Sunday 4:00 pm - 8:00 pm Arrival and Check-in 6:00 pm Dinner 7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff 7:40 pm - 9:30 pm Keynote Session: Cancer Initiation Discussion Leader: Allison Bardin (Genetics and Developmental Biology Unit (INSERM U934), Institut Curie, France) 7:40 pm - 7:50 pm Opening Remarks 7:50 pm - 8:25 pm Ronald Depinho (University of Texas MD Anderson Cancer Center, USA) "Targeting Cancer Specific Vulnerabilities" 8:25 pm - 8:40 pm Discussion 8:40 pm - 9:15 pm Hans Clevers (Hubrecht Institute, The Netherlands) "Lgr5 Stem Cell-Grown Organoids and Their Applications" 9:15 pm - 9:30 pm Discussion Monday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Stem Cell Biology Discussion Leader: Sean Morrison (University of Texas Southwestern Medical Center, USA) 9:00 am - 9:30 am Hans-Reimer Rodewald (German Cancer Research Center (DKFZ), Germany) "Resolving Hematopoiesis by Endogenous Barcoding" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am David Traver (University of California, San Diego, USA) "Development of Hematopoietic Stem Cells" 10:10 am - 10:20 am Discussion 10:20 am - 10:50 am Coffee Break 10:50 am - 11:20 am Leanne Jones (University of California, Los Angeles, USA) "Evolution of Stem Cell-Niche Interactions During Aging" 11:20 am - 11:30 am Discussion 11:30 am - 12:00 pm Helen Blau (Stanford University, USA) "Rejuvenation of Muscle Stem Cell Function" 12:00 pm - 12:10 pm Discussion 12:10 pm - 12:25 pm Selected from Poster Abstracts: John Schell (University of Utah, USA) "Limiting Mitochondrial Pyruvate Entry Alters Intestinal Stem Cell Maintenance and Proliferation" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:30 pm Free Time 4:30 pm - 6:00 pm Poster Session 6:00 pm - 8:00 pm Genome Integrity Discussion Leader: Emmanuelle Passegue (Columbia University Medical Center, USA) 6:00 pm - 6:30 pm Andre Nussenzweig (National Cancer Institute, NIH, USA) "Endogenous and Exogenous DNA Breaks" 6:30 pm - 6:40 pm Discussion 6:40 pm - 7:10 pm Allison Bardin (Genetics and Developmental Biology Unit (INSERM U934), Institut Curie, France) "Spontaneous Somatic Stem Cell Mutations" 7:10 pm - 7:20 pm Discussion 7:20 pm - 7:50 pm Bjoern Schmacher (University of Cologne, Germany) "Non-Cell-Autonomous Regulation of the C. elegans p53 Response in Primordial Germ Cells" 7:50 pm - 8:00 pm Discussion 8:00 pm Dinner Tuesday 7:30 am - 8:30 am Breakfast 8:30 am Group Photo 9:00 am - 12:30 pm Epigenome Discussion Leader: Andre Nussenzweig (National Cancer Institute, NIH, USA) 9:00 am - 9:30 am Maarten Van Lohuizen (Netherlands Cancer Institute, The Netherlands) "Role of Polycomb Repressor Complex 2 in NSCLC: Consequences for Epigenetic Therapy" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Anne Brunet (Stanford University, USA) "Mechanisms of Neural Stem Cell Aging" 10:10 am - 10:20 am Discussion 10:20 am - 10:50 am Coffee Break 10:50 am - 11:20 am Elaine Fuchs (Rockefeller University, USA) "Skin Stem Cells and Cancer: From Signaling to Chromatin Landscapes" 11:20 am - 11:30 am Discussion 11:30 am - 12:00 pm Thomas Rando (Stanford University, USA) "Epigenetic Determinants of Stem Cell Aging and Rejuvenation" 12:00 pm - 12:10 pm Discussion 12:10 pm - 12:25 pm Selected from Poster Abstracts: Francesco Neri (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany) "Dnmt3b-Dependent Intragenic DNA Methylation Prevents RNA Polymerase II Spurious Entry on Gene Bodies and Cryptic Transcription Initiations" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:30 pm Free Time 4:30 pm - 6:00 pm Poster Session 6:00 pm - 8:00 pm Stem Cell Niche and Environment Discussion Leader: Leanne Jones (University of California, Los Angeles, USA) 6:00 pm - 6:30 pm Valentina Greco (Yale University, USA) "Capturing the Interface Between Homeostasis and Cancer by Live Imaging" 6:30 pm - 6:40 pm Discussion 6:40 pm - 7:10 pm Sean Morrison (University of Texas Southwestern Medical Center, USA) "Metabolic Mechanisms Regulating Cancer Initiation" 7:10 pm - 7:20 pm Discussion 7:20 pm - 7:50 pm Amy