Category Archives: Cell Therapy

In May of 2018 Kite Pharma, a Gilead Company, announced the opening of a new Neo Antigen Facility in Gaithersburg, MD. Less than one year later in April of 2019, the company, announced that it was building a new biomanufacturing facility on a 20-acre site in Frederick, MD. Since then, Kite has been diligently working to build a world-class leadership team at both sites to achieve an important mission.

Those leaders are now onboard and are out sharing their important mission by engaging the regional community to recruit and hire the talent they need to fill more than 360 job openings across Maryland..

This November, in one of its first regional community events, Kite sponsored a BioBuzz Meet and Greet networking event to get their message out to the local industry. A few dozen of Kites employees, including Chris McDonald, VP of Manufacturing and Frederick Site Head, and Wayne Hardy, Senior Director of Manufacturing and Site Head at Kites Neo Antigen Facility, shared the powerful, patient-focused why behind Kites mission.

Kite is pleased and happy to be part of this community. Were here to make a difference. Were on a mission to cure cancer, stated Hardy.

There are a lot of people out there who are suffering there is probably not a single person in this room untouched by cancer. Think about 10 years from now. You could be telling your kids or grandkids I was part of the solution to cure cancer. Thats why were here in this room right now, he added.

More than 125 people from across the BioHealth Capital Region (BHCR) gathered to hear Kites inspirational mission, learn first-hand about the company and get to personally meet its executives, hiring teams and staff.

At the event, McDonald shared that Kite had hired approximately 50 staff to date and anticipates bringing about 160 employees on board by the end of 2020 when the new facility is complete. McDonald understands that the talent market for cell therapy and biomanufacturing is highly competitive in the BHCR and sees regional collaborations and community engagement as important mechanisms to ensure Kite is able to develop and attract the right talent. The meet and greet event with BioBuzz is a good example of how Kite is accomplishing this.

In the end, the best thing you can do as an employer is to value your employees. At Kite, were totally focused on creating a workplace environment where our people are excited to come to work each and every day. Thats my aspiration for the Frederick facility, he added.

McDonalds philosophy appears to be one that extends throughout Kite as a company. BioSpace recently rated Kite in its Ideal Employer Report as one of the top 15 Biopharma Employers to provide opportunities for promotion.

Kites expansion in Maryland will provide many industry professionals with the opportunity to join a company that is a world leader in the rapidly emerging field of cell therapy. As the company grows in the coming years they expect much of their hiring to be focused around manufacturing, engineering, facilities, process development, and R&D positions.

Kites growth is built on the foundation of its industry-leading position in the cell therapy field. In late August 2017, Kite Pharma was acquired by Gilead Life Sciences for $12B. Shortly thereafter, the FDA approved Kites CAR-T cancer therapy, YESCARTA, making it one of the first autologous cell therapies ever approved by the FDA for cancer. The success of YESCARTAwhich is a treatment for non-hodgkins lymphomahas sparked significant growth at Kite, including the construction of its new 280,000 square foot advanced cell manufacturing facility that is set to open toward the end of 2020. The new facility will allow Kite to significantly expand its ability to manufacture next-generation oncology treatments, including YESCARTA and other investigational therapies.

YESCARTA is an amazing product thats really curing cancer. Making autologous cell therapies is labor-intensive and expensive, as we all know. Thats what makes our new facility so interesting: were implementing automation and innovation at the new facility to drive down costs and to make more reliable products for patients, stated McDonald.

McDonald also shared the news that Kite is currently preparing to present its ZUMA-1 trial 3-year survival data at the upcoming American Society of Hematology (ASH) Conference in December, which will mark a major milestone for the company that could lead to the possible treatment of other blood cancers beyond non-hodgkins lymphoma.

With this news on the horizon and the impending opening of its new facility, recruiting and hiring the right talent for its two Maryland facilities will prove critical to Kites continued overall success.

The collaborative, patient-first spirit driving Kite Pharmas mission to cure cancer was palpable at the BioBuzz event. McDonald and Hardys inspirational words, along with the hundreds of conversations with other Kite employees that night, made a memorable first impression on the audience and served as powerful signals that Kite Pharma will be an active and important player in the BHCR for years to come.

Though the event was only a few hours long, Kites powerful message is now resonating across the BHCR around water coolers, break rooms and kitchen tables as it gets shared by the attendees that experienced it.

For more on Kite, visit their career page.

