosterone that, unlike most of your testosterone, is not bound to a protein in your blood.

One particular 2014 study demonstrated an increase in magnesium consumption leads to an increase in testosterone in men. The increase occurred in both athletes and people who live a sedentary lifestyle.

Dark leafy greens and vegetables contain high magnesium levels. In fact, 100 g of spinach contains 93 mg of magnesium.

The NIH recommends 400420 mg of magnesium daily for males and 310320 mg for females.

Avocados are another good source of magnesium. The U.S. Department of Agriculture reports that 100 grams of avocado contain 29 mg of magnesium.

There is also another reason why avocados may increase testosterone. A 2015 research review states that this fruit contains boron, a chemical element linked with increased testosterone.

Increased boron intake may relate to higher levels and better use of testosterone in the body, according to the same review.

However, a 2018 study suggests that supplementing with boron supplementation is likely ineffective for increasing testosterone levels specifically for athletic performance purposes.

One 2020 study found a correlation between fish oil supplementation and higher free testosterone in males. Other research from 2020 also suggests a positive relationship between DHA-enriched fish oil and increased testosterone in males.

You do not need to take a supplement to get fish oil into your diet. Fatty fish contain high levels of fish oil.

Types of fatty fish include:

A 2018 study by researchers at Taipei Medical University suggests that following a diet high in Western-style foods may decrease serum testosterone levels. These Western-style foods include bread, pastries, dairy products, and desserts.

The study participants who ate diets high in these foods and ate out often had lower serum testosterone levels.These diets were also low in homemade meals and leafy greens.

Learn more about low testosterone levels.

Exercising is good for your overall health, including your hormone health, 2020 research suggests. Avoiding testosterone-affecting behaviors can also help increase levels naturally.

One peer review of studies in 2016 examined the effects of smoking cigarettes and testosterone levels. The results suggest that smoking cigarettes may actually increase testosterone levels in males. This is because nicotine prevents your body from disposing of testosterone.

Yet other researchers in an older 2007 study noted that this correlation might mask borderline hypogonadism.

Read our tips for quitting smoking.

BPA exposure can also decrease testosterone in males, a 2019 research review suggests. Avoiding plastics with this chemical may help with low levels.

Learn more about BPA plastics.

Fish oil, zinc, and magnesium supplements may increase testosterone. You should always consult with your doctor before starting a new supplement. Additionally, taking certain testosterone-boosting supplements may pose a health risk, according to a 2018 case report.

The Food and Drug Administration (FDA) does not extensively regulate dietary supplements. Contact your doctor before starting use.

Here are some frequently asked questions about testosterone.

How can I raise my testosterone levels fast?

Eating a nutrient-rich diet, exercising, and avoiding activities that lower your testosterone levels may help raise your testosterone levels quickly.

Hormone replacement therapy may be the fastest option for aging males experiencing symptoms of low testosterone, per 2021 research.

Does milk increase testosterone?

There is conflicting information on whether milk increases testosterone. Researchers at the National Taipei University of Nursing and Health Sciences hypothesized in 2021 that low fat dairy products may have a positive effect on male fertility, whereas full fat dairy products may have a negative effect.

Yet they note that more research is necessary to draw a conclusion.

Nutrient- and antioxidant-rich foods may boost your bodys ability to produce testosterone. Eating a diet high in fatty fish, avocados, and leafy greens can have a positive effect on your overall health.

Other natural methods for increasing your testosterone include exercising. While some supplements may improve your testosterone levels, you should talk with your doctor before taking any of these.

Read the original post:
Foods That Boost Testosterone: 7 Options and How They Work - Healthgrades

Posted in Testosterone Replacement Therapy | Comments Off on Foods That Boost Testosterone: 7 Options and How They Work – Healthgrades

Shirley Ballas on her difficult experience with menopause – Good Housekeeping

Posted: October 4, 2022 at 2:13 am

Strictly Come Dancings Head Judge Shirley Ballas has forged a glittering career to date and is gracing our screens once more, as the latest celebrities take to the dance floor for a new Strictly series.

But, as Shirley explains in her own words, its not all baubles, bangles and beads. Behind the scenes, Shirley has been managing her ongoing menopause journey, and she describes the early part of her experience as one of the darkest periods of her life.

Following her own difficulties, Shirley decided to speak out to help other women and has now joined the new Menopause Your Way campaign with QVC.

According to research commissioned by the campaign, only one in 10 women feel prepared for the landmark change. Of those who believed they knew what symptoms to expect, two in five still felt they did not have a clear understanding of how to manage them.

