Category Archives: Cell Therapy

The positioning of the Global Cell Therapy Technologies Market vendors in FPNV Positioning Matrix are determined by Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) and placed into four quadrants (F: Forefront, P: Pathfinders, N: Niche, and V: Vital).

New York, March 25, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Cell Therapy Technologies Market - Premium Insight, Competitive News Feed Analysis, Company Usability Profiles, Market Sizing & Forecasts to 2025" - https://www.reportlinker.com/p05872139/?utm_source=GNW

The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Cell Therapy Technologies Market including are Ge Healthcare, Lonza Group, Merck KGaA, Terumo Bct, Inc., Thermo Fisher Scientific, Inc., Beckman Coulter, Inc., Becton, Dickinson and Company, Miltenyi Biotec GmbH, Sartorius, and Stemcell Technologies.

On the basis of Product, the Global Cell Therapy Technologies Market is studied across Consumables, Equipment, and Systems & Software.

On the basis of Process, the Global Cell Therapy Technologies Market is studied across Cell Preservation, Distribution, and Handling, Cell Processing, and Process Monitoring and Quality Control.

On the basis of Cell Type, the Global Cell Therapy Technologies Market is studied across Animal Cells and Human Cells.

On the basis of End User, the Global Cell Therapy Technologies Market is studied across Life Science Research Companies and Research Institutes.

For the detailed coverage of the study, the market has been geographically divided into the Americas, Asia-Pacific, and Europe, Middle East & Africa. The report provides details of qualitative and quantitative insights about the major countries in the region and taps the major regional developments in detail.

In the report, we have covered two proprietary models, the FPNV Positioning Matrix and Competitive Strategic Window. The FPNV Positioning Matrix analyses the competitive market place for the players in terms of product satisfaction and business strategy they adopt to sustain in the market. The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisitions strategies, geography expansion, research & development, new product introduction strategies to execute further business expansion and growth.

Research Methodology:Our market forecasting is based on a market model derived from market connectivity, dynamics, and identified influential factors around which assumptions about the market are made. These assumptions are enlightened by fact-bases, put by primary and secondary research instruments, regressive analysis and an extensive connect with industry people. Market forecasting derived from in-depth understanding attained from future market spending patterns provides quantified insight to support your decision-making process. The interview is recorded, and the information gathered in put on the drawing board with the information collected through secondary research.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on sulfuric acid offered by the key players in the Global Cell Therapy Technologies Market 2. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments in the Global Cell Therapy Technologies Market 3. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets for the Global Cell Therapy Technologies Market 4. Market Diversification: Provides detailed information about new products launches, untapped geographies, recent developments, and investments in the Global Cell Therapy Technologies Market 5. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players in the Global Cell Therapy Technologies Market

The report answers questions such as:1. What is the market size of Cell Therapy Technologies market in the Global?2. What are the factors that affect the growth in the Global Cell Therapy Technologies Market over the forecast period?3. What is the competitive position in the Global Cell Therapy Technologies Market?4. Which are the best product areas to be invested in over the forecast period in the Global Cell Therapy Technologies Market?5. What are the opportunities in the Global Cell Therapy Technologies Market?6. What are the modes of entering the Global Cell Therapy Technologies Market?Read the full report: https://www.reportlinker.com/p05872139/?utm_source=GNW

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The Global Cell Therapy Technologies Market is expected to grow from USD 10,423.12 Million in 2018 to USD 25,712.23 Million by the end of 2025 at a...

DUBLIN and TAMPA, Florida, March 24, 2020 /PRNewswire/ -- Avectas, a cell engineering technology business andVycellix, Inc. an immuno-discovery cell & gene therapy company, today announced that the companies have entered into a collaboration agreement to develop proprietary approaches for cell-based immunotherapeutic products.

The companies will collaborate on the delivery of Vycellix's novel RNA immunomodulator VY-M using Avectas' cell engineering platform, Solupore. The collaboration will address current limitations for cell-based therapies, in particular with respect to the need to accelerate the manufacturing process, reduce the cost of manufacture, and ultimately improve patient outcomes.

"We are delighted to partner with Vycellix and join forces in the development of novel cell-based products," says Michael Maguire, PhD, CEO of Avectas. "We believe Solupore will play a critical role in the manufacture of cell-based therapies and will support a path towards effective patient outcomes."

According to Vycellix's President, Douglas Calder, "Solupore represents a new paradigm for delivery of transgenes, and our initial studies will evaluate Solupore to deliver our new product candidate, VY-M, to T cells and NK cells. We expect to accelerate the expansion-time of T cells and NK cells by decreasing the non-dividing lag time, resulting in much shorter "vein-to-vein" delivery-time to patients." The studies will be conducted at Avectas' Dublin-based facility and at Karolinska Institutet, Stockholm, Sweden.

Both Avectas and Vycellix are collaborative partners within NextGenNK, a newly established competence center for development of next-generation NK cell-based cancer immunotherapies based at Karolinska Institutet, Stockholm, Sweden. It is envisioned that Avectas and Vycellix will further expand their collaboration within the NextGenNK constellation.

"We are excited to see the NextGenNK competence center catalysing interactions among its industrial partners to advance NK cell-based immunotherapies," says Hans-Gustaf Ljunggren, MD PhD, Director of the NextGenNK competence center. "The present collaboration may pave the way for similar collaborations among NextGenNK partners."

In February 2020, Avectas announced that it had entered an agreement with the Centre for Commercialization of Regenerative Medicine (CCRM) based in Toronto, Canada to accelerate the translation of Avectas' non-viral cell engineering platform (Solupore) into the clinic.

About Avectas:Avectas is a cell engineering technology business developing a unique delivery platform to enable the ex-vivo manufacture of our partners' gene-modified cell therapy products, which will retain high in-vivo functionality. Our vision is to be a leading non-viral cell engineering technology provider, integrated into manufacturing processes for multiple autologous and allogeneic therapies, commercialized through development and license agreements. For more information, please visit the Company's website at http://www.avectas.com

About Vycellix:Vycellix, Inc.is a private, immuno-discovery, life science company at the forefront of innovation in the development of cell & gene-based therapies targeting indications in, but not limited to, hematology/oncology, autoimmunity/chronic inflammatory diseases, and organ/tissue transplantation.