Over the past 8 years, Chris has grown BioBuzz into a respected brand that is recognized for its community building, networking events and news stories about the local biotech industry. In addition, he runs a Recruiting and Marketing Agency that helps companies attract top talent through a blended model that combines employer branding and marketing services together with a high powered recruiting solution.

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Kite Energizes Marylands Cell Therapy and Biomanufacturing Community Around Mission to Cure Cancer - BioBuzz

This article is sponsored by The Art of Pain Management and Regenerative Medicine.

Having performed more than 25,000 procedures throughout the last decade, Dr. Jarrad Teller and Dr. Michael Schina of the Art of Pain Management (AOPM) are just getting started. Ten years ago, Dr. Teller, a chiropractor with degrees in physiotherapy and kinesiology, partnered with Dr. Schina, a vascular and trauma surgeon. Together, the pair has created one of the most successful interventional pain management practices in the tri-state area thanks to their multifaceted approach to patients. Modalities of treatment that are used by AOPM include yoga, meditation, vitamins and herbs, diet programs and spine and joint injections.

"Two years ago, our office began using stem cells to treat arthritic conditions. Previously, injections with cortisone and local anesthetic temporarily relieved a patient's pain. With stem cell injections, the patient's injury began to heal and osteoarthritis improved."

Stem cell therapy utilizes multi-potent cells that are capable of differentiating and growing into various types of tissue in the body. Stem cells act as beacon cells that find areas of inflammation (areas of need in the body) and reprogram the body's own stem cells to regenerate tissue. Stem cell function requires a healthy milieu. That is why blood analysis and correction of abnormalities prior to stem cell therapy is so important.

Osteoarthritis of the spine (neck and back), shoulder, knee, hip and ankle are the most common conditions that AOPM treats. Other conditions for which patients seek treatment include COPD, autoimmune disorders and spinal injuries, in addition to unexplained illnesses.

With traditional pain management that utilizes cortisone injections, yoga, meditation, lifestyle changes and diet, about half of patients fail to improve. This is largely related to the fact that cortisone treats only the patient's symptoms and does nothing to alleviate the underlying osteoarthritis. For the other half of patients, stem cell therapy offers the potential to improve the osteoarthritis by regenerating tissue and may be a viable option.

Art of Pain Management and Regenerative Medicine

3300 Grant Ave. Philadelphia, PA 19114

610-352-1710

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Why Stem Cell Therapy Might Be Your Answer To Chronic Pain - Patch.com

The market study report by reportsvale.com entitled Global Cell Therapy and Tissue Engineering Market Size, Status and Forecast 2019-2025 emphasizes on changing dynamics, growth-driving factors, restraints, and limitations. This allows understanding of the Global Seed Germination Trays market and benefits from any fruitful opportunities available in the report. It includes a detailed analysis of the Global Cell Therapy and Tissue Engineering in customer requirements, customer preferences, and the competitive landscape of the overall market. The study is divided into two segments i.e type and applications.

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The competition in the global Cell Therapy and Tissue Engineering Market is analyzed, taking into consideration price, revenue, sales, and market share by company, market concentration rate, competitive situations and trends, expansion, merger and acquisition, and market shares of top 5 and 10 companies.

The study includes the following key players in the Cell Therapy and Tissue Engineering market-

Detailed Segmentation of the market:

By Type-

By Application-

Based on regions, the market is expected to grow across various geographic regions, such as:-

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There are 13 chapters to present the Cell Therapy and Tissue Engineering Market.

Table of contents 1. Report Overview2. Global Growth Trends3. Market Share by Manufacturers4. Cell Therapy and Tissue Engineering Market Size by Type5. Cell Therapy and Tissue Engineering Market Size by Application6. Production by Regions7. Cell Therapy and Tissue Engineering Consumption by Regions8. Company Profiles9. Cell Therapy and Tissue Engineering Market Forecast10. Value Chain and Sales Channels Analysis11. Opportunities & Challenges, Threat and Affecting Factors12. Key Findings13. Appendix

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Cell Therapy and Tissue Engineering Market Future Scope With Upcoming Opportunities 2025 (Betalin Therapeutics, BioCardia, Inc, BioReliance...

A lack of a uniform policy allows convicted and accused perpetrators to access some dating apps and leaves users vulnerable to sexual assaults, according to an investigation. Public health news is on stem cell heart therapy, flu season, Parkinson's disease, poetry therapy, problems with blood-sugar monitors, warnings about ski helmets, a grateful transplant patient, children prone to violent outbursts, and more.

