USA College of Medicine – University of South Alabama …

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Research Interests Access to health care Actin cytoskeleton remodeling and the ARP 2/3 complex in cancer cell metastasis Anticancer activity of nonsteroidal anti-inflammatory drugs Autoimmunity Bacterial Physiology and Genetics Basic mechanisms and clinical pharmacology of pulmonary arterial hypertension Calcium signaling and autoantibodies in pulmonary endothelial barrier disruption Cancer drug discovery and development Cancer metastasis Cancer prevention through behavioral intervention Cancer progression and metastasis Cancer stem cells Cancer survivorship studies Cancers that are diagnosed late stage such as ovarian and pancreatic cancer Carcinogenesis and drug resistance Cardiac Physiology Cell cycle regulation and DNA replication Cellular mechanisms of DNA repair and metabolism Cellular metabolism and its relevance to health through balanced and informed vitamin supplementation Chemokine signaling in cancer progression, angiogenesis and metastasis Childhood, adolescent, and young adult cancers Clinical/preclinical studies in vaccine development Collateral Vessels Colorectal cancer Convergent role of enzymes and pathways in response to environmental Geno toxins and chemotherapy Developing new screening methods for issues such as complications of pregnancy DNA damage response and repair pathways (special focus on Fanconi anemia pathway and homologous recombination) DNA topoisomerases and their inhibitors Emerging viruses Endometrial Cancer Enzyme Binding and Kinetics Flow Cytometry Fostering health care networks Gene regulation Glycochemistry and pulmonary glycocalyx Health communications Health disparities Hematopathology Herpes simplex Eye Infections HIV-1 Host-Pathogen Interactions Identification of novel targets for cancer therapy Identifying proteomic biomarkers using proteomic and glycomic methods for the early detection and monitoring of cancer Immune Regulation Inflammation Influenza viruses Ischemic Preconditioning Laboratory of Infectious Diseases Lung injury and repair Mechanism of base excision repair Melanoma and non-melanoma skin cancer Metabolism and cancer Methods to improve the test for prostate cancer MicroRNA and cancer MicroRNAs in cancer Mitochondrial Disease and Cancer Molecular cancer therapeutics (identification of novel drug targets and therapeutics development) Molecular diagnosis, prognosis and sub-classification of cancer Molecular libraries screening and cellular imaging Natural products as cancer prevention and therapy agents Novel chemical entities as putatives anti-cancer lead compounds Obligate Intracellular Parasitism Ovarian Cancer Oxidative DNA Damage and Repair PARP and NAD+ metabolism in human cells Phosphodiesterases, cyclic GMP signaling, and apoptosis Posttranslational modifications (special focus on ubiquitin ligases and their role in DNA damage response and repair) Progression of pulmonary arterial hypertension (PAH) Pulmonary Immunology and Infections Regulation of transcription and RNA splicing in cancer stem cells Response of DNA repair pathways to damage induced by exposure to endocrine disrupting chemicals (EDCs) Role of cAMP-phosphodiesterases (PDEs) in the temporal and spatial control of cAMP signals Roles of non-coding RNAs in cancer development and progression Select Agents and Biodefense Sepsis SON-mediated constitutive/alternative RNA splicing and cancer Structural Biology including Macromolecular X-ray Crystallography and Small Angle X-ray Scattering Targeted cancer therapy Telehealth Therapeutic resistance Therapeutic resistance in cancer Tumor-stromal interactions Vaccine Development Vascular remodeling in lung circulation and its impact on blood flow pattering Viral transmission and pathogenesis Vitamin B3 (Niacin) metabolism and its impact on disease management, treatment and prevention

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USA College of Medicine - University of South Alabama ...