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Category Archives: Cell Therapy

Studies On Stem Cell Therapy After Heart Attack Show Mixed Results

Posted: November 9, 2012 at 2:45 am

April Flowers for redOrbit.com Your Universe Online

Conflicting studies were highlighted at this years American Heart Association Scientific Sessions meeting concerning stem cell therapy for heart attack patients.

The first study, from the University of Louisville and Brigham and Womens Hospital, reported holy grail results for a Phase I clinical trial: marked sustained improvement in all patients with zero adverse effects.

Roberto Bolli, M.D., of the University of Louisville and Piero Anversa, M.D., of Brigham and Womens Hospital presented data from their groundbreaking research in the use of autologous adult stem cells with patients who had previous heart attacks in a Late-Breaking Clinical Trial session.

The researchers report that all patients receiving the stem cell therapy showed improved heart function after two years, with an overall 12.9 absolute unit increase in left ventricular ejection fraction (LVEF). LVEF is a standard measure of heart function that shows the amount of blood ejected from the left ventricle during a heartbeat. They saw no adverse effects from the therapy. In fact, nine patients showed evidence of myocardial regeneration new tissue replacing formerly dead tissue killed by heart attack in MRI scans.

The trial shows the feasibility of isolating and expanding autologous stem cells from virtually every patient, said Bolli, who is the Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology and director of the Institute for Molecular Cardiology in the Department of Medicine at UofL. The results suggest that this therapy has a potent, beneficial effect on cardiac function that warrants further study.

In all patients, cells with high regenerative reserve were obtained and employed therapeutically, said Anversa, professor of Anesthesia and Medicine at Brigham and Womens Hospital and Harvard Medical School. Our efforts to carefully characterize the phenotype and growth properties of the cardiac stem cells may have contributed to these initial positive results.

The Stem Cell Infusion in Patients with Ischemic CardiOmyopathy, or SCIPIO, trial was a randomized open-label trial of cardiac stem cells (CSCs) in patients who were diagnosed with heart failure following a myocardial infarction and had a LVEF of 40 percent or lower. A normal LVEF reading is 50 percent or higher.

The CSCs, referred to as c-kit positive cells because they express the c-kit protein on their surface, were harvested from 33 patients during coronary artery bypass surgery. The stem cells were then purified and processed so that they could multiply, and once an adequate number was produced about one million for each patient they were reintroduced into the region of the patients heart that suffered scarring during the heart attack.

At four months after infusion, the researchers report that LVEF increased from 29 percent to 36 percent for 200 patients. On average, the 13 control patients who did not receive a CSC infusion showed any improvement.

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Stem cell therapy to be regulated in PH

Posted: November 8, 2012 at 10:42 pm

MANILA, Philippines -- The Department of Health (DOH) has announced its plan to regulate stem cell therapy in the country.

Stem cell treatment involves the use of adult stem cells to treat a range of diseases.

The Health Department believes that because of the complex preparation and invasive procedure involved, there needs to be a regulatory framework to protect Filipino citizens.

The regulation of laboratories and practitioners involves five key points.

First is a check on the credentials of people involved in the service, as stem cell treatment is a specialized field. The supply of raw materials will also have to be monitored, making sure especially that they do not come from aborted fetuses.

Laboratories will be scrutinized for their procedures, sanitation and safety. Therapeutic claims, on the other hand, are also up for strict assessment, to make sure that these are based on solid scientific evidence.

Finally, the DOH also wants a report on the possible failure of treatments, to find out if there are negative outcomes to stem cell therapy.

"Those who are going to other countries for stem cell treatment should also check if their destination allows stem cell tourism," clarified FDA Acting Director Dr. Kenneth Hartigan-Go.

The DOH said consultations with stakeholders are still ongoing, but it expects a set of guidelines to be released by next month.

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Stem cell therapy improves heart function 2 years after heart attack

Posted: November 8, 2012 at 10:41 pm

Washington, November 7 (ANI): Stem cell therapy improves heart function in patients who had previous heart attacks, according to researchers from the University of Louisville and Brigham and Women's Hospital.

In a Late-Breaking Clinical Trial session at the American Heart Association Scientific Sessions 2012 meeting, Roberto Bolli, M.D., of the University of Louisville and Piero Anversa, M.D., of Brigham and Women's Hospital, Boston, presented data from their groundbreaking research in the use of autologous adult stem cells with patients who had previous heart attacks.

They report that after two years, all patients receiving the stem cell therapy show improvement in heart function, with an overall 12.9 absolute unit increase in left ventricular ejection fraction (LVEF), a standard measure of heart function that shows the amount of blood ejected from the left ventricle during a heartbeat.

No adverse effects resulting from the therapy were seen. Moreover, MRIs performed on nine patients in the trial showed evidence of myocardial regeneration - new heart tissue replacing former dead tissue killed by heart attack.