The Company's platforms were all initially discovered by scientists at the world-renowned Karolinska Institutet (KI) in Stockholm, Sweden. KI is globally recognized for its Nobel Assembly, which awards the Nobel Prize in Physiology or Medicine. For more information, please visit the Company's website at http://www.vycellix.com

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SOURCE Avectas; Vycellix

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Avectas and Vycellix Announce Collaboration to Advance Next-Generation Solutions for the Optimized Manufacture of Cell & Gene Therapies - BioSpace

CAMBRIDGE, Mass & HOUSTON--(BUSINESS WIRE)--AlloVir, a late-clinical stage T-cell immunotherapy company, today announced the expansion of its research and development collaboration with Baylor College of Medicine to include the discovery and development of allogeneic, off-the-shelf, virus specific T-cell therapies to combat SARS-CoV-2, the virus that causes COVID-19. With AlloVirs proprietary technology, in addition to targeting SARS-CoV-2, the investigational virus specific T-cell therapy may also address other coronavirus (CoV) strains including SARS-CoV, MERS-CoV, and also the endemic CoVs that commonly afflict immunocompromised patients. AlloVir aims to develop a therapy for CoVs that can be used as a stand-alone treatment or incorporated into the companys multi-respiratory virus investigational therapy, ALVR106, which is designed to address other devastating and life-threatening community-acquired respiratory viruses.

Given the worldwide coronavirus pandemic and risks to immunocompromised patients now and in the future, we believe it is our responsibility to leverage our scientific expertise and allocate resources for an allogeneic, off-the-shelf, coronavirus-specific T-cell program, said Ann Leen, Ph.D., AlloVir Co-Founder, Chief Scientific Officer, and Professor of Pediatrics at Baylor College of Medicine. Together with Baylor College of Medicine we have already advanced two highly innovative allogeneic, off-the-shelf, multi-virus specific T-cell investigational immunotherapies. We believe we can apply this same approach to develop a cell therapy to treat and prevent coronavirus infections and diseases in immunocompromised patients.

AlloVir and Baylor College of Medicine are leading the way in the clinical development of novel immunotherapies designed to restore natural T-cell immunity to fight off viral infections and diseases in immunocompromised patients, including recipients of stem cell and solid organ transplants, said Michael Dilling, Executive Director of Baylor Licensing Group within Baylor College of Medicine Ventures. Expanding upon this collaboration and technology platform to treat and possibly prevent other emerging life-threatening community-acquired virus infections and diseases is a natural extension of our partnership.

About AlloVirs Approach:

T cells are vital to the immune systems ability to detect and kill virus-infected cells. In healthy individuals, virus-specific T cells form a critical component of the bodys natural defense system and provide protection against thousands of disease-causing viruses.

However, these viruses can go unchecked in immunocompromised patients, such as those undergoing hematopoietic stem cell transplantation (HSCT), solid organ transplantation, and cancer treatment; in patients with HIV infection; and in the elderly. Typically, when viruses attack immunocompromised patients, standard of care therapies do not address the underlying problem of a weakened immune system and, therefore, many patients suffer with life-threatening outcomes such as multi-organ damage and failure, and even death.

AlloVir uses natural immune stimulant proteins called cytokines combined with non-harmful fragments of the virus to activate and expand naturally occurring cells against target viruses. These cells are then provided to immunocompromised patients in order to restore natural T-cell immunity to prevent and/or treat associated viral infections and diseases. AlloVir has developed a proprietary manufacturing process that allows for a bank of virus-specific T cells to be developed from a small number of carefully chosen, healthy, virus-immune, third-party donors. AlloVirs virus-specific T-cells therapies do not require exact immunological matching to patients, allowing hundreds of patients to be treated with virus-specific T-cells manufactured from a single donor. AlloVirs therapies can be stored in a frozen state and thus supplied rapidly and globally as an off-the-shelf therapy for patients suffering from, or at risk for, one or more viral infections and diseases.

About AlloVir

AlloVir, formerly ViraCyte, is an ElevateBio portfolio company that was founded in 2013 and is the leader in the development of novel cell therapies with a focus on restoring natural immunity against life-threatening viral diseases in patients with severely weakened immune systems. The companys technology platforms deliver commercially scalable solutions by leveraging off-the-shelf, allogeneic, multi-virus specific T cells targeting devastating viral pathogens for immunocompromised patients under viral attack. AlloVirs technology and manufacturing process enables the potential for the treatment and prevention of a spectrum of devastating viruses with each single allogeneic cell therapy. The company is advancing multiple mid- and late-stage clinical trials across its product portfolio.

AlloVirs lead product Viralym-M (ALVR105) is in late-stage clinical development as an allogeneic, off-the-shelf, multi-virus specific T-cell therapy targeting six common viral pathogens in immunocompromised individuals: BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus, human herpesvirus 6, and JC virus. In a positive Phase 2 proof-of-concept study, published in the Journal of Clinical Oncology (Tzannou, JCO, 2017), greater than 90% of patients who failed conventional treatment and received the companys lead allogeneic T-cell therapy, Viralym-M, demonstrated a predefined criteria for a complete or partial clinical response, most with complete elimination of detectable virus in the blood and resolution of major clinical symptoms. The company plans to initiate pivotal and proof-of-concept studies with Viralym-M in 2020 for treatment and prevention of severe and life-threatening viral infections and diseases.

AlloVirs second allogeneic, off-the-shelf, multi-virus specific T-cell therapy, ALVR106, targets four common and devastating community-acquired respiratory viruses: respiratory syncytial virus, influenza, parainfluenza virus, and human metapneumovirus (Vasileiou, Haematologica, 2019). The company anticipates initiating clinical studies with ALVR106 in 2020.

AlloVirs investors include Fidelity Research and Management Company, Gilead Sciences, F2 Ventures, The Invus Group, Redmile Group, EcoR1, Samsara Biocapital, and Leerink Partners Co-investment Fund, LLC.

For more information visit http://www.allovir.com

About ElevateBio

ElevateBio, LLC, is a Cambridge-based biotechnology company, established to create and operate a broad portfolio of cell and gene therapy companies with leading academic researchers, medical centers and entrepreneurs. ElevateBio builds companies by providing scientific founders with fully integrated bench-to-bedside capabilities including world-class scientists, manufacturing facilities, drug developers and commercial expertise. ElevateBio BaseCamp, a company-owned Cell and Gene Therapy Center of Innovation, will serve as the R&D, process development and manufacturing hub across the entire ElevateBio portfolio while also supporting selected strategic partners. For more information, visit http://www.elevate.bio.

About Baylor College of Medicine

Baylor College of Medicine (www.bcm.edu) in Houston is recognized as a health sciences university and is known for excellence in education, research and patient care. It is the only private medical school in the greater southwest and is ranked 22nd among medical schools for research and 4th for primary care by U.S. News & World Report. Baylor is listed 20th among all U.S. medical schools for National Institutes of Health funding and No. 1 in Texas. Located in the Texas Medical Center, Baylor has affiliations with seven teaching hospitals and jointly owns and operates Baylor St. Lukes Medical Center, part of CHI St. Lukes Health. Currently, Baylor has more than 3,000 trainees in medical, graduate, nurse anesthesia, physician assistant, orthotics and genetic counseling as well as residents and postdoctoral fellows. Follow Baylor College of Medicine on Facebook (http://www.facebook.com/BaylorCollegeOfMedicine) and Twitter (http://twitter.com/BCMHouston).

