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UIC Launches Stem Cell, Regenerative Medicine Center Chicago Tonight | WTTW The University of Illinois at Chicago is launching a new center that will focus on understanding tissue regeneration and spearheading future developments in stem cell biology as a means to repair diseased organs and tissues, according to a university ...

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UIC Launches Stem Cell, Regenerative Medicine Center - Chicago Tonight | WTTW

Prostaglandin E2, or PGE2, is a metabolite produced by immune cells that infiltrate the muscle fiber as well by the muscle tissue itself in response to injury. Anti-inflammatory treatments have been shown to adversely affect muscle recovery, but because they affect many different pathways, its been tough to identify who the real players are in muscle regeneration.

Ho and Palla discovered a role for PGE2 in muscle repair by noting that its receptor was expressed at higher levels on stem cells shortly after injury. They found that muscle stem cells that had undergone injury displayed an increase in the expression of a gene encoding for a receptor called EP4, which binds to PGE2. Furthermore, they showed that the levels of PGE2 in the muscle tissue increased dramatically within a three-day period after injury, indicating it is a transient, naturally occurring immune modulator.

To determine its mechanism of action, Ho and Palla created a genetically engineered strain of laboratory mice that allowed them to dynamically monitor the number and activities of muscle stem cells over time. They then studied how the stem cells responded to leg muscle injuries caused by injection of a toxin or by application of cold temperatures. (The mice were anesthetized during the procedure and given pain relief during recovery.)

This transient pulse of PGE2 is a natural response to injury, said Blau. When we tested the effect of a one-day exposure to PGE2 on muscle stem cells growing in culture, we saw a profound effect on the proliferation of the cells. One week after a single one-day exposure, the number of cells had increased sixfold compared with controls.

After seeing what happened in laboratory-grown cells, Ho and Palla tested the effect of a single injection of PGE2 into the legs of the mice after injury.

When we gave mice a single shot of PGE2 directly to the muscle, it robustly affected muscle regeneration and even increased strength, said Palla. Conversely, if we inhibited the ability of the muscle stem cells to respond to naturally produced PGE2 by blocking the expression of EP4 or by giving them a single dose of a nonsteroidal anti-inflammatory drug to suppress PGE2 production, the acquisition of strength was impeded.

We are excited about this finding because it is counterintuitive, said Ho. One pulse of this inflammation-associated metabolite lingers long enough to significantly affect muscle stem cell function in these animals. This could be a natural way to clinically boost muscle regeneration.

The researchers next plan to test the effect of PGE2 on human muscle stem cells in the laboratory, and to study whether and how aging affects the stem cells response. Because PGE2 is also produced by the fetus and placenta during pregnancy, and is approved by the Food and Drug Administration for use in the induction of labor, a path to the clinic could be relatively speedy, they said.

Our goal has always been to find regulators of human muscle stem cells that can be useful in regenerative medicine, said Blau. It might be possible to repurpose this already FDA-approved drug for use in muscle. This could be a novel way to target existing stem cells in their native environment to help people with muscle injury or trauma, or even to combat natural aging.

Other Stanford authors are former technician Matthew Blake; graduate student Nora Yucel; postdoctoral Yu Xin Wang, PhD; former graduate student Klas Magnusson, PhD; research associate Colin Holbrook; research assistant and lab manager Peggy Kraft; and Scott Delp, PhD, professor of bioengineering, of mechanical engineering and of orthopaedic surgery.

The study was supported by the Muscular Dystrophy Association, the Baxter Foundation, the California Institute for Regenerative Medicine and the National Institutes of Health (grants AG044815, AG009521, NS089533, AR063963 and AG020961).

Stanfords Department of Microbiology and Immunology also supported the work.

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Inflammatory molecule essential to muscle regeneration in mice - Stanford Medical Center Report

The Center for Stem Cell and Regenerative Medicine will use a team-oriented, multidisciplinary approach, says Asrar Malik, head of pharmacology.

The College of Medicine launched a new center that focuses on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues.

The opening of the fwas commemorated Monday with a symposium on stem cell and regenerative medicine.

The center will partner with colleges and departments across the University of Illinois System.

Researchers in the new center will investigate the molecular signals that drive stem cells to mature into different cell types, such as blood, heart and blood vessel cells. The center will also study the epigenetic regulation of stem cells; determine the best approaches to transplant engineered cells, tissues and organs; and look for ways to efficiently produce the regenerative cells needed for novel treatments.

The center will use a team-oriented, multidisciplinary approach that incorporates experts in biochemistry, biophysics, bioengineering and the clinical sciences to investigate stem cell biology and tissue regeneration, said Asrar Malik, the Schweppe Family Distinguished Professor and head of pharmacology, who is guiding the effort.

A search has begun to recruit a director and additional faculty members, he said.

The current program in stem cell biology and regenerative medicine includes seven faculty members, most within the department of pharmacology, who together have more than $10 million in research grants from the National Institutes of Health.

The intent in the next few years will be to carry out additional recruitments with other departments, to build from this interdisciplinary foundation and capitalize on our strengths, Malik said.

Three new faculty members in pharmacology have joined the center in the last two years. Owen Tamplin studies stem cells in zebrafish; Kostandin Pajcini investigates the role of stem cells in the development of leukemia; and Jae-Won Shin engineers stem cells and tissues with an eye toward transplantation.

As the only dedicated stem cell and regenerative medicine center in Chicago with a focus on basic biology and translational science, it will affirm UICs leadership role in these fields and help attract additional talent, Malik said.

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Center to advance tissue regeneration, stem cell discoveries - UIC News

When President Donald Trump urged the biopharmaceutical industry to reduce the price of new medicines and to increase its manufacturing in the United States, many took it as a threat.

We believe its a call to action. Americas ingenuity in biomedical research is unsurpassed. However, our country is losing out to other nations in the fastest growing biotechnology sector, called regenerative medicine: harnessing the capacity of our cells to repair and restore health and sustain well-being.

Second place is not an option. The regenerative medicine market is growing about 21 percent a year and is expected to be worth over $350 billion by 2050. Today, the U.S. regenerative medicine sector is generating $3.6 billion in revenues and has produced 14,000 jobs. By 2050, the industry could create nearly a million new jobs nationwide.

Regenerative medicine will also reduce the cost of disease. Such therapies will replace drugs, devices, and surgery, saving lives, increasing productivity, and reducing the cost of care. This transformation will add trillions in value to our economy.

Finally, regenerative medicine will also make America more secure. Our nation still lacks the ability to quickly and cheaply mass produce vaccines, antidotes, and cell therapies to counter pandemics and bioterrorism. Our fighting forces need reliable sources of these countermeasures and deserve immediate access to treatments that give them back their lives. We shouldnt outsource the safety and well-being of our nation and our Armed Forces to other countries.

To regain leadership in regenerative medicine, U.S. firms dont need government loans, tax credits or massive de-regulation. Instead, it needs the opportunity to invest in reducing the time and cost of manufacturing cellular therapies. To the extent that regenerative medicine is curative it must be made available at vaccine like prices. At present, only a handful of people can afford such treatments.

China and Japan are now in forefront of reducing the cost of producing stem cells, tissue, and other products with restorative biological properties. As a result, they are attracting more capital and forming more new companies than the U.S.

In 2014 Japan became the first country in the world to adopt an expedited approval system specifically for regenerative medical products and to allow outsourced cell culturing. Two products were approved under the new system within a year of its adoption.

By contrast, the Food and Drug Administration regulates any use of manufactured stem cells as equally risky without regard to prior use, health benefit, or therapeutic potential. Indeed, many of the most common stem cell therapies including bone marrow transplants and blood transfusions would require 10 years of FDA review if they were brought to market today.

The problem isnt over-regulation. Its outdated regulation. Safety checks and benchmarks for cell manufacturing should be based on real world evidence of past applications. Regulation should focus on the specific potential side effects for each specific potential use. In this regard, we agree with incoming FDA Commissioner Scott Gottlieb, who has noted, Expediting the development of these novel and transformative technologies like gene- and cell-based therapies doesnt necessarily mean lowering the standard for approval, as I believe other countries have done. But it does mean having a framework thats crafted to deal with the unique hypothetical risks that these products pose.

In fact, the United States has the best regenerative medicine manufacturing technology in the world. But it is literally sitting unused in warehouses.

For example, under the Accelerated Manufacture of Pharmaceuticals program, private companies partnered with the Defense Advanced Research Projects Agency to develop mobile cell and tissue manufacturing plants that can be set up almost anywhere. The facilities can produce cells and tissues at a fraction of the current cost. These mobile factories make real-time production of vaccines and biologics for potential bioterrorist threats and pandemics possible. They are also low-cost, high-tech platforms for experimental evaluation of any type of regenerative medicine.

AMPs are operating in Indonesia, Singapore, China, and Japan where cell products including vaccines are being mass produced. Not a single AMP is being used in the United States because of outdated regulations.

To remove this regulatory obstacle, the Trump administration should establish a separate regenerative medicine pathway. This pathway, which could be developed by DARPA, FDA, and the Centers for Disease Control and Prevention, would develop regulatory standards for the safe manufacturing and testing of development of regenerative products to treat battlefield related traumas such as traumatic brain injury, life-threatening limb damage, and drug-resistant pathogens.