"The trial shows the feasibility of isolating and expanding autologous stem cells from virtually every patient," said Bolli, who is the Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology and director of the Institute for Molecular Cardiology in the Department of Medicine at UofL.

"The results suggest that this therapy has a potent, beneficial effect on cardiac function that warrants further study," he stated.

The trial - called SCIPIO for Stem Cell Infusion in Patients with Ischemic CardiOmyopathy - was a randomized open-label trial of cardiac stem cells (CSCs) in patients who were diagnosed with heart failure following a myocardial infarction and had a LVEF of 40 percent or lower; the normal LVEF is 50 percent or higher.

The investigators harvested the CSCs, referred to as "c-kit positive" cells because they express the c-kit protein on their surface, from 33 patients during coronary artery bypass surgery. The stem cells were purified and processed in Anversa's lab in Boston so that they could multiply. Once an adequate number of stem cells was produced - about one million for each patient - Bolli's team in Louisville reintroduced them into the region of the patient's heart that had been scarred by the heart attack.

The researchers reported that in the 20 patients receiving CSCs, LVEF increased from 29 percent to 36 percent at four months following infusion. None of the 13 control patients in the trial received CSCs and this group showed, on average, no improvement.

The beneficial effect of the CSCs persisted and became progressively greater at the one- and two-year mark following infusion. At the one-year mark following infusion, LVEF increased by 8.1 percent, and at the two-year mark, by 12.9 percent.

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Stem cell therapy improves heart function 2 years after heart attack

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stem cells | Cryo-Cell – Cord Blood Banking Information For Parents – Video

Posted: November 5, 2012 at 8:48 am


stem cells | Cryo-Cell - Cord Blood Banking Information For Parents
http://www.cordbloodrecommendation.com You never know when you might need this blood and it might give your child a new life. Why Bank Cord Blood?Cell therapy has become a more ideal method to treat certain diseases than bone morrow transplants. Most of the private and public banks were founded during the 1990s. In a laboratory test, cord blood stem cells were transplanted into rodents with controlled strokes. With the success from transfusions creating immune system stability, and creating new oxygen baring cells for many diseases, researchers are hoping that more diseases can not only be treated effectively, but possibly stopped in their tracks altogether. In cancer patients, such as those with leukemia, the introduction of HSC #39;s into the body may rapidly produce healthy cells that can replace destroyed cells from chemotherapy and/or hopefully prevent infections that often create complications or even death, during the treatment process. If you pass all the tests you will be free to donate your baby #39;s blood. Although some will allow you to prepay during your pregnancy so as to not have to pay the amount all in one lump sum, but in general all initial fees must be paid well in advance of delivery in order to utilize the private storage services. According to the most current data, the prospect of needing a stem cell transplant in any individuals Life is 1 in 217! So you can imagine that the likelihood of your baby, or one of your family members needing this kind of help is ...From:kristinagraddyViews:0 0ratingsTime:01:31More inTravel Events

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stem cells | Cryo-Cell - Cord Blood Banking Information For Parents - Video

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cord blood center | Cord Blood Transplantation – A Life Savior Technique – Video

Posted: November 5, 2012 at 8:48 am


cord blood center | Cord Blood Transplantation - A Life Savior Technique
http://www.cordbloodrecommendation.com Storing your babies blood is painless, and causes no harm or pain to the child or mother. Anything that can help cure illnesses and several genetic diseases is worth at least researching and contemplating because you really do never know when you may need it. This type of stem cells is found in baby cord blood and adult bone marrow. Umbilical blood banking provides the ideal stem cell match should a patient require stem cell therapy in their lifetime. Hence opt for cord blood storage banks that can show proof of successful transplants from the cord blood units they have stored in order to avoid rude shocks. If you are an expecting mother, you can look for a bank or designated donation hospital in your community. In cases of leukemia, stem cells can be used to generate healthy blood and fight off the cancer cells in the body. Furthermore, collecting umbilical cord blood has no controversy since the process does not cause the destruction on the embryos and fetus. ""Leukemia is a type of cancer that begins from those tissues in the body that form blood. Ultra-modern cord blood banking technologies induce multiplication of cord blood stem cells by ex vivo expansion. Last but not the least, if you do not want to store the blood for your personal usage in any of these banks you can also donate it to the Medical Institutes for research purposes. Stem cells, researchers discovered, could cure many diseases such as leukemia and help others such as ...From:Implantes DentalesViews:0 0ratingsTime:01:31More inTravel Events

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cord blood center | Cord Blood Transplantation - A Life Savior Technique - Video

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blood banks | Cryo-Cell – Cord Blood Banking Information For Parents – Video

