Category Archives: Colorado Stem Cells

Thousands of startups call Houston home. According to the Greater Houston Partnership's data, the Houston area added 11,700 firms between 2013 to 2018. And, if you consider Crunchbase's tally, at the end of 2018, Houston had over 1,400 tech startups on the investment tracking website's radar.

This past year, InnovationMap featured profiles on dozens of these Houston startups from blockchain and software companies to startups with solutions in health care and oil and gas. Here are 10 that stood out throughout 2019.

Houston-based Topl can track almost anything using its blockchain technology. Getty Images

For Topl, 2019 was a year of laying the groundwork. In a January 2019 article on InnovationMap, Kim Raath, president of the Houston-based blockchain company, explained that Topl's mission originated out of the fact that 60 percent of the world lives on $10 a day and it's in the poorest regions of the world where it's the hardest to get funding for a new business.

Raath says that in her experience backpacking and volunteering all around the world she learned that banks are too overwhelmed to evaluate these potential businesses. Topl has created a technology where banks can easily generate a report on these entrepreneurs that evaluates and makes a loan or investment recommendation on the business.

"We are a generation that wants a story," she says. "We want an origin, and don't want to be fooled. And, because you might be able to reduce the cost by having this transparency, you might be able to bring down the cost on both sides."

Later that year, the company closed a 20 percent oversubscribed $700,000 seed round. With the money, Topl will be able to grow its platforms, provide better product features, and increase marketing efforts. Topl's customers are drawn to the technology because of the business efficiency the blockchain adds to their supply chain, but they are also excited about how having this technology differentiates them from their competition. Raath says she's interested in growing Topl's ability to do joint marketing campaigns with their customers.

Natalie Goodman founded Incentifind, which connects home builders and commercial developers with green incentives. Courtesy of Incentifind

When asked about the origin story of IncentiFind a Houston-based startup that connects real estate developers and home builders with green construction incentives founder Natalie Goodman doesn't mince words.

"We're a complete accident," Goodman tells InnovationMap in an interview in March. "I'm an architect. We didn't set out to have a startup."

IncentiFind's mission is to increase the amount of green developments and construction projects in the U.S. The company is equipped with a massive database of green incentives that are offered by utility, county, city, state and federal agencies. Many home builders or commercial developers don't take advantage of green incentives because they're simply not aware of them, Goodman says. Commercial developers can expect to spend around $1,500 with IncentiFind, while homeowners can expect to spend between $50 and $150.

Lazarus 3D is using 3D printing to help advance surgeons' skills. Photo via laz3d.com

It's pretty standard for surgeons in training to practice complicated surgeries on produce slicing bananas open and sewing grapes back together. But for a pair of Baylor College of Medicine-educated doctors, that didn't seem like sufficient prep for working with living bodies; fruit surgery was not fruitful enough. In 2014, Drs. Jacques Zaneveld and Smriti Agrawal Zaneveld founded Lazarus3D to build a better training model and layer by layer, they created models of abs and ribs and even hearts with a 3D printer.

"We adapted pre-existing 3D printing technology in a novel proprietary way that allows us to, overnight, build soft, silicone or hydrogel models of human anatomy," Jacques, who serves as CEO, tells InnovationMap in July. "They can be treated just like real tissue."

This year, the company grew to seven people and aims to expand even more to add to its sales and manufacturing teams. Having been funded mostly by friends and family investors, Lazarus3D plans enter its first equity round to raise $6 million, InnovationMap reported last summer.

Ryan Schwartz realized online dating was easier than finding a therapist. He created a tool to change that. Courtesy of Mental Health Match

Nearly five years ago, Ryan Schwartz sat in a coffee shop in crisis mode. His mother had just died suddenly and he was struggling to find an appropriate therapist. Across the table, his friend sat making a profile on a dating app. Quickly, her endeavor was complete and she was ready to swipe right, but Schwartz was still on the hunt for mental help.

"In two minutes she could have a profile matching her with a partner potentially for the rest of her life and I was sitting there for hours and hours trying to find a therapist," he told InnovationMap in June. "I thought it should be easier to find a therapist than a life partner. That's what sent me on my journey."

That journey reached a watershed last month when Schwartz launched Mental Health Match, a website designed to pair patients with their ideal therapist. The idea gained traction as Schwartz described it to people he met and found that many said they had experienced similar difficulties in finding the right practitioner for their needs.