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AlloVir Expands Its Research Collaboration with Baylor College of Medicine to Discover and Develop Allogeneic, Off-the-Shelf, Virus-Specific T-Cell...

SEATTLE, March 25, 2020 /PRNewswire/ -- According to Coherent Market Insights, the global viral vector and plasmid DNA manufacturing market is estimated to be valued at US$ 427.2 million in 2019, and is expected to exhibit a CAGR of 22.8% over the forecast period (2019-2027).

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Key Trends and Analysis of the Global Viral Vector and Plasmid DNA Manufacturing Market:

Key trends in the market include increasing incidences of cancer, rising number of product launches, and increasing collaboration and acquisition activities by key market players.

According to World Health Organization (WHO), in 2018, around 9.6 million cancer deaths occurred globally. Over the last decade, development of gene therapy for the treatment of the cancer has increased significantly. Gene therapy treatment for cancer include transfer of foreign genetic material in the targeted cancer cell in the host's body. Various types of viral vectors and plasmid DNA such as retrovirus and HGF plasmidare used in the development of gene therapy.

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Increasing product launches and approvals by regulatory authorities are expected to drive growth of the global viral vector and plasmid DNA manufacturing market over the forecast period. For instance, in December 2017, Spark Therapeutics received the U.S. FDA approval to launch the LUXTURNA in the U.S. market. It is the first FDA approved gene therapy for treatment for an inherited retinal disease (IRD) and the first adeno-associated virus (AAV) vector gene therapy approved in the U.S.

Furthermore, key players operating in the market are focused on adopting acquisition, agreement, and collaboration strategies, in order to expand their product offerings in markets. For instance, in December 2017, Merck KGaA entered into a commercial supply agreement with bluebird bio, Inc., a clinical-stage biopharmaceutical company. According to the agreement, Merck agreed to manufacture viral vectors for bluebird's gene therapy products targeting the rare genetic disorders.

Key Market Takeaways:

Key players operating in the global viral vector and plasmid DNA manufacturing market include

Lonza Group AG, FinVector Vision Therapies, Cobra Biologics and Pharmaceutical Services, Sigma-Aldrich Co. LLC, VGXI, Inc., VIROVEK, SIRION Biotech GmbH, FUJIFILM Diosynth Biotechnologies U.S.A., Inc., Sanofi, Cell and Gene Therapy Catapult, Brammer Bio, and MassBiologics.

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Market Segmentations:

Did not find what you were looking for? Here are some other topics:

DNA AND RNA SAMPLE PREPARATION MARKET

DNA and RNA samples are necessary for variety of applications in drug research and development and cancer studies. High quality DNA and RNA samples are important for a wide variety of research and clinical applications. Biological studies require purified and isolated nucleic acids as the first step and in all recombinant DNA techniques. The extraction of nucleic acids from biological material requires cell lysis, inactivation of cellular nucleases, and separation of the desired nucleic acid from cellular debris.

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LIFE SCIENCE PRODUCTS MARKET

Life science products include laboratory supplies & accessories, cell culture & fermentation processes, cell therapy technologies, chromatography products, bioprocess filtration, fixed and live cell research through imaging and analysis, sample collection products, recombinant proteins, cell lines, and antibodies. These products are used for drug discovery, tissue engineering, drug screening, forensic testing, and genetic analysis.

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GLYCOBIOLOGY MARKET

Glycobiology involves study of structural aspects, biosynthesis, and biology of polysaccharides and how they function in an organism. Study of glycobiology has variety of application in areas such as drug discovery and development, diagnostic applications, therapeutic application, and industrial applications.Complex structure of glycan's and difficulty in its study, high costs of spectrometry and high performance liquid chromatography are expected to hinder growth of the market.

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Global Viral Vector and Plasmid DNA Manufacturing Market to Surpass US$ 2,205.6 Million by 2027 - CMI - Yahoo Finance

The global Canine Stem Cell Therapy market registered a value of ~US$ xx Mn/Bn in 2019 and is spectated to grow at CAGR of xx% during the foreseeable period 2019-2029. In terms of product type, segment holds the largest share, while segment 1 and segment 2 hold significant share in terms of end use.

The Canine Stem Cell Therapy market study outlines the key regions Region 1 (Country 1, Country 2), region 2 (Country 1, Country 2), region 3 (Country 1, Country 2) and region 4 (Country 1, Country 2). All the consumption trends and adoption patterns of the Canine Stem Cell Therapy are covered in the report. Prominent players, including player 1, player 2, player 3 and player 4, among others, account for substantial shares in the global Canine Stem Cell Therapy market.

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Market Taxonomy

The global canine stem cell therapy market has been segmented into:

Product Type:

Application:

End User:

Region:

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The Canine Stem Cell Therapy market research answers important questions, including the following:

The Canine Stem Cell Therapy market research serves a platter of the following information:

Why go for Canine Stem Cell Therapy Market Research?

Our analysts work irrespective of the time-zone, the result, we are being recognized worldwide. We abide by the notion that each client has his/her own set of requirements. With extensive primary and secondary research, our experts churn out the most accurate information regarding the desired the Canine Stem Cell Therapy market.

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Canine Stem Cell Therapy Market top key players, size, Analysis, growth, research, Types, Regions and Forecast from 2019-2024 - Packaging News 24

Patients with certaintypes of relapsed/refractory leukemia or lymphoma showed a favorable responsewhen treated with natural killer (NK) cells modified to express an anti-CD19receptor, according to a recent study from the University of Texas MD Anderson CancerCenter in Houston.

In the study, 11 patientswith CD19-positive chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphomareceived the modified cells, known as chimeric antigen receptor-NK (CAR-NK)cells. Seven of the patients experienced complete remission, while in 1 otherpatient, treatment reduced the aggressiveness of their disease. The responsesoccurred within 30 days, and treatment was well tolerated. Administration ofCAR-NK cells did not lead to cytokine release syndrome, an inflammatoryresponse commonly seen after CAR-T cell therapy. The results were published inthe New England Journal of Medicine.1

Im super excited aboutour data, and what weve seen in the patients, but Im cognizant of the factthat this was a handful of patients, said Katy Rezvani, MD, PhD, the studyssenior author. We are making great strides, but we also have to be cautious interms of what conclusions we can draw.

Adoptive cell therapyusing CAR-T cells has shown promise against CD19-positive cancers, but itshindered by several important drawbacks. For one thing, it requires isolatingand modifying the patients own cells, which eats up valuable time. Because thepatient will have already endured multiple rounds of therapy, it may not bepossible to generate useful doses of CAR-T cells from the patients depletedsupply. CAR-T cells also inflict some unpleasant side effects, includingcytokine release syndrome (CRS), an inflammatory response that causes fatigue,body aches, and fever.