The focus on the conditions and circumstances unique to war or counter-terrorism is both appropriate and strategic. After World War II, Franklin Roosevelt directed that the scientific and entrepreneurial talents used to achieve ramp up war-time production of penicillin and blood plasma be used in the days of peace ahead for the improvement of the national health, the creation of new enterprises bringing new jobs, and the betterment of the national standard of living.

What was created exceeded that vision. The cooperative efforts to achieve mass production of penicillin and blood plasma inspired and supported the creation of industries that employ millions of people today.

Similarly,developing an affordable source of cell therapies to heal our fighting forces and protect the homeland will yield a wide array of affordable technologies and cures that will produce, in FDRs words, a fuller and more fruitful employment and a fuller and more fruitful life. Simply put, by making the manufacture of regenerative medicine affordable can help make America great.

Robert Hariri is CEO of Celularity. Robert Goldberg is vice president of Center for Medicine in the Public Interest.

Morning Consult welcomes op-ed submissions on policy, politics and business strategy in our coverage areas. Updated submission guidelines can be foundhere.

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Regenerative Medicine Can Help Make America Great - Morning Consult

Mitochondria are tiny, free-floating organelles inside cells. New Northwestern Medicine research has discovered that they play an important role in hematopoiesis, the bodys process for creating new blood cells.

New Northwestern Medicine research published in Nature Cell Biology has shown that mitochondria, traditionally known for their role creating energy in cells, also play animportant role in hematopoiesis, the bodys process for creating new blood cells.

Historically, mitochondria are viewed as ATP energy producing organelles, explained principal investigator Navdeep Chandel, PhD,the David W. Cugell Professor ofMedicinein the Division ofPulmonary and Critical Care Medicine. Previously, my laboratory provided evidence that mitochondria can dictate cell function or fate independent of ATP production.We established the idea that mitochondria are signaling organelles.

In the currentstudy, Chandels team, including post-doctoral fellow Elena Ans, PhD, and graduate students Sam Weinberg and Lauren Diebold, demonstrated that mitochondria control hematopoietic stem cell fate by preventing the generation of a metabolite called 2-hydroxyglutarate (2HG). The scientists showed that mice with stem cells deficient in mitochondrial function cannot generate blood cells due to elevated levels of 2HG, which causes histone and DNA hyper-methylation.

This is a great example of two laboratories complementing their expertise to work on a project, said Chandel, also a professor ofCell and Molecular Biologyand a member of theRobert H. Lurie Comprehensive Cancer Center of Northwestern University.

Sam Weinberg, a graduate student in the Medical Scientist Training Program, and Lauren Diebold, a graduate student in the Driskill Graduate Program in Life Sciences, were co-authors on the paper.

Paul Schumacker, PhD, professor of Pediatrics, Cell and Molecular Biology and Medicine, was also a co-author on the paper.

Chandel co-authored an accompanying paper in Nature Cell Biology, led by Jian Xu, PhD, at the University of Texas Southwestern Medical Center, which demonstrated that initiation of erythropoiesis, the production of red blood cells specifically, requires functional mitochondria.

These two studies collectively support the idea that metabolism dictates stem cell fate, which is a rapidly evolving subject matter, said Chandel, who recently wrote a review in Nature Cell Biology highlighting this idea. An important implication of this work is that diseases linked to mitochondrial dysfunction like neurodegeneration or normal aging process might be due to elevation in metabolites like 2HG.

This research was supported by National Institutes of Health grants R35CA197532, T32GM008061, T32 T32HL076139, K01DK093543 and R01DK111430, and Cancer Prevention and Research Institute of Texas New Investigator award RR140025.

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Mitochondria Behind Blood Cell Formation - Northwestern University NewsCenter

Chennai: It is believed to be a general practice that technological advancements and new concepts from the western world and other countries percolate into the Indian market. Breaking this taboo and general practice, LifeCell International has made an entry into global platform with their recently launched concept of Community Stem Cell Banking. In 15 years, LifeCell is thesecond stem cell bank to present its innovation at such a prestigious global platform.

Acknowledging the merit of this concept, LifeCell has been invited by AABB (formerly known as American Association of Blood Banks) to portray itsrecently launched concept of Community Stem Cell Banking at the15th International Cord Blood Symposium scheduled to be held at San Diego, USA between 8th 10th June, 2017.

The International Cord Blood Symposium (ICBS) brings all the umbilical cord blood related fields of hematopoietic stem cell transplantation, banking and potential in regenerative medicine together in one interactive three-day conference where world-renowned experts in the field of cord blood will present their new innovations on advancements in the industry.

LifeCell, Indias first and the largest stem cell bank, a pioneer in stem cell industry has been adding new innovations to its services. The innovative concept of Community Stem Cell Banking allows access to donor stem cells within the community, thereby extending the protection of stem cells to all conditions treatable by stem cells. In addition to the child, its siblings, parents and grandparents too can access the community pool of preserved stem cells for treatments when required thereby extending the protection of stem cells to the entire family. Also, there is no limit on number of withdrawals of stem cell units from the community providing a comprehensive protection.

Mr Mayur Abhaya, CEO & Managing Director, LifeCell International said, We are delighted with this acknowledgment for our innovations in stem cell industry. It is a prestigious moment for us being given an opportunity to present Community Stem Cell Banking in a global platform of industry leaders.

Community Stem Cell Banking will be the future of umbilical cord stem cell banking especially in a country like India where the inventory of donor stem cells or bone marrow registries of Indian ethnicity is very low at less than 1% of global inventory and hence the availability of matching donor stem cells is very low. LifeCell, with this new concept, aims to create a huge inventory of donor stem cells within the next few years, which could even exceed the global standards and this will pave way for the highest probability of finding a matching stem cell unit. It is notable to mention that this initiative of LifeCell was featured in Parents Guide to Cord Blood Foundation when this concept was launched in India.

Mr Vinesh Mandot, Technical Lead at LifeCell, would be presenting this innovative model in a session chaired by Dr. Frances Verter, Director of Parents Guide to Cord Blood Foundation at the international symposium.

Source: Press Release

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LifeCell Community Stem Cell Banking Receives Global Recognition - Medical Dialogues

Future issues are now being published by SAGE. Please visit their website for new issues:

https://us.sagepub.com/en-us/nam/cell-transplantation/journal203416

(Scroll down to view tables of contents for all Volumes and Issues)

Volume 26, Number 6 Reviews Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future 925Zhengzhao Liu,Wenbao Hu, Tian He,Yifan Dai, Hidetaka Hara, RitaBottino, David K. C. Cooper,Zhiming Cai, andLisha Mou

Using Electrical Stimulation to Enhance the Efficacy of Cell Transplantation Therapies for Neurodegenerative Retinal Diseases: Concepts, Challenges, and Future Perspectives 949Abby LeighManthey, Wei Liu,Zhi Xin Jiang, MarcusHiu Kong Lee, Jian Ji, Kwok-Fai So, JimmyShiu Ming Lai, Vincent Wing Hong Lee, and Kin Chiu

Original Contributions

OlfactoryEnsheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Mller Cell Notch Signaling Pathway 967JingXie,Shujia Huo,Yijian Li,Jiaman Dai,Haiwei Xu, and Zheng Qin Yin

EarlySubretinal Allograft Rejection Is Characterized by Innate Immune Activity 983Kevin P. Kennelly, Toby M. Holmes, Deborah M. Wallace, ClionaOFarrelly, and David J. Keegan

Human Dental Pulp Stem Cells Are More Effective Than Human Bone Marrow-Derived Mesenchymal Stem Cells in Cerebral Ischemic Injury 1001Miyeoun Song, Jae-Hyung Lee,Jinhyun Bae,Youngmin Bu, andEun-Cheol Kim

The Timing of Immunomodulation Induced by Mesenchymal Stromal Cells Determines the Outcome of the Graft in Experimental RenalAllotransplantation 1017Ana Merino, Elia Ripoll, Laura de Ramon,Nuria Bolaos, Montserrat Goma, OriolBestard,Nuria Lloberas,Josep M.Grinyo, and JuanTorras Ambrs

Human Umbilical Cord Mesenchymal Stem Cells Inhibit T Follicular Helper Cell Expansion Through the Activation ofiNOS in Lupus-Prone B6.MRL-Faslpr Mice 1031Zhuoya Zhang,Ruihai Feng,Lingying Niu,Saisai Huang, Wei Deng,Bingyu Shi,Genhong Yao,Weiwei Chen,Xiaojun Tang, Xiang Gao,Xuebing Feng, andLingyun Sun

CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells 1043Yoshikazu Matsuoka, Masaya Takahashi, KeisukeSumide, Hiroshi Kawamura,Ryusuke Nakatsuka, Tatsuya Fujioka, and YoshiakiSonoda