Houston-based Grab makes it so you're waiting in one less line at the airport. Getty Images

Most airport lines are unavoidable, but a Houston startup has cut out at least some of those lines with its mobile ordering app. Houston-based software company Grab was founded by Mark Bergsrud in 2015, who worked in senior leadership roles for almost 20 years at Continental Airlines and then United Airlines, following the merger. For Bergsrud, Grab feels like another major mobile game changer the industry experienced.

"I spent many years thinking about the travel experience and how to make it better and faster," Bergsrud told InnovationMap in July. "This feels like how mobile check in felt. There was a problem customers didn't know they had check in wasn't that difficult anyway, but to be able to have that control, people love it."

Grab now has a presence in over 37 airports around the world, including Dallas and Austin though, ironically, not yet either of Houston's airports. Expansion is in the works for Grab, which closed a multimillion-dollar Series A round this year London-based Collinson Group was the sole contributor.

Houston-based NurseDash is the Uber of staffing nursing shifts in medical facilities. Photo via nursedash.com

Across the country, medical facilities are short on nurses. Agencies play a role in matchmaking nurses to open shifts, but agencies charge a high percentage for placement and lack transparency, says Andy Chen, former CFO for Nobilis Health Corporation. That's why he and Jakob Kohl created their app, NurseDash in 2017. The project manager for the app is in New York, but official headquarters in Houston's Galleria area, where a staff of five works with the team spread out around the world.

Since its debut, NurseDash has attracted 40 facilities in Houston, InnovationMap reported in May, including hospitals, surgery centers, and senior living, and about 400 nurses. Chen says he isn't sure just what to call his technology yet, but compares it to the ride hailing of Uber or Lyft and calls it "a virtual bulletin board."

Trevor Best, CEO of Syzygy Plasmonics, walked away from EarthX $100,000 richer. Photo via LinkedIn

A Houston technology company is doing something that, for many decades, wasn't thought to be possible. Syzygy Plasmonics is creating a hydrogen fuel cell technology that produces a cheaper source of energy that releases fewer carbon emissions. The hydrogen-fueled technology originated out of research done over two decades by two Rice University professors, Naomi Halas and Peter Nordlander.

Syzygy's technology, CEO Trevor Best told InnovationMap in August, is structured more like a battery than that of a combustion engine. Inside the technology, there are cells, lights, and mirrors making as bright as possible, which then spurs a reaction that creates energy. It has the potential to be cheaper it's made with cheaper materials and, of course, cleaner than traditional fueling technology with fewer carbon emissions released.

This new photocatalytic chemical reactor has the potential to shake up the industrial gas, chemical, and energy industries something that hasn't gone unnoticed by investors. Syzygy just closed a $5.8 million Series A round, and the funds will allow for Syzygy to continue to develop its technology and grow its team. Best tells InnovationMap that he expects to launch a full-size pilot by the end of 2020 and is already in talks with potential clients who are interested in the technology for industrial purposes.

Houston researchers are commercializing their organ 3D printing technology. Jordan Miller/Rice University

There may come a time when you or someone you love is in need of a new pair of lungs. Or perhaps it's a liver. It's not a scenario anyone dreams of, but thanks to Houston company Volumetric, you may never end up on a waiting list. Instead, that organ is made to order and 3D printed using a mix of medical plastics and human cells.

And this possibility isn't necessarily in the distant future. On the cover of the May 3 issue of the journal Science, is a contraption that looks a bit like a futuristic beehive. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. And it was crafted on a 3D printer in Jordan Miller's lab at Rice University. Miller and his bioengineering graduate student Bagrat Grigoryan are primed to profit from their inventions.

In 2018, they started Volumetric Inc., a company that sells both the hydrogel solutions used for printing organs like theirs and the printers themselves. Touring Miller's lab in the Houston Medical Center is a visual timeline of his team's progress designing printers. The version being manufactured is a slick little number, small enough to fit under chemical exhaust hoods, but fitted with everything necessary to print living tissues. It's made and sold in cooperation with CellInk, a larger bioprinting company.

"Our technology is based on projection," Miller told InnovationMap in May. Specifically, it's stereolithography, a type of 3D printing that produces the finished product layer-by-layer. Shining colored light of the right intensity turns the polymers into a solid gel.

Voyager, a Houston SaaS company, has received fresh funds to develop its bulk shipping software. Tom Fisk/Pexels

Houston software startup Voyager is making waves in its quest to improve efficiency and stem billions of dollars in losses in the maritime bulk-shipping business. Now, it's got some fresh capital to help it achieve that mission.

InnovationMap reported in August that Houston-based Voyager revealed it secured $1.5 million in seed funding from four investors from around the world: Austin-based ATX Venture Partners, Houston- and California-based Blue Bear Capital, New York City-based GreenHawk Capital, and Oman-based Phaze Ventures. Previous investors include Boulder, Colorado-based Techstars and Spring-based Knightsgate Ventures.