Some researchers areturning to NK cells as an alternative. The aptly named natural killer cellshave the innate ability to hunt down and kill cancer cells, which makes them anenticing tool for potential therapies. Unfortunately, they dont do wellagainst some leukemias without a little help. Professor Dario Campana, MD, PhD,of the National University of Singapore was among the first to express CARs inNK cells.2 We found at that time that acute lymphocytic leukemiaswere resistant to NK cells, recalled Dr Campana, who was not involved in thecurrent trial. When you add the CAR, then the killing is tremendous. The CARoverrides any inhibitor signals that the NK cells have.

In the current phase 1/2trial, Dr Rezvani and her team created CAR-NK cells from banked cord bloodcells. Because they lack the T-cell receptors that cause graft-vs-host disease,in which the transplanted cells attack the hosts own body, NK cells can comefrom an unrelated donor and dont have to be human leukocyte antigen-matched.This means CAR-NK cells could one day be manufactured as an off-the-shelfproduct, rather than created specifically for each patient.

For this trial, eachpatient received CAR-NK cells developed from a separate cord blood donor, butDr Rezvani said that, in theory, 1 donor could provide CAR-NK cells to multiplepatients.

None of the 11 patientsdeveloped the CRS or neurotoxicity that have been observed in patientsadministered CAR-T cells, and they the researchers never reached the maximumtolerated dose. No increase in inflammatory cytokine levels was observed.

Read more:
CAR-NK Cells Make Their Debut in Hematologic Cancers - Cancer Therapy Advisor

Five real-life cases of adult patients with relapsed/refractory CD19-positiveB-cell acute lymphoblastic leukemia (ALL) were recently detailed in an articlein Blood along with the rationalesfor selecting CD19-directed CAR-T therapy or the CD3/CD19 bispecific antibody,blinatumomab, as the first CD19-targeted treatment approach for each patientcase.

While both blinatumomab and CD19-directed CAR-T therapy (ie,tisagenlecleucel in patients 25 years or younger) are approved by the US Foodand Drug Administration (FDA) for the treatment of relapsed/refractory B-cellALL, the mechanisms of action of these therapies are very different: the formerdrug activates T cells by linking them through their CD3 receptor to the CD19surface antigen on B cells, whereas CD19-directed CAR-T therapy uses autologousT cells that have been genetically modified to express the CD19 receptor.

Nevertheless, both treatment approaches are considered tolerable and potentiallycurative in the setting of relapsed/refractory B-cell ALL. Furthermore, it maybe possible to subsequently offer the alternative CD19-targeted treatment ifdisease progression occurs following treatment with either CD19-directed CAR-Ttherapy or blinatumomab. However, some patients will become ineligible for subsequenttreatment with the alternative approach due to loss of B-cell expression ofCD19.

Oncethe decision to use CD19-targeted immunotherapy to treat a patient withadvanced ALL has been made, the physician faces the challenge of selectingbetween blinatumomab and CAR T cells, the study authors noted, adding that itis crucial to weigh all considerations for each individual patient beforeselecting one immunotherapy over another.

Inthe patient cases highlighted in this article, multiple factors were consideredin making individualized treatment decisions.

Forexample, initial treatment with blinatumomab was selected for an older patientwith low-burden disease, given its FDA approval across all age groups, itslower associated risks of severe cytokine release syndrome and neurotoxicitycompared with CAR-T therapy, and its demonstrated efficacy in patients withlow-burden disease. Furthermore, because allogeneic hematopoietic stem celltherapy (allo-HCT) was planned for this patient who had a matched siblingdonor, another factor weighing in favor of blinatumomab was the avoidance of delaysassociated with CAR-T manufacturing.

Factorsassociated with selection of CD19-directed CAR-T therapy as the initialCD19-directed approach included the presence of extramedullary disease in the centralnervous system (CNS), as there is evidence supporting CNS penetration by CAR-Tcells, as well as promising antileukemic activity in patients with extramedullarydisease.

Inaddition, CAR-T therapy was preferred for a patient who experienced diseaseprogression following allo-HCT and was unlikely to receive a second allo-HCT,given evidence for long-lasting remissions even without consolidation allo-HCTfollowing treatment with CAR-T therapy.

Inthis context, the study authors stated that blinatumomab in this setting isbetter used as a bridging therapy rather than a definitivecurative treatment.

The study authors concluded that treatment with blinatumomab and CD19 CAR T cells holds promise in advanced ALL, allowing more patients to attain remission and possible cure with and without additional therapies. Both treatments have unique limitations and advantages, and the treating physician should be discerning when selecting treatment of each case.

Reference

Aldoss I, Forman SJ. How I treat adults with advanced acute lymphoblastic leukemia eligible for CD19-targeted immunotherapy.[published online March 12, 2020]. Blood. 2020;135:804-813. doi:10.1182/blood.2019002132

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Rationales for Selecting CD19-Targeted Therapy in R/R B-Cell ALL - Cancer Therapy Advisor

Coherent Market Insights recently published a detailed study of CAR T Cell Therapy Market covering interesting aspects of the market with supporting development scenarios ranging from 2020-2026. The report delivers the clean elaborated structure of the Market comprising each and every business-related information of the market at a global level. The complete range of information related to the Global Market is obtained through various sources and this obtained bulk of the information is arranged, processed, and represented by a group of specialists through the application of different methodological techniques and analytical tools such as SWOT analysis to generate a whole set of trade-based study regarding the CAR T Cell Therapy.

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This report assesses the growth rate and the market value on the basis of the key market dynamics, as well as the growth inducing factors. The complete study is based on the up-to-date industry news, growth potentials, and Market trends. It also contains an in-depth analysis of the market and competitive scenario, together with the analysis of the leading competitors.

Competitive Analysis:

The key players are highly focusing on innovation in production technologies to improve efficiency and shelf life. The best long-term growth opportunities for this sector can be captured by ensuring ongoing process improvements and financial flexibility to invest in optimal strategies. Few Market Key Players areNovartis International AG, Kite Pharma, Inc. (Gilead Sciences, Inc.), Juno Therapeutics (Celgene Corporation), Bluebird Bio, Inc. (Celgene Corporation), Sorrento Therapeutics Inc., Mustang Bio, Inc., Aurora Biopharma Inc., Legend Biotech (Genscript Biotech Corporation), Pfizer, Inc., CARsgen Therapeutics, Ltd., and others.

This report examines and evaluates the market for a CAR T Cell Therapy at a global and regional scale. The market has been projected on the basis of revenue (USD Million) and volume (million square meters) from 2020 to 2026. The report further includes the different factors that are responsible for driving and restraining the growth of the market. It also covers the consequences of these driving and restraining factors on demand for the Market during the forecast period. The study also consists of potential growth opportunities in the global and regional markets.

