Category Archives: Colorado Stem Cells

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Dr. Max Gomez of WCBS TV reports on a clinic near Denver, Colorado that is using adult stem cells to treat osteo-arthritis of the knee, hip, ankle, and even back pain. Dr. Christopher Centeno and two of his patients discuss the process and their experience.

One patient, 52-year-old Robert Wilson, was facing knee replacements in his near future until discovering the new stem cell treatment which uses his own adult stem cells harvested from bone marrow in his hip. After the stem cells are extracted, they're brought to the lab where they're grown in special tissue cultures to multiply their numbers. Wilson now receives a series of injections that deposit his stem cells in the arthritic areas, and because they're his own stem cells, there's no risk of rejection or contracting infectious diseases.

Dr. Centeno says that the stem cells are used to form new cartilage or even repair torn ligaments. "They actually may make new cartilage or repair a ligament by becoming a piece of that ligament or a tendon or a bone if there was a defect in bone," he said. The stem cell treatments have been successful in other cases as well. Knee MRI's of other patients have shown where new cartilage is growing in and x-rays of broken arms that wouldn't heal have revealed new bone after stem cell injections.

Because of the growing use of stem cells in clinical therapy, the concept of people collecting and storing their own stem cells is growing in popularity. An advantage to storing or using ones own stem cells is that there's no risk of rejection or contracting infectious disease. There are clinical trials showing promising results using adult stem cells for heart failure, diabetes, lupus, MS and even macular degeneration.

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Adult Stem Cells Help Ease Arthritis - Stem Cell Research

Stem Cell and PRP Therapy Patient Information

Dr. Christopher Jones of Colorado Springs Orthopaedic Group offers the most technologically advanced operative and non-operative treatment options for patients with common orthopaedic conditions. While surgery is a mainstay of treating orthopaedic conditions, Dr. Jones believes in taking a conservative approach when considering surgery and thus has been utilizing biologic treatments for over 5 years as a form of Regenerative Medicine. He started using Platelet Rich Plasma (PRP) injections for treatment of conditions such as tennis elbow, golfers elbow, patella tendinitis, plantar fascitis and osteoarthritis when research began to show it as a viable alternative. He has seen great success in treating these conditions with fewer and fewer patients requiring surgery.

More recently, Stem Cell Therapy has entered the clinical arena of Regenerative Medicine as a viable treatment option. Stem cells have been shown in laboratory and clinical studies to regenerate or regrow new viable tissue and cartilage. The conditions that are amenable to these biologic treatments include:

Commonly Asked Questions

REFERENCES: Presented below is a sample of the research that has been done on these regenerative medicine techniques.

Can platelet-rich plasma enhance tendon repair? A cell culture study.

A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery.

PRP and Articular Cartilage: A Clinical Update.

Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration.

Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis.

Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions.

Does platelet-rich plasma enhance microfracture treatment for chronic focal chondral defects? An in-vivo study performed in a rat model.

The treatment of chondral lesions of the knee with the microfracture technique and platelet-rich plasma.

Isolation of amniotic stem cell lines with potential for therapy

Stem cells derived from amniotic fluid: new potentials in regenerative medicine.

Amniotic fluid stem cells: a promising therapeutic resource for cell-based regenerative therapy.

Amniotic membrane transplant for articular cartilage repair: an experimental study in sheep.

The effects of staged intra-articular injection of cultured autologous mesenchymal stromal cells on the repair of damaged cartilage: a pilot study in caprine model.

A preliminary study comparing the use of allogenic chondrogenic pre-differentiated and undifferentiated mesenchymal stem cells for the repair of full thickness articular cartilage defects in rabbits.

Amniotic fluid stem cells and their application in cell-based tissue regeneration.

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PRP and Stem Cells More Patient Information

George Reed's heart wasn't doing so well: He's 71, and after suffering a heart attack years earlier, Reed had undergone open heart surgery and was put on multiple medications. But nothing seemed to help the dizziness and chest pain he experienced daily.

"I'd get dizzy and just fall over -- sometimes twice a day. I would run my head into the concrete. I was a bloody mess," the Perry, Ohio, native says. Despite his doctor's best efforts, Reed continued to experience angina, a type of chest pain that occurs when the heart doesn't get enough oxygen-rich blood; it can be accompanied by dizziness. So when he was recommended for an experimental study that would inject his own stem cells into his damaged heart, Perry signed on. "I needed something to change," he says.

Researchers gave Reed a drug commonly used in bone marrow transplants that stimulates the marrow to make more stem cells. Then they removed some of Reed's blood, isolated the stem cells and injected them into and around the damaged areas of his heart.

"The goal was to grow new blood vessels with stem cells from the patient's own body," says Dr. Tim Henry, a co-author of the study and director of research at the Minneapolis Heart Institute Foundation.

Within a few months, Reed, along with many of the other 100 or so patients at 26 hospital centers who'd received this stem cell treatment, reported feeling better than he had in years.

"When it started kicking in, I felt like a kid. I felt good," Reed says. He wasn't passing out and falling down anymore.

For Jay Homstad, 49, who was part of the Minnesota branch of the study, he felt the changes most in his ability to walk and be active.

