Category Archives: Diabetes

REIDSVILLE Since Fall 2015, the Cone Health Nutrition and Diabetes Management Center in Reidsville has been tackling diabetes head on as the first clinic of its kind in Rockingham County.

We provide education to patients that have diabetes and other medical problems, said Penny Crumpton, registered dietician and certified diabetes educator with the center. Our goal is to try to help provide knowledge and education to those who need assistance in helping improve their diabetes and reducing the complications that we know diabetes can cause.

According to Crumpton, diabetes is a serious issue in Rockingham County.

The rates of diabetes are extremely high in Rockingham County so the need is very great in terms of reaching out to those who are most in need, Crumpton said. While we educate patients with diabetes, we also try to reach out and address the epidemic of pre-diabetes that certainly puts patients at high risk for developing diabetes down the road.

Uncontrolled diabetes can lead to long time and irreversible problems, including damage to the eyes and kidneys, cardiovascular complications and peripheral vascular disease.

In the year and a half since the center opened, Crumpton and Gebre Nida, the centers endocrinologist, have been working with patients to help address those problems.

At the office, patients can come for one-on-one counseling sessions to discuss their situation or guests can attend free community education classes at 9 a.m. on the first and third Monday of the month at Annie Penn Hospital.

Yet with diabetes a prevalent problem in the area, Crumpton and Nida are pushing for awareness through the diabetes task force. This task force unites local health care providers and other community stakeholders around making a change.

Were working through the diabetes task force to try to increase the public awareness of the rates of diabetes and getting the resources more visible to the community and being able to connect patients with resources, Crumpton said.

For Norbert Hector, the center has already made a difference in his life after visiting the center for the first time in February.

According to Hector, he was diagnosed with diabetes about 20 years ago and has been on insulin for about 11 years.

About two months ago, my readings became very erratic, and so I called (my primary care provider) and tried to do some self-adjusting and really messed it up, he said.

His doctor referred him to Nida at the Cone Health Nutrition and Diabetes Management Center in Reidsville.

As a diabetic, I had been concerned about it, Hector said. I know its a progressive disease, and Ive watched other diabetics including my brother get progressively worse and my brother eventually died.

By following the directions given to him by Nida and Crumpton and with the support of his wife, Hector has already seen improvements in his condition.

I feel a lot more optimistic now than I did two months ago, he said.

As the center creates more stories like Hectors and the practice builds, they will consider adding another endocrinologist and diabetes educator to widen the centers impact and reach the growing population affected by diabetes.

For more information about the Cone Health Nutrition and Diabetes Management Center in Reidsville, call 336-951-6070 or visit the center at 1107 S. Main St., Reidsville.

You have nothing to lose and whole lot to gain, Hector said. Give it a shot.

Contact JustynMelrose at (336) 349 -4331, ext. 6140 and follow@jljmelrose on Twitter.

Visit link:
Cone Health clinic fights diabetes in Rockingham County - Greensboro News & Record

Type 2 diabetes is a serious health concern in the United States and across the globe. New research shows that a high consumption of legumes significantly reduces the risk of developing the disease.

The legume family consists of plants such as alfalfa, clover, peas, peanuts, soybeans, chickpeas, lentils, and various types of beans.

As a food group, they are believed to be particularly nutritious and healthful. One of the reasons for this is that they contain a high level of B vitamins, which help the body to make energy and regulate its metabolism.

Additionally, legumes are high in fiber and contain minerals such as calcium, magnesium, and potassium. They also comprise a variety of so-called phytochemicals - bioactive compounds that further improve the body's metabolism and have been suggested to protect against heart disease and diabetes.

Finally, legumes are also considered to be a "low glycemic index food," which means that blood sugar levels increase very slowly after they are consumed.

To make people aware of the many health benefits of legumes, the year 2016 has been declared the International Year of Pulses by the Food and Agriculture Organization of the United Nations. Pulses are a subgroup of legumes.