Here, Shirley opens up to Good Housekeeping about her experience with menopause, how she found support and where she is on her journey today.

I didnt know what was wrong to begin with, I didnt put the menopause tag on it. It started with all those sweats and the bad skin and generally feeling low all the time. It was overwhelming.

I can only say it feels like a volcano in your tummy, and it goes all the way up and starts erupting. You start sweating, you're uncomfortable, you're agitated. I didn't want to go out anymore, I was struggling to go to work. Doctors gave me anti-anxiety medication and then they gave depression medicine, nobody understood it.

Your body starts to change during menopause, it gets a little more rounded because it starts to protect itself and thats absolutely fine. But at the time, I didnt know why I was gaining weight when Id always been physically fit.

My skin was drying out, my nails were chipping, I felt dehydrated all the time and I had no libido.

It was my son, Mark, who first sat me down and said, Okay, lets talk about it. He was willing to take a whole afternoon to listen to me. He introduced me to his doctor in the United States, where we were living at the time. From there, I started taking bio-identical hormones (an alternative to HRT, hormone replacement therapy) which was life changing.

Allen Berezovsky

Other than my brother taking his own life [Shirleys brother, David, died in 2003 after battling depression], I would say it was one of the other darkest periods of my life. Some women, like my mother, they sail through the menopause, but that certainly wasn't the case for me. I just wanted to get up in the morning and feel better.

Not everyone can take hormones, but I found hormone replacement life changing and I regularly check my oestrogen and testosterone levels with a doctor. Its all about understanding your own body and using a combination of approaches.

Ive always had a healthy way of eating, Ive always exercised. I love yoga and going for a walk in the park. I try to find time for myself, even just half an hour is better than no time at all.

I want women to know that its not all baubles, bangles and beads just because Im seen dressed up in glad rags on a Saturday.

Being on Strictly has given me a platform. I feel like I have a responsibility to try to help women understand what their bodies are going through when they hit menopause at 45 or 50 or whenever they go through it, because early menopause can happen even in your 20s.

I do a lot of work around other causes like cancer and suicide and I feel that menopause is just as a strong conversation that needs to be happening. Thats why I joined the campaign with QVC, to help educate people and move conversations forward.

The key for me is education. This message is not just for women, it's also for men, for workplaces, for families and younger generations. We learn about puberty when were younger, but we dont know about how our bodies will change after that. I think its just as key to understand the whole biological process all the way up until menopause is complete.

If you notice a sudden change in your body, particularly around the age of menopause, then you have to find help. Go and see a doctor because if you start early enough when it comes to taking hormones or accessing support, then it can be a non-frightening experience.

You can also find information to read up on and links for support through the QVC campaign.

We want to help put the message out to help women of all ages and educate the whole family. The people around you need to understand the high and the low moods, the night sweats and whats going on in your body. Dont suffer in silence. Thats the key message, no more suffering.

I would say its ongoing with my hormones but generally, Im in a much better period now than 10 years ago which was horrific. Id say when I was around 57 my body started to balance out.

Of course, Ive been looking forward to the new Strictly series so it's a very exciting period, but Ill still be going to get my hormone levels checked during the Strictly run. Its an ongoing journey.

Shirley Ballas is partnering with QVC UK's Menopause Your Way campaign, to offer reassurance, insight and inspiration to empower women experiencing the menopause.

You can get tickets to join Shirley Ballas for fizz and cake at Good Housekeeping Live in partnership with Dyson on Friday 14 October.

FIND OUT MORE

Read the original post:
Shirley Ballas on her difficult experience with menopause - Good Housekeeping

Posted in Testosterone Replacement Therapy | Comments Off on Shirley Ballas on her difficult experience with menopause – Good Housekeeping

The One Thing This Doctor Says Is A Game Changer When It Comes To Hormones And Aging – TravelAwaits

Posted: October 4, 2022 at 2:13 am

Hormone changes affect everyone, yet 73 percent of women in the U.S. do not seek medical help for menopause, according to the 2021 State of Menopause Study by Bonafide. These changes are one of the top reasons women come to see me. As a functional medicine doctor, Ive helped women manage this stage of their lives for more than 20 years. Its the visible symptoms that bring them in: night sweats or loss of hair. However, there are silent results of changing hormones that are equally as important to address. Before I explain a solution, I want to walk you through why women experience those symptoms, the different types of symptoms, and finally, what you can do to combat some of the issues.