"My activity level increased tenfold. Before, I struggled with chest pain every day. My activity level was about as close to zero as you could get. Now I can participate ... just in life. It may sound silly, but the best part is that in the wintertime I could go out and walk with my dog along the Red River. When you're walking through snow that is waist deep, you can tell there's a difference," Homstad says.

Homstad had had about a dozen surgeries and nine stents put in before he enrolled in the study, but he still struggled with angina daily. Within a few months of the stem cell shots, he could walk farther, and his chest pain subsided and was kept at bay for nearly four years.

"These are people for whom other treatment hasn't worked. They're debilitated by their chest pain, but their other options are really limited, that's why we picked them," says Henry. If the positive results seen in this study hold up in the next phase of the study, which is set to begin enrollment in the fall, this type of cardiac stem cell injection could be added to the arsenal of weapons against angina. The upcoming phase three trial has already been approved by the Food and Drug Administration.

Shot to the Heart, Before It's too Late

While several smaller studies have suggested that injecting stem cells into damaged heart tissue might be effective, this study, in its scope and rigor, was the first of its kind. A total of 167 patients were recruited and randomly assigned to receive a lower dose of stem cells, a higher dose or a placebo. The patients didn't know who got what treatment, and neither did the doctors treating them.

When tracked for a year after the injection, patients who received the lower dose of stem cells could last longer during a treadmill exercise than those who had received the placebo, and they averaged seven fewer episodes of chest pain in a week. To put this in perspective, a popular drug to treat angina, Ranolazine, reduced chest pain by fewer than two episodes a week in clinical trials.

Although the goal of the stem cell shots was to grow new blood vessels, it's impossible to tell if these stem cells were actually growing into blood vessels or if they were just triggering some other kind of healing process in the body, Henry says. Tests in animal models, however, do suggest that new blood vessels are forming, says Dr. Marco Costa, a co-author of the study and George Reed's doctor at UH Case Medical Center in Cleveland.

For now, the only gauge of the injections is improvement in symptoms.

Despite the positive results of the study, cardiologists remain "cautiously optimistic" about stem cells as a treatment for angina.

"The number of patients is relatively small, so this trial would probably not carry much scientific weight," says Dr. Jeff Brinker, a professor of cardiology at Johns Hopkins University. The results did justify the next, larger trial, he says, which would offer more answers as to whether this treatment is actually working the way researchers suspect.

The fact that lower doses of stem cells were puzzlingly more effective than larger ones is cause for caution, says Dr. Steve Nissen, chairman of the department of cardiovascular medicine at the Cleveland Clinic.

"The jury is still out for stem cell therapies to treat heart disease," says Dr. Cam Paterson, a cardiologist at the University of North Carolina at Chapel Hill.

But the results so far provide cautious hope for heart patients like George Reed and Jay Homstad.

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Injecting the Heart With Stem Cells Helps Chest Pain - ABC ...

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18:0020:00

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Provide a stimulating and dynamic overview of some of the major ideas and trends shaping the field.

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Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.

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Cooperativity, niche and immune interaction.

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Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.

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Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.

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EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.

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New therapeutic opportunities to target CSCs.

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Therapeutic strategies for targeting CSC in the clinic.

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CSC metabolism, ROS involvement-control, epigenetics and miRNA.

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Keystone Symposia Stem Cells and Cancer

Here we have compiled a list of several clinics offering stem cell treatments. Please note that the "conditions treated" refers to the conditions that THEY claim to treat. Most, if not all, stem cell treatments (except hematopoietic stem cell transplantation) aren't FDA approved, meaning that they haven't been clincally tested for safety or efficacy. Please be aware that receiving an unapproved medical treatment isrisky and may cause serious complications and possibly death.

It was only a few years ago when Europe's most popular stem cell clinic (XCell-center) was forced to close after one of the treatments caused the death of a boy. In the past, we have also covered the case of a woman that had serious adverse effects following an unapproved cosmetic stem cell treatment(facelift).

We have not included clinics offering hematopoietic stem cell transplantation, as this treatment is medically approved and offered virtually in any country that has an above the average hospital.

The stem cell clinics are categorised by alphabetical order. We are not paid by any of them and we have listed them for your ease. We have probably missed a few ones, feel free to leave a comment and we will add them asap.

Stem cell clinics list

Beijing Puhua International Hospital

Conditions Treated:Diabetes, Epilepsy, Stroke, Ataxia, Spinal Cord Injuries, Parkinson's Disease, Brain Injury, Multiple Sclerosis, Batten's Disease

Interview of a patient treated in Beijing Puhua International Hospital. The video is from the hospital's official youtube channel, so it may be biased

Elises International

Conditions Treated: No info available at their website

Advertisement video ofElises International

EmCell

Conditions Treated:ALS, Alzheimer's,Anemia, Cancer, Eye Diseases, Diabetes, Liver Diseases, Multiple Sclerosis Parkinson, and other

Location:Ukraine

EmCell Advertisement

Global Stem Cells

Conditions Treated:Type 2 Diabetes, Hepatitis C, Osteoarthritis, joint pain, hair regrowth, cosmetic anti-aging, ulcerative colitis, heart disease

Location:Bangkok Thailand

MD Stem Cells

New Zealand Stem Cell Clinic

Stem Cell Institute

Video of a patient treated in theStem Cell Institute. The video is taken from the clinic's official youtube channell,so it may be biased.