ProPublica:Tinder Lets Known Sex Offenders Use The App. Its Not The Only One.Susan Deveau saw Mark Papamechails online dating profile on PlentyofFish in late 2016. Scrolling through his pictures, she saw a 54-year-old man, balding and broad, dressed in a T-shirt. Papamechail lived near her home in a suburb of Boston and, like Deveau, was divorced. His dating app profile said he wanted to find someone to marry. Deveau had used dating websites for years, but she told her adult daughter the men she met were dorky. (Flynn, Cousins and Picciani, 12/2)

The Washington Post:Benefits Of Stem Cell Heart Therapy May Have Nothing To Do With Stem Cells, A Study On Mice SuggestsFor 15 years, scientists have put various stem cells into seriously ill patients hearts in hopes of regenerating injured muscle and boosting heart function. A new mouse study may finally debunk the idea behind the controversial procedure, showing the beneficial effects of two types of cell therapy are caused not by the rejuvenating properties of stem cells, but by the bodys wound-healing response which can also be triggered by injecting dead cells or a chemical into the heart. (Johnson, 11/27)

The Associated Press:Flu Season Takes Off Quickly In Deep South StatesThe flu season is off and running in the Deep South. The most recent weekly flu report from the Centers for Disease Control and Prevention finds high levels of flu-like illness in Alabama, Arkansas, Georgia, Nevada, South Carolina and Texas. The highest level in that report for the week ended Nov. 16 was in Mississippi. Doctors in the Magnolia State say theyre already seeing lots of patients. (11/29)

The New York Times:Swimmers Beware Of Deep Brain StimulationA lifelong swimmer leapt into deep water near his lakeside home, and was horrified to find himself completely unable to swim. Had his wife not rescued him, he might have drowned. He had recently received an electronic brain implant to control tremors and other symptoms of Parkinsons disease, and somehow the signals from the device had knocked out his ability to coordinate his arms and legs for swimming. (Grady, 11/27)

The Wall Street Journal:A Prescription Of Poetry To Help Patients Speak Their MindsDr. Joshua Hauser approached the bedside of his patient, treatment in hand. But it wasnt medicine he carried. It was a copy of a 19th-century poem titled Invictus. It isnt often that doctors do rounds with poetry. But Dr. Hauser, section chief of palliative care at the Jesse Brown VA Medical Center, and colleagues are testing it as part of a pilot study. He entered Mr. Askews room. The patient had asked for Invictus, a dark poem by William Ernest Henley that he remembered from his past. (Reddy, 12/1)

The Wall Street Journal:Diabetes Patients Blood-Sugar Data Arent Being SharedParents of young diabetes patients say they havent been getting crucial readings from blood-sugar monitors worn by their children since early Saturday. The technological breakdown, the origin of which isnt certain, threatens the proper care of the young diabetes patients. (Loftus, 12/1)

The New York Times:Study Warns Helmets Dont Offer Full Protection On SlopesCONCORD, N.H. For several years now, it has been almost de rigueur for skiers and snowboarders to strap on a helmet amid rising concerns about safety on the slopes. But a new study caution that helmets cannot protect skiers from all head injuries. (11/28)

Kaiser Health News:For Artist Inspired By Illness, Gratitude Outweighs PainPeople often ask Dylan Mortimer how it feels to breathe through transplanted lungs. He gets that a lot because while most people go through life with one pair of lungs, Mortimer is on his third. The 40-year-old artist has endured two double lung transplants in the past two years. He often shares his journey onstage as a speaker. But when the curtain closes, he leaves the rest of the storytelling to art. Im alive because of what someone else did, Mortimer said. That is humbling in all the best ways. (Anthony, 12/2)

NPR:Teens Who Threaten And Hit Their Parents: That's Domestic Violence TooNothing Jenn and Jason learned in parenting class prepared them for the challenges they've faced raising a child prone to violent outbursts. The couple are parents to two siblings whom they first fostered as toddlers and later adopted. In some ways, the family today seems like many others. Jenn and Jason's 12-year-old daughter is into pop star Taylor Swift and loves playing outside with her older brother. (Herman, 11/29)