Long-Term Follow-Up of Patients After Autologous Bone Marrow Cell Infusion for Decompensated Liver Cirrhosis 1059Ja Kyung Kim, Soo-Jeong Kim, Yuri Kim, YongEun Chung, YoungNyun Park, Hyun Ok Kim,Jin Seok Kim,Mi-Suk Park, IsaoSakaida, Do Young Kim, Jung Il Lee, SangHoon Ahn, KwanSik Lee, and Kwang-HyubHan

Calcium Concentration in Culture Medium as a Nondestructive and Rapid Marker of Osteogenesis 1067Yohei Tanikake, ManabuAkahane, Akira Furukawa,Yasuaki Tohma, Yusuke Inagaki, Tsutomu Kira, andYasuhito Tanaka

Cisplatin-ImpairedAdipogenic Differentiation of Adipose Mesenchymal Stem Cells 1077Yu-Hsun Chang, Hwan-Wun Liu, Tang-Yuan Chu, Yao-Tseng Wen,Rong-Kung Tsai, and Dah-Ching Ding

Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells 1089Kunikazu Tsuji,Miyoko Ojima, KojiOtabe,Masafumi Horie, Hideyuki Koga, Ichiro Sekiya, and TakeshiMuneta

Human Muscle Precursor Cells Overexpressing PGC-1a Enhance Early Skeletal Muscle Tissue Formation 1103DeanaHaralampieva, SouzanSalemi, IvanaDinulovic,Tullio Sulser, Simon M.Ametamey, ChristophHandschin, and DanielEberli

Volume 26, Number 5

GeoffreyRaisman, 19392017: Opening a Scientific Door and Giving Hope 733 Paul R.Sanberg

Review

Conceptual Design and Procedure for an AutonomousIntramyocardial Injection Catheter 735 Weyland Cheng and Peter K. Law

Original Contributions

Hydrogen Sulfide Reduces Recruitment of CD11b+Gr-1+Cells in Mice With Myocardial Infarction 753 Ting Wu, Hua Li, Bing Wu, Lei Zhang, San-wu Wu,Jia-ning Wang, and You-en Zhang

Developing a Rapid Algorithm to Enable Rapid Characterization of Alginate Microcapsules 765 Ka Hei Chan, Rahul Krishnan, Michael Alexander, and Jonathan R. T.Lakey

StemCell Keep Is Effective for Cryopreservation of Human Embryonic Stem Cells byVitrification 773 Akemi Ota, Kazuaki Matsumura, Jun-Jae Lee,Shoichiro Sumi, andSoung-Hyu Hyon

In VitroMicrovibration Increases Implantation Rate After Embryonic Cell Transplantation 789 VladimirIsachenko, KarlSterzik, RobertMaettner,Evgenia Isachenko,Plamen Todorov,Gohar Rahimi, PeterMallmann, ErwinStrehler, IgorPereligin, Jos LuisAlabart, and MarkusMerzenich

Changes in Sexual Behavior ofOrchidectomized Rats Under Influence ofAllotransplantation of Testicular Interstitial Cell Suspension 795 Bo Deng, TatyanaBondarenko, andOleksandr Pakhomov

Precise Regulation of miR-210 Is Critical for the Cellular Homeostasis Maintenance and Transplantation Efficacy Enhancement of Mesenchymal Stem Cells in Acute Liver Failure Therapy 805 Yingxia Liu,Yongjia Xiong,Feiyue Xing,Hao Gao,Xiaogang Wang,Liumin He,Chaoran Ren, Lei Liu, Kwok-Fai So, andJia Xiao

Human Muse Cells,Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis 821 Masahiro Iseki, YoshihiroKushida,Shohei Wakao, Takahiro Akimoto,Masamichi Mizuma,Fuyuhiko Motoi,Ryuta Asada,Shinobu Shimizu, MichiakiUnno, GregorioChazenbalk, and MariDezawa

Phenotypical and Functional Characteristics of In Vitro-Expanded Adipose-Derived Mesenchymal Stromal Cells From Patients With Systematic Sclerosis 841 ChiaraCapelli, EleonoraZaccara, Paola Cipriani, Paola Di Benedetto, WandaMaglione, RominaAndracco, Gabriele Di Luca, FrancescaPignataro, RobertoGiacomelli, MartinoIntrona,ClaudioVitali, and Nicoletta Del Papa

Are Adipose-Derived Stem Cells From LiverFalciform Ligaments Another Possible Source of Mesenchymal Stem Cells? 855 Sang Woo Lee, JaeUk Chong,Seon Ok Min,Seon YoungBak, and KyungSik Kim

Effect of Bone Marrow Aspirate ConcentratePlatelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear 867 SunJeong Kim, Da Hyun Song, JongWook Park, Silvia Park, and Sang Jun Kim

Human Bone Progenitor Cells for Clinical Application: What Kind of Immune Reaction Does Fetal Xenograft Tissue Trigger in Immunocompetent Rats? 879 Tanja C.Hausherr,Katja Nuss, Eric Thein, Lee A. Applegate, and Dominique P.Pioletti

Clinical Study ofNeuroRegen Scaffold Combined With Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury 891 Yannan Zhao,Fengwu Tang,Zhifeng Xiao,Guang Han,NuoWang, Na Yin, Bing Chen,Xianfeng Jiang, Chen Yun,Wanjun Han, Changyu Zhao,Shixiang Cheng, Sai Zhang, andJianwu Dai

Transgenic Expression of Glucagon-Like Peptide-1 (GLP-1) and Activated Muscarinic Receptor (M3R) Significantly Improves Pig Islet Secretory Function 901 Nizar I.Mourad, AndreaPerota,Daela Xhema, Cesare Galli, and PierreGianello

Transplantation of Cultured Olfactory Bulb Cells Prevents Abnormal Sensory Responses During Recovery From Dorsal Root Avulsion in the Rat 913 Andrew Collins, Daqing Li, Stephen B. McMahon, GeoffreyRaisman, and Ying Li

SPECIAL ISSUE 24th MEETING OF THE AMERICAN SOCIETY FOR NEURAL THERAPY AND REPAIR (ASNTR)Recent Progress in Cell Therapy and Regenerative Medicine for Neurological Disorders: Introduction to the ASNTR Special Issue From the 2016 Meeting 529 Cesar V.Borlongan

Is Immune Modulation the Mechanism Underlying the Beneficial Effects of Amniotic Cells and Their Derivatives in Regenerative Medicine? 531 Antonietta R.Silini, MartaMagatti, AnnaCargnoni, and OrnellaParolini

Human Amnion Epithelial Cells Protect Against White Matter Brain Injury After Repeated Endotoxin Exposure in the Preterm Ovine Fetus 541 TamaraYawno,Tharani Sabaretnam,Jingang Li, Courtney McDonald, Rebecca Lim, Graham Jenkin, Euan M. Wallace, and Suzanne L. Miller

Repetitive and Prolonged Omega-3 Fatty Acid Treatment After Traumatic Brain Injury Enhances Long-Term Tissue Restoration and Cognitive Recovery 555 Hongjian Pu,Xiaoyan Jiang,Zhishuo Wei,Dandan Hong,Sulaiman Hassan,Wenting Zhang,Jialin Liu,Hengxing Meng,Yejie Shi, Ling Chen, and Jun Chen

A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain 571 Kuo-Jen Wu,Seong-Jin Yu,Kak-Shan Shia,Chien-Huang Wu, Jen-Shin Song,Hsuan-HaoKuan, Kai-ChiaYeh,Chiung-Tong Chen,Eunkyune Bae, and Yun Wang

A Comparative Study of Three Different Types of Stem Cells for Treatment of Rat Spinal Cord Injury 585 JiriRuzicka, LuciaMachova-Urdzikova, JohnGillick, TakashiAmemori,Nataliya Romanyuk,Kristyna Karova,Kristyna Zaviskova, JanaDubisova,Sarka Kubinova, RajMurali, EvaSykova,Meena Jhanwar-Uniyal, andPavla Jendelova

Fate of Neural Progenitor Cells Transplanted Into Jaundiced andNonjaundiced Rat Brains 605 Fu-Chen Yang, Sean M. Riordan, Michelle Winter, Li Gan, Peter G. Smith, Jay L. Vivian, Steven M. Shapiro, and John A. Stanford

Real-Time Intraoperative MRI Intracerebral Delivery of Induced Pluripotent Stem Cell-Derived Neurons 613 Scott C.Vermilyea,Jianfeng Lu, Miles Olsen, Scott Guthrie,Yunlong Tao, Eva M.Fekete, Marissa K. Riedel, Kevin Brunner, Carissa Boettcher,Viktorya Bondarenko, Ethan Brodsky, Walter F. Block, Andrew Alexander, Su-Chun Zhang, and Marina E.Emborg

A Comparison of Exogenous Labels for the Histological Identification of Transplanted Neural Stem Cells 625 Francesca J. Nicholls, Jessie R. Liu, and MichelModo

Transplantation of Mesenchymal Stromal Cells in Patients With Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial 647 EvaSykov, PetrRychmach, IvanaDrahordov,imona Konrdov,Kateina Rikov, IvanVoek,Serhiy Forostyak,Ale Homola, and MartinBojar

