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Category Archives: Cell Therapy
FAQ-4 of 19: What Chance That Stem Cells Will Help Me When I Get Stem Cell Therapy – Video
Posted: November 1, 2012 at 11:50 pm
FAQ-4 of 19: What Chance That Stem Cells Will Help Me When I Get Stem Cell Therapy
youtu.be When considering stem cell treatment, it is only natural to wonder what one #39;s chances of success are. This brief video explains several of the key factors in assuring successful stem cell therapy. For more detailed information, visit StemCell-Asia.infoFrom:John PepperViews:0 0ratingsTime:01:28More inPeople Blogs
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FAQ-4 of 19: What Chance That Stem Cells Will Help Me When I Get Stem Cell Therapy - Video
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Dr. William Rader – Breakthrough Stem Cell Therapy for Epilepsy – Video
Posted: November 1, 2012 at 11:50 pm
Dr. William Rader - Breakthrough Stem Cell Therapy for Epilepsy
http://www.drwilliamrader.com - New Stem Cell Therapy for EpilepsyFrom:William RaderViews:7 0ratingsTime:01:59More inScience Technology
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Dr. William Rader - Breakthrough Stem Cell Therapy for Epilepsy - Video
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Cardiovascular and Chronic Liver Disease Cell Therapy Clinical Studies Approved in Japan
Posted: November 1, 2012 at 11:50 pm
SAN DIEGO--(BUSINESS WIRE)--
Cytori Therapeutics (CYTX) today announced two independent investigator-sponsored and funded cell therapy clinical studies in Japan have been approved by the Ministry of Health, Labor and Welfare under the Guidelines on Clinical Research Using Human Stem Cells. One study will investigate the use of Cytoris cell therapy as a treatment for ischemic heart failure and the other as a treatment for cirrhosis of the liver. The studies will be performed by Shuichi Kaneko, M.D., Ph.D., Professor and Chairman of Departments of Gastroenterology, and Disease Control and Hemostasis, Graduate School of Medicine at Kanazawa University Hospital School of Medicine.
In each study, patients will receive an injection of Cytoris cell therapy, which consists of their own adipose-derived stem and regenerative cells (ADRCs) processed at the point-of-care using the Cytoris proprietary and automated Celution System. The ischemic heart failure study will enroll patients with low left ventricular function due to a prior heart attack and the ADRCs will be delivered through the coronary artery. In the study of patients with cirrhosis of the liver, the ADRCs will be delivered through the hepatic artery.
About Cytori
Cytori Therapeutics, Inc. is developing cell therapies based on autologous adipose-derived regenerative cells (ADRCs) to treat cardiovascular disease and repair soft tissue defects. Our scientific data suggest ADRCs improve blood flow, moderate the immune response and keep tissue at risk of dying alive. As a result, we believe these cells can be applied across multiple "ischemic" conditions. These therapies are made available to the physician and patient at the point-of-care by Cytori's proprietary technologies and products, including the Celution system product family. http://www.cytori.com
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Cardiovascular and Chronic Liver Disease Cell Therapy Clinical Studies Approved in Japan
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Stem cell therapy for muscle, sports injury alternative to surgery
Posted: November 1, 2012 at 11:50 pm
By Erika Sauler Philippine Daily Inquirer
MANILA, Philippines This type of stem cell therapy does not claim to be the fountain of youth, but an alternative treatment to arthritis, muscle pain and tendon tear.
Two Filipino doctors who trained in the United States said in a media forum on Sunday that autologous stem cell therapy could speed up the healing of musculoskeletal and sports-related injuries, which could be an optional remedy before undergoing surgery.
Dr. Jeimylo de Castro explained that the procedure would involve taking stem cells from the patients blood, fat tissue or bone marrow and injecting them to the injured area of the same person. This type of therapy is different from the controversial embryonic stem cells which are harvested from animals or fertilized eggs.
With stem cell therapy being a current fad for anti-aging, the Department of Health has warned the public that the benefits of stem cell therapy are still under evaluation. The DOH will soon issue guidelines for the use of stem cell therapy and the licensing of facilities offering this service.