In typical cases, hormones start to change in your early forties. Most women will feel like they have estrogen dominance symptoms. This is not because they make too much estrogen, but rather their ability to make enough progesterone which counters the effects of estrogen slows down. The symptoms may be heavy, irregular, and painful periods, breast tenderness and moodiness, insomnia, painful sex, vaginal dryness, and loss of libido. Symptoms tend to be worse, especially just before they start their period.

Several years later, usually between 48-52 years old, woman transition to menopause. This is a particularly difficult time as women may start having heavy periods off and on, worsening mood swings, highs and lows with irritability, insomnia, hot flashes, night sweats, weight gain, painful intercourse, vaginal dryness, urinary frequency, loss of libido, hair thinning and loss. Then, when a woman hasnt had a period for a year, she has officially entered menopause.

When it comes to hormone changes, women see me for two specific reasons: feelable and invisible symptoms. Feelable symptoms are the ones you can physically feel. These affect your daily life. They can range from hot flashes to night sweats, insomnia to mood swings, irritability to memory loss, and even weight gain and hair loss.

These are symptoms you cannot feel but greatly impact your life. Hormone changes can wreak havoc on your bones and muscles in the form of osteoporosis or osteopenia, leading to hip fractures which can be life-changing. Your cognitive health can decline as well as increasing fears of memory loss and Alzheimers dementia. You may experience heart disease in the forms of high blood pressure and high cholesterol which are leading causes of strokes and heart attacks. Another silent symptom is an increase in insulin resistance leading to belly fat weight gain and diabetes.

Many women feel they just have to deal with all of these changes. That could not be further from the truth. The information Im about to provide can be an absolute game changer in your life.

Bioidentical hormone replacement, as opposed to synthetic hormone replacement, is using hormones like estradiol, that your body recognizes as biologically identical to the hormones that you naturally make. Synthetic hormones, like the ones found in Premarin, come from a horses urine and are not identical to what your body naturally makes.

The old thoughts that hormones are dangerous for you are based on studies done on synthetic hormones that are bad for you. However, Ive found that bioidentical hormones are recognized by your body and it reacts accordingly.

I use specialized testing to look at how a woman is breaking down estrogen. The goal is to make sure her body can process the hormones properly. The next step is to balance hormones using bio-identical estrogen, progesterone, and testosterone. Once a balance is established, there is lab testing before and during to make sure the dosage is correct. Of course, I have follow-up visits to make sure symptoms have improved. When you combine all this together, not only do you not have to live with these menopause symptoms, but you can safely navigate this period of your life and improve longevity and vitality for years to come.

If hormone replacement therapy is done properly, it can reduce the risk of heart attacks, strokes, Alzheimers dementia, and broken hip bones. Not to mention improving quality of life, improving libido, vaginal dryness complaints, insomnia, hot flashes/night sweats, mood stabilization and decreasing risk of depression.

Clinical trials, including Heart and Estrogen/Progestin Replacement Study I and the Womens Health Initiative, have shown that conventional hormone replacement results in increased thrombotic events, an increased risk of breast cancer, and dementia. However, biodentical hormone therapy used by functional medicine doctors do not carry these increased risks.

Using transdermal creams or patches or bioidentical estrogen hormones and progesterone, not progestin, does not afford the same risks. This is why current and more advanced hormone replacement therapy is safer.

I have found additional ways to help my patients navigate their changing hormones. However, you would want to consult your doctor if you have any questions about trying these yourself.

In addition to bioidentical hormone replacement therapy, there are things you can do to limit your symptoms and yes, it does start with your diet. I recommend limiting your processed foods. Essentially, this is anything that comes out of a box or a bag. Try to eat about 3 to 4 cups of vegetables, 1 to 2 servings of fruit, healthy fats, and proteins every day.

Get a good nights sleep, exercise, and make sure you incorporate self-care, like a bath, sauna, or massage to alleviate stress. I also recommend taking magnesium, taurine, NAC, and B complex vitamins to help mitigate some symptoms.

You can help your bone density by doing weight-bearing exercises or joining a club called OsteoStrong. There are some supplements I recommend like Ossopan MD. Its a highly absorbable form of calcium plus essential minerals that you can get from a functional medicine doctor along with Vitamin K2 and D3.

If youre concerned about heart disease, you should limit simple sugars, basically anything white like bread, pasta, candy, and ice cream. The foods I recommend are whole food oils like avocado and olives, proteins, and foods found in the Mediterranean diet. I will also recommend Omega-3 fatty acids, magnesium, CoQ10, niacin, bergamot, berberine, alpha lipoic acid, and taurine based on a specialized lipid study. HITT workouts and intermittent fasting can also help lower your risk for heart disease. Always consult with your doctor first.