With its software-as-a-service offering, Voyager aims to modernize the workflows of operators in the maritime bulk-commodities industry. The company says its technology will become more vital as autonomous shipping and internet- and Internet of Things-enabled cargo vessels grow in popularity. Voyager's technology enables all communication tied to a shipment to be handled via its web dashboard and app, essentially creating a one-stop shop for people who need to track messages about maritime bulk shipments.

"With Voyager, what it allows companies to do is essentially have all of those counter parties working together in a shared environment to manage the voyage together entirely email free," Matthew Costello, CEO, tells InnovationMap in December.

Educated as an engineer, Chris DuPont has stepped outside his professional comfort zone to generate funding for his Houston-based startup, Galen Data Inc. DuPont's pool of technical contacts in Houston is "wide and deep," he says, but his pool of financial contacts had been shallow.

Overcoming obstacles in Houston's business waters, DuPont has raised two rounds of angel funding he declines to say how much that have enabled Galen Data to develop and market its cloud-based platform for connecting medical devices to the internet, including pacemakers and glucose monitors. DuPont is the startup's co-founder and CEO.

Galen Data's patent-pending technology lets medical device manufacturers tailor the cloud-based software to their unique needs. DuPont says his company's software is geared toward medical devices that are outside, not inside, hospitals and other healthcare facilities. He declines to divulge how many customers the startup has.

Hatched within Houston-based Tietronix Software Inc., DuPont's previous employer, Galen Data launched in 2016 but didn't roll out its first product until 2018. Galen Data's emergence comes as the market for internet-connected mobile health apps keeps growing. One forecast envisions the global space for mobile health exceeding $94 billion by 2023.

"We want to be at the forefront of that technology curve," DuPont tells InnovationMap in May. "We might be six months early, we might be a year early, but it's starting to happen."

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5 most popular innovation stories in Houston this week - InnovationMap

Colorado Medical Solutions brings Hormone Replacement Therapy Denver that can keep patients young by overcoming their aging related complications.

People in Denver and Colorado can now fight their aging problem with the perfect Hormone Replacement Therapy offered by Colorado Medical Solutions. The anti-aging clinic is located in Denver and Colorado Springs, and specializes in hormone replacement therapies and functional medicines for both men and women. The clinics Hormone Replacement Therapy Denver is ideal for men and women who want to remain young and feel youthful forever. The therapy helps aging people in overcoming their sluggishness and to feel more energetic to work with more energy.

According to the spokesperson of the clinic, people may come across many types of physical or emotional complications with the growing age. While the aging process cannot be reversed, but there are certain therapies that can delay the age related complications. They offer bio-identical hormone replacement therapy that brings transformative results both in men and women. The spokesperson reveals that the male population often experiences a hormonal imbalance after the age of 40 years. In some men, the complication may appear earlier or later. However, the problem can cause several kinds of medical conditions and to avoid these complications, men can take advantage of the Hormone Replacement Therapy Colorado Springs.

The problem of hormonal imbalance trouble many women as well. The common HRT for women include estrogen therapy, progesterone therapy, thyroid treatment, and testosterone replacement therapy. The Chiropractor Denver offers a set of hormonal replacement therapies for women to avoid common menopause symptoms. Many women complain of symptoms, such as night sweats, hot flashes, cramping, breast tenderness, vaginal dryness, and others due to hormonal imbalance only. The clinic offers female hormone optimization, so that a woman will not to suffer from such complications any more. The HRT for women helps improve a womans condition after the menopause.

Colorado Medical Solutions also specializes in regenerative medicine or IV Therapy Colorado Springs. In this therapy, a human beings cells, tissues or an organ can be replaced to restore normal human functions, which otherwise may have affected due to aging or any other reason. The clinic employs the most cutting-edge technology to offer the IV therapy to alleviate the pain and sufferings of the patients. The clinics advanced stem cell therapy is a comprehensive procedure to overcome the cell or tissue loss in humans due to aging. The clinic also excels in providing Platelet Rich Plasma therapy or PRP therapy in which blood can be injected into any body part to increase the healing potential of the organ.

One can learn more about these advanced therapies by visiting the website https://coloradomedicalsolutions.com

About Colorado Medical Solutions

Colorado Medical Solutions is an Anti-Aging and Functional Medicine Clinic with two locations in Denver and Colorado Springs. The clinics specialize in Bio-Identical Hormone Replacement Therapy (HRT) for men and women, Regenerative Medicine and IV Therapy. Furthermore, they offer an array of regenerative medicine modalities, such as Stem Cell Therapy, Medical Weight Loss ED Treatment and other sexual enhancement options for men and women.