Because of their various health benefits, it has been suggested that legumes protect against the onset of type 2 diabetes - a serious illness that affects around 29 million people in the U.S. and more than 400 million adults worldwide. However, little research has been carried out to test this hypothesis.

Therefore, researchers from the Unit of Human Nutrition at the Universitat Rovira i Virgili in Tarragona, Spain, together with other investigators from the Prevencin con Dieta Mediterrnea (PREDIMED) study, set out to investigate the association between legume consumption and the risk of developing type 2 diabetes in people at an increased risk of cardiovascular disease.

The study also analyzes the effects of substituting legumes with other foods rich in proteins and carbohydrates, and the findings were published in the journal Clinical Nutrition.

The team investigated 3,349 participants in the PREDIMED study who did not have type 2 diabetes at the beginning of the study. The researchers collected information on their diets at the start of the study and every year throughout the median follow-up period of 4.3 years.

Individuals with a lower cumulative consumption of legumes had approximately 1.5 weekly servings of 60 grams of raw legumes, or 12.73 grams per day. A higher legume consumption was defined as 28.75 daily grams of legumes, or the equivalent of 3.35 servings per week.

Using Cox regression models, the researchers analyzed the association between the incidence of type 2 diabetes and the average consumption of legumes such as lentils, chickpeas, dry beans, and fresh peas.

Overall, during the follow-up period, the team identified 266 new cases of type 2 diabetes.

The study revealed that those with a higher intake of legumes were 35 percent less likely to develop type 2 diabetes than their counterparts who consumed a smaller amount of legumes. Of all the legumes studied, lentils had the strongest association with a low risk of type 2 diabetes.

In fact, individuals with a high consumption of lentils (defined as almost one weekly serving) were 33 percent less likely to develop diabetes compared with their low-consumption counterparts - that is, the participants who had less than half a serving per week.

Additionally, the researchers found that replacing half a serving per day of legumes with an equivalent portion of protein- and carbohydrate-rich foods including bread, eggs, rice, or potatoes also correlated with a reduced risk of diabetes.

The authors conclude that:

"A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk."

Learn how a healthful vegetarian diet could substantially reduce type 2 diabetes risk.

See the original post here:
Legumes may lower risk of type 2 diabetes - Medical News Today

Diabetes Product Solutions

A look at some of the latest diabetes product offerings.

While the business of providing diabetes products and services has seen its fair share of obstacles competitive bidding slashing Medicare funding, private payer cuts, audits, customer retention, and the problem of low-quality devices on the market it still serves a critical market need.

The population of adults living with diabetes has quadrupled since 1980, growing to 422 million people, according to a report from the World Health Organization. A separate study by the Health Care Cost Institute showed that spending for children with diabetes who are covered by employer-sponsored insurance grew faster than any other age group. Clearly, there is a need for the devices just based on how many people in the United States must have them.

So how do diabetic supply providers keep ahead of these market trends? Their best bet for fostering business growth is to stock a wide variety of diabetes-related products that help you serve patients spectrum of needs. Manufacturers are doing a great job of providing products that cater to every aspect of a diabetic persons life. Good examples of related products would be items such as compression socks or diabetic footwear.

In addition to stocking up a well-rounded group of products, be sure to educate consumers on what the latest offerings are and how they can help them manage their condition. Learn about the customer and find out what their top concerns and priorities are, then assist them in finding the product or products that works best for them.

Compact and highly productive urine chemistry analyzer

ARKRAY Inc. (877) 538-8872 http://www.arkrayusa.com

Smart Blood Sugar connects to mobile phone

Bewellconnect (800) 250-7170 http://www.bewell-connect.us

Tie-less athletic shoes ensure comfort, protection

Orthofeet Inc. (800) 524-2845 http://www.orthofeet.com

Reduced friction, risk of infection for diabetes patients

SIGVARIS Inc. (800) 322-7744 http://www.sigvarisusa.com

Color coded results helps users manage care

LifeScan, Inc. (800) 227-8862 http://www.lifescan.com

Glucometer syncs into smartphones using audio

GlucoMe 972-3-372-8168 http://www.glucome.com

This article originally appeared in the April 2017 issue of HME Business.