To comprehend Global Market dynamics in the world mainly, the worldwide market is analyzed across major global regions. Coherent Market Insights also provides customized specific regional and country-level reports for the following areas.

This report also provides historical data from 2011 to 2020 and forecast until 2026, which makes it a valuable source of information for all the individuals looking for relevant market information in readily accessible documents with clearly presented graphs and statistics, including but not limited to the industry executives, analysts, consultants, and marketing, sales, and product managers.

Whats In The Offering:

The research study evaluates the overall size of the market, by making use of a bottom-up approach, wherein data for different industry verticals, and end-user industries and its applications across various product types have been recorded and predicted during the forecast period. These segments and sub-segments have been documented from the industry specialists and professionals, as well as company representatives, and are outwardly validated by analyzing previous years data of these segments and sub-segments for getting an accurate and complete market size.

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Highlights of theCAR T Cell Therapy Market

Some Important TOC:

The Following Queries Are Answered In This Comprehensive Document:

1. What is the market size of the global and regional levels?2. Which are the top countries and what is their market size?3. Which are the growth opportunities in the coming years?4. Which are the top players and what is their market share?5. Which are the risk factors affecting market growth?

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Thanks for reading this article, you can also get individual chapter wise section or region wise report versions like North America, Europe or Asia.

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CAR T Cell Therapy Market boosting the growth: Market dynamics and trends, efficiencies Forecast 2026 - Skyline Gazette

publication date: Mar. 24, 2020

By Paul Goldberg

This story is part of The Cancer Letters ongoing coverage of COVID-19s impact on oncology. A full list of our stories, as well as the latest meeting cancellations, are availablehere.

A class of drugs that has been used to treat adverse events associated with CAR T-cell therapy is emerging as a potential treatment for COVID-19.

The available drugs, both interleukin-6 receptor antagonists, have the capacity to treat the cytokine release syndrome, sometimes also known as the cytokine storm syndrome, a large, rapid release of cytokines into the blood as a result of viral infections or immunotherapy.

The drugstwo of which are now being rushed into late-stage clinical trialsare approved by FDA for rheumatology indications:

Actemra (tocilizumab), sponsored by Genentech, was approved in 2011.

Kevzara (sarilumab), sponsored Regeneron Pharmaceuticals and Sanofi, was approved in 2017.

Sylvant (siltuximab), sponsored by EUSA Pharma, was approvedin 2014.

Tocilizumab was used in mitigation of CRS for both approved CAR T-cell therapies on the market: the Novartis agent Kymriah (tisagenlecleucel)and the Gilead Sciences agent Yescarta (axicabtagene ciloleucel). Sarilumab isnt mentioned specifically on either of the CAR T labels, though the tisagenlecleucel label states that alternative methods of controlling CRS are acceptable after repeated failures of tocilizumab.

The sponsors of both tocilizumab and sarilumab said they are initiating clinical trials of the agents. The studies involve the Biomedical Advanced Research and Development Authority, an HHS agency focused on chemical, biological, radiological, and nuclear threats, pandemic influenza, and emerging infectious diseases.

The federal government has also obtained 10,000 vials of tocilizumab to the U.S. Strategic National Stockpile for potential future use at the direction of the HHS, Genentech announced.

The studies that are being launched will test whether blocking IL-6 would stop the overactive inflammatory response in the lungs of patients who are severely or critically ill with COVID-19. The hypothesis regarding the role of IL-6 is based on preliminary data from a 20-patient single-arm study in China using tocilizumab.

An abstract from the study follows:

Background: In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, which spread rapidly and has become a world-wide public health challenge. We aimed to assess the efficacy of tocilizumab in severe patients with Corona Virus Disease19 (COVID-19) and seek a new therapeutic strategy.

Methods: The patients diagnosed as severe or critical COVID-19 in The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) and Anhui Fuyang Second Peoples Hospital were given tocilizumab in addition to routine therapy between February 5 and February 14, 2020. The changes of clinical manifestations, CT scan image, and laboratory examinations were retrospectively analyzed.

Findings: Within a few days, the fever returned to normal and all other symptoms improved remarkably. Fifteen of the 20 patients (75.0%) had lowered their oxygen intake and one patient need no oxygen therapy. CT scans manifested that the lung lesion opacity absorbed in 19 patients (90.5%). The percentage of lymphocytes in peripheral blood, which decreased in 85.0% patients (17/20) before treatment (mean, 15.52 8.89%), returned to normal in 52.6% patients (10/19) on the fifth day after treatment. Abnormally elevated C-reactive protein decreased significantly in 84.2% patients (16/19). No obvious adverse reactions were observed. Nineteen patients (90.5%) have been discharged on average 13.5 days after the treatment with tocilizumab and the rest are recovering well.

Interpretation: Tocilizumab is an effective treatment in severe patients of COVID-19, which provided a new therapeutic strategy for this fatal infectious disease.

The entire paper is posted here.

Earlier this month, Chinas National Health Commission published a treatment guidelinethat allows the tociluzumab to be used to treat coronavirus patients who have high IL-6 levels and who show serious lung damage.

The data on tocilizumab and sarilumab fall short of a demonstration of safety and efficacy in COVID-19-related indications, and the tidbits of information from Chinaas well as the news of 10,000 vials of tocilizumab going to the U.S. Strategic National Stockpileconstitute a threat to equipoise in ongoing studies, drug developers warn. Its self-evident that equipoise here is all the more important, because fundamental questions about appropriateness of these drugs for COVID-19 remain unanswered while the drugs are available for off-label use.

The Society for Immunotherapy of Cancer has published an editorial, Insights from immuno-oncology: The Society for Immunotherapy of Cancer statement on access to IL-6-targeting therapies for COVID-19 that calls for creating a compassionate use protocol based on existing templates as well as making effort for emergency approval of using of IL-6 receptor blocking antibodies by local institutional review boards within 24 hours of the request being made.

The editorial was submitted to JITC for publication and was posted on the societys website without peer review to allow the rapid dissemination of this information.

The editorial reads:

Although randomized data definitively showing that IL-6 receptor blockade benefits patients with COVID-19 induced pneumonitis are currently lacking, we propose that an effort should be made to maximize the availability of anti-IL-6 agents, including tocilizumab and sarilumab for use on a compassionate basis to hospitalized critically ill COVID-19 infected patients during this extraordinary situation.

In addition, consideration should be given to focus efforts on rapidly expanding the ability of clinicians and clinical investigators to access investigational anti-IL-6 agents, in particular for those agents where Phase 1 and/or Phase 2 studies have been completed, and acceptable safety has been demonstrated. Even if the primary impact of a single dose of these drugs is to accelerate recovery and get patients off ventilator support and out of the ICU more rapidly, this could significantly decompress our severely over-burdened healthcare systems.