Step Sequence Is a Critical Gait Parameter of Unilateral 6-OHDA Parkinsons Rat Models 659 Heather A. Baldwin,Pyry P.Koivula, Julie C.Necarsulmer, Keith W. Whitaker, and Brandon K. Harvey

Brilliant Blue G, But Not Fenofibrate, Treatment RevertsHemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinsons Disease 669 Enas G.Ferrazoli,Hllio D.N. de Souza, Isis C.Nascimento,gatha Oliveira-Giacomelli,Telma T.Schwindt, Luiz R.Britto, and Henning Ulrich

A Subpopulation of Dopaminergic NeuronsCoexpresses Serotonin in Ventral Mesencephalic Cultures But Not AfterIntrastriatal Transplantation in a Rat Model of Parkinsons Disease 679 Stefano Di Santo, Stefanie Seiler,Anglique D.Ducray, Morten Meyer, and Hans RudolfWidmer

Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimers Disease 693 Scott E. Counts and Elliott J.Mufson

Abstracts for the 24th Annual Meeting of the American Society for Neural Therapy and Repair 703

Volume 26, Number 3

Precision Therapy: Cell Therapy and Development of New Drugs 379 ShinnZong Lin

The Regulatory Effects of Transforming Growth Factor- on Nerve Regeneration 381 Shiying Li,Xiaosong Gu, and Sheng Yi

GSK-3 Inhibition Induced Neuroprotection, Regeneration, and Functional Recovery After Intracerebral Hemorrhagic Stroke 395 Yingying Zhao, ZhengZachory Wei, JamesYa Zhang,Yongbo Zhang,Soonmi Won,Jinmei Sun, Shan Ping Yu,Jimei Li, and Ling Wei

Neuroprotection of Granulocyte Colony-Stimulating Factor for Early Stage Parkinsons Disease 409 Sheng-Tzung Tsai, Sung-Chao Chu, Shu-Hsin Liu, Cheng-Yoong Pang, Ting-WenHou, Shinn-Zong Lin, and Shin-Yuan Chen

Chondrogenic Differentiation of Mesenchymal Stem Cells in Three-Dimensional Chitosan Film Culture 417 Tsai-Jung Lu, Fang-Yao Chiu, Hsiao-Ying Chiu, Ming-Chau Chang, and Shih-Chieh Hung

Pre-S2 Mutant-Induced Mammalian Target of Rapamycin Signal Pathways as Potential Therapeutic Targets for Hepatitis B Virus-Associated Hepatocellular Carcinoma 429 Chiao-FangTeng, Han-Chieh Wu,Woei-Cherng Shyu, Long-BinJeng, andIh-Jen Su

Mesenchymal Stem Cells: The Magic Cure for Intraventricular Hemorrhage? 439 Won Soon Park, So YoonAhn, Se In Sung,Jee-YinAhn, and Yun Sil Chang

Commercial Production of Autologous Stem Cells and Their Therapeutic Potential for Liver Cirrhosis 449 Yi-Chun Lin,Horng-Jyh Harn, Po-Cheng Lin, Ming-Hsi Chuang, Chun-Hung Chen, Shinn-Zong Lin, andTzyy-WenChiou

Novel Therapeutic Transplantation of Induced Neural Stem Cells for Stroke 461 Toru Yamashita,Wentao Liu, Yoshiaki Matsumura,Ryosuke Miyagi, YunZhai,Momoko Kusaki,Nozomi Hishikawa,Yasuyuki Ohta, Sung Min Kim, Tae HwanKwak, DongWook Han, and Koji Abe

Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery 469 Zhijian Cheng, Dale B. Bosco, Li Sun,Xiaoming Chen,Yunsheng Xu,Wenjiao Tai, Ruth Didier, Jinhua Li,Jianqing Fan,Xijing He, and Yi Ren

Cell Therapy Regulation in Taiwan 483 Yuan-Chuan Chen,Hwei-Fang Cheng, and Ming-KungYeh

Adiponectin Potentially Contributes to theAntidepressive Effects ofBaduanjin Qigong Exercise in Women With Chronic Fatigue Syndrome-Like Illness 493 Jessie S. M. Chan, Ang Li, Siu-man Ng, Rainbow T. H. Ho,Aimin Xu,Tzy-jyun Yao, Xiao-Min Wang, Kwok-Fai So, and Cecilia L. W. Chan

Treatment of Spinocerebellar Ataxia With Mesenchymal Stem Cells: A Phase I/IIa Clinical Study 503 Yun-An Tsai, Ren-Shyan Liu,Jiing-FengLirng, Bang-Hung Yang, Chin-Hao Chang, Yi-Chen Wang, Yu-Shan Wu, Jennifer Hui-Chun Ho, Oscar K. Lee, and Bing-Wen Soong

Imbalanced Production of Reactive Oxygen Species and Mitochondrial Antioxidant SOD2 inFabry Disease-Specific Human Induced Pluripotent Stem Cell-Differentiated Vascular Endothelial Cells 513 Wei-Lien Tseng, Shih-Jie Chou, Huai-Chih Chiang, Mong-Lien Wang, Chian-Shiu Chien,Kuan-Hsuan Chen,Hsin-BangLeu,Chien-Ying Wang,Yuh-Lih Chang, Yung-Yang Liu,Yuh-Jyh Jong, Shinn-Zong Lin, Shih-HwaChiou,Shing-Jong Lin, and Wen-Chung Yu

Volume 26, Number 2

Human Adipose-Derived Stem Cells Suppress Elastase-Induced Murine Abdominal Aortic Inflammation and Aneurysm Expansion Through Paracrine Factors 173 Jie Xie, Thomas J. Jones,Dongni Feng, Todd G. Cook, Andrea A. Jester, Ru Yi,Yameena T. Jawed, CliffordBabbey, Keith L. March, and Michael P. Murphy

CXCR4 Overexpression in Human Adipose Tissue-Derived Stem Cells Improves Homing and Engraftment in an Animal Limb Ischemia Model 191 MiJung Kim, Dong-Ik Kim,Eun Key Kim, and Chan-Wha Kim

ALLogeneic HeartSTem Cells to Achieve Myocardial Regeneration (ALLSTAR) Trial: Rationale and Design 205 Tarun Chakravarty, Raj R.Makkar, Deborah D.Ascheim, Jay H. Traverse, Richard Schatz, AnthonyDeMaria, Gary S. Francis, Thomas J.Povsic, Rachel R. Smith, Joao A. Lima, Janice M.Pogoda, LindaMarbn, and Timothy D. Henry

A Nerve Conduit Containing a Vascular Bundle and Implanted With Bone Marrow Stromal Cells and Decellularized Allogenic Nerve Matrix 215 YukitoshiKaizawa,Ryosuke Kakinoki,Ryosuke Ikeguchi,Soichi Ohta, Takashi Noguchi,Hisataka Takeuchi, Hiroki Oda, HirofumiYurie, and Shuichi Matsuda

Bone Marrow Stromal Cells Combined With SodiumFerulate andn-Butylidenephthalide Promote the Effect of Therapeutic Angiogenesis via Advancing Astrocyte-Derived Trophic Factors After Ischemic Stroke 229 Qian Zhang, Zhen-Wei Chen, Yong-Hua Zhao, Bo-Wen Liu,Nai-Wei Liu, Chien-ChihKe, and Hong-Mei Tan

Secondary Release of Exosomes From Astrocytes Contributes to the Increase in Neural Plasticity and Improvement of Functional Recovery After Stroke in Rats Treated With Exosomes Harvested From MicroRNA 133b-Overexpressing Multipotent Mesenchymal Stromal Cells 243 Hongqi Xin,Fengjie Wang,Yanfeng Li, Qing-e Lu, Wing Lee Cheung, Yi Zhang, Zheng Gang Zhang, and MichaelChopp

Efficacy of Two Delivery Routes for Transplanting Human Neural Progenitor Cells (NPCs) Into the Spastic HanWistar Rat, a Model of Ataxia 259 Toni L.Uhlendorf, Ruslan L.Nuryyev, Alex O.Kopyov, Jessica Ochoa, ShahabYounesi, Randy W. Cohen, and Oleg V.Kopyov

Establishment and Characterization of Immortalized Minipig Neural Stem Cell Line 271 Sung S. Choi,Seung-Bin Yoon, Sang-Rae Lee, Sun-Uk Kim, YoungJoo Cha, Daniel Lee,Seung U. Kim,Kyu-Tae Chang, and Hong J. Lee

Safety of Intra-Arterial Injection With Tumor-Activated T Cells to the Rabbit Brain Evaluated by MRI and SPECT/CT 283 Johan Lundberg, EmmaJussing, Zhenjiang Liu,Qingda Meng, Martin Rao, ErikSamn,Rikard Grankvist, PeterDamberg, ErnestDodoo, MarkusMaeurer, andStaffan Holmin

Significantly Accelerated Wound Healing of Full-Thickness Skin Using a Novel Composite Gel of Porcine Acellular Dermal Matrix and Human Peripheral Blood Cells 293 Vijay K. Kuna, Arvind M. Padma,Joakim Hkansson, JanNygren, RobertSjback,Sarunas Petronis, andSuchitra Sumitran-Holgersson