NPR:Give Thanks For Adult Siblings And The Ties That BindWe didn't expect to need the card table for spillover seating at this year's Thanksgiving dinner. We would be fewer than usual, just nine altogether, and the littlest one's high chair needs no place setting. As we got things ready, I felt deep gratitude for the family members who would be here my husband, our two daughters, their husbands, my sister-in-law's 90-year-old mother and our two delightful granddaughters. But I also knew I would deeply miss the ones who couldn't make it. (Henig, 11/28)

The Washington Post:Doctors In China Found Tapeworms In Brain Of Man Who Ate Undercooked Meat In Hot PotA Chinese man sought medical attention for seizures and a headache that lasted nearly a month. Doctors found that tapeworms from undercooked meat were causing his pain. Researchers at the First Affiliated Hospital of Zhejiang University published a paper last week that details the plight of 46-year-old construction worker Zhu (an alias for the patient) in the eastern Zhejiang province of China who bought pork and mutton about a month ago for a spicy hot pot broth. (Beachum, 11/27)

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Hidden Dangers Of Dating Apps: Sex Offenders, Including Rapists, Are Using Them. Why Do Companies Allow It? - Kaiser Health News

2 December 2019

Stem cell therapies may become redundant in repairing cardiac function after a heart attack, suggests a new study in mice.

It showed how stem cell treatments can heal hearts by triggering an immune response which can be achieved by using a chemical instead.

'This work is paradigm-shifting because it demonstrates a mechanism to explain a perplexing phenomenon that has intrigued cardiologists as a result of decades of cardiac stem cell trials,' Dr Jonathan Epstein at the University of Pennsylvania's Perelman School of Medicine in Philadelphia told The Scientist.

Stem cell therapies to repair damaged heart tissue are currently being tested in human clinical trials. In these treatments, human stem cells are injected into the heart and this leads to an improvement in heart function. However, how this works is not fully understood.

One possibility is that the injected stem cells are incorporated into the heart tissue and repair the damage. However, the latest study, published in the journal Nature, suggests that this may not be the case. Instead, the study indicated that the repair is actually a result of triggering the innate immune response.

Researchers injected different types of stem cell or a chemical inducer (zymosan) of the innate immune response into an experimental mouse model of heart disease. They saw improvement in heart function that was similar in all cases, and showed that this repair occurs via activation of macrophage cells of the innate immune system.

'The innate immune response acutely altered cellular activity around the injured area of the heart so that it healed with a more optimised scar and improved contractile properties,' said Dr Jeffery Molkentin at the University of Cincinnati and Cincinnati Children's Hospital Medical Centre, Ohio, who led the study. 'The implications of our study are very straightforward and present important new evidence about an unsettled debate in the field of cardiovascular medicine.'

The work could open up new possibilities for optimising the treatments currently in development, as well as alternative new therapies.

'If there is a chemical off-the-shelf, it would be a much more feasible therapy [than stem cell transplants],'Dr Kory Lavine at Washington University in St Louis, Missouri, told Nature News.

Read more:
Stem cells may trigger immune repair to mend hearts - BioNews

The market research report is a perfect tool for digging deep into critical aspects of the Global Animal Stem Cell Therapy Market and closely understanding factors that influence its growth. Our research analysts are experienced enough to provide you the right information about the global Animal Stem Cell Therapy market to help your business propel forward in the coming years. What makes us different from other market researchers is our high level of analysis that helps you to identify key opportunities available in the global Animal Stem Cell Therapy market. The report provides every bit of information about the global Animal Stem Cell Therapy market related to major market segments, vendor landscape, geographical growth, and other significant factors.

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We deliver market intelligence according to your requirements. This report can be customized as per your business needs. We meet client expectations with the help of our peerless pre-execution, execution, and post-execution engagement models. Our analysts offer quantified B2B research on market threats and opportunities. They also provide qualitative analysis of the global Animal Stem Cell Therapy market.

Get detailed segmentation of the global Animal Stem Cell Therapy market according to type of product and application. The report also covers important technologies used and services provided by leading companies of the global Animal Stem Cell Therapy market. It provides details about latest industry trends observed in different market segments. By providing market forecasts of each segment in terms of volume and revenue, the report enables market players to focus on high-growth areas of the global Animal Stem Cell Therapy market.

The authors of the report profile leading companies of the global Air Purifiers market, such as

Medivet Biologics LLC, VETSTEM BIOPHARMA, J,ARM, U.S. Stem Cell, Inc, VetCell Therapeutics, Celavet Inc., Magellan Stem Cells, Kintaro Cells Power, Animal Stem Care, Animal Cell Therapies, Cell Therapy Sciences, Animacel

They provide details about important activities of leading players in the competitive landscape.