Media ContactCompany Name: Colorado Medical Solutions Contact Person: Dr. Dean JonesEmail: Send EmailPhone: +1 (720) 550-6907City: DenverState: COCountry: United StatesWebsite: https://coloradomedicalsolutions.com/

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Chiropractor Denver Announces Hormone Replacement Therapy Colorado Springs to Transform Life of Aging People - Press Release - Digital Journal

Cord Blood Banking Services Market by Bank Type (Public, Private, Hybrid) Global Industry Analysis & Forecast to 2025

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Based On Profile & Business Performance Outstanding Competitors In The Market Are The University of Colorado Cord Blood Bank, CBR Systems, Cryo-Cell International, Inc, Lifeforce Cryobanks, ViaCord, Inc., CordVida, CryoHoldco, China Cord Blood Corporation, Cordlife Group Limited, Virgin Health Bank.

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The Cord Blood Banking Services Market has encountered significant development over the recent years and is anticipated to grow tremendously over the forecast period. Umbilical cord blood is gathered from the hospitals and nursing homes after the birth of a child. This blood contains a lot of stem cells, which can be utilized to treat different sicknesses. The public cord blood banks function by the non-profit associations with the assistance of government subsidizing, which are given by families after the delivery of child.

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Cord Blood Banking Services Market size with global investment, top companies analysis, new business developments and forecast 2025 - Montana Ledger

Typically, a hybrid bone marrow stem cell therapy protocol is used. In this protocol, a small amount of the filtered bone marrow aspirate is set aside and not processed, but the majority of the total bone marrow aspirate is centrifuged to concentrate the nucleated cells with stemness potential. Stem cells numbers are important, but we might be discarding important healing agents like pluripotent Muse cells and very small embryonic-like stem cells (VSELs), that have even greater potential for healing than MSCs.

Historically, for the bone marrow concentration technique, most of the emphasis was put on increasing the density of nucleated cells. Many of the techniques employed by stem cell providers and bedside kits use centrifuge RPMs and g-forces that are extremely high. In our testing, we found that these excessively high forces come at a steep price in terms of the end result for the viability of the cells that are isolated. This has led us to employ a much safer approach to our cellular isolation techniques. We see below in Fig 2., a Wrights stained peripheral smear of our bone marrow concentrate after centrifugation with a higher density of nucleated cells.

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Stem Cell Therapy - Boulder, Colorado | Boulder Biologics |Jason Glowney, MD | Stem Cells - Denver, Colorado | PRP | Regenerative Medicine | EPAT |...

Stem cells have an extraordinary power: the ability to divide for indefinite periods in culture and to give rise to specialized cells. Countless research studies have focused on stem cells and the many conditions that could potentially be treated using them, which has led audiologists to wonder about the relationship between stem cells and hearing loss. Do stem cells hold the key to a cure for hearing loss or tinnitus?

Over 25,000 hair cells exist in the cochlea, an organ in the inner ear. These cells are extremely important to the process of hearing, as they detect and respond to sound, transmitting nerve signals to the brain. Unfortunately, hair cells are also sensitive and unable to regenerate. Exposure to loud noises, aging, infections, and drugs can all inflict permanent damage on these vital structures.

Research on stem cells and hearing loss has focused on the potential for stem cells to develop and function as hair cells. Scientists have discovered the presence of stem cells in the inner ears of mice, chicks, and zebra fish (source). Under the right conditions, the stem cells can develop into cells that are remarkably similar to hair cells. The question is, can we transfer this amazing ability to humans?

Although a cure does not yet exist, the results obtained thus far are promising. Researchers at Stanford Medicine, Rutgers University, MIT, Brigham and Womens Hospital, and Massachusettes Eye and Ear have all been making progress with research involving stem cells and hearing loss. In addition, scientists at Kyoto University in Japan have conducted research that may help with hearing loss and tinnitus.

Researchers at Stanford Medicine are working to develop a biological method to repair the cochlea and treat hearing loss. Their approach involves the surgical placement of stem cells within the cochlea, which then develop and function as hair cells. In their laboratory, they have mimicked the formation of embryonic mouse ears to create stem cells that look and act like hair cells. If millions of hair cells could be produced in the ear, this research could restore normal hearing to people afflicted by hearing loss.