Human Recombinant Antithrombin (ATryn) Administration Improves Survival and Prevents Intravascular Coagulation After Intraportal Islet Transplantation in a Piglet Model 309 ValeryGmyr, Caroline Bonner, ErickaMoerman, AntoineTournoys, NathalieDelalleau, AudreyQuenon, JulienThevenet, MikaelChetboun, Julie Kerr-Conte, FranoisPattou, Thomas Hubert, andMerce Jourdain

Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation 319 Kevin V. Chow, Emma M. Carrington,Yifan Zhan, Andrew M. Lew, and Robyn M. Sutherland

Thrombospondin-1-Derived Peptide RFYVVMWK Improves the Adhesive Phenotype of CD34+ Cells From Atherosclerotic Patients With Type 2 Diabetes 327 SylvieCointe, ricRhaume, Catherine Martel, Olivier Blanc-Brude,Evemie Dub, Florence Sabatier, FranoiseDignat-George, Jean-Claude Tardif, and ArnaudBonnefoy

Fetal Tissues Tested for Microbial Sterility by Culture- and PCR-Based Methods Can be Safely Used in Clinics 339 Yakov Vitrenko,Iryna Kostenko,Kateryna Kulebyakina,Alla Duda,Mariya Klunnyk, and KhrystynaSorochynska

Adult-Derived Human Liver Stem/Progenitor Cells Infused 3 DaysPostsurgery Improve Liver Regeneration in a Mouse Model of Extended Hepatectomy 351 Astrid Herrero, JuliePrigent, Catherine Lombard,Valrie Rosseels, MartineDaujat-Chavanieu,Karine Breckpot, MustaphaNajimi,Gisle Deblandre, and Etienne M.Sokal

-Catenin Accumulation Is Associated With Increased Expression ofNanog Protein and Predicts Maintenance of MSC Self-Renewal 365 Sang-Jin Yu, Hyun-Je Kim,Eui Seok Lee, Chung-Gyu Park, SuJin Cho, andSoung-Hoo Jeon

Volume 26, Number 1

Original Contributions

Identification of Donor Origin and Condition of Transplanted IsletsIn Situ in the Liver of a Type 1 Diabetic Recipient 1Cornelis R. van der Torren, Jessica S.Suwandi,DaHae Lee, Ernst-Jan T.vant Wout, GabyDuinkerken,Godelieve Swings,Arend Mulder, Frans H. J.Claas,Zhidong Ling, Pieter Gillard, BartKeymeulen, Peterint Veld, and Bart O.Roep

Physiologic Doses of Bilirubin Contribute to Tolerance of Islet Transplants by Suppressing the Innate Immune Response 11Christopher A. Adin, Zachary C.VanGundy, Tracey L. Papenfuss, Feng Xu, MostafaGhanem, JonathanLakey, and Gregg A. Hadley

Active Subjects With Autoimmune Type 1 Diabetes Have Better Metabolic Profiles Than Sedentary Controls 23M.Adamo, R.Codella, F. Casiraghi, A.Ferrulli, C.Macri, E.Bazzigaluppi, I.Terruzzi, L.Inverardi, C.Ricordi, and L.Luzi

Effect of Manufacturing Procedures on Human Islet Isolation From DonorPancreata Standardized by the North American Islet Donor Score 33Chun-Chieh Yeh, Ling-jia Wang, James J.McGarrigle, Yong Wang,Chien-Chang Liao, MustafaOmami, Arshad Khan, MohammadNourmohammadzadeh, Joshua Mendoza-Elias, Benjamin McCracken,Enza Marchese, BarbaraBarbaro, and JoseOberholzer

Transplantation of Human Placenta-Derived Mesenchymal Stem Cells Alleviates Critical Limb Ischemia in Diabetic Nude Rats 45Lu Liang,Zongjin Li, Tao Ma,Zhibo Han,Wenjing Du,Jie Geng,Honghong Jia, Meng Zhao,Jimin Wang,Bingjing Zhang,Jie Feng,Lanzhen Zhao, AlainRupin,Youwei Wang, andZhong Chao Han

Excluding Anti-cytomegalovirus Immunoglobulin M-Positive Cord Blood Units Has a Minimal Impact on the Korean Public Cord Blood Bank Inventory 63Sue Shin,Eun Youn Roh,Sohee Oh,Eun Young Song,Eui Chong Kim, and Jong Hyun Yoon

Control of IBMIR Induced by Fresh and Cryopreserved Hepatocytes by Low Molecular Weight Dextran Sulfate Versus Heparin 71Elisabet Gustafson, Sana Asif, HudaKozarcanin, GracielaElgue,Staffan Meurling, Kristina N.Ekdahl, and Bo Nilsson

Poor Mobilization in T-Cell-Deficient Nude Mice Is Explained by Defective Activation of Granulocytes and Monocytes 83MarcinWysoczynski, MateuszAdamiak,Malwina Suszynska, Ahmed Abdel-Latif, JaninaRatajczak, andMariusz Z.Ratajczak

Differences inTfh Cell Response Between the Graft and Spleen With Chronic Allograft Nephropathy 95Jian Shi,Xianlin Xu,Fengbao Luo,Qianqian Shi,Xiaozhou He, and Ying Xia

Improved Transplanted Stem Cell Survival in a Polymer Gel Supplemented With Tenascin C Accelerates Healing and Reduces Scarring of Murine Skin Wounds 103Cecelia C. Yates, AustinNuschke, Melanie Rodrigues, Diana Whaley, Jason J.Dechant, Donald P. Taylor, and Alan Wells

Effect of Gelatin on Osteogenic Cell Sheet Formation Using Canine Adipose-Derived Mesenchymal Stem Cells 115Ah young Kim,Yongsun Kim,Seung Hoon Lee,Yongseok Yoon, Wan-Hee Kim, and Oh-Kyeong Kweon

Biliary Polyunsaturated Fatty Acids andTelocytes in Gallstone Disease 125Artur Pasternak,Jolanta Bugajska,Mirosaw Szura, Jerzy A.Walocha, AndrzejMatyja,Mariusz Gajda, KrystynaSztefko, and Krzysztof Gil

Cellular Evidence ofTelocytes as Novel Interstitial Cells Within the Magnum of Chicken Oviduct 135Ping Yang,Xudong Zhu,Lingling Wang,Nisar Ahmed,Yufei Huang, Hong Chen, Qian Zhang,Shakeeb Ullah,Tengfei Liu,Dawei Guo,Sarfaraz AhmedBrohi, andQiusheng Chen

Pivotal Role of Brain-Derived Neurotrophic Factor Secreted by Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage in Newborn Rats 145So YoonAhn, Yun Sil Chang, Dong Kyung Sung, Se In Sung,Jee-YinAhn, and Won Soon Park

Intramyocardially Transplanted Neonatal Cardiomyocytes (NCMs) Show Structural and Electrophysiological Maturation and Integration and Dose-Dependently Stabilize Function of Infarcted Rat Hearts 157MartinaMaass, BenjaminKrausgrill, SimonEschrig, TobiasKaluschke,Katja Urban, GabrielPeinkofer, Tobias G.Plenge, SimonOeckenpohler, MartinRaths, DennisLadage, MarcelHalbach,Jurgen Hescheler, andJochen Muller-Ehmsen

Excerpt from:
Cell Transplantation : The Regenerative Medicine Journal

June 9, 2017 Clearance of SnCs by GCV reduces the development of post-traumatic OA. Credit: UNIST

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.

This breakthrough research has been led by Dr. Chaekyu Kim of the Johns Hopkins University School of Medicine, who is now at UNIST, and Dr. Ok Hee Jeon of the Johns Hopkins University School of Medicine in collaborations with the Mayo Clinic College of Medicine, the Buck Institute for Research on Aging, the University Medical Center Groningen, Unity Biotechnology, Inc., and the University of California, Berkeley.

In the study, the research team presented a novel pharmacologic candidate that alleviates age-related degenerative joint conditions, such as osteoarthritis (OA) by selectively destroying SnCs. Their findings, published April 24th in Nature Medicine (Impact Factor: 30.357), suggest that the selective removal of old cells from joints could reduce the development of post-traumatic OA and allow new cartilage to grow and repair joints.

Senescent cells (SnCs) accumulate with age in many vertebrate tissues and are present at sites of age-related pathlogy. Although these cells play an essential role in wound healing and injury repair, they may also promote cancer incidence in tissues. For instance, in articular joints, such as the knee and cartilage tissue, SnCs often are not cleared from the area after injury, thereby contributing to OA development.

To test the idea that SnCs might play a causative role in OA, the research team took both younger and older mice and cut their anterior cruciate ligaments (ACL) to minic injury. They, then, administered injections of an experimental drug, named UBX0101 to selectively remove SnCs after anterior cruciate ligament transection (ACLT) surgery.

Preclinical studies in mice and human cells suggested that the removal of SnCs significantly reduced the development of post-traumatic OA and related pain and created a prochondrogenic environment for new cartilage to grow and repair joints. Indeed, the research team reported that aged mice did not exhibit signs of cartilage regeneration after treatment with UBX0101 injections,

According to the research team, the relevance of their findings to human disease was validated using chondrocytes isolated from arthritic patients. The research team notes that their findings provide new insights into therapies targeting SnCs for the treatment of trauma and age-related degenerative joint disease.