About the Author

Sydny Shepard is the Products Editor for HME Business and Mobility Management and can be reached via email at SShepard@1105media.com.

Originally posted here:
Diabetes Product Solutions - HME Business (press release) (blog)

Men's Health

Eat 3 Servings Of This a Week to Cut Your Diabetes Risk By 35% Men's Health After analyzing the food consumption of 3,349 people at high risk of heart disease but without type 2 diabetes, they discovered that those who ate about 3 servings a week of lentils, chickpeas, beans, and peas were 35 percent less likely to develop ... Eat legumes to reduce your risk of type 2 diabetes by 35%Daily Mail Eat legumes to cut the risk of Type 2 diabetesHindustan Times Eating Legumes May Reduce Diabetes Risk by 35 Per CentNDTV Malay Mail Online -Diabetes.co.uk all 11 news articles »

Read more from the original source:
Eat 3 Servings Of This a Week to Cut Your Diabetes Risk By 35% - Men's Health

A diabetic woman has her blood sugar tested. (Photo by Marcelo Camargo, Agencia Brasil/Creative Commons)

Alton Villegas offered an unusual call to action on March 29 for an 11-year-old boy: Destroy the ice cream man.

Alton is a member of the Salt River Pima-Maricopa Indian Community, where nearly 10 percent of tribal members have Type 2 diabetes, including members of his family.

My mom and my grandma have diabetes. A lot of people in Salt River have diabetes, sadly, said Alton, who has been diagnosed as pre-diabetic. I think a lot of people have diabetes because they dont eat healthy and they dont exercise.

Thats what brought Alton to Washington on March 29, where he was the youngest of six witnesses urging the Senate Indian Affairs Committee to reauthorize theSpecial Diabetes Programfor Native Americans.

Alton Villegas, 11, is a member of the Salt River Pima-Maricopa Indian Community, which is plagued by diabetes. He charmed a Senate committee with his own story at a hearing on saving tribal diabetes funding. (Photo by Marisela Ramirez/Cronkite News)

The program grants$150 milliona year to about 300 programs that push diabetes prevention to tribes in 35 states, said Rear Adm. Chris Buchanan, acting director of the Indian Health Service. If not reauthorized, the program will end after September.

Since the program began in 1997, tribal obesity rates have remained stubbornly high, said Sen. John Hoeven, R-North Dakota. He said Native Americans still have a greater chance of being diagnosed with Type 2 diabetes than any other group in America, and that diabetes is their fifth-leading cause of death.

But Hoeven, the committee chairman, also acknowledged atthe hearingthat the grants have helped lower diabetes and its complications, such as limb amputations, heart disease and kidney failure.

But theres still more work to be done, he added.

The Salt River Pima-Maricopa Indian Community, like other grantees, uses the funds to educate families about the benefits of exercise and balanced diet, and to offer free family-oriented exercise classes and programs that promote healthy lifestyles.

After a 6-year-old on the reservation was diagnosed with Type 2 diabetes about three years ago, the tribal council began more screening at schools and found 52 percent of students were above the 95th percentile for weight.

When a screening showed that Alton was at risk for Type 2 diabetes, his family learned that he qualified for theYouth Wellness Campin Prescott. Grant money from the federal program lets the tribe send at-risk youth to the camp.

I wanted to be healthier, so I went to camp, Alton said. I wanted to be able to help my mom and my grandma be healthier.

The healthy eating and daily exercise at camp helped Alton lose almost 16 pounds. His mother, Felicia Jimerson, said that Altons new outlook on eating healthy and exercising is rubbing off on her three other kids.

Alton said that he tries to help his family and friends make healthier decisions, but they do not always listen.

I tell them all the time but not a lot of people care, cause that means they have to give up Hot Cheetos, said Alton, who has seen his friends buy at least four bags of the snack a day from the ice cream man.