Market Segmentation

By Product

DogsHorsesOthers

By Application

Veterinary HospitalsResearch Organization

A market research study is incomplete without regional analysis, and we are well aware of it. That is why, the report includes a comprehensive and all-inclusive study that solely concentrates on the geographical growth of the global Animal Stem Cell Therapy market. The study also includes accurate estimations about market growth at the global, regional, and country levels. It empowers you to understand why some regional markets are flourishing while others are seeing a decline in growth. It also allows you to focus on geographies that hold the potential to create lucrative prospects in the near future.

Regions Covered in the Global Animal Stem Cell Therapy Market:

Using the competitive analysis offered in the report, players can gain sound understanding of certain behaviors of other market participants. This equips them to make the required changes in their marketing strategies and improve their business tactics to strongly position themselves in the global Animal Stem Cell Therapy market. With detailed mapping of the vendor landscape, the report highlights highly competitive areas of the global Animal Stem Cell Therapy market. The report also talks about the nature of the vendor landscape and reasons supporting it. It profiles some of the prominent names in the Animal Stem Cell Therapy industry.

Few of the questions answered through the report

(1) How will the global Animal Stem Cell Therapy market perform during the forecast period? What will be the market size in terms of value and volume?

(2) Which segment will drive the global Animal Stem Cell Therapy market? Which regional market will show extensive growth in the future? What are the reasons?

(3) How will the market dynamics change because of the impact of future market opportunities, restraints, and drivers?

(4) What are the key strategies adopted by players to sustain themselves in the global Animal Stem Cell Therapy market?

(5) How will these strategies influence the market growth and competition?

For more details and inquiry to buy the report:https://www.qyrconsulting.com/checkout/7937

Key Picks from TOC

Market Overview: It begins with scope of products offered in the global Animal Stem Cell Therapy market and ends with a chapter on global market size by production and revenue.

Market Competition: Here, the report explains various competitive situations and trends and gives estimations of market share by manufacturer vis--vis revenue and production.

Market Share by Region: In this section is included a study on the production of Animal Stem Cell Therapy in different regions and countries. Each geographical market studied in the report is analyzed on the basis of gross margin, price, revenue, and production.

Company Profiles: This section is entirely dedicated for company profiling where leading market players are evaluated on the basis of different factors.

Global Animal Stem Cell Therapy Market Forecast

Research Methodology

We follow an ideal mix of primary and secondary research methodologies. One of the most extensive stages in our research process is information procurement. Under information analysis, we map and analyze all the information procured by our analysts. This step also involves analyzing data discrepancies found across different data sources. In order to deduce viable conclusions, we place data points at appropriate market spaces. Validation is the final and a very important step before the publishing of the report. We employ an intricately designed process for validation and re-validation to finalize data points for their use in final calculations.

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About Us:QYR Consulting established as a research firm in 2007 and have since grown into a trusted brand amongst many industries. Over the years, we have consistently worked toward delivering high-quality customized solutions for wide range of clients ranging from ICT to healthcare industries. With over 50,000 satisfied clients, spread over 80 countries, we have sincerely strived to deliver the best analytics through exhaustive research methodologies.

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Animal Stem Cell Therapy Market Size, Key Manufacturers, Sales, Demand, Application Forecasts And Opportunities By 2025 - ToplatestDailynews

The 23rd Annual Meeting is expected to be the Societys largest ever, and attendees are encouraged to register early and to reserve their hotel rooms as soon as possible.

MILWAUKEE (PRWEB) December 02, 2019

Registration is now open for the American Society of Gene & Cell Therapys (ASGCT) 23rd Annual Meeting, which will be held at the Hynes Convention Center May 12-15, 2020, in Boston. The meeting is the premier event in the field of gene and cell therapy and brings together scientists, physicians, patient advocates, and other stakeholders with the goal of advancing gene and cell therapies to alleviate human disease.

The 23rd Annual Meeting is expected to be the Societys largest ever, and attendees are encouraged to register early and to reserve their hotel rooms as soon as possible as the latter will sell out well before the meeting. An early registration discount is available through April 10, and groups of five or more are eligible for an additional discount. Pre-Meeting Workshops and the Closing Night Reception can be added to annual meeting registration.

Abstract submission for the 23rd Annual Meeting is now open and runs through January 29.International attendees can generate invitation letters online to apply for a VISA immediately after registering or submitting an abstract. More information about registration is available on the annual meeting website.