Prior to this study, Johns Hopkins Technology Ventures (JHTV) granted UNITY Biotechnology Inc. the right to use the intellectual property around the senescent cell technology. UNITY is a company aiming to develop therapeutics that address age-related diseases. Last October, the company announced $116 million in Series B funding from some of the big names in venture capital, including Amazon CEO Jeff Bezo's venture fund Bezos Expeditions, Mayo Clinic Ventures, Venrock, and ARCH Venture Partners. UNITY has completed a rigorous screening and preclinical testing process of candidate drugs, discovered in this study, and is launching a new clinical trial to assess its first drug, for patients with osteoarthritis of the knee this year.

Explore further: Clearing out old cells could extend joint health, stop osteoarthritis

More information: Ok Hee Jeon et al, Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment, Nature Medicine (2017). DOI: 10.1038/nm.4324

In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

Researchers at Mayo Clinic have reported a causal link between senescent cellscells that accumulate with age and contribute to frailty and diseaseand osteoarthritis in mice. Their findings appear online in The Journals ...

Among patients with knee osteoarthritis, an injection of a corticosteroid every three months over two years resulted in significantly greater cartilage volume loss and no significant difference in knee pain compared to patients ...

Mayo Clinic researchers have uncovered three new agents to add to the emerging repertoire of drugs that aim to delay the onset of aging by targeting senescent cells - cells that contribute to frailty and other age-related ...

Injury to the anterior cruciate ligament (ACL) in the knee frequently leads to early-onset osteoarthritis, a painful condition that can occur even if the patient has undergone ACL reconstruction to prevent its onset. A new ...

Dear Mayo Clinic: I'm interested in the new procedure approved by the U.S. Food and Drug Administration that can repair cartilage in the knee. How does it work? Who's a good candidate for this procedure?

(Medical Xpress)A large team of researchers from the Netherlands, Italy and the U.S. has found a possible explanation for the injury and death to patients in a clinical trial held last year in France. In their paper published ...

(HealthDay)Exercise doesn't just trim your tummy. It may also improve bone thickness, boost bone quality, and whittle away the fat found inside bones, new animal research suggests.

Drexel University and Georgia Institute of Technology researchers have discovered how the Rad52 protein is a crucial player in RNA-dependent DNA repair. The results of their study, published today in Molecular Cell, reveal ...

Despite many studies looking at which bread is the healthiest, it is still not clear what effect bread and differences among bread types have on clinically relevant parameters and on the microbiome. In the journal Cell Metabolism ...

Yale scientists produced increased grooming behavior in mice that may model tics in Tourette syndrome and discovered these behaviors vanish when histaminea neurotransmitter most commonly associated with allergiesis ...

Some bodily activities, sleeping, for instance, mostly occur once every 24 hours; they follow a circadian rhythm. Other bodily functions, such as body temperature, cognitive performance and blood pressure, present an additional ...

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Read the original:
Removal of aging cells could extend human life - Medical Xpress

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Volume 9, Number 1 JSOPMB Issue

Facilitating Transplantation 1 Hirofumi Noguchi

Cell Therapy for Liver Disease Using Bioimaging Rats 3 JunkoHaga, ShinEnosawa, andEiji Kobayashi

Challenges for Production of Human Transplantable Organ Grafts 9 Eiji Kobayashi

Evaluation of Serum-Free,Xeno-Free Cryopreservation Solutions for Human Adipose-Derived Mesenchymal Stem Cells 15 Chika Miyagi-Shiohira,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice 21 Yasuma Yoshizumi, Hiroshi Yukawa,Ryoji Iwaki,Sanae Fujinaka,Ayano Kanou, YukiKanou, Tatsuya Yamada, Shingo Nakagawa, TomomiOhara, KentaNakagiri, YusukeOgihara, YokoTsutsui,Yumi Hayashi, MasatoshiIshigami,Yoshinobu Baba, and Tetsuya Ishikawa

EnhancedAdipogenic Differentiation of Human Adipose-Derived Stem Cells in an In Vitro Microenvironment: The Preparation of Adipose-Like Microtissues Using a Three-Dimensional Culture 35 Yoshitaka Miyamoto, MasashiIkeuchi, Hirofumi Noguchi,Tohru Yagi, and Shuji Hayashi

The Evaluation of Islet Purification Methods That Use Large Bottles to Create a Continuous Density Gradient 45 Chika Miyagi-Shiohira,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Comparison of Purification Solutions With Different Osmolality for Porcine Islet Purification 53 Chika Miyagi-Shiohira,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Measurement of DNA Length Changes UponCpG Hypermethylation by Microfluidic Molecular Stretching 61 DaisukeOnoshima, NaokoKawakita, Daiki Takeshita,Hirohiko Niioka, Hiroshi Yukawa, Jun Miyake, andYoshinobu Baba

Volume 8, Number 3

Allogeneic Mesenchymal Stem Cell Transplantation in Dogs WithKeratoconjunctivitis Sicca 63 Maura K. W.Bittencourt, Michele A. Barros, JooFlvio P. Martins, Jose Paulo C.Vasconcellos, Bruna P.Morais, CelinePompeia, MatheusDomingues Bittencourt,Karine dos SantosEvangelho, IrinaKerkis, andCristiane V.Wenceslau

SMA Expression in Large Colonies of Colony-Forming Units-Fibroblast as an Early Predictor of Bone Marrow MSC Expandability 79 IrinaAizman, William S. Holland, Cher Yang, and Damien Bates

Stability Enhancement Using Hyaluronic Acid Gels for Delivery of Human Fetal Progenitor Tenocytes 87 A.Grognuz, C.Scaletta, A.Farron, D. P.Pioletti, W.Raffoul, and L. A. Applegate

Aggregation of Engineered Human -Cells IntoPseudoislets: Insulin Secretion and Gene Expression Profile inNormoxic and Hypoxic Milieu 99 Marie-JosLecomte,Sverine Pechberty, Ccile Machado, Sandra DaBarroca, PhilippeRavassard, RaphalScharfmann, PaulCzernichow, and BertrandDuvilli

Volume 8, Numbers 12 JSOPMB Issue

Creating a Future of Transplantation 1 Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Review Cryopreservation of Adipose-Derived Mesenchymal Stem Cells 3 Chika Miyagi-Shiohira, KiyotoKurima,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Choice of Feeders Is Important When First EstablishingiPSCs Derived From Primarily Cultured Human Deciduous Tooth Dental Pulp Cells 9Issei Saitoh, Emi Inada, Yoko Iwase, Hirofumi Noguchi,Tomoya Murakami, Miki Soda, Naoko Kubota, Hiroko Hasegawa,Eri Akasaka, Yuko Matsumoto, Kyoko Oka,Youichi Yamasaki, HaruakiHayasaki, Masahiro Sato

Review Islet Culture/Preservation Before Islet Transplantation 25 Hirofumi Noguchi, Chika Miyagi-Shiohira, KiyotoKurima,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, and Masayuki Matsushita

Efficient Gene Transduction of Dispersed Islet Cells in Culture Using Fiber-Modified Adenoviral Vectors 31HiroyukiHanayama, KazuoOhashi,Rie Utoh, Hirofumi Shimizu, KazuyaIse,Fuminori Sakurai, Hiroyuki Mizuguchi, Hiroyuki Tsuchiya,Teruo Okano, andMitsukazu Gotoh

Human Laminin Isotype Coating for Creating Islet Cell Sheets 39Shingo Yamashita, KazuoOhashi,Rie Utoh,Teruo Okano, and Masakazu Yamamoto

Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device 47Yoshitaka Miyamoto, MasashiIkeuchi, Hirofumi Noguchi,Tohru Yagi, and Shuji Hayashi

Fluorescence Quenching ofCdSe/ZnS Quantum Dots by Using Black Hole Quencher Molecules Intermediated With Peptide forBiosensing Application 57Sreenadh Sasidharan Pillai, Hiroshi Yukawa, DaisukeOnoshima,Vasudevanpillai Biju, andYoshinobu Baba

Volume 7, Number 3

Immature Dental Pulp Stem Cells ShowedRenotropicandPericyte-Like Properties in Acute Renal Failure in Rats 95 Michele A. Barros, Joao FlavioPanattoniMartins,DurvaneiAugusto Maria,CrisitianeValverdeWenceslau,DenerMadeiroDe Souza, AlexandreKerkis, Niels Olsen S.Camara, Julio Cesar C.Balieiro, and IrinaKerkis

A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium 109

Micha Sam BrickmanRaredon,MahboobeGhaedi, Elizabeth A.Calle, and Laura E.Niklason

A Combination of Low-Intensity Pulsed Ultrasound andNanohydroxyapatiteConcordantly Enhances Osteogenesis of Adipose-Derived Stem Cells From Buccal Fat Pad 123 Rika Nagasaki,YoshikiMukudai,YasumasaYoshizawa, Masahiro Nagasaki,SunaoShiogama, Maiko Suzuki, Seiji Kondo, SatoruShintani, and Tatsuo Shirota