Okyanos Heart Institute

Conditions Treated:Cardiac conditions

Okyanos Promotinal Video

StemGenex

Conditions Treated: Multiple sclerosis, Alzheimer, Parkinson, Diabetes, Rheumatoid Arthritis and other

Location:San Diego, California.

Stem Cells Thailand

Conditions Treated:Alzheimer, Autism, Diabetes, Erectile Dysfunction, Face lift, Multiple Sclerosis, Arthritis and other

Regennex

Conditions Treated: Regennex mainly offers treatments for bone and cartilage regeneration in all major joints like knee, ankle, hip, back, shoulder etc

Dr. Centeno, founder of the clinic, talking about Regenexx

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Stem Cell Clinics List | Stem Cells Freak

The overall theme of the Stem Cell group is to combine mouse embryonic stem (ES) cells and hydrogel-based biomaterials to model and study defined aspects of neural development and stem cell biology. First, we are interested in developing hydrogel matrices for encapsulation of ES cell derived motor neurons (ES motor neurons) and for directing motor axon outgrowth using developmentally relevant axon guidance cues and extracellular-matrix (ECM) based peptides or proteins. In addition, we are interested in recapitulating molecular gradients that drive the patterning of the developing central nervous system (CNS) in vivo using various hydrogel-based approaches. Moreover, we are testing the ability of 3D hydrogel systems to maintain the pluripotent ES cell state under long-term culture regiments when tethered with ECM and cell-cell contact based cues. Finally, we are investigating the effects of hydrogel stiffness on differentiation of ES cells. Together these studies will likely provide novel insights into the molecular mechanisms that drive neural development and stem cell differentiation, and operate to maintain pluripotency of ES cells. These approaches are of significant interest to studies on stem cell biology, neural development and regenerative medicine.

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Stem Cell | Anseth Research Group - University of Colorado ...

The Premier Stem Cell Institute is a research and treatment facility in Johnstown, Colorado. It was founded by Dr. Kenneth Pettine,an extremely skilled, world renowned, spine surgeon who employs the latest concepts, developments, and therapies for innovative techniques using the bodys natural healing resources. Dr. Pettine is a pioneer in spinal and joint stem cell therapies and has created thePremierStem Cell Institute for his patients seeking a possible alternative to surgical procedures. We offer two revolutionary therapies; Self-Derived Stem Cells and Platelet Rich Plasma. Dr. Pettine and his team of fellowship trained orthopedic surgeons work with patients from around the world, using the newest and most advanced technology to treat orthopedic injuries in thespine,knees,hips,shoulders,feet and ankles, and other joints.

The Premier Stem Cell Institutealso serves patients who haveOsteoarthritis, Avascular Necrosis, Osteoporosis, Rheumatoid Arthritis, Multiple Sclerosis, Fibromyalgia, Parkinsons Disease and Crohn's Disease,

Our adult stem cell therapies utilize adult mesenchymal, multipotent stem cells, taken from a patients own bone marrow concentrate, which is then directly injected into the area of damage on the patient. Our facility has years of data supporting the positive attributes that stem cell therapies provide. Pleasecontact ustoday for more information!

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Stem Cell Therapy | Colorado | Premier Stem Cell Institute

Sandy Francis, a tennis player, has received four stem cell treatments to both elbows, right knee, and most recently his back and has been able to go back to playing. Advocates and patients say that this technique works wonders, and keeps people from having to get knee replacements. Photo by Logan Riely, The Gazette

He opted for liposuction and a shot.

The unusual treatment - an injection of stem cells culled from fat in his abdomen - ranks among one of the fastest growing, yet least regulated or researched trends in medicine.

Clinics offering stem cell injections for worn-down knees, bad backs or even face-lifts have sprouted across the nation, growing from just a handful in 2010 to more than 170 as of mid-May, according to The Associated Press.

In Colorado Springs, one such center opened in February offering orthopedic stem cell treatments, touting itself as the first of its kind in the Pikes Peak region. Leaders of that clinic, Spine & Joint Solutions, declined to be interviewed for this article.

The leader of another clinic, Robert Andrews Laser and Medical Aesthetics, said it offers a face-lift using another treatment apparently rich in stem cells.

Francis said the treatment to his knees - one of which appeared ready for a replacement - and an elbow has helped him regain an active lifestyle of tennis, biking and sailing.

"For me, it's been fantastic," said Francis, who owns three salons in Colorado Springs.

But while such stem cell procedures have exploded in popularity, researchers say the treatments are poorly studied and unproven.

For example, more research is needed to determine the treatment's effectiveness and proper dosing techniques before it is used on a regular basis, said Jay Lieberman, professor and chairman of the department of orthopedic surgery at the University of Southern California's Keck School of Medicine.

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Colorado Springs man: Experimental stem-cell procedure ...