Hotel blocks for the Sheraton Boston Hotel and Boston Marriott Copley Place are also available now. ASGCT room blocks historically sell out months before the annual meeting, and once the ASGCT block is completely full, there's no guarantee attendees will be able to get the same room rate during the meeting.

More details about annual meeting programming will be posted on the website as they are confirmed. For any questions about the annual meeting, please contact mailto:info@asgct.org [info@asgct.org __title__ ].

About ASGCTThe American Society of Gene & Cell Therapy is the primary professional membership organization for scientists, physicians, patient advocates, and other professionals with interest in gene and cell therapy. Our members work in a wide range of settings including universities, hospitals, government agencies, foundations, biotechnology and pharmaceutical companies. ASGCT advances knowledge, awareness, and education leading to the discovery and clinical application of gene and cell therapies to alleviate human disease to benefit patients and society.

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Registration Opens Today for ASGCT's 23rd Annual Meeting in Boston - PR Web

No longer just for professional athletes, these are the stem cell and regenerative medicine options DCs need to know about

The health care landscape continues to evolve at a dizzying pace. Insurance deductibles are increasing, and this has placed a financial burden on patients who are required to self-pay for necessary and yet uncovered services.

The opioid crisis has left physicians with limited clinical options to treat chronic pain and dysfunction. At the same time, pressure has been placed on health care providers to provide affordable alternatives to invasive procedures that provide limited clinical options with high failure rates. This confluence of supply and demand has resulted in the growth of emerging therapies in the field of stem cell and regenerative medicine. These therapies are bringing hope to patients and new opportunities to health care providers who deliver them.

Regenerative medicine is the process of replacing or regenerating cells and tissues to restore normal function. Initially popularized by professional athletes, these therapies have become mainstream. More than 27 million Americans suffer from osteoarthritis today, and in 2030 25% of U.S. adults will be diagnosed with osteoarthritis. The global regenerative medicine market is predicted to reach more than $100 billion by 2022.

These moderately-invasive regenerative procedures are eclipsing traditional highly-invasive procedures, such as hip and knee implantation, which will have a global market of $35 million over the same period.

There are four primary regenerative medicine options:

Irritant therapies include prolotherapy, ozone and prolozone. Theyincludeadding multipleirritatingsubstances along with numbing agents into degenerated or injured joints, and areas of pain.

These therapies cause inflammation to kick-start regeneration by stimulating the body to send in macrophages, which are cells that ingest and destroy theirritantsolution and trigger the healing response. Irritant therapies are an excellenttreatmentfor all forms of musculoskeletal and joint pain includingchronic neck and back pain, and rotator cuff injuries.

The effect of irritant therapies is analogous to jump-starting the battery in a tractor to get the engine to turn over.

Protease inhibition therapy eliminates the factors causing cartilage degradation, tissue breakdown, inflammation and pain. It cleans and protects joints. It is most commonly used for patients with osteoarthritis (OA) and degenerative disc disease (DDD).

It includes therapies such as alpha-2-macroglobulin (A2M) and interleukin-1 receptor antagonist protein (IRAP). A2M and IRAP are proteins found naturally in our blood. They act as protease inhibitors by binding to and inactivating damaging proteases in the body. Proteases are catabolic enzymes that break larger molecules into smaller units. Proteases trapped in the joints catabolize cartilage and break it down, causing arthritis. A2M is a large protein made in the liver. It blocks activity for all known molecules that cause cartilage breakdown. It works like a Venus flytrap by having a bait-and-trap mechanism on two sides.

Once the proteases are bound on both sides, the molecule initiates a suicide cascade and dies, allowing it to be flushed out of the area by the body.

The binding effect of protease inhibition therapy is analogous to de-weeding a garden and tilling the soil before planting.

A fibronectin-aggrecan complex test (FACT) may be used to determine the presence of FAC, which is a biomarker or indicator of cartilage breakdown caused by proteases. FAC is a unique molecular complex that is specific for painful inflammation of the spine and cartilage.

A small sample of fluid is taken from the joint or disc and sent to a lab for testing. The test looks for the presence of FAC in the fluid sample and determines where you are: FAC+ or FAC-. FAC+ patients are identified as ideal candidates for A2M injections and have a 90% rate of responding to the A2M therapy.