De Castro and Dr. Franklin Domingo are both fellows of the Philippine Academy of Rehabilitation Medicine. They underwent training for stem cell therapy under Dr. Joseph Purita of the Institute of Regenerative and Molecular Orthopaedics, and Dr. Sherwin Kevy of Harvards Immune Disease Institute.
If you have arthritis and you take anti-inflammatory drugs, you will not feel the pain so you will move around and further damage the cartilage. Whereas stem cells will regenerate tissues and ease the pain, making the damaged cells become young again, De Castro said.
Domingo likened the stem cells to high school students who have no career yet and could be trained to be professionals in a field where they are needed. So if the stem cells are injected into an injured knee, they will develop into tissues that hasten the recovery of the area.
According to Domingo, stem cell therapy is not for everybody and is not a quick-fix solution because it uses the bodys natural ability to heal.
Patients who have cancer and infection are not allowed to undergo stem cell therapy, and so are those under the influence of alcohol or who have taken blood-thinning medicine like Coumadin at the time of extraction.
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Stem cell therapy for muscle, sports injury alternative to surgery
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Irvine Scientific Offers Cell Therapy Products
Posted: November 1, 2012 at 11:50 pm
SANTA ANA, Calif.--(BUSINESS WIRE)--
Irvine Scientific, a leading cell culture media/ medical device company for more than 40 years, announced their newly launched cell therapy PRIME-XV product portfolio as part of the companys commitment to accelerate basic research and clinical applications in cell therapy and regenerative medicine. Using their expertise in cell culture media development, PRIME-XV products were designed to function as part of an integrated workflow solution in culturing primary cells, where all products have been pre-validated to decrease end user qualification time. Initially, PRIME-XV products will comprise of a serum-free medium for the expansion of human mesenchymal stromal/ stem cells (MSCs), biopreservation solutions and extracellular matrix proteins. However, Irvine Scientific intends to expand this product line to offer other cell culture media and reagents, such as stem cell qualified fetal bovine serum, tumorsphere and neural progenitor cell expansion media. Examples of existing PRIME-XV products include:
PRIME-XV MatrIS F: a recombinant human matrix protein intended for the culture of human stem/ progenitor cells under serum-free conditions. PRIME-XV MatrIS F provides an alternative substrate to the PRIME-XV Human Fibronectin product, which has a wide variety of applications in primary cell spreading and attachment.
PRIME-XV MSC EXPANSION SFM: a complete, serum-free expansion medium specifically designed for the culture of primary human MSCs derived from bone marrow and adipose tissues. This medium is supplied as a convenient one 250mL bottle and is ready-to-use without the need of additional cytokine/ growth factor supplements. MSCs cultured in PRIME-XV MSC EXPANSION SFM out performed serum-containing medium as well as leading competitors in cell expansion studies without losing their multipotent characteristics or immune modulation functions.
PRIME-XV Hypothermic Biopreservation Solution: a protein-free, defined solution intended for storage and stable shipping of cells and tissue samples under hypothermic (2-8C) condition. By preserving cells above freezing temperature, it reduces cellular stress response associated from chilling and re-warming of cells and tissues, and retains high culture viabilities after recovery. Simply replace the culture medium with this animal component-free, cGMP manufactured product for short term storage. To recover from preservation, PRIME-XV Hypothermic Biopreservation Solution is removed and replaced with growth medium of choice.
As an alternative to the PRIME-XV Hypothermic Biopreservation Solution, Irvine Scientific also carries a protein-free, defined PRIME-XV Cryogenic Preservation Solution, which allows for cryopreservation of biologics at -80C to -196C.
About Irvine Scientific
Irvine Scientific, a member of JX group, is a worldwide leader in the design, manufacture and distribution of medical devices, including Cell Therapy, Industrial Cell Culture, Cytogenetic and Assisted Reproductive Technology products. We are a large scale producer of advanced quality cell culture media for the cell therapy, industrial bioprocess, medical and diagnostic markets. Our companys extensive experience in the design of culture media, compliance with ISO and FDA regulations for class II/III medical devices and industrial scale manufacturing capacity provides our customers with unique capabilities and support. Irvine Scientific delivers products worldwide to the biopharmaceutical industry, research and medical laboratory communities.