Wagers (Harvard University, USA) "Muscle Stem Cells and Metabolism in Aging, Regeneration and Tumorigenesis" 7:50 pm - 8:00 pm Discussion 8:00 pm Dinner Wednesday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Clonal Selection Discussion Leader: Andreas Trumpp (German Cancer Research Center / HI-STEM, Germany) 9:00 am - 9:30 am Catriona Jamieson (University of California, San Diego, USA) "The Role of RNA Processing Deregulation in Malignant Reprogramming" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Douglas Winton (Cancer Research UK Cambridge Institute, United Kingdom) "Fate and Fidelity of Stem Cells in the Intestinal Epithelium" 10:10 am - 10:20 am Discussion 10:20 am - 10:50 am Coffee Break 10:50 am - 11:20 am Irving Weissman (Stanford University School of Medicine, USA) "Normal and Neoplastic Stem Cell Competitions" 11:20 am - 11:30 am Discussion 11:30 am - 12:00 pm Cedric Blanpain (Universite Libre de Bruxelles, Belgium) "Reprograming Stem Cells During Cancer Initiation" 12:00 pm - 12:10 pm Discussion 12:10 pm - 12:25 pm Selected from Poster Abstracts: Olivier Cinquin (University of California, Irvine, USA) "Quantification of In Vivo Progenitor Mutation Accrual with Ultra-Low Error Rate and Minimal Input DNA Using SIP-HAVA-seq" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:30 pm Free Time 4:30 pm - 6:00 pm Poster Session 6:00 pm - 8:00 pm Stem Cell Metabolism and Signaling Discussion Leader: Helen Blau (Stanford University, USA) 6:00 pm - 6:30 pm Emmanuelle Passegue (Columbia University Medical Center, USA) "HSC, Metabolism and Fate Decisions" 6:30 pm - 6:40 pm Discussion 6:40 pm - 7:10 pm David Sabatini (Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, USA) "Regulation of Growth by the mTOR Pathway" 7:10 pm - 7:20 pm Discussion 7:20 pm - 7:50 pm Andreas Trumpp (German Cancer Research Center / HI-STEM, Germany) "Quiescence and Dormancy in Normal and Malignant Stem Cells" 7:50 pm - 8:00 pm Discussion 8:00 pm Dinner Thursday 7:30 am - 8:30 am Breakfast 8:30 am - 9:00 am Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 9:00 am - 12:30 pm Plasticity and Heterogeneity Discussion Leader: Maarten Van Lohuizen (Netherlands Cancer Institute, The Netherlands) 9:00 am - 9:30 am Fred De Sauvage (Genentech, USA) "Targeting Intestinal Stem Cells in Cancer" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Tannishtha Reya (University of California, San Diego, USA) "Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance" 10:10 am - 10:20 am Discussion 10:20 am - 10:50 am Coffee Break 10:50 am - 11:20 am Christopher Heeschen (Barts Cancer Institute, Queen Mary University of London, United Kingdom) "Novel Precision Medicine Approaches for Pancreatic Cancer Stem Cells" 11:20 am - 11:30 am Discussion 11:30 am - 12:00 pm Henri Jasper (Buck Institute for Research on Aging, USA) "Control of Intestinal Stem Cell Activity: Lessons from Drosophila" 12:00 pm - 12:10 pm Discussion 12:10 pm - 12:25 pm Selected from Poster Abstracts: Jagdeep Nanchahal (University of Oxford, United Kingdom) "HMGB1 Accelerates Regeneration of Multiple Tissues by Transitioning Stem Cells to G(Alert)" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:30 pm Free Time 4:30 pm - 6:00 pm Poster Session 6:00 pm - 8:00 pm Keynote Session: Developmental Pathways Discussion Leader: Hans-Reimer Rodewald (German Cancer Research Center (DKFZ), Germany) 6:00 pm - 6:15 pm Selected from Poster Abstracts: Ana Carolina Dantas Machado (University of Southern California, USA) "Mechanisms of Protein-DNA Recognition Provide Insights into Gene Regulation" 6:15 pm - 6:20 pm Discussion 6:20 pm - 7:00 pm Margaret Goodell (Baylor College of Medicine, USA) "Aging HSCs and Epigenetic Modulation" 7:00 pm - 7:10 pm Discussion 7:10 pm - 7:50 pm Manuel Serrano (Centro Nacional de Investigaciones Oncologicas, Spain) "Tissue Repair: An Integrative View of Senescence and Reprogramming" 7:50 pm - 8:00 pm Discussion 8:00 pm Dinner Friday 7:30 am - 8:30 am Breakfast 9:00 am Departure
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