We must destroy the ice cream man! Altontold the committee,to laughter.

Rachel Seepie, another member of the Salt River Pima-Maricopa Indian Community who testified, credits some of her success against her Type 2 diabetes to educational programs funded by the grant program.

After initially managing her condition with medication, she decided to turn instead to exercise and eating well. That has helped her lose weight, lower her blood sugar, decrease her average heart rate and complete two Iron Man triathlons, Seepie said.

Now, she is a senior fitness specialist with the Diabetes Service Program and teaches group exercise classes on the reservation.

My vision is that the Salt River Pima-Maricopa Indian Community and our members will learn how to become healthier, and they will have long full lives without Type 2 diabetes, Seepie told the committee.

After the hearing, Jimerson said that can only happen if the grant program is reauthorized.

I think if they can continue that funding, its definitely going to make a change, she said. If that funding goes away, were in huge trouble.

Follow this link:
Arizona youth joins tribal officials to push for continued diabetes program funding - Arizona Capitol Times

(Reuters Health) Diabetes can lead to blindness, but children and teens with diabetes may not receive recommended eye exams in the years following their diagnosis, a U.S. study suggests.

Researchers found that just 65 percent of youth with type 1 diabetes and 42 percent of those with type 2 diabetes had vision-loss screening within six years of their diabetes diagnosis.

More youth now than ever are being diagnosed with diabetes. By 2050, the prevalence with type 1 will triple and the prevalence with type 2 will quadruple, with the greatest increase in minority populations, said lead study author Dr. Sophia Wang of the University of Michigan Medical School in Ann Arbor.

The American Academy of Ophthalmology recommends screening for diabetic retinopathy five years after an initial diabetes diagnosis for youth with type 1 diabetes while the American Diabetes Association and the American Academy of Pediatrics recommend screening within three to five years. For kids with type 2 diabetes, screening is recommended at diagnosis.

Diabetic retinopathy is a complication of diabetes that may not have symptoms in early stages but can progress to vision loss. The damage to the retina of the eye results from damage to tiny blood vessels that affects other parts of the body as well.

About half of people with retinopathy develop diabetic macular edema, a fluid build-up in the retina, or glaucoma.

Diabetic retinopathy is the number one cause of vision loss in ages 20-74, so screening is an important component of diabetes care, Wang told Reuters Health by email.

To see how many kids with diabetes are getting the recommended screening, Wang and colleagues analyzed data from a national managed care network, which included more than 5,400 youth under age 21 with type 1 diabetes and 7,200 with type 2 diabetes.

Overall, researchers found that about 4,000 kids, or 31 percent, had an eye exam.

Those with type 1 diabetes were more likely to have had an eye exam compared with those who had type 2 diabetes, the study team reports in JAMA Ophthalmology . White and Asian youth were more likely to have had exams than black and Latino youth. Those with a higher household net worth were also more likely to receive an eye exam compared with those in lower-income households.

Despite the fact that all the youth in our study possessed health insurance, we found disparities by race and family affluence, suggesting that they may be particularly at risk, Wang said.

In the study, 11 percent of black children and teens and 18 percent of Latino youth were less likely to undergo an eye exam compared to white kids. Younger patients were also less likely to receive an exam than older ones.

We must educate adolescents and caregivers on the importance of screening to improve care coordination between different medical specialists such as pediatricians, endocrinologists, ophthalmologists and optometrists, said study author Dr. Joshua Stein of the University of Michigan Kellogg Eye Center in Ann Arbor.

More research is needed on new technologies which might render ophthalmic screening more accessible, such as retinal photography performed in primary care physicians clinics, he told Reuters Health by email.

Diabetic retinopathy is considered the most common microvascular complication of diabetes and is projected to grow at an alarming rate, said Dr. Seema Garg of the University of North Carolina at Chapel Hill, who wrote a commentary accompanying the study.