The key may be induced pluripotent stem cells (iPS), adult cells, taken for example from a patients own skin that have been genetically reprogrammed to revert back to stem cells. These cells would allow the treatment of hearing loss using the patients own cells. Embryonic stem cells also present an exciting opportunity for progress.

The team at Stanford is currently attempting to produce human hair cells in a culture dish, which would be a revolutionary achievement and could lead to effective hearing loss therapy through cell transplantation.

Scientists at Rutgers UniversityNew Brunswick are also working with inner ear stem cells, converting them to auditory neurons and potentially reversing hearing loss. The challenge is controlling the division of the stem cells; if they divide too quickly, they pose a cancer risk.Currently, researchers can control the stem cells in a Petri dish.

The study relies on the gene NEUROG1, which the scientists overexpress to transform the inner ear stem cells into auditory neurons. Due to its potential for proliferation, the researchers must be cautious when working with this gene. Managing the chromatin state of the targeted genes can reduce this dangerous tendency to rapidly reproduce.

Researchers at MIT, Brigham and Womens Hospital, and Massachusetts Eye and Ear stumbled upon their research with stem cells and hearing loss. While studying intestinal cell regeneration, they noticed a similarity between intestinal stem cells and the cochleas structural support cells. They conducted a test to explore whether regeneration would work in the cochlea as it had in the intestines, and their theory proved correct. This discovery could help reverse sensorineural hearing loss. Although the treatment will require more research, testing, and approval by the FDA before it hits the market, the researchers are optimistic and predict that the drugs will be injected into the middle ear.

Finally, researchers at Kyoto University discovered a new way of applying stem cells that prevents their deaths. Stem cells often die due to failure to bypass the glial scar, a hallmark of neural damage that is thought to act as a barrier for cell transplantation (source). The scientists found that applying the stem cells to the surface of the glial scar instead of underneath it helped them survive. The cells grew from the damaged segment of the auditory nerve, which carries information from the cochlea to the brain, and could help restore auditory function. Tinnitus sometimes results from an issue with the connection between external sound and the central nervous system, which is often caused by damaged hair cells in the cochlea. Thus, restoring this connection through stem cell transplantation could eliminate tinnitus.

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Keep an eye out or should I saykeep an ear out? for future news regarding the connection between stem cells and hearing loss. Although the discoveries are exciting, a lot more research must be done to address the issues presented by stem cells. Scientists must find a way to prompt stem cells to differentiate in the ear without allowing them to die or grow uncontrollably. This solution isnt perfect yet, but the future looks bright for stems cells and hearing loss.

If you areexperiencing hearing loss, tinnitus, hyperacusis, or another auditory issue, please contact theSound Relief Hearing Centerin Colorado. We are independently owned, so we always have the patients best interests at heart, and our state-of-the-art technology ensures that our patients receive the best treatment available. With our unparalleled excellence in the hearing industry, our dedication to patient satisfaction, and our commitment to helpingpeople control and conquer their hearing issues, you can count on Sound Relief Hearing Center forsupport and assistance.

To learn more about us, please browseour website, visit ourYoutube channel, or give us a call at 720-259-9962. You can alsoschedule an appointment onlineto meet with one of our audiologists. We look forward to hearing from you!

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Stem Cells and Hearing Loss - Sound Relief Hearing Center

Introduction

Stem cell therapy is a form of regenerative medicine where progenitor cells - a biological cell that has a tendency to differentiate into a specific type of cell -are used to augment the body's innate ability to heal.Common sources of stems cells are from one's own body (autologous), as well as from fetal sources, such as umbilical cord and amniotic fluid.For orthopedic application, we are interested in mesenchymal stem cells for their innate ability to turn into cartilage, tendon, ligament, muscle and vasculature. The process includes harvesting these mesenchymal stem cells from an individual's bone marrow and adipose tissue, then delivering treatment specifically to the area of injury by way of image-guided injection.

We treat a wide variety of conditions with mesenchymal stem cells in the clinic, including:

Stem cell therapy is a single day procedure throughout which patients remain awake and comfortable. An anxiolytic is available as pre-medication to reduce anxiety by request, and a local numbing medicine is used throughout the procedure.

Taking care to not expose any stem cell tissues to agents that decrease viability,bone marrow is harvested from a patient's posterior pelvis in an area called the posterior superior iliac spine (PSIS). Using a special needle that is designed to enter the bone,marrow is withdrawn from several different directions. For an adipose stem cell harvest,tissues are normally harvested from the flank/abdominal region, using special needles designed to infiltrate non-toxic numbing medicine with saline and to gently aspirate adipose tissues.