We suggest that straightforward parameters including complete blood counts and differentials, serum LDH, ferritin, CRP and IL-6 be recorded in treated patients, that serum be retained for future analyses, and simple clinical parameters be assessed including time in ICU, days of hospitalization, and pulmonary parameters including FEV1, Fi02, PaO2/FiO2 ratio and oxygen need be recorded. A simple compassionate use protocol could be assembled from existing templates, and all efforts should be made for emergency approval of the use of IL-6 receptor blocking antibodies by local institutional review boards within 24 hours of the request being made.

Additionally, consideration should be given by pharma and biotech to redirect the use of facilities and increase personnel involved in drug manufacturing and those serving as liaisons to the frontlines to facilitate drug availability. Extraordinary times call for extraordinary measures, and SITC calls on all involved, including pharmaceutical sponsors, health authorities and IRBs, to continue to move swiftly and creatively to respond and unite in removing barriers to provide our patients with care.

SITCs resources for immuno-oncology are also found on the newSITC COVID-19 Resourcespage, which includes:

Online discussion forums for patient management as well as basic and translationalresearch.

SITC statement urging scientific journals to grant open access to COVID-19publications.

FDA clinical trials guidance.

CDC COVID-19 resources.

On March 23, Genentech, a member of the Roche Group, said FDA has cleared the way a randomized, double-blind, placebo-controlled phase III clinical trial, COVACTA, which would be conducted with in collaboration with BARDA, Genentech said.

The trial will seek to evaluate the safety and efficacy of intravenous tocilizumab plus standard of care in hospitalized adult patients with severe COVID-19 pneumonia.

The primary and secondary endpoints include clinical status, mortality, mechanical ventilation and intensive care unit variables. Patients will be followed for 60 days post-randomization, and an interim analysis will be conducted to look for early evidence of efficacy, the company said.

Genentech has also been working with distributors to manage product supply to enable both Genentech and its distributors to meet patient needs.

We thank the FDA for rapidly expediting the approval of this clinical trial to evaluate Actemra in critically ill patients suffering from pneumonia following coronavirus infection and were moving forward to enroll as quickly as possible, Alexander Hardy, Genentech CEO said in a statement. Conducting this clinical trial in partnership with BARDA and providing Actemra to support the national stockpile, through the efforts of Secretary Azar and HHS, are important examples of how the U.S. government the biotechnology industry and healthcare communities are working together in response to this public health crisis.

The company said that several independent clinical trials have begun globally to explore the efficacy and safety of Actemra for the treatment of patients with COVID-19 pneumonia. However, this new trial is vital, because there are no well-controlled studies and limited published evidence on the safety or efficacy of Actemra in the treatment of patients suffering from COVID-19, the company said.

On March 16, Regeneron and Sanofi saidthey have started a clinical program evaluating sarilumab.

This phase II/III, randomized, multi-center, double-blind, phase II/III trial has an adaptive design with two parts and is anticipated to enroll up to 400 patients, the companies said. The trial will begin in New York and will recruit patients at approximately 16 U.S. sites.

The trial uses an adaptive design. To be eligible, patients must be hospitalized with laboratory-confirmed COVID-19 that is classified as severe or critical, or who are suffering from multi-organ dysfunction. All patients must have pneumonia and fever. After receiving the study dose, patients will be assessed for 60 days, or until hospital discharge or death.

In the phase II component of the trial, patients will be randomized 2:2:1 into three groups: sarilumab high dose, sarilumab low dose, and placebo. The primary endpoint is reduction of fever and the secondary endpoint is decreased need for supplemental oxygen.

The phase II findings will be utilized in an adaptive manner to determine transition into phase III, helping to determine the endpoints, patient numbers and doses. The second, larger part of the trial will evaluate the improvement in longer-term outcomes including preventing death and reducing the need for mechanical ventilation, supplemental oxygen and/or hospitalization.

If the trial continues with all three treatment arms to the end, it is expected to enroll approximately 400 patients, depending on the status of the COVID-19 outbreak and the proportion of patients with severe COVID-19 and high levels of IL-6.

To initiate this trial quickly, so that the results may inform evidence-based treatment of this ongoing pandemic, Regeneron and Sanofi have worked closely with FDA and the Biomedical Advanced Research and Development Authority, George D. Yancopoulos, co-founder, president and chief scientific officer of Regeneron, said in a statement. Data from China suggest that the IL-6 pathway may play an important role in the overactive inflammatory response in the lungs of patients with COVID-19. Despite this encouraging finding, its imperative to conduct a properly designed, randomized trial to understand the true impact.

Our trial is the first controlled trial in the U.S. to evaluate the effect of IL-6 inhibition prospectively in COVID-19 patients. In addition to our Kevzara program, Regeneron is also rapidly advancing a novel antibody cocktail for the prevention and treatment of COVID-19, which we hope to have available for human testing this summer. Both of these programs are made possible by our unprecedented end-to-end antibody discovery, development and manufacturing technologies, starting with our proprietary VelocImmune human antibody mouse, and incorporating our associated rapid manufacturing technologies designed to select and produce the best neutralizing antibodies. Collectively, these technologies expedite a typically years-long process into a matter of months. This same technology was applied to the Ebola virus, where our therapy, REGN-EB3, was shown to dramatically improve survival in infected patients last year.

To delve deeper into the fundamental questions that surround the role treatments for the cytokine release syndromeespecially IL-6 receptor antagonistsmay play in COVID-19 indications, The Cancer Letter administered a questionnaire to the following experts:

John DiPersio, MD, PhDChief, Division of Oncology, and Virginia E. and Samuel J. Golman Endowed Professor of Oncology, Washington University School of Medicine in St. LouisDeputy Director, Siteman Cancer Center, and

Armin Ghobadi, MDAssociate Professor of Medicine, Washington University School of Medicine in St. Louis.

Randy Q. Cron, MD, PhDProfessor of pediatrics and medicine,Director of the Division of Pediatric Rheumatology at the University of Alabama at Birmingham,Author of Cytokine Storm Syndrome, a textbook on cytokine storms, and

Winn Chatham, MDProfessor of medicine, clinical immunology, and rheumatologySenior scientist at the Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)Director of Rheumatology Clinical ServicesUniversity of Alabama at Birmingham.

Carl H. June: First of all, as far as the terminology goes, I prefer to distinguish cytokine release syndrome from cytokine storm.

Cytokine release syndrome is due to a targeted immune response and can be delayed in onset. With CAR T-cell therapy we have seen cytokine release syndrome delayed for as long as 50 days after the infusion of CAR T in patients with leukemia; this is an on-target response that almost always correlates with beneficial anticancer effects.