Review

Disease and Stem Cell-Based Analysis of the 2014 ASNTR Meeting 133 David J. Eve

Volume 7, Number 2

JSOPMB Issue

Basic and Clinical Science for Organ Biology

Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Synergistic Effects ofCalcineurinInhibitors and Steroids on Steroid Sensitivity of Peripheral Blood Mononuclear Cells Hironori Takeuchi, Hitoshi Iwamoto, Yuki Nakamura, Toshihiko Hirano, Osamu Konno, YuKihara,NaokazuChiba, Takayoshi Yokoyama,KiminoriTakano,TatsunoriToraishi, KiyoshiOkuyama, Chie Ikeda, Sachiko Tanaka, KenjiOnda, Akiko Soga, Yukiko Kikuchi, Takashi Kawaguchi, ShigeyukiKawachi, SakaeUnezaki, andMotohideShimazu

Improvement of Infusion Process in Cell Transplantation: Effect of Shear Stress on Hepatocyte Viability Under Horizontal and Vertical Syringe Orientation

SandiSufiandi,HiromichiObara, ShinEnosawa,Huai-CheHsu, NaotoMatsuno, and HiroshiMizunuma

Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device

Yoshitaka Miyamoto, MasashiIkeuchi, Hirofumi Noguchi,TohruYagi, andShujiHayashi

Influence ofAutofluorescenceDerived From Living Body on In Vivo Fluorescence Imaging Using Quantum Dots

Hiroshi Yukawa, Masaki Watanabe,NoritadaKaji, andYoshinobuBaba

Potential Factors for the Differentiation of ESCs/iPSCsInto Insulin-Producing Cells

TakakoTsugata,NaruoNikoh, Tatsuya Kin,IsseiSaitoh,YasufumiNoguchi, Hideo Ueki, Masami Watanabe, Andrew M. James Shapiro, and Hirofumi Noguchi

Volume 7, Number 1

Review

Application of InducedPluripotent Stem Cells in Liver Diseases 1Yue Yu, Xuehao Wang, and Scott L. Nyberg

Original Contribution

Integration-Free Human InducedPluripotent Stem Cells From Type 1 Diabetes Patient Skin Fibroblasts Show Increased Abundance of Pancreas-SpecificmicroRNAs 15 Jun Liu, Mugdha V. Joglekar, Huseyin Sumer, Anandwardhan A. Hardikar, Halena Teede, and Paul J. Verma

Human Menstrual Blood-DerivedMesenchymal Cells as New Human Feeder Layer System for Human Embryonic Stem Cells 25Danubia Silva dos Santos, Vanessa Carvalho Coelho de Oliveira, Karina Dutra Asensi, Leandro Vairo, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, and Regina Coeli dos Santos Goldenberg

Preculturing Islets With Adipose-DerivedMesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically PreferredIntraportal SiteChloe L. Rackham, Paramjeet K. Dhadda, Aurelie M. Le Lay, Aileen J. F. King, and Peter M. Jones

Volume 6, Number 3

Original Contribution

Autologous Skeletal Myoblast Sheet Therapy for Porcine Myocardial Infarction Without Increasing Risk of Arrhythmia Yutaka Terajima, Tatsuya Shimizu, Shinpei Tsuruyama, Hidekazu Sekine, Hikaru Ishii, Kenji Yamazaki, Nobuhisa Hagiwara, and Teruo Okano

Reviews

Estrogen Replacement Therapy for Stroke Mibel Pabon, Cyrus Tamboli, Sarosh Tamboli, Sandra Acosta, Ike De La Pena, Paul R. Sanberg, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Oligodendrocytes Engineered With Migratory Proteins as Effective Graft Source for Cell Transplantation in Multiple Sclerosis Ike De La Pena, Mibel Pabon, Sandra Acosta, Paul R. Sanberg, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Disease and Stem Cell-Based Analysis of the 2013 ASNTR Meeting David J. Eve

Volume 6, Numbers 12

Organ BiologyNew Development Hirofumi Noguchi, Guest Editor in Chief, JSOPMB Issue

Comparison of New Preservation Solutions, HN-1 and University of Wisconsin Solution, in Pancreas Preservation for Porcine Islet Isolation Akihiro Katayama, Hirofumi Noguchi, Takashi Kuise, Atsuko Nakatsuka, Daisho Hirota, Hitomi Usui Kataoka, Takashi Kawai, Kentaro Inoue, Noriko Imagawa, Issei Saitoh, Yasufumi Noguchi, Masami Watanabe, Jun Wada, and Toshiyoshi Fujiwara

Comparison of Incubation Solutions Prior to the Purification of Porcine Islet Cells Takashi Kawai, Hirofumi Noguchi, Takashi Kuise, Atsuko Nakatsuka, Akihiro Katayama, Noriko Imagawa, Hitomi Usui Kataoka, Issei Saitoh, Yasufumi Noguchi, Masami Watanabe, and Toshiyoshi Fujiwara

Maintenance of Viability and Function of Rat Islets With the Use of ROCK Inhibitor Y-27632 Yasuhiro Kubota, Hirofumi Noguchi, Masayuki Seita, Takeshi Yuasa, Hiromi Sasamoto, Shuhei Nakaji, Teru Okitsu, Toshiyoshi Fujiwara, and Naoya Kobayashi

Development of Canine Models of Type 1 Diabetes With Partial Pancreatectomy and the Administration of Streptozotocin Masayuki Seita, Hirofumi Noguchi, Yasuhiro Kubota, Hironobu Kawamoto, Shuhei Nakaji, Naoya Kobayashi, and Toshiyoshi Fujiwara

Quality of Air-Transported Human Islets for Single Islet Cell Preparations Shingo Yamashita, Kazuo Ohashi, Rie Utoh, Tatsuya Kin, A. M. James Shapiro, Masakazu Yamamoto, Mitsukazu Gotoh, and Teruo Okano

Comparison of the Pharmacological Efficacies of Immunosuppressive Drugs Evaluated by the ATP Production and Mitochondrial Activity in Human Lymphocytes Hiroyasu Sasahara, Kentaro Sugiyama, Mahoto Tsukaguchi, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saitoh, Yuki Nakagawa, Kota Takahashi, Sachiko Tanaka, Kenji Onda, and Toshihiko Hirano

Peripheral Lymphocyte Response to Mycophenolic Acid In Vitro and Incidence of Cytomegalovirus Infection in Renal Transplantation Kentaro Sugiyama, Hiroyasu Sasahara, Mahoto Tsukaguchi, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saitoh, Yuki Nakagawa, Kota Takahashi, Sachiko Tanaka, Kenji Onda, and Toshihiko Hirano

Experimental Nonalcoholic Steatohepatitis Induced by Neonatal Streptozotocin Injection and a High-Fat Diet in Rats Huai-Che Hsu, Masaharu Dozen, Naoto Matsuno, Hiromichi Obara, Ryou Tanaka, and Shin Enosawa

Electron Therapy Attenuated Elevated Alanine Aminotransferase and Oxidative Stress Values in Type 2 Diabetes-Induced Nonalcoholic Steatohepatitis of Rats Shin Enosawa, Masaharu Dozen, Yuki Tada, and Keisuke Hirasawa

STO Feeder Cells Are Useful for Propagation of Primarily Cultured Human Deciduous Dental Pulp Cells by Eliminating Contaminating Bacteria and Promoting Cellular Outgrowth Tomoya Murakami, Issei Saitoh, Emi Inada, Mie Kurosawa, Yoko Iwase, Hirofumi Noguchi, Yutaka Terao, Youichi Yamasaki, Haruaki Hayasaki, and Masahiro Sato

Induced Pluripotent Stem Cell Labeling Using Quantum Dots Hiroshi Yukawa, Kaoru Suzuki, Yuki Kano, Tatsuya Yamada, Noritada Kaji, Tetsuya Ishikawa, and Yoshinobu Baba

Adipose Tissue-Derived Stem Cell Imaging Using Cadmium-Free Quantum Dots Yoshiyuki Miyazaki, Hiroshi Yukawa, Hiroyasu Nishi, Yukihiro Okamoto, Noritada Kaji, Tsukasa Torimoto, and Yoshinobu Baba

Volume 5, Numbers 2-3 Japan Society for Organ Preservation and Medical Biology (JSOPMB) Long-Expected New Start Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue Reviews

Bioimaging of Transgenic Rats Established at Jichi Medical University: Applications in Transplantation Research Takumi Teratani and Eiji Kobayashi

ER Stress and b-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation Hitomi Usui Kataoka and Hirofumi Noguchi

A Review of Autologous Islet Transplantation Michihiro Maruyama, Takashi Kenmochi, Naotake Akutsu, Kazunori Otsuki, Taihei Ito, Ikuko Matsumoto, and Takehide Asano

Original Contributions Culture Conditions for Mouse Pancreatic Stem Cells Hirofumi Noguchi, Issei Saitoh, Hitomi Usui Kataoka, Masami Watanabe, Yasufumi Noguchi, and Toshiyoshi Fujiwara