The harvested stem cell tissues are then minimally processed to isolate the mesenchymal stem cells. Once isolated and using high-frequency ultrasound imaging,stem cells are guided into the target tissues.

Dr. Glowney has more than ten years of experience completing successful image-guided procedures. In our in-house lab, we utilize flow cytometry to ensure optimal stem cell counts and viabilities, a bio-cabinet to process orthobiologics that ensures a sterile procedure, and tested protocols to produce the best stem cell yields. The clinic includes state-of-the-art imaging equipment to further ensure the best possible outcome for patient healing.

Boulder Biologics is employee-owned and operated in an effort to make the most advanced treatments more accessible to our patients. Without compromising quality or experience, we are able to offer stem cell therapy at a competitive level. Our goal is always to work with our patients in order to assist and guide informed choices about their treatment options.

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Stem Cell Therapy - Boulder, Colorado | Boulder Biologics ...

We use adipose-derived stem cells, which are harvested from the patients abdominal fat reserves our bodys richest source of mesenchymal adult stem cells. We also harvest stem cells from bone marrow to provide an additional cornucopia of regenerative cells. Although bone marrow has up to 1,000 times fewer stem cells per volume than fat, its unique growth factors and significant hematopoietic cells additional help to drive tissue regeneration.

By utilizing the combination of these biologic solutions, we maximize the healing potential from an autologous stem cell procedure.Once we have isolated the specific stem cells, they are then injected into the specific area of damage using real-time x-ray (fluoroscopic)or ultrasound guidance.

At this time, we also introduce a PRP injection (platelet-rich plasma) to further the growth and differentiation of these cells. Once there, these regenerative cells have the potential to dramatically reduce inflammation, encourage new vascularity and stimulate the body to repair and replace tissue that has deterioratedover time or been traumatized from injury or overuse.

Four weeks after the initial stem cell injection, a second injection of platelet rich plasma (PRP)or bone marrow concentrate is performed to enhance the regenerative process.For more details, please visit our page dedicated to thestem cell therapy procedure.

Whether the damagedarea is the result of a traumatic sports injury or the product of daily wear and tear (osteoarthritis), stem cell therapy for joints and soft tissue may offer a powerful solution to resolving the ongoing discomfort. Both long standing and more newly acquired injuries have the potential to benefit from this state-of-the-art treatment.

ThriveMDs newest biologic treatment, Alpha 2 macroglobulin (A2M), is proving to be an excellent complimentary treatment to our regenerative stem cell procedures. Scientific evidence points to A2M being the key to stopping arthritis at the molecular level. A2M is a Broad Spectrum Multi-Purpose Protease Inhibitor that captures and inactivates the three major chemicals that lead to joint breakdown and cartilage damage.

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Stem Cell Therapy for Joint Pain and Soft Tissue, Colorado

Stromal vascular fraction was dramatically better than bone marrow concentrate in its ability to differentiate into cartilage.Two other important features were also well documented in this study. SVF created significantly more colony forming units than BMC, another significant predictor of healing response. Perhaps most importantly, SVF was dramatically better than BMC in its ability to differentiate into cartilage.

Second, a study by Han Chao et al has also demonstrated that fat derived stem cells also have a higher proliferation potential for neural tissue and are a better source for not only cartilage regeneration but also for nervous system regeneration.

The studies gave a very comprehensive look at comparing BMC and SVF in the ability to repair cartilage damage in a same procedure protocol. Every significant measurement comparing bone marrow to adipose tissue for stem cell harvesting demonstrated that adipose derived stem cells provided better cell content and superior ability to differentiate into cartilage than bone marrow. Our extensive clinical experience with the procedure for Colorado patients suffering from pain in the knees, other joints, soft tissue, and a wide range of back problems clearly demonstrates the same.

Using the most effective combination of autologous stem cell sources is one of several criteria to identify a legitimate stem cell clinic. Other important characteristics we recommend paying attention to when choosing a stem cell clinic, include the presence of a physician who owns and operates the clinic, X-ray guided injections administered by a trained injection specialist, and a clinic that takes time to discuss your questions. A review of your imaging and clinical data is needed in order to determine if stem cell therapy is right for you.

*Individual patient results may vary. Contact us today to find out if stem cell therapy may be able to help you.

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Stem Cells from Fat vs. Bone Marrow Best Sources for ...

With over 22 years experience treating musculoskeletal conditions, Colorado Rehabilitation and Occupational Medicine is a leader in Regenerative Medicine in Denver, Colorado, offering both Stem Cell Therapy and Platelet Rich Plasma Therapy (PRP).