Visual impairment is detrimental to patients personal independence, economic productivity, employment and overall quality of life, she told Reuters Health by email. The opportunity costs of a lifetime of blindness are enormous.

Socioeconomics, geographical barriers, delayed referrals from primary care doctors, language barriers and cultural barriers also play a part in the screening gap. Retina screening via telemedicine could help address the issue, especially for racial minorities and economically disadvantaged youth, Garg writes in the commentary.

Telemedicine is an emerging strategy for improving screening with remote expert interpretation, she writes. Telemedicine is effective in reaching underserved populations in remote, rural or urban settings where patients may be at risk for more advanced disease.

SOURCE: bit.ly/2nAJHv1 and bit.ly/2nQkjn2 JAMA Ophthalmology, online March 23, 2017.

A federal judge in Delaware on Friday struck down key patents held by Acorda Therapeutics Inc related to its multiple sclerosis drug Ampyra, causing the stock to tumble 24 percent before trading was halted.

A U.S. patent board on Friday ruled against Danish drugmaker Forward Pharma A/S, finding Biogen's patents on its blockbuster multiple sclerosis drug Tecfidera to be valid.

Go here to see the original:
Youth with diabetes need vision loss screening | Reuters - Reuters

Please enable Javascript to watch this video

The incidence of type 1 diabetes, previously known as juvenile diabetes, has been steadily rising in the United States. Type 1 diabetes is an auto-immune disease in which the body is destroying the cells in the pancreas that make insulin, and is often diagnosed in children and young adults. While the exact cause of type 1 diabetes is unknown, it most likely is triggered by a combination of genetic predisposition and environmental factors not diet or nutrition.

Diabetes is not an easy disease because it requires constant attention, its even more difficult for children to understand and to manage their own care properly. Most kids dont want to stand out among their peers or seem different and will minimize management of the disease at school or in front of their friends. It may take some time and adjustment, but advancements in the treatment of type 1 diabetes are allowing children who are diagnosed with the disease to live much more normal and high-quality lifestyles.

Signs of type 1 diabetes include weight loss, increased thirst and/or drinking, increased urination, increased appetite, and in some cases, vomiting, stomachaches, headaches and fatigue. These signs can often be mistaken for another illness, but if they persist, talk to your childs provider about testing their blood sugar levels. Everyone manages diabetes differently, and solutions that work for your child may not be the same as what works for someone else. The team of pediatric endocrinologists and medical support staff at Cone Health Pediatric Sub-Specialists of Greensboro is dedicated to educating children and families about diabetes and providing individualized treatment for children with the condition here in our community.

Spokesperson Background:

Dr. Ashley Jessup is a pediatric endocrinologist at Cone Health Pediatric Sub-Specialists of Greensboro and a member of Cone Health Medical Group. She received her Bachelor of Science in biology from North Carolina State University and completed medical school at the Brody School of Medicine at East Carolina University. Dr. Jessup completed her pediatric residency at nationwide Childrens Hospital in Columbus, Ohio and a pediatric endocrinology fellowship at the University of North Carolina Chapel Hill.

Here is the original post:
Diabetes: Kids and Type 1 Diabetes - myfox8.com

Metformin in breast cancer Nature.com A new study published in the Journal of Clinical Oncology reports that metformin improves the prognosis of patients with HER2-positive, hormone receptor (HR)-positive breast cancer and diabetes mellitus. The phase III randomized ALTTO trial included ...

See the rest here:
Metformin in breast cancer - Nature.com

When a 92-year-old woman with dementia in my companys managed long term care (MLTC) plan had to switch from oral diabetes medication to insulin recently, Yael Reich, a nurse diabetes specialist with the Visiting Nurse Service of New York (VNSNY), was the person who arranged for a friend to administer the shots. In her dual role as diabetes educator and complex case manager, Yael advises VNSNY nurses across New York City, Westchester and Nassau on how to help our patients and health plan members with diabetes manage their glucose levels. Approximately one-third of our patients have diabetes in addition to their primary diagnosis, says Yael, whos worked with VNSNY for 23 years and has been a diabetes specialist and educator since 2004. This means our nurses are treating thousands of patients with diabetes on any given day.