Stem cell therapy is focused on concentrating the workhorses of regeneration and restoration of tissues: stem cells. This results in greater cell signaling and cell recruitment than other regenerative therapies. Stem cells are known as mesenchymal signaling cells. They are considered pluripotent, which means they are undifferentiated and can replicate into various cell and tissue types.

Stem cells are found in bone marrow, the soft spongy tissue found at the center of large bones. Introducing stem cells into an injured area initiates the healing response, repairing damaged tissue by growing new, healthy tissue. The most common stem cell therapies include bone marrow aspirate concentrate (BMA), nanofat and stromal vascular fraction.

Injecting stem cells into an injured area is analogous to planting seeds in a garden.

Growth factor therapies are focused on cell signaling and cell recruitment. Blood is made up of white blood cells, red blood cells, and platelets that are suspended in plasma. Platelets are most widely known for their ability to clot blood. Platelets are also highly rich in growth factors that are proteins that stimulate healing. When an injury occurs, platelets become activated, migrate to the site of injury and release growth factors.

Growth factor therapies are the most popular provider choice for the low-cost regeneration of tissues and include platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM). The therapy includes drawing the patients blood followed by centrifugation to concentrate the platelets and exclude other unwanted blood products.

Another type of growth factor therapy is amniotic fluid growth factor (GF) injection therapy. Amniotic fluid surrounds the fetus during pregnancy and provides protection and nourishment. Human amniotic fluid is sourced from consenting mothers during full-term C-sections. It contains over 200 growth factors, cytokines and proteins. The therapeutic use of amniotic fluid is regulated by the FDA. It must be tested for disease and may not include any viable cells. Amniotic fluid GF therapy has both anti-inflammatory and anti-microbial properties and includes naturally-occurring hyaluronic acid for lubrication. It is most commonly used to promote the repair and reconstruction of soft tissues including cartilage and tendons.

Exosomes are being heralded as the next frontier of growth factor therapies. While they are not cells, exosomes play a vital role in the communication and rejuvenation of all the cells in the body. Exosomes are extracellular vesicles, or small bubbles, released from cells, especially from stem cells. These culture-expanded cell secretions are derived from human placental tissue. They allow for cell-to-cell communication, transporting molecules that are important regulators of intracellular information. Exosomes act as a food source for stem cells and prolong their activity. Exosomes are anti-inflammatory and include more than 300 growth factors, cytokines and proteins.

Patients with Lyme disease, burns, chronic inflammation, autoimmune disease and other chronic degenerative diseases may benefit from including exosomes in their treatment regimen. The application of growth factor therapies is analogous to applying fertilizer to a garden to help the crop grow and flourish.

Moving stem cell and regenerative medicine forward in the treatment algorithm may eliminate the need for other ineffective or potentially harmful therapies. These therapies provide new hope for patients whose only alternatives have been long-term medication, steroid injections, and costly and time-consuming surgery and rehab.

Stem cell and regenerative medicine therapies may only be provided by licensed medical professionals following all appropriate rules and regulations. An understanding of these emerging therapies and the benefits they may provide is essential as the collaboration between doctors of medicine and chiropractic increases and we join forces to combat chronic pain, dysfunction and disease.

MARK SANNA, DC, ACRB LEVEL II, FICC, is a member of the Chiropractic Summit and a board member of the Foundation for Chiropractic Progress. He is the president and CEO of BreakthroughCoaching, and can be reached at mybreakthrough.com or800-723-8423.

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A primer: stem cell and regenerative medicine as 'the' emerging therapy - Chiropractic Economics

SAN CARLOS, Calif., Dec. 02, 2019 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc., (NASDAQ: IOVA), a late-stage biotechnology company developing novel T cell-based cancer immunotherapies, today announced that the company plans to present at the following conferences in December:

Live and archived webcasts of the presentations will be available in the Investors section of the Iovance website at http://ir.iovance.com.

AboutIovance Biotherapeutics, Inc.

Iovance Biotherapeutics aims to improve patient care by making T cell-based immunotherapies broadly accessible for the treatment of patients with solid tumors and blood cancers. Tumor infiltrating lymphocyte (TIL) therapy uses a patients own immune cells to attack cancer. TIL cells are extracted from a patients own tumor tissue, expanded through a proprietary process, and infused back into the patient. After infusion, TIL reach tumor tissue, where they attack tumor cells. The company is currently conducting pivotal studies in patients with metastatic melanoma and advanced cervical cancer. In addition, the companys TIL therapies are being investigated for the treatment of patients with locally advanced, recurrent or metastatic cancers including head and neck and non-small cell lung cancer. A clinical study to investigate Iovances T cell therapy for blood cancers called peripheral blood lymphocyte (PBL) therapy is being initiated. For more information, please visit http://www.iovance.com.