The final invisible symptom I would like to address is cognitive decline. In addition to exercise and sleep, I highly recommend Grain Brain by Dr. David Permutter. You can also find other suggestions in my previous article about improving cognitive function.

Hormone changes are inevitable. I strongly recommend arming yourself with information and asking lots of questions. You may have to live with changing hormones, but that does not have to adversely change your life.

Go here to read the rest:
The One Thing This Doctor Says Is A Game Changer When It Comes To Hormones And Aging - TravelAwaits

Posted in Testosterone Replacement Therapy | Comments Off on The One Thing This Doctor Says Is A Game Changer When It Comes To Hormones And Aging – TravelAwaits

What To Know About Perimenopause, And How To Manage Symptoms Once They Kick In – The Zoe Report

Posted: October 4, 2022 at 2:13 am

A few months ago, a friend of mine in her early 40s said she was having hot flashes, mood swings, and a lower sex drive. She wondered if she could be experiencing symptoms of menopause. Youre too young, I thought. But, as it turns out, shes not. After speaking to her OB/GYN, my friend realized she is experiencing perimenopause symptoms of menopause without actual menopause (which is marked by a year without a menstrual cycle). She learned it can start as early as your mid-30s (though mid-40s is more common).

It turned out my friend wasnt alone in her surprise and lack of knowledge of this hormonal phase. Earlier this year, Bonafide, a wellness company that makes non-prescription products to help alleviate common health issues in women, came out with their Second Annual State of Menopause Survey. The goal was is to shed light on the need to destigmatize talking about menopause and perimenopause for that matter. The company surveyed more than 2,000 women ages 40 to 65 about various menopausal-related things, from their knowledge about the process to their general feelings and sentiments surrounding it.

Twenty-five percent were not aware of when perimenopause typically starts while 31% did not know their treatment options. In addition, just 28% knew how to care for themselves during perimenopause before it started.

Ahead, womens health experts weigh in and unpack what, exactly, perimenopause is and how you can best be prepared for it.

Perimenopause begins years before actual menopause, OB/GYN Kecia Gaither, tells TZR in an email. It reflects a period of time when the ovaries begin to gradually make less estrogen and when no more eggs are released by the ovaries. Perimenopause ends when women have gone a year without having a menstrual cycle. She also says its important to note that each woman is different and, as such, perimenopause will occur at different ages. However, in general, perimenopause typically begins for a woman in her 40s. Again, this transition period varies from woman to woman from months in some to a decade or so in others.

Dr. Sherry Ross, womens sexual health expert, and author of she-ology and she-ology the she-quel, agrees. This hormonal change typically happens within a couple years of menopause, which usually happens around age 51, she tells TZR in an email. But for some, it can happen much earlier. Every decade brings about some emotional and physical change, but for women, the decade of ones 40s may pack the biggest punches of all.

Echoing Gaither, Ross says that every woman will experience perimenopause differently, including when the hormonal storm begins. There is also evidence that women who smoke, have a family history of early menopause, undergo treatment for cancer with chemotherapy or radiation, or have a hysterectomy (without removing the ovaries) may experience perimenopause earlier than other women, she explains.

Symptoms of perimenopause are similar to menopause, so you may wonder what the difference is. Perimenopause is a transitional period before and after a woman is still menstruating, but beginning to experience symptoms, Dr. Tamika K. Cross, OB/GYN and pH-D Feminine Health advisor, tells TZR in an email. While menopause is defined as 12 months without a menstrual cycle.

Ross says symptoms may include:

And not every woman will have symptoms, Cross says. This just varies with genetics, but more often than not, there are at least a few of the symptoms experienced, although the severity may vary.

Gaither says diagnosis of perimenopause is made clinically by presenting symptoms and getting your hormonal levels (FSH) checked. Although there is no treatment, per se, she says there are many options to help alleviate symptoms.

It depends on each womans specific situation and medical history, Cross explains. Its important to talk with your doctor to see what options are best for you. Ross also points out that different symptoms will require different treatments.

That said, there are some avenues to explore for specific concerns. For instance, for heavy and irregular periods, The best treatment for this tends to be with hormones, such as low-dose oral contraception (as a way to control erratic periods), says Ross. Experiment with different pills in order to find the one with the least side effects. Other options include cyclic progesterone, IUDs with progesterone, hormone replacement therapy (HRT), and non-hormonal alternatives, such as acupressure and herbal therapy. Ross says your healthcare provider can explain the ins and outs of these, and what may work best for you.