Isolation Efficiency of Mouse Pancreatic Stem Cells Is Age Dependent Takashi Kuise, Hirofumi Noguchi, Issei Saitoh, Hitomi Usui Kataoka, Masami Watanabe, Yasufumi Noguchi, and Toshiyoshi Fujiwara

Use of Mesenchymal Stem Cell-Conditioned Medium to Activate Islets in Preservation Solution Naoya Kasahara, Takumi Teratani, Junshi Doi, Yuki Iijima, Masashi Maeda, Shinji Uemoto, Yasuhiro Fujimoto, Naohiro Sata, Yoshikazu Yasuda, and Eiji Kobayashi

Inhibition of Hepatic Ischemic Reperfusion Injury Using Saline Exposed to Electron Discharge in a Rat Model Masaharu Dozen, Shin Enosawa, Yuki Tada, and Keisuke Hirasawa

Observation of Positively Charged Magnetic Nanoparticles Inside HepG2 Spheroids Using Electron Microscopy Yoshitaka Miyamoto, Yumie Koshidaka, Hirofumi Noguchi, Koichi Oishi, Hiroaki Saito, Hiroshi Yukawa, Noritada Kaji, Takeshi Ikeya, Satoshi Suzuki, Hisashi Iwata, Yoshinobu Baba, Katsutoshi Murase, and Shuji Hayashi

Improved Recovery of Hepatocytes Isolated From Warm Ischemic Rat Liver by Citrate Phosphate Dextrose (CPD)-Supplemented Euro-Collins Solution Huai-Che Hsu, Naoto Matsuno, Noboru Machida, and Shin Enosawa

Volume 5, Number 1

ReviewHuman Liver Progenitor Cells for Liver Repair Catherine A. Lombard, Julie Prigent, and Etienne M. Sokal

Original Contributions

Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Restores the Neurobehavioral Disorders of Rats With Neonatal Hypoxic-Ischemic Encephalopathy Dongsun Park, Sun Hee Lee, Dae Kwon Bae, Yun-Hui Yang, Goeun Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Jin Tae Hong, Il Seob Shin, Sung Keun Kang, Jeong Chan Ra, and Yun-Bae Kim

Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells Wanja Wolber, Ruhel Ahmad, Soon Won Choi, Sigrid Eckardt, K. John McLaughlin, Jessica Schmitt, Christian Geis, Manfred Heckmann, Anna-Leena Siren, and Albrecht M. Muller

Volume 4, Number 3

Simple Machine Perfusion Significantly Enhances Hepatocyte Yields of Ischemic and Fresh Rat LiversMaria-Louisa Izamis, Candice Calhoun, Basak E. Uygun, Maria Angela Guzzardi, Gavrielle Price, Martha Luitje, Nima Saeidi, Martin L. Yarmush, and Korkut Uygun

Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem CellsTomoko Shofuda, Daisuke Kanematsu, Hayato Fukusumi, Atsuyo Yamamoto, Yohei Bamba, Sumiko Yoshitatsu, Hiroshi Suemizu, Masato Nakamura, Yoshikazu Sugimoto, Miho Kusuda Furue, Arihiro Kohara, Wado Akamatsu, Yohei Okada, Hideyuki Okano, Mami Yamasaki, and Yonehiro Kanemura

Brief Communication

Cell Persistence of Allogeneic Keratinocytes and Fibroblasts Applied in a Fibrin Matrix to Acute, Full Thickness WoundsJaime E. Dickerson Jr., John V. Planz, Barry T. Reece, Kathy A. Weedon, Sandy D. Kirkpatrick, and Herbert B. Slade

Volume 4, Number 2

Nestin Overexpression Precedes Caspase-3 Upregulation in Rats Exposed to Controlled Cortical Impact Traumatic Brain InjuryYuji Kaneko, Naoki Tajiri, SeongJin Yu, Takuro Hayashi, Christine E. Stahl, Eunkyung Bae, Humberto Mestre, Nicholas Franzese, Antonio Rodrigues Jr., Maria C. Rodrigues, Hiroto Ishikawa, Kazutaka Shinozuka, Whitney Hethorn, Nathan Weinbren, Loren E. Glover, Jun Tan, Anilkumar Harapanahalli Achyuta, Harry van Loveren, Paul R. Sanberg, Sundaram Shivsankar, and Cesar V. Borlongan

The Effect of CXCR4 Overexpression on Mesenchymal Stem Cell Transplantation in Ischemic StrokeOh Young Bang, Kyung Sil Jin, Mi Na Hwang, Ho Young Kang, Byoung Joon Kim, Sang Jin Lee, Sangmee Kang, Yu Kyeong Hwang, Jong Seong Ahn, and Ki Woong Sung

Use of Magnetocapsules for In Vivo Visualization and Enhanced Survival of Xenogeneic HepG2 Cell TransplantsThomas W. Link, Dian R. Arifin, Christopher M. Long, Piotr Walczak, Naser Muja, Aravind Arepally, and Jeff W. M. Bulte

Improved Hepatocyte Engraftment After Portal Vein Occlusion in LDL Receptor-Deficient WHHL Rabbits and Lentiviral-Mediated Phenotypic Correction In VitroSylvie Goulinet-Mainot, Hadrien Tranchart, Marie-Thrse Groyer-Picard, Panagiotis Lainas, Papa Saloum Diop, Delphine Holopherne, Patrick Gonin, Karim Benihoud, Nathalie Ba, Olivier Gauthier, Dominique Franco, Catherine Guettier, Danile Pariente, Anne Weber, Ibrahim Dagher, and Tuan Huy Nguyen

Behavior of Human Articular Chondrocytes During In Vivo Culture in Closed, Permeable ChambersIigo Martinez-Zubiaurre, Tuija Annala, and Martin Polacek

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Cell Medicine~Cognizant Communication Corporation

LEXINGTON, Mass.--(BUSINESS WIRE)--CBSET Inc., a non-profit GLP translational research institute that specializes in the advancement of novel therapies, announced today that it has expanded its preclinical cell therapy offerings. CBSET recognizes the importance of preclinical partners capable of supporting the needs of the rapidly advancing cell therapy field by providing technical and regulatory support services in the cell therapy and regenerative medicine sectors.

In vivo assessments include (1) stem cell-derived lines, (2) engineered cell lines, (3) autologous strategies, (4) engineered tissues and tissue products, and (5) combination products.

Scientific progress in the cell therapy and regenerative medicine world has advanced rapidly in the last decade, and the need for experienced preclinical support services with translational experience has never been greater for investigators in these fields, said Michael Naimark, CBSETs Director of Business Development. Novel cell and tissue therapies require expanded technical and regulatory approaches to ensure an appropriate level of project support.

Our status as a 501(c)(3) nonprofit research institute and our long track record of safety assessments and successful regulatory submissions give our collaborations impeccable credibility, Naimark added. Applying this experience to support translational programs in regenerative medicine will allow our partners to focus on the scientific integrity of their technology, rather than the conduct and documentation of their critical preclinical projects.

Prior to establishing the new service, CBSET appointed Michael Naimark as Director of Business Development in October 2016. Most recently, he had been employed by the Neural Stem Cell Institute (NSCI) as project manager overseeing the development of a cell-based therapy for macular degeneration under a 4-year award from the New York Stem Cell Foundation.

Michaels significant hands-on experience in managing complex preclinical studies in a variety of animal models puts him in a unique position to interact on CBSETs behalf with existing and potential new sponsors about study goals and regulatory requirements. His industry experience and knowledge of cell-based and biologics therapies are a valuable addition to the CBSET team, said Peter Markham, CEO.

CBSET will launch its new cell-based therapies service at next weeks ISSCR 2017 Annual Meeting in Boston, June 14-17. Visitors to the CBSET Exhibit Booth (#843) can receive a copy of Cell-Based Therapy and FDA Review: Partnering for Success at Your Pre-IND Meeting, meet Mr. Naimark and learn more about CBSETs multi-disciplinary paradigm for in vivo cell-based therapy assessments.

Expert Biomedical Research Services

CBSET was conceived to enable the advancement of novel therapeutics, devices and techniques through ongoing collaboration with its sponsors in the biomedical research community. CBSET provides a full range of GLP (Good Laboratory Practice) and non-GLP research services to support early target validation, lead optimization, and safety and efficacy testing. Whether a Sponsor is developing a new device, surgical model, or needs support for its drug development programs, CBSET offers a wide array of preclinical resources to meet these needs.

For more information about CBSET, contact Michael Naimark, Director of Business Development: +1-781-541-5627, mnaimark@cbset.org

About CBSET CBSET Inc. 500 Shire Way, Lexington, Mass. is the preclinical research leader in critically important therapeutic fields such as interventional cardiology, renal disease and dialysis, chronic drug-resistant hypertension, womens health, minimally invasive surgery, orthopedics, biological and synthetic tissue repair, drug delivery, bioresorbable devices, and combination medical device and drug-eluting products. Learn more about CBSETs expert biomedical research services or please contact us.

Originally posted here:
CBSET Expands Its Preclinical Research Services by Adding GLP-Compliant Cell-Based-Therapies Support Capability - Business Wire (press release)