For more information:
- Visit http://www.irvinesci.com
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Irvine Scientific Offers Cell Therapy Products
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A first: Stem cell therapy cures HIV patient in Germany
Posted: October 28, 2012 at 6:42 am
By Philip C. Tubeza Philippine Daily Inquirer
Stem cell therapy might provide a remedy for acquired immunodeficiency syndrome (AIDS) after it was used on an HIV patient in Germany, the first person known to have been cured of the disease, a Department of Health (DOH) official said Tuesday.
Dr. Gerald Belimac, program manager of the DOH National AIDS/Sexually Transmitted Infection Prevention and Control Program, said American Timothy R. Brown, the so-called Berlin Patient who had been infected with the human immunodeficiency virus, was cured after getting stem cells in 2007 from a donor who was genetically resistant to the virus that caused AIDS.
However, he said that this procedure was very complex and was still under study.
It takes the right person, the right recipient, the right donor, for a stem cell transplantation particularly on HIV to be successful, Belimac said.
If it comes from other donors, there is really a high chance that the recipient would reject it, she added.
Brown was infected with HIV in 1995 and was later diagnosed with leukemia, or cancer of the blood.
He underwent a transplant of stem cells for the leukemia and it turned out that those stem cells had genes that were resistant to HIV, Belimac said.
Medical research has shown that almost 5 percent of Caucasians are genetically resistant to HIV, he said, but there are still no studies showing Filipinos having similar genes.
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A first: Stem cell therapy cures HIV patient in Germany
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Cardiovascular and Chronic Liver Disease Cell Therapy Clinical Studies Approved in Japan
Posted: October 28, 2012 at 6:42 am
SAN DIEGO--(BUSINESS WIRE)--
Cytori Therapeutics (CYTX) today announced two independent investigator-sponsored and funded cell therapy clinical studies in Japan have been approved by the Ministry of Health, Labor and Welfare under the Guidelines on Clinical Research Using Human Stem Cells. One study will investigate the use of Cytoris cell therapy as a treatment for ischemic heart failure and the other as a treatment for cirrhosis of the liver. The studies will be performed by Shuichi Kaneko, M.D., Ph.D., Professor and Chairman of Departments of Gastroenterology, and Disease Control and Hemostasis, Graduate School of Medicine at Kanazawa University Hospital School of Medicine.
In each study, patients will receive an injection of Cytoris cell therapy, which consists of their own adipose-derived stem and regenerative cells (ADRCs) processed at the point-of-care using the Cytoris proprietary and automated Celution System. The ischemic heart failure study will enroll patients with low left ventricular function due to a prior heart attack and the ADRCs will be delivered through the coronary artery. In the study of patients with cirrhosis of the liver, the ADRCs will be delivered through the hepatic artery.
About Cytori
Cytori Therapeutics, Inc. is developing cell therapies based on autologous adipose-derived regenerative cells (ADRCs) to treat cardiovascular disease and repair soft tissue defects. Our scientific data suggest ADRCs improve blood flow, moderate the immune response and keep tissue at risk of dying alive. As a result, we believe these cells can be applied across multiple "ischemic" conditions. These therapies are made available to the physician and patient at the point-of-care by Cytori's proprietary technologies and products, including the Celution system product family. http://www.cytori.com
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Cardiovascular and Chronic Liver Disease Cell Therapy Clinical Studies Approved in Japan
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Q Therapeutics CEO to Present at 2012 Stem Cell Meeting on the Mesa
Posted: October 28, 2012 at 6:40 am
SALT LAKE CITY, UT--(Marketwire - Oct 25, 2012) - Q Holdings, Inc., dba Q Therapeutics, Inc., an emerging biotechnology company utilizing its proprietary innovative technology to develop breakthrough cell therapy products for the treatment of debilitating diseases of the central nervous system, today announced that Deborah Eppstein, PhD, President and CEO, will be presenting at the 2012 Stem Cell Meeting on the Mesa's Investor and Partnering Forum -- a premier business development and partnering meeting for regenerative medicine companies.