For the dreaded hot flashes, Dressing in layers and staying in cool temperatures are the first steps in dealing with hot flashes, explains Ross. Air conditioning is your friend! Plan ahead. Bring a cooler with ice for your hands or feet. If you know that hot beverages, spicy foods, red wine, and hot climates bring on hot flashes, avoid them (if possible). And she says herbal remedies (more on those below) may include black cohosh and other traditional Chinese medicine. Acupressure may help with mild hot flashes, as well, she adds.

For mood swings, Antidepressants are effective in controlling depression, anxiety, and panic attacks, and a therapist may also give added support, says Ross. And, of course, exercise, the elixir to all. When you exercise, theres a natural release of mood-boosting endorphins and serotonin, the feel-good hormones that your body can naturally produce.

For those experiencing low sex drive, low libido, and/or vaginal dryness, Testosterone therapy may be helpful for a low libido, says Ross. For help with vaginal dryness, lubricants (such as KY and extra virgin coconut oil) are a good and affordable investment. Sometimes, once you gain control of the annoying hot flashes, irregular bleeding, and emotional distress of perimenopause, sexual interest is regained and your libido is rescued. She also points out that there is an FDA-approved medication called Addyi, known as the pink pill for women. It works on neurotransmitters in the brain, including serotonin, dopamine, and norepinephrine, all found to be involved with sexual desire.

When it comes to trying to combat perimenopause or at least manage its effects better a great initial plan of attack against symptoms is with a thoughtful and healthy lifestyle. A well-balanced, and colorful, diet of fruit, vegetables, whole grains, and nuts and a limited amount of saturated fats, oils, sugar, and dairy will help, says Ross. Drinking water, warm or hot, helps relax the uterine muscles, too. In fact, drink as much water as possible, 2-3 liters a day, to help minimize water retention and bloating. She adds that you can also try consuming water-based foods, including berries (strawberries, blueberries), celery, cucumber, lettuce, and watermelon. Adding ginger to hot water is another useful remedy, she says. And find an exercise routine that will keep you interested well beyond this perimenopausal period, too.

If diet and lifestyle changes dont curb the symptoms of perimenopause, Ross says there are some safe alternatives to help you get through your day. There are many scientifically studied herbs and vitamins that can help manage the symptoms, so you can avoid prescription medications given to you by your healthcare provider, she explains. Passion flower extract, chasteberry, royal jelly, ashwagandha, and maca root are some of the more researched herbs that can actually improve your symptoms and life. She notes that herbs are not FDA-approved like pharmaceutical medications, but that using a well-regulated manufactured herbal supplement can achieve the same effects as prescription medication. And they will safely treat hormonal unrest caused by perimenopause, she adds. Vitamins are important, too. Ross suggests taking calcium, vitamins E and D, thiamine, magnesium, and omega 3-fish oil to help relieve the period bloat and swelling.

Getting a good nights sleep is imperative, too. Hot flashes can mess with ones sleep patterns, Ross explains. First and foremost, avoid excessive caffeine and alcohol (if you dont care to give it up entirely). Seriously, consume your favored vices in moderation. Theyre not bad, per se its just better to have less. She recommends one large cup of coffee in the morning and not more than three to four alcoholic beverages a week (if at all). Set a regular bedtime, limit your liquids after dinner (so you need not take a midnight bathroom break), and try a warm bath before bed, she adds. And is your mattress comfortable and supportive? If not, make it so. Lastly, put your electronic devices (phone included) far from your night table. You dont need the lure (or the light) of them at bedtime.

And acupuncture is another way to manage perimenopauses symptoms. This ancient Chinese treatment for maintaining health and vitality by balancing energy flow works for many medical conditions, says Ross. For women especially, headaches, lower back pain, and menstrual cramps are helped through acupuncture. Even though the studies are not conclusive, hot flashes and heart palpitations may improve with acupuncture treatment, too.

But in addition to the above, getting psychological support and reassurance from others is also key. Sometimes, what we need most is a thorough understanding of exactly what is happening physiologically, if only to realize that what were going through is completely normal, says Ross. Therapy and support groups are often helpful in navigating this hormonal obstacle course.

Lastly, Ross says that women in their 40s (give or take) who are experiencing unusual hormonal symptoms need to find a healthcare provider to help them navigate the changes caused by perimenopause. There are simple treatment remedies, along with reassurance, that these are natural symptoms that need to be taken seriously not just by the patient, but also by the healthcare provider.