In contrast, cytokine storm is a nonspecific release of cytokines and chemokines by many cells in the immune system and can occur immediately. The scientific community became commonly aware of cytokine storms about a decade ago, after the administration of super agonistic administration CD28 antibodies to healthy volunteers.

However, during the Cold War, both the United States government and the Soviet Union studied the use of bacterial superantigens, such as staphylococcus enterotoxin B as biologic warfare agents. These bacterial superantigens can kill mice and larger animals within hours after administration.

John DiPersio and Armin Ghobadi: CRS is an inflammatory syndrome, which is due to the excessive activation of human monocytes/macrophages by multiple etiologic agents, which either directly activate monocytes or activate macrophages via the activation of T cells.

In the case of CRS associated with CAR T therapy, it is the interaction of activated and rapidly expanding CAR T with their target cells and the release and/or direct interaction with neighboring monocytes to release specific inflammatory cytokines, such as IL-6 and IL-1, as well as other cytokines and chemokines that result in CRS (fever, edema, capillary leak, new oxygen requirement).

The release of IL-6 by monocytes is largely responsible for the fevers associated with CRS; however, the neurotoxicity may or may not be related to IL-6 and may be mediated by other cytokines and chemokines, such as IL-1, TNF, GM-CSF, and even other vascular trophic cytokines such as VEGF, Angiopoietin-1 etc.

The entire syndrome mimics other macrophage activation syndromes, such as HLH (primary or secondary), and is manifested by elevation of temperature, vascular leak, hypoxia and then even altered mental status.

All can be mild, moderate or life-threatening/ending. Serum markers can be used to follow the disease, such as IL-6 levels, ferritin and C-reactive protein (CRP).

There is some increasing evidence (although still controversial) that COVID-19 is associated with a component of CRS, and that CRS may accompany terminal event of respiratory failure and death, which is not necessarily due to progression of pneumonia, but to excessive macrophage activation syndrome (MAS), which is driving terminal events such as hypotension, vascular leak and increasing O2 requirements from the both the inflammation induced by the pneumonia, but also to the bodys immune response (excessive immune response resulting in CRS and MAS) to the viral infection and to the pneumonia caused by COVID-19.

Paolo A. Ascierto: Cytokine release or cytokine storm is a severe systemic inflammatory response to an injury.

Randy Q. Cron and W. Winn Chatham: An illness complication whereby there is unchecked immune activation leading to ongoing accentuated release of pro-inflammatory cytokines that cause injury to multiple organs, frequently resulting in death if not treated.

June: I have no first-hand knowledge of the immunopathology in COVID`-19. However, a preprint from Chinahas some intriguing data in about 20 COVID-19 patients who had progressed on supportive care for about five days and were then given an infusion of tocilizumab. The temporal relationship of the fall in C-reactive protein and the resolution of fever are compelling in the data that is shown.

DiPersio and Ghobadi: See above. Still controversial, but yes, we believe that there is increasing evidence that CRS is occurring co-incident with the progressive pneumonia and in severe cases may be driving the pathology and increasing the risk of death above and beyond what would be expected by the viral infection by itself.

Ascierto: Xu et al. (chinaXiv:202003.00026) reported data from biopsy samples coming from autopsy in a patient who died for COVID-19, suggested that an inflammatory factor or a cytokine storm have occurred. They also found that aberrant pathogenic T cells and inflammatory monocytes are rapidly activated and are responsible of an inflammatory storm.

Cron and Chatham: There are increasing reports of series of patients critically ill with Covid-19 that have clinical features and blood abnormalities that are hallmarks of CSS (sepsis syndrome, ARDS, coagulopathy, hepatobiliary dysfunction, cytopenias). There are no formal studies we have seen yet that would answer the question of what percentage of deaths from Covid-19 are attributable to CSS as this is not routinely being assessed (it needs to be!).

June: Cytokine release syndrome is best thought of as a subset of secondary haemophagocytic lymphohistiocytosis (HLH), which also goes by an alternative name of macrophage activation syndrome.

Related to secondary HLH are cases of primary HLH generally seen by pediatricians that are caused by certain genetic lesions. It is possible that some of the COVID-19 patients that have hyper-inflammation have some of the predisposing genetic abnormalities that are found in other people with secondary HLH.

It is good to remember that a subset of patients with systemic viral infections are diagnosed with secondary HLH. In many of these patients, interleukin-6 is at the center of the immunopathology, along with high levels of interferon-gamma and serum ferritin levels.

DiPersio and Ghobadi: See above, again. We have not seen the inflammatory state of COVID-19 as well characterized as it has been with CAR T-associated CRS.

This needs to be done. This includes cytokine assays, fibrinogen, ferritin, CRP, IL-6, etc., as well as neurocognitive testing. It would appear different than CAR T in one important feature, and that is CRS and fever is an acute and dramatic early feature of CAR T CRS, while the CRS associated with feature of CAR T in an acute and early and fulminant (in first 1-4 days), while the CRS associated with COVID-19 is slow to develop and appears late with fevers and progressive pulmonary insufficiency.

Also, the fatal events in CAR T CRS (neurotoxicity) occurs late with progressive neurotoxicitystill, we have no idea what is causing this, although IL-1 has been implicated in some preclinical studies which may not have any relevance to what we see in patients receiving CAR Twhen the CRS and CRS markers have often returned to normal, while the COVID-19 CRS are more associated with the terminal events high fever and worsening pneumonia and excessive tissue damage and death.

Ascierto: In CAR T-cell therapy the cytokine release syndrome is due to the activation of T cells armed with CAR, while in the COVID-19 such aberrant response seems to be mainly due to monocytes/macrophages.

According to Xu et al., and previous studies in SARS and MERS, it seems that IL-6 is still the most important cytokine involved in the cytokine storm by COVID-19.

Cron and Chatham: The clinical phenotype is the same and IL-6 levels have been noted to be elevated in Covid-19 critical illness, but the principal inflammatory mediators in Covid-19 CSS have not been well characterized as of yet.

June: Exactly, it is likely that COVID-19 cases of hyper-inflammation are the same syndrome as seen in other systemic viral infection, such as with some strains of influenza (1918 pandemic) and beta coxsackie viruses such as MERS and SARS.

DiPersio and Ghobadi: No, not really.

Ascierto: Even if some other viral infection could hypothetically trigger a cytokine storm, coronavirus infections seems to be those with a higher incidence of such condition.

Cron and Chatham: Other viruses (particularly influenza and herpes viruses such as EBV, CMV, HSV) are well known triggers of CSS in genetically susceptible individuals.

June: Extreme elevations of serum ferritin requiring dilutions by the laboratory technicians as well as high levels of C-Reactive Protein are characteristic if not pathognomonic of cytokine release syndrome and secondary HLH.