Posted: November 5, 2012 at 8:48 am


blood banks | Cryo-Cell - Cord Blood Banking Information For Parents
http://www.cordbloodrecommendation.com One main reason behind the importance of saving your newborn #39;s blood is that its use is mostly geared to close relatives within your direct bloodline. Why Bank Cord Blood?Cell therapy has become a more ideal method to treat certain diseases than bone morrow transplants. Human umbilical cord blood cells are rich in mescenchymal progenitor cells and contain a large number of endothelial cell precursors. I know this all sounds very technical and expensive. Relatives or other close friends who haven #39;t gone through cord blood banking may also benefit from the stem cells that can be derived from cord blood banking if and only if they will pose a close match with the cord blood banking donor #39;s stem cells. How is it stored?At the time of the baby #39;s birth, the doctor or nurse takes the cord blood and cryogenically freezes it. 4. As for other applications, though promising, they are still in the research stage. Stem cells are early cells that are capable of developing into red and white blood cells, and platelets. Numerous study reports reveal that more than 50 per cent of the potential donors are not eligible to donate cord blood. There is no clear proof to validate that stem cells of a relative are more successful than those taken from a stranger. So, day-by-day man is trying to reach the ultimate knowledge. Even if a lot of people think that extracting stem cells from human embryos is unethical, those stem cells can also be extracted from ...From:LosHotelesEnBogotaViews:2 0ratingsTime:01:31More inTravel Events

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blood banks | Cryo-Cell - Cord Blood Banking Information For Parents - Video

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FAQ-11 of 19: For Stem Cell Therapy, Why Thailand’s Licensed Stem Cell Treatments? – Video

Posted: November 5, 2012 at 8:48 am


FAQ-11 of 19: For Stem Cell Therapy, Why Thailand #39;s Licensed Stem Cell Treatments?
youtu.be You may wonder why coming to Thailand is a better investment of time, energy and resources, so here are some answers. For more personalized information as to how your condition might respond to stem cell therapy, go to the Apply Now page and send in copies of your medical records with an Application for Consideration. StemCell-Asia.infoFrom:Karridine1Views:0 0ratingsTime:01:16More inPeople Blogs

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FAQ-14 of 19: Do We Provide a Guarantee for Stem Cell Therapy? – Video

Posted: November 5, 2012 at 8:48 am


FAQ-14 of 19: Do We Provide a Guarantee for Stem Cell Therapy?
youtu.be This video addresses the ethical, practical aspects of a #39;guarantee #39; for stem cell therapy or stem cell treatments. For more detailed information concerning guarantees, stem cell therapy and your particular problem, visit bit.ly today.From:Karridine1Views:0 0ratingsTime:01:15More inPeople Blogs

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stem cells | Cryo-Cell – Cord Blood Banking Information For Parents – Video

Posted: November 3, 2012 at 8:47 pm


stem cells | Cryo-Cell - Cord Blood Banking Information For Parents
http://www.cordbloodrecommendation.com You never know when you might need this blood and it might give your child a new life. Why Bank Cord Blood?Cell therapy has become a more ideal method to treat certain diseases than bone morrow transplants. Most of the private and public banks were founded during the 1990s. In a laboratory test, cord blood stem cells were transplanted into rodents with controlled strokes. With the success from transfusions creating immune system stability, and creating new oxygen baring cells for many diseases, researchers are hoping that more diseases can not only be treated effectively, but possibly stopped in their tracks altogether. In cancer patients, such as those with leukemia, the introduction of HSC #39;s into the body may rapidly produce healthy cells that can replace destroyed cells from chemotherapy and/or hopefully prevent infections that often create complications or even death, during the treatment process. If you pass all the tests you will be free to donate your baby #39;s blood. Although some will allow you to prepay during your pregnancy so as to not have to pay the amount all in one lump sum, but in general all initial fees must be paid well in advance of delivery in order to utilize the private storage services. According to the most current data, the prospect of needing a stem cell transplant in any individuals Life is 1 in 217! So you can imagine that the likelihood of your baby, or one of your family members needing this kind of help is ...From:kristinagraddyViews:0 0ratingsTime:01:31More inTravel Events

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stem cells | Cryo-Cell - Cord Blood Banking Information For Parents - Video

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FAQ-10 of 19: Can Stem Cells Cause Cancer From Stem Cell Therapy? – Video

Posted: November 3, 2012 at 8:47 pm


FAQ-10 of 19: Can Stem Cells Cause Cancer From Stem Cell Therapy?
youtu.be People ask us if stem cell therapy can CAUSE cancer, and they are wise to be wary, but stem cell therapy has been proving effective AGAINST cancer, and has not cause any known cases of cancer to-date. For more personalized information, visit StemCell-Asia.info now.From:Karridine1Views:0 0ratingsTime:01:06More inPeople Blogs

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