(Stay Up To Date)

Become A Style Insider

Join The Zoe Reports exclusive email list for the latest trends, shopping guides, celebrity style, and more.

Go here to read the rest:
What To Know About Perimenopause, And How To Manage Symptoms Once They Kick In - The Zoe Report

Posted in Testosterone Replacement Therapy | Comments Off on What To Know About Perimenopause, And How To Manage Symptoms Once They Kick In – The Zoe Report

Cord blood bank – Wikipedia

Posted: October 4, 2022 at 2:13 am

A cord blood bank is a facility which stores umbilical cord blood for future use. Both private and public cord blood banks have developed in response to the potential for cord blood in treating diseases of the blood and immune systems. Public cord blood banks accept donations to be used for anyone in need, and as such function like public blood banks. Traditionally, public cord blood banking has been more widely accepted by the medical community.[1] Private cord blood banks store cord blood solely for potential use by the donor or donor's family. Private banks typically charge around $2,000 for the collection and around $200 a year for storage.[2]

The policy of the American Academy of Pediatrics states that "private storage of cord blood as 'biological insurance' is unwise" unless there is a family member with a current or potential need to undergo a stem cell transplantation.[3][4][5] The American Academy of Pediatrics also notes that the odds of using one's own cord blood is 1 in 200,000[6] while the National Academy of Medicine says that only 14 such procedures have ever been performed.[6] Private storage of one's own cord blood is unlawful in Italy and France, and it is also discouraged in some other European countries. The American Medical Association states "Private banking should be considered in the unusual circumstance when there exists a family predisposition to a condition in which umbilical cord stem cells are therapeutically indicated. However, because of its cost, limited likelihood of use, and inaccessibility to others, private banking should not be recommended to low-risk families."[1] The American Society for Blood and Marrow Transplantation and the American Congress of Obstetricians and Gynecologists also encourage public cord banking and discourage private cord blood banking. Nearly all cord blood transfusions come from public banks, rather than private banks,[2][5] partly because most treatable conditions can't use one's own cord blood.[3][7]

Cord blood contains hematopoietic stem cells (which can differentiate only into blood cells), and should not be confused with embryonic stem cells or pluripotent stem cells, which can differentiate into any cell in the body.[2][3] Cord blood stem cells are blood cell progenitors which can form red blood cells, white blood cells, and platelets. This is why cord blood cells are currently used to treat blood and immune system related genetic diseases, cancers, and blood disorders. Cord blood is also a source of mesenchymal stem cells, which can further be differentiated to form connective tissues, bones and cartilage.[8] On the possibility that cord blood stem cells could be used for other purposes, the World Marrow Donor Association and European Group on Ethics in Science and New Technologies states "The possibility of using ones own cord blood stem cells for regenerative medicine is currently purely hypothetical....It is therefore highly hypothetical that cord blood cells kept for autologous use will be of any value in the future and the legitimacy of commercial cord blood banks for autologous use should be questioned as they sell a service which has presently no real use regarding therapeutic options.[9][10]

In the United States, the Food and Drug Administration regulates cord blood under the category of Human Cells, Tissues, and Cellular and Tissue Based-Products. The Code of Federal Regulations under which the FDA regulates public and private cord blood banks is Title 21 Section 1271.[11] Several states also require accreditation, including New York, New Jersey, and California. Any company not accredited within those states are not legally permitted to collect cord blood from those states, even if the company is based out of state. Potential clients can check the New York accreditation status from the New York Umbilical Cord Blood Banks Licensed to Collect in New York.[12] Both public and private cord blood banks are also eligible for voluntary accreditation with either the American Association of Blood Banks (AABB) or the Foundation for the Accreditation of Cellular Therapy (FACT). Potential clients can check the current accreditation status of laboratories from the AABB list of accredited cord blood laboratories or the FACT search engine of accredited cord blood banks (on their home page).[13] Other countries also have regulations pertaining to cord blood.[14]

Cord blood collection happens after the umbilical cord has been cut and is extracted from the fetal end of the cord, diverting up to 75 +/- 23mL from the neonate. It is usually done within ten minutes of giving birth. Additional stem cells may be collected from the placenta. After the health care provider draws the cord blood from the placental end of the umbilical cord, the placenta is couriered to the stem cell laboratory, where it is processed for additional stem cells. An adequate cord blood collection requires at least 75mL in order to ensure that there will be enough cells to be used for a transplantation. Before the cord blood is stored for later use, it undergoes viral testing, including tests for HIV and Hepatitis B and C, and tissue typing to determine Human Leukocyte Antigen type. It will also be examined for nucleated cell count, cell viability, blood group antigen ABO & Rh blood group system, molecule cluster (CD34), and bacterial and fungal growth.[citation needed]