Our group, in conjunction with the scientists at Childrens Hospital in Philadelphia, have studied the cytokines and other biomarkers in serum that are found elevated in cytokine release syndrome after CAR T and have compared this to markers that are found elevated in sepsis (PMID: 27632680 and 27076371).

DiPersio and Ghobadi: See above. Fibrinogen, ferritin, CRP, cytokine levels (especially IL-6).

Ascierto: From my point of view the evaluation of serum IL-6, C-reactive protein (which is strongly related to IL-6 level) and ferritin are the most relevant

Cron and Chatham: An elevated serum ferritin should be a danger signal that should prompt immediate assessment for CSS. The higher the ferritin level, the greater the likelihood of CSS.

June: It is really interesting that the first use of tocilizumab for hyper-inflammation and secondary HLH was in the case of Emily Whitehead, our first pediatric patient given the experimental form of Kymriah (PMID 23527958).

It clearly saved her life, and later became co-labeled by the FDA for therapy of CRS after CAR T for both Kymriah and axicab [Yescarta]. I think it is highly likely that interruption of interleukin-6 signaling (and probably IL-1) will be beneficial in the subset of patients with COVID-19 that have hyper-inflammation and immunopathology.

There are many questions in this area, such as when to initiate such therapy, how long should it be given, and should it be given preemptively rather only in reaction to progressive ventilatory failure.

Fortunately, many trials are being started in China and here in the United States that will provide answers to these questions.

One major issue that needs to be answered is whether or not this therapy will lead to delayed clearance of the virus and therefore potentially more patients who could be asymptomatic vectors of the virus?

Read more here:
Class of drugs used to treat CAR T-cell toxicity may reduce COVID-19 deaths - The Cancer Letter

Dublin, March 10, 2020 (GLOBE NEWSWIRE) -- The "Cell Therapy Market Size, Share & Trends Analysis Report by Use-type (Research, Commercialized, Musculoskeletal Disorders), by Therapy Type (Autologous, Allogeneic), by Region, and Segment Forecasts, 2020 - 2027" report has been added to ResearchAndMarkets.com's offering.

The global cell therapy market size is expected to reach USD 8.8 billion by 2027 at a CAGR of 5.4%, over the forecast period.

Cellular therapies hold a great therapeutic promise across various clinical applications. This has resulted in substantial global investments in research and clinical translation. Moreover, rapid advances in stem cell research hold the potential to fulfill the unmet demand of pharmaceutical entities, biotech entities, and doctors in disease management. These factors have boosted revenue growth for the market.

Currently, there are a limited number of FDA-approved commercial stem and non-stem cell therapies in the market. Furthermore, LAVIV (Azficel-T), manufactured and commercialized by Fibrocell Technologies, witnessed revenue wind-down in the past years. Key developers are making substantial investments in the adoption of advanced technologies to address the aforementioned challenges.

The introduction of proprietary cell lines is recognized as the primary means by which a single cell can be exploited for the production of a robust portfolio of candidates. Companies are leveraging new technologies not only for the expansion of their product portfolio but also for establishing out-licensing or co-development agreements with other entities to support their product development programs.

For instance, MaxCyte has more than 40 high-value cellular therapy partnership programs within immune-oncology, regenerative medicine, and gene editing, including fifteen clinical-stage programs. Increase in the number of collaborations between entities for product commercialization is anticipated to accelerate market revenue to a major extent in the coming years.

In Asia-Pacific, the market is anticipated to witness significant growth over the forecast period. This is attributed to rising awareness cellular therapies among patients and healthcare entities in chronic disease management. In addition, availability of therapeutic treatment at lower prices is also driving the regional market. Japan is likely to witness fast growth over the forecast period attributed to increasing research activities on regenerative medicine.

Further key findings from the report suggest:

Key Topics Covered

Chapter 1 Executive Summary

Chapter 2 Research Methodology

Chapter 3 Cell Therapy Market Variables, Trends & Scope3.1 Market Segmentation & Scope3.1.1 Market driver analysis3.1.1.1 Rise in number of clinical studies pertaining to the development of cellular therapies3.1.1.2 Rising adoption of regenerative medicine3.1.1.3 Introduction of novel platforms and technologies3.1.2 Market restraint analysis3.1.2.1 Ethical concerns related to stem cell research3.1.2.2 Clinical issues pertaining to development & implementation of cell therapy3.1.2.2.1 Manufacturing issues3.1.2.2.2 Genetic instability3.1.2.2.3 Stem cell culture condition3.1.2.2.4 Stem cell distribution after transplant3.1.2.2.5 Immunological rejection3.1.2.2.6 Challenges associated with allogeneic mode of transplantation3.2 Penetration & Growth Prospect Mapping For Therapy Type, 20193.3 Cell Therapy Market (Stem & Non-stem Cells)-Swot Analysis, by Factor (Political & Legal, Economic and Technological)3.4 Industry Analysis - Porter's3.5 Cell Therapy Market (Stem & Non-stem Cells)-Regulatory Landscape

Chapter 4 Cell Therapy Market (Stem & Non-stem Cells) Categorization: Use-type Estimates & Trend Analysis4.1 Cell Therapy Market (Stem & Non-stem Cells): Use-type Movement Analysis4.2 Clinical-use4.3 Research-use

Chapter 5 Cell Therapy Market (Stem & Non-stem Cells) Categorization: Therapy Type Estimates & Trend Analysis5.1 Cell Therapy Market (Stem & Non-stem Cells): Therapy Type Movement Analysis5.2 Allogeneic Therapies5.3 Autologous Therapies

Chapter 6 Cell Therapy Market (Stem & Non-stem Cells) Categorization: Regional Estimates & Trend Analysis, by Product6.1 Cell Therapy Market (Stem & Non-stem Cells) Share by Regional, 2019 & 20276.2 North America6.3 Europe6.4 Asia-Pacific6.5 Latin America6.6 MEA

Chapter 7 Competitive Landscape7.1 Strategy Framework7.2 Company Profiles7.2.1 Kolon TissueGene, Inc.7.2.2 JCR Pharmaceuticals Co. Ltd.7.2.3 MEDIPOST7.2.4 Osiris Therapeutics, Inc.7.2.5 Stemedica Cell Technologies, Inc.7.2.6 Cells for Cells7.2.7 NuVasive, Inc.7.2.8 Fibrocell Science, Inc.7.2.9 Vericel Corporation7.2.10 Pharmicell Co. Ltd.7.2.11 Anterogen Co. Ltd.7.2.12 Celgene Corporation

For more information about this report visit https://www.researchandmarkets.com/r/5bjbpt

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Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

CONTACT: ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.comFor E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

See original here:
Global Cell Therapy (Autologous, Allogeneic) Markets to 2027 - Yahoo Finance