Type 2 diabetes, in which a persons blood glucose levels become chronically elevated, can lead to kidney and eye damage, cardiovascular disease and other health problems. In addition to reviewing with our nurses and their patients the proper way to administer diabetes medications that keep blood glucose levels under control, Yael will also explain to them how weight loss, a healthy diet, exercise, and other lifestyle changes can help prevent diabetes in those who are at risk of developing it, and minimize the need for medication in those who already have diabetes.

According to the CDC, more than 29 million Americans are living with diabetes, and 86 million are living with prediabetes, a serious health condition that increases a persons risk of type 2 diabetes and other chronic diseases. With type 2 diabetes rates in the U.S. continuing to riseone in eleven Americans now has the disease, according to the most recent estimates, including one out of four people aged 65 or olderunderstanding how to prevent and control the condition through lifestyle changes and proper medical care is more important than ever. And since people who have diabetes or are at high risk of developing the condition make up a disproportionate share of home care patients and clients, the visiting nurses and nurse educators employed by home care agencies like VNSNY play a lead role in helping to keep this dangerous condition in check.

Bridging the Gap Between Medical Advice and How People Really Live

One important way that frontline home care clinicians make a difference is by helping their patients bridge the gap between advice they receive from medical professionals and taking steps to follow this advice on a daily basis in the real world. For example, when registered nurse Sheniqua Johnson was providing care recently for a patient with elevated blood glucose levels, her patient agreed readily with her advice to avoid foods high in sugar and processed carbohydratesbut then consistently refused to act on her recommendations. He didnt want someone coming in from the outside telling him what to do, Sheniqua says. On speaking with him further during her home visits, she learned that he was originally from West Africa, and with that information in hand, she was able to engage him around healthy foods hed grown up with and steer him toward a healthier diet.

By visiting with people in their homes, our nurses and nurse educators also come to understand real-life barriers that may not be as obvious to other medical professionals. Fresh vegetables and fruit are often difficult to access in lower income neighborhoods, and can be costly when they are available. As a result, people frequently turn to more convenient and affordablebut less healthyalternatives. Nurse Johnson recalls caring for a woman who was struggling with diabetes, and noticing that her kitchen shelves were crowded with boxes of sugar-sweetened cereal. To save money, thats what I eat for dinner, the woman told her, explaining that she thought she was following her doctors instructions. Johnson was able to help her patient identify easy-to-prepare alternative foods, such as frozen vegetables and lentils, in her local grocery store, that she could buy for the same price to provide better nutrition and help keep blood glucose levels in check.

Our frontline clinicians can also help people who havent developed diabetes identify and correct their risk factors, by walking them through diabetes risk assessments such as the one the American Diabetes Association (ADA) offers onlinea test which you can take yourself by accessing it here. When an assessment indicates that someones risk of developing type 2 diabetes is high, our clinicians will then arrange for them to have their blood glucose levels tested to determine whether they have diabetes or prediabetes (an early warning sign that blood glucose levels arent being adequately controlled).

Encouraging Daily Diabetes-Fighting Behavior

Whether someone has diabetes, prediabetes, or is simply at risk of getting the disease, our nurses and diabetes educators regularly encourage them to take evidence-based steps to prevent diabetes from developing, or manage their condition more effectivelyincluding losing weight, engaging in physical activity each day, and eating healthier foods. Many of our home health aides are now also trained as Health Coaches, and are using proven techniques such as motivational interviewing to help patients make and maintain important lifestyle changes that help them better manage their diabetes and other chronic medical conditions.

In addition to frontline nurses, diabetes educators and home health aides at home care agencies, community-based clinicians also play a significant role in combating the diabetes epidemic. Primary care physicians now routinely refer patients to diabetes educators for practical advice on how to make changes in their daily diets and safely increase physical activity. This is one more confirmation that when it comes to defeating type 2 diabetes, the solution begins at home.