After the collection, the cord blood unit is shipped to the lab and processed, and then cryopreserved. There are many ways to process a cord blood unit, and there are differing opinions on what the best way is. Some processing methods separate out the red blood cells and remove them, while others keep the red blood cells. However the unit is processed, a cryopreservant is added to the cord blood to allow the cells to survive the cryogenic process. After the unit is slowly cooled to 90C, it can then be added to a liquid nitrogen tank which will keep the cord blood unit frozen at 196C. The slow freezing process is important to keep the cells alive during the freezing process. There is no consensus yet on optimal procedures for these cord blood cells, although many cryopreservation strategies suggest using dimethyl sulfoxide (DMSO), slow or controlled rate cooling, and rapid thawing.[citation needed]

Cord blood stem cells (though usually from donors) are currently used in the treatment of several life-threatening conditions, mainly blood and immune system related genetic diseases, cancers, and blood disorders. The first clinically documented use of cord blood stem cells was in the successful treatment of a six-year-old boy afflicted by Fanconi anemia in 1988. Since then, cord blood has become increasingly recognized as a source of stem cells that can be used in stem cell therapy.[3] Recent studies have shown that cord blood has unique advantages over traditional bone marrow transplantation, particularly in children, and can be life-saving in rare cases where a suitable bone-marrow donor cannot be found. Cord blood stem cells can also be used for siblings and other members of your family who have a matching tissue type. Siblings have a 25% chance of compatibility, and the cord blood may even be a match for parents (50%) and grandparents.[3]

Public cord blood banks function like public blood banks, in that they accept donations from anyone, discard donations that fail to meet various quality control standards, and use national registries to find recipients for their samples. Since patients who need cord blood frequently need more cells than a single collection would have provided, public banks frequently combined multiple samples together when preparing the treatment for a single patient. Unlike bone marrow transplantation, cord blood transplantation doesn't require an exact genetic match, which makes it easier to provide patients samples from unrelated donors.[3] The percentage of public bank donations discarded as medical waste is often cited to be between 60 and 80%. Some of this is due to contamination that occasionally occurs during collection or complications arising from shipping, though this is mostly due to the fact that most cord blood collections fail to collect enough usable cells.[14] Because matches are almost always likely to be better in a public than a private bank, and cord blood from public banks doesn't suffer from the problems it commonly suffers from at private banks (such as potential lower quality control and lower medical usefulness of using a patient's own potentially diseased cord blood), public cord blood banking has been more widely accepted by the medical community.[1] One important obstacle facing public banks is the high cost required to maintain them, which has prevented more than a handful from opening. Because public banks do not charge storage fees, medical centers do not always have the funds required to establish and maintain them.[15]

A recent large study by the journal Pediatrics concluded that almost all cord blood transplants come from public banks:[16]

In the Pediatrics study, transplant specialists who collectively have performed thousands of stem cell transplants for childhood leukemia and other illnesses report that only 50 involved privately banked blood. (Support for public cord-blood banking is widespread in the medical community.) Forty-one cases involved blood used to treat a family member, often a sibling; in 36 of those cases the need for a transplant was known before the cord blood was collected. Only nine cases involved giving cord blood back to the donor, a practice known as autologous transplantation and the chief selling point for private cord-blood banking.

Private banking is typically costly to parents and not covered by insurance. The ability to use the cord blood may also depend on the long-term commercial viability of the enterprise.[7] Accordingly, whether cord blood banking is a worthwhile expenditure for the expectant parent depends in part upon whether the expenditure is offset by the likelihood of ultimately using the cord blood and by the benefits of such use.[7] It is important to ensure the credentials of any potential private bank. In the United States, the Food and Drug Administration regulates cord blood under the category of Human Cells, Tissues, and Cellular and Tissue Based-Products. Since the FDA considers cord blood stored at public banks to be "drugs", but doesn't consider cord blood stored at private banks for use by the donor to be drugs, private banks are held to a lower regulatory standard.[14]

Cord blood transplants require less stringent matching between the tissue types of the donor and patient, known as their human leukocyte antigen (HLA) types. Bone marrow transplants require a complete match on six key antigens, which are measures of graft-versus-host reaction, known as a 6/6 match. Cord blood transplants achieve the same medical success with only a 4/6 match.[14] HLA type is inherited from both parents, so siblings are particularly likely to be a match, and people from the same ethnic heritage are more likely to match. Minority ethnic groups have difficulty finding a perfectly matched transplant donor. Studies have found that allogeneic transplants have a better outcome when the donor and patient are related. The odds that two siblings will have the 6/6 match required for a bone marrow transplant are 25%.[7] The odds that two siblings will have the 4/6 match required for a cord blood transplant are 39%.[citation needed]