Stem Cell Therapy is a cutting-edge treatment with the capacity to repair injured, torn, or arthritic tissue by delivering biological material directly to the site of the problem. Stem Cells have the ability to release biological signals to the cells in your own body that initiate them to regenerate. CROM uses only non-controversial, non-fetal Stem Cells. Much of the excitement surrounding Stem Cells lies in their potential to repair labral tears, rotator cuff tears or partial tears, and osteoarthritis, while avoiding surgical treatment and joint replacements.

Similar to Stem Cell therapy, Platelet Rich Plasma (PRP) is another regenerative medicine approach whereby blood is drawn from the patient, and then spun in a centrifuge to separate the blood plasma, which contains concentrations of healing growth factors and platelets. This therapeutic concentration is then injected to the area of injured tissue, where it can assist in healing tendonitis, tendon or labral tears, and arthritis.

Many professional athletes have decided to use Stem Cell Therapy treatments to help them heal from athletic injuries and reach peak condition. Based on mounting case studies, we are closer to Regenerative Medicine being covered through commercial (private) insurance.

Now these advanced medical treatments are available in Colorado from the states premiere physical medicine and rehabilitation physicians-CROM. CROM performs stem cell therapy and PRP at multiple offices in the Denver area If you do not live in the Denver area or Colorado, feel free to contact us about setting up an appointment, and how our treatments work.

Stem Cell Therapy treatments are performed after an initial consultation to determine if these treatments are suitable for your specific problem, or whether other treatments, which may be less expensive and/or covered by insurance, are optimal.

Stem Cells injections are performed under ultrasound guidance by trained physical medicine and rehabilitation doctor. Follow up exams with ultrasound evaluations will evaluate your progress after the injection.

CROMs Dr. Scott Primack discusses Regenerative Medicine andSports Injuries on The Big Show on Mile High Sports Radio

CROM physicians are Board Certified in Physical Medicine and Rehabilitation. Our Musculo-skeletal specialists administer tissue grafts containing Stem Cells directly into an injury site (through ultrasound or X ray guidance) to help regenerate cartilage, tendons and muscle in order to provide pain relief and increased function.

Patients who have chronic joint, muscle or tendon conditions that have not responded to traditional treatment. Also, patients who do not wish to consider surgery for labral tears, partial thickness rotator cuff tears, a knee or hip replacement or have other severe arthritic or tendon problems may wish to consider stem cell therapy. In some cases, stem cell therapy may be appropriate for treatment of spinal conditions.

Under usual circumstances, the bodys ability to repair and replace damaged cartilage, tendons, or other specialized tissue in adults is limited. Use of bone marrow concentrate or amniotic tissue grafts may offer the ability to help repair these tissues. Stem Cell Therapy is only performed after an initial consultation by a CROM Physician specializing in Musculo-Skeletal Care. The physician will review your medical history, perform a clinical examination, and discuss stem cell treatments as well as other potential treatments in order to give you the information necessary for you to determine if stem cell therapy is the best option.

1. Obtain tissue containing stem cells through a simple procedure that concentrates your own bone marrow. This marrow contains stem cells, platelets, and other factors which promote tissue growth. Or, a graft of amniotic tissue from a specially selected and screened donor (which also contains stem cells) may be used. This is obtained in advance and because of the unique properties of amniotic tissue no tissue typing is required, and there is no rejection of this type of graft.

2. Whichever approach you and your CROM Physician specialist select, your doctor will numb the site of injection with a local anesthetic.

3.The Bone Marrow Concentrate or amniotic tissue graft will be administered by your CROM Physician through an ultrasound-guided injection. In some cases, X-ray guidance may be used.

4.You will then be able to relax and let the tissue graft get to work. Your CROM Physician Specialists will discuss an appropriate follow up and, if indicated, rehabilitation program with you. In most cases, there are few activity restrictions required, and no restrictions on usual activities such as driving.

We utilize two types of tissue grafts containing stem cells:

Amniotic Tissue Graft Stem Cells- Amniotic tissue is collected under sterile technique from screened donors at the time of cesarean section.

Grafts of amniotic tissue (which include stem cells) from a donor do not involve fetal tissue, nor is there any harm to a fetus, baby, or mother in obtaining these stem cells from the donor. This type of stem cell therapy is not opposed by the Catholic Church or any other group on religious or ethical grounds.

Bone Marrow Graft Stem Cells-Bone marrow tissue containing stem cells is obtained by a simple aspiration procedure from your own bone marrow, and then concentrated before injection at the site of injury.