The Investor and Partnering Forum is being organized by the Alliance for Regenerative Medicine (ARM) and the California Institute for Regenerative Medicine (CIRM) to profile the industry's most exciting technologies.Thirty-five companies and organizations will be presenting over the course of two days, ranging from translational research centers to emerging-growth biotech companies, as well as established, publicly traded industry leaders.
The following are specific details regarding Q Therapeutics' presentation at the conference:
Date: October 29, 2012
Time: 10:15 AM PDT
Location: Sanford Consortium for Regenerative Medicine Building Auditorium, Second Floor Terrace 2880 Torrey Pines Scenic Drive La Jolla, California
The Investor and Partnering Forum was created in 2011 to facilitate translational research, promote engagement between the scientific and business communities and provide opportunities for business, academic research and investor participants to connect in one-on-one strategic partnering meetings.It will be held immediately prior to the Stem Cell Meeting on the Mesa's Scientific Symposium organized by the Sanford Consortium, and the combined meetings are expected to attract over 800 attendees from around the globe. The company presentations will be recorded by ARM and will be made available on ARM's website shortly after the event. To learn more or to register for the 2012 Stem Cell Meeting on the Mesa Symposium and Investor & Partnering Forum, please visit http://www.stemcellmeetingonthemesa.com.Registration is required.
About Q Therapeutics, Inc. Headquartered in Salt Lake City, Utah, Q Holdings, Inc., dba Q Therapeutics, Inc., is a fully reporting, non-trading company, engaged in developing adult stem cell therapies to treat debilitating diseases of the central nervous system.The Company's first product, Q-Cells, is a cell-based therapeutic intended to restore or preserve normal function of neurons by providing essential support functions that occur in healthy central nervous system tissues.Q-Cells may be applicable to a wide range of central nervous system diseases, including demyelinating conditions such as multiple sclerosis, transverse myelitis, cerebral palsy, and stroke, as well as other neurodegenerative diseases and injuries, such as ALS (Lou Gehrig's disease), spinal cord injury, Parkinson's disease and Alzheimer's disease.Q Therapeutics' initial clinical target is ALS, with a first IND filing expected in 2013.For more information, visit http://www.qthera.com.
Cautionary Statement Regarding Forward Looking Information This news release may contain forward-looking statements made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such forward-looking statements in this press release regarding potential applications of Q Therapeutics' technologies constitute forward-looking statements that involve risks and uncertainties, including, without limitation, risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of its intellectual property rights.Actual results may differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors that could affect results and other risks and uncertainties are detailed from time to time in Q Therapeutics' periodic reports, including the quarterly report on Form 10-Q for the period ended June 30, 2012.
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Q Therapeutics CEO to Present at 2012 Stem Cell Meeting on the Mesa
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Doctors don’t promise cure with stem cell therapy
Posted: October 28, 2012 at 6:40 am
MANILA, Philippines Amid the recent warning issued by the Department of Health (DOH) regarding stem cell therapy, doctors who are offering the treatment in the Philippines clarified that they are not promising a cure.
We are very careful about claiming cure. These days ang dami nagsasalita, nawala ang sakit. All of a sudden siya (stem cell therapy) na yung magic bullet ng buong mundo, like if you get stem cell, you get cured, said Dr. Michelle de Vera, deputy director of the Institute of Personalized Molecular Medicine at The Medical City.
Kapag may narinig na ganyan dapat lalo silang mag-ingat. Cure is zero evidence of disease or kung genetic yung disease dapat napalitan yung genes mo. Hindi mangyayari yun at this point," he stressed.
De Vera, an allergologist and immunologist, does stem cell therapy on her patients at The Medical City but he said he believes that the DOH is right in warning patients on stem cell therapy.
Tama naman na magbigay sila ng warning,I think what their trying to do is regulate stem cell therapy, the doctor said.
Public advisory
The DOH recently came out with a public advisory on stem cell therapies saying that there is an "observed proliferation of centers offering stem cell treatments for medical and aesthetic purpose, and although this technology holds promise, stem cell therapy is not yet part of the standard of care and is considered an investigative procedure for compassionate use."