Start your workday the right way with the news that matters most.

See the original post here:
Frontline Homecare Professionals Make a Difference in Keeping Diabetes In Check - Huffington Post

Diabetes medications were the most expensive traditional therapy drugs in 2016, with an overall trend of 19.4%, according to the latest Express Scripts drug trend report. This positive trend is reflective of increases in both utilization and cost.

Heres how pipeline developments could change the landscape.

Pipeline treatments

Peterson

While I do not see any game-changing medications within the diabetes class that will reach the market within the next several years, there are a few updates that we are watching, says Chris Peterson, director in the emerging therapeutics department at Express Scripts.

He points to the continued growth of the sodium-dependent glucose cotransporter-2 (SGLT-2) inhibitor classsparked by the positive cardiovascular outcomes from empagliflozin (Jardiance, Boehringer Ingelheim/Eli Lilly), a previously approved SGLT2 inhibitor. Pipeline SGLT-2 inhibitors include investigational ertugliflozin (Merck and Pfizer) and bexagliflozin (Chugai Pharma), both in phase 3 development at press time. Sotagliflozin (Lexicon Pharmaceuticals),a first-in-class oral dual SGLT-1 and SGLT-2 inhibitor for type 1 and type 2 diabetes, also in phase 3. If approved, it will be the first oral drug approved for type 1 diabetes, a disease that typically has been managed by lifestyle modifications and insulins, says Farrah Wong, PharmD, director, pipeline and drug surveillance at OptumRx.

Wong

The glucagon-like peptide-1 (GLP-1) analog class is also expected to grow, says Peterson. This is driven by cardiovascular outcomes data with liraglutide (Victoza, Novo Nordisk) and the introduction of the fixed-dose combination GLP-1 agonist/long-acting insulin products, insulin glargine and lixisenatide injection (Soliqua 100/3, Sanofi) and insulin degludec/liraglutide (Xultophy, Novo Nordisk).

Semaglutide is a GLP-1 agonist in development for glycemic control in patients with type 2 diabetes. It is being developed as both subcutaneous formulation from Novo Nordisk and oral form from Novartis. If approved, it will be the first oral GLP-1 agonist on the market.

As oral drugs are easier to administer and less invasive than injectable drugs, oral semaglutide may offer these advantages over other GLP-1 agonists, says Wong. Furthermore, type 2 diabetics will have another oral therapeutic option in a class of drugs that thus far were only injectable drugs.

Exenatide osmotic mini-pump (ITCA 650, Intarcia Therapeutics, Inc.) is a subcutaneous implant that continuously delivers the GLP-1 agonist, exenatide, for three months (introductory dose) or six months (maintenance dose) to treat type 2 diabetes. Approval is expected in November 2017, says Peterson.

New insulin products are also expected to receive approval soon, including insulin tregopil (Biocon Ltd.), an oral insulin in phase 2 development for type 1 and type 2 diabetes.

Currently, insulins are either injected or inhaled, says Wong. If an oral insulin product is available, the ease of administration may drive some of the market share to shift from injectable/inhaled insulins to the oral product.

Insulin glargine injection (Basaglar, Eli Lilly/Boehringer Ingelheim) approved last year, was the first follow-on insulin glargine product to treat diabetes. Another follow-on insulin glargine product, known as MK-1293 (Merck/Samsung Bioepis), will be competing as a brand product within the market and is expected to be approved in the second quarter of 2017. Basalog is yet another insulin glargine product currently in phase 3 development; however, it is not yet clear whether the manufacturer, Mylan, will seek approval as a competing brand or as a generic to Lantus (Sanofi). Finally, Sanofi is developing SAR342434, a follow-on protein to Lilly's Humalog (insulin lispro), for the treatment of diabetes mellitus. If approved, it will compete as a brand with the other rapid-acting insulins.

Link:
New therapies show promise in treating diabetes - ModernMedicine