Most insurance companies do not cover Bone Marrow Aspirate Concentrate or Amniotic Tissue Graft at this time. However, we have had some success with workers compensation coverage for this treatment, and many insurance companies may cover the initial consultation as well as some aspects of the treatment, such as the ultrasound or X-ray guidance and follow up appointments.

CROMs self-pay pricing is very competitive and we strive to provide this treatment as cost-effectively as possible. The cost of Bone Marrow Aspirate or Amniotic Tissue Graft Stem Cell treatments varies depending on the site of injury, the amount of graft material required, and whether or not Bone Marrow Aspirate or Amniotic Tissue Graft is utilized. Because of this, final prices can be determined after an initial consultation with your CROM Physician Specialist. Please contact us for more information.

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CROM Stem Cell Therapy- Denver, Colorado

Adam working in the lab at Colorado State University.

Theactivitiesare as follows:

Every cell in your body contains the same DNA. How is it that genetically identical skin, brain, and muscle cells can look very different and perform very different functions from each other? Cells differentiate, or become different from one another, by turning certain genes on and off. This process is called gene expression. For example, when you spend time in the sun your skin cells turn on the gene for pigment, which protects your cells from bright sunlight. In the winter when there is less sunlight, your cells turn off this gene. This process your body uses to turn genes on and off is the same one it uses to develop from one cell into the many different cell types that make up your body. Stem cells have the ability to turn into any other type of cell in the body, an ability known as pluripotency. Your body retains some stem cells for your entire life.

Some genes are only turned on in specific types of cells because they have specialized jobs for those cell types, like muscle or brain cells. Other genes are more like managers, controlling which genes are turned on and off. The activity of these manager genes maybe more common in stem cells because they could control which type of cell the stem cell will become. In recent years, scientists discovered they could reprogram specialized cells back into non-specialized stem cells, simply by turning on several manager genes. They call these reprogrammed cells induced pluripotent, or iPS.

Adam working under the hood, reprogramming specialized cells into induced pluripotent stem cells for his experiments.

Adam was working as a biologist in Colorado when he learned that many cool medical advances in regenerative and personalized medicine will happen when we figure out which genes are turned on, and which are turned off, in pluripotent stem cells. In his research, Adam wanted to look at gene expression for two genetically identical cell lines, those that have specialized and those that have been reprogrammed to be iPS stem cells. He was interested to see which genes are expressed by both types of cells and which genes are only expressed in one type of cell.

He decided to work with fibroblast cells because they are easy to grow in the lab. Fibroblasts cells are mainly responsible for production and maintenance of the extracellular matrix (including joints, ligaments, tendons and connective tissues), which is critical in holding the bodys tissues together. From reading the work of other scientists, Adam learned how to transform fibroblast cells into iPS stem cells. This knowledge lead him to two genetically identical types of cells (1) specialized fibroblast cells and (2) unspecialized iPS cells. When fibroblast cells are transformed into unspecialized iPS cells, their function changes and they become responsible for wound healing and generating new tissues, acting like a reserve set of cells. Because fibroblast and iPS cells perform very different functions, Adam thinks it is likely that each cell line will expresses genes that are specific to its individual function.

Adam looked at expression in 10 different genes that are thought to have important functions for fibroblast or iPS cells. Adam measured the expression for each gene by looking at RNA abundance of each gene in the different cell types. RNA is the intermediate between DNA (the genetic blueprint) and protein (the functional worker of the cell). Adam chose to look at RNA, because it is often representative of how much protein is present in a cell, which is very difficult to measure directly. Adam analyzed three replicates for each cell type. He replicated in order to get a more accurate representation for each cell type. This is important in case the samples were in slightly different conditions, like warmer or cooler temperatures, which could alter gene expression. This experiment allowed Adam to figure out which genes are turned on in iPS cells, allowing him to better understand how stem cells work.

iPS cells display different gene expression and physical appearance than HFF cells: Figures A and B are low magnification images of two different iPS cell colonies. iPS cells are usually small, round, and like to grow in circular-like colonies. Figures C is a low magnification image of HFF cells. HFF cells tend to appear long and slender almost like trees. Generally, HFF cells like to grow near each other, but not in colonies. Figure D is a higher magnification image of the black box in figure C, showing a group of HFF cells growing in close proximity with each other.

Featured scientist: Adam Heck from Colorado State University. Written withSandra Weeks from the Poudre Valley School District.

FleschKincaid Reading Grade Level= 10.6

To learn more about the researching being done in Adams lab, click here.

The gene expression data found in this activity wasgathered from the following paper citation and link below:

Read more here:
Gene expression in stem cells | Data Nuggets