Forward-Looking Statements

Certain matters discussed in this press release are forward-looking statements of Iovance Biotherapeutics, Inc. (hereinafter referred to as the Company, we, us, or our). We may, in some cases, use terms such as predicts, believes, potential, continue, estimates, anticipates, expects, plans, intends, may, could, might, will, should or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. The forward-looking statements include, but are not limited to, risks and uncertainties relating to the success, timing, projected enrollment, manufacturing and production capabilities, and cost of our ongoing clinical trials and anticipated clinical trials for our current product candidates (including both Company-sponsored and collaborator-sponsored trials in both the U.S. and Europe), such as statements regarding the timing of initiation and completion of these trials; the timing of and our ability to successfully submit, obtain and maintain FDA or other regulatory authority approval of, or other action with respect to, our product candidates, including those product candidates that have been granted breakthrough therapy designation (BTD) or regenerative medicine advanced therapy designation (RMAT) by the FDA and new product candidates in both solid tumor and blood cancers; the strength of the Companys product pipeline; the successful implementation of the Companys research and development programs and collaborations; the Companys ability to obtain tax incentives and credits; the guidance provided for the Companys future cash, cash equivalent, and short term investment positions; the success of the Companys manufacturing, license or development agreements; the acceptance by the market of the Companys product candidates, if approved; and other factors, including general economic conditions and regulatory developments, not within the Companys control. The factors discussed herein could cause actual results and developments to be materially different from those expressed in or implied by such statements. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in the Companys business, including, without limitation: the preliminary clinical results, which may include efficacy and safety results, from ongoing Phase 2 studies may not be reflected in the final analyses of these trials or subgroups within these trials; a slower rate of enrollment may impact the Companys clinical trial timelines; enrollment may need to be adjusted for the Companys trials and cohorts within those trials based on FDA and other regulatory agency input; the new version of the protocol which further defines the patient population to include more advanced patients in the Companys cervical cancer trial may have an adverse effect on the results reported to date; the data within these trials may not be supportive of product approval; changes in patient populations may result in changes in preliminary clinical results; the Companys ability or inability to address FDA or other regulatory authority requirements relating to its clinical programs and registrational plans, such requirements including, but not limited to, clinical, safety, manufacturing and control requirements; the Companys interpretation of communications with the FDA may differ from the interpretation of such communications by the FDA; risks related to the Companys ability to maintain and benefit from accelerated FDA review designations, including BTD and RMAT, which may not result in a faster development process or review of the Companys product candidates (and which may later be rescinded by the FDA), and does not assure approval of such product candidates by the FDA or the ability of the Company to obtain FDA approval in time to benefit from commercial opportunities; the ability or inability of the Company to manufacture its therapies using third party manufacturers or its own facility may adversely affect the Companys potential commercial launch; and additional expenses may decrease our estimated cash balances and increase our estimated capital requirements. A further list and description of the Companys risks, uncertainties and other factors can be found in the Companys most recent Annual Report on Form 10-K and the Companys subsequent filings with the Securities and Exchange Commission. Copies of these filings are available online at http://www.sec.gov or http://www.iovance.com. The forward-looking statements are made only as of the date of this press release and the Company undertakes no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.

Investor Relations Contacts:Annie ChangSolebury Trout646-378-2972achang@troutgroup.com

Chad RubinSolebury Trout646-378-2947crubin@troutgroup.com

Media Relations Contact: Rich AllanSolebury Trout646-378-2958rallan@troutgroup.com

Link:
Iovance Biotherapeutics to Present at Upcoming Investor Conferences in December - BioSpace

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2 Executive Summary

3 Research Methodology of Verified Market Research

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Stem Cell Therapy Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Stem Cell Therapy Market, By Deployment Model

5.1 Overview

6 Stem Cell Therapy Market, By Solution6.1 Overview

7 Stem Cell Therapy Market, By Vertical

7.1 Overview

8 Stem Cell Therapy Market, By Geography8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Stem Cell Therapy Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Stem Cell Therapy Market Analysis by Top Companies, Driver, Existing Trends and Global Forecast by 2026 - The Market Publicist