The DOH further stated that "applications of stem cells for the treatment of malignancies, blood disorders, degenerative diseases (e.g. Alzhimer's), metaboloc diseases (eg diabetes), and immune cell therapy are still under clinical evaluation and study."
I did not say it doesn't work but it takes a while, a lot of experiments and clinical studies before it is considered a standard of care in medicine, clarified Health Secretary Enrique T. Ona.
Ona also added in his statement that "the public is strongly advised to avoid stem cell therapies which use the following as sources for stem cells: embryonic stem cells, aborted fetuses, genetically-altered and animal fresh cells." Not from animals
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Doctors don't promise cure with stem cell therapy
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The C4C consortium Announces the Implementation of France’s First Ever Facility for the Industrialization of Cell …
Posted: October 25, 2012 at 6:43 am
PARIS--(BUSINESS WIRE)--
The C4C consortium today announced the implementation of France's first ever dedicated technical facility for the manufacture of cell therapy products. The C4C project (coordinated by CELLforCURE, a subsidiary of the leading French biopharmaceutical company LFB Biotechnologies) brings together the skills of two biotech companies (Celogos and CleanCells) and seven public-sector organizations and university medical centers (the French Blood Agency's [Etablissement Franais du Sang, EFS] directorates in the Aquitaine-Limousin and Pyrnes-Mditerrane regions of France, Bordeaux University Medical Center [CHU de Bordeaux], Lille University Medical Center/University of Lille 2 [CHU de Lille], Nantes University Medical Center, [CHU de Nantes] and the Biological Resource Center at Lyons University Medical Center [Banque de Tissus et de Cellules des Hospices Civils de Lyon]. The first five products are currently being developed, with a view to validating the facility dedicated to the routine production of clinical trial and therapeutic batches. This facility is located on LFB's site in Les Ulis, close to Paris.
C4C is an ambitious project that has attracted 80 million euros in investment from the consortium members and 30 million euros in public-sector financial aid (provided by OSEO, France's state innovation agency). In fact, C4C was selected by OSEO as part of the "Investing in the Future" call for tenders for France's first industry-academic gateway in the field of cell therapy research, development and industrial production. The project has attracted 30 million euros in public-sector financial aid. Thanks to C4C, academic, public- and private-sector stakeholders are provided with an industrial tool for producing both their Phase 3 clinical trial batches and commercial batches.
Lastly, the C4C project corresponds to Europe's first ever modular unit for the large-scale industrial production of novel, cell-based advanced therapy medicinal products.
Cell therapy: definitions and issues
Cell therapy involves the administration of human cells to prevent, treat or alleviate an illness. In some situations, the administered cells repair and/or rebuild damaged tissue. In others, modified cells are used to provide tissue with compounds that it previously lacked. The cell therapy market is set to be worth an estimated 5.2 billion US dollars by 2015 and could double again to reach 10 billion US dollars in 2020.
The five therapeutics currently under development and their target diseases are as follows:
1. The GRAPA Program in Phase I/II development at Bordeaux University Medical Center in collaboration with Frances National Blood Service (EFS). Hematopoietic stem cells are obtained from placental blood and amplified ex vivo prior to use for the treatment of bone marrow or lymph node malignancies (leukemia, lymphoma, myeloma), aplastic anemia, congenital immunodeficiencies and congenital enzyme deficiencies.
2. The CEL-02 cell therapeutic from Celogos, in Phase II clinical development for the treatment of anal incontinence A Phase II clinical trial is currently recruiting at Rouen University Medical Center and the start of the Phase III clinical program (to include investigators across Europe) is scheduled for 2014.
3. Autologous islet of Langerhans grafts (Lille University Medical Center/University of Lille 2), in Phase I/II clinical development for the treatment of post-pancreatectomy diabetes The procedure developed by Professor Franois Pattous group in Lille is based on an intramuscular, autologous transplant of islets of Langerhans that makes it possible to obtain long-term insulin independence in the majority of patients.
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The C4C consortium Announces the Implementation of France's First Ever Facility for the Industrialization of Cell ...
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