The policy of the Society of Obstetricians and Gynaecologists of Canada (SOGC) supports public cord blood banking (similar to the collection and banking of other blood products, i.e. altruistic, anyone can use it), as well as stating that it should only be considered under certain circumstances. The policy of the American Academy of Pediatrics states that "private storage of cord blood as 'biological insurance' is unwise" unless there is a family member with a current or potential need to undergo a stem cell transplantation. Private storage of one's own cord blood is unlawful in Italy and France, and it is also discouraged in some other European countries.[1]

The American Society for Blood and Marrow Transplantation states that public donation of cord blood is encouraged where possible, the probability of using one's own cord blood is very small, and therefore storage of cord blood for personal use is not recommended, and family member banking (collecting and storing cord blood for a family member) is recommended when there is a sibling with a disease that may be treated successfully with an allogeneic transplant.[citation needed]

As of 2007, contracts of the largest cord blood banks do not explicitly state that the cord blood belongs to the donors and child with all the rights and privileges one would reasonably expect from ownership. The ambiguity leaves open future uses not approved by the donors and child. At the majority of private cord blood banking facilities, the mother owns all rights to the cord blood that was banked, until the minor in which the cord blood was taken turns eighteen. At that time the minor has all rights to his or her own banked cord blood.[citation needed]

Concerns have been raised that the current interest in cord blood could cause a perception that cord blood is "unused" by the birth process, thus decreasing the amount of blood which is infused into the child as part of the birth process.[3] The pulsation of the cord pushes blood into the child, and it has been recommended that the cord cease pulsation prior to clamping. With the demand for cord blood increasing, there is a possibility that the cord could be clamped prematurely to preserve even more "extra" cord blood. The American Academy of Pediatricians notes: "if cord clamping is done too soon after birth, the infant may be deprived of a placental blood transfusion, resulting in lower blood volume and increased risk for anemia."[3]

Using one's own cord blood cells might not be wise or effective, especially in cases of childhood cancers and leukemia. Children who develop an immunological disorder often are unable to use their own cord blood for transplant because the blood also contains the same genetic defect.[9]

Additional issues include the possible contamination of the cord blood unit with the same cancer diagnosed later in life; for example, abnormal cells have been detected in filters containing newborn blood of children who were not diagnosed with acute leukemia until the age of 2 to 6 years. The high relapse rates after autologous or syngeneic transplant and the benefit of a graft-vs.-leukemia effect of an allogeneic transplant suggest that autologous cord blood would not be the ideal source of stem cells for patients with leukemia needing a transplant.[citation needed]

The public in the United States has a general awareness of embryonic stem cells because of the stem cell controversy. However, cord blood stem cells (hematopoietic stem cells) are not embryonic stem cells (pluripotent stem cells).[2][3]

See original here:
Cord blood bank - Wikipedia

Posted in New Jersey Stem Cells | Comments Off on Cord blood bank – Wikipedia

Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and …

Posted: October 4, 2022 at 2:12 am

A large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach for the treatment of cardiovascular diseases. Since the first transplantation into human patients, several stem cell types have been applied in this field, including bone marrow derived stem cells, cardiac progenitors as well as embryonic stem cells and their derivatives. However, results obtained from clinical studies are inconsistent and stem cell-based improvement of heart performance and cardiac remodeling was found to be quite limited. In order to optimize stem cell efficiency, it is crucial to elucidate the underlying mechanisms mediating the beneficial effects of stem cell transplantation. Based on these mechanisms, researchers have developed different improvement strategies to boost the potency of stem cell repair and to generate the "next generation" of stem cell therapeutics. Moreover, since cardiovascular diseases are complex disorders including several disease patterns and pathologic mechanisms it may be difficult to provide a uniform therapeutic intervention for all subgroups of patients. Therefore, future strategies should aim at more personalized SC therapies in which individual disease parameters influence the selection of optimal cell type, dosage and delivery approach.

Keywords: Cardiac regeneration; Cardiovascular diseases; Cell replacement; Mesenchymal stem cells; Stem cell modification.

View original post here:
Stem Cell Therapy in Heart Diseases - Cell Types, Mechanisms and ...

Posted in Stem Cell Therapy | Comments Off on Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and …