Category Archives: Diabetes

Low carbohydrate diets should be considered for diabetes ... Science Daily Following a reduced carbohydrate diet can help to lower blood glucose levels, providing a safe and effective strategy for managing diabetes, new research ... and more »

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Low carbohydrate diets should be considered for diabetes ... - Science Daily

VALLEY COTTAGE, New York, March 8, 2017 /PRNewswire/ --

Growing number of diabetics in the US, Canada and European countries has been compelling hospitals to keep artificial pancreas systems in stock. Government-funded organisations in North America and Europe are collaborating with local as well as global medical device manufacturers to meet the rising demand for artificial pancreas systems. A latest report published by Future Market Insights reveals that the value of artificial pancreas systems market in North America and Europe reached US$ 86.5 Mn by the end of 2016. The report also predicts that people suffering from diabetes in these regions will keep opting for artificial pancreas systems in order to control their blood sugar levels externally.

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Lifestyle of residents in Europe and North America is triggering the incidence of diabetes (type 1 as well as type 2) in these regions. Substantial rise in diabetic patients compels doctors, pathologists and endocrinologists to treat patients' malfunctioning pancreas superficially. The rate at which a physiological pancreas get replaced with a substitute (artificial pancreas system) will keep gaining momentum in this region. By the end of 2026, more than US$ 280 Mn worth of artificial pancreas systems will be sold in North America and Europe, registering a revenue growth at 12.6% CAGR.

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Almost every artificial pancreas system sold in these regions will treat patients suffering from type 1 diabetes. In US, the occurrence of diabetes mellitus type 1 is expected to surge beyond control. The US artificial pancreas systems market is presently valued at just over US$ 40 Mn, and will account for over two-third of North America's artificial pancreas system revenues through 2026. Canada's artificial pancreas system revenues, on the other hand, will surge rampantly at 13.8% CAGR.

Hospitals will remain the largest distribution channel for artificial pancreas systems across North America and Europe. Although, the report does highlight a noticeable presence of e-commerce websites in global distribution of medical devices as critical as artificial pancreas systems. Among these regions, North America will remain dominant over Europe's artificial pancreas system market. Likewise, the demand for artificial pancreas systems will be fairly high in Western Europe, compared to Eastern Europe. Germany, France, the UK and Poland are leading European countries that are more likely to showcase revenue growth at over 11.5% CAGR.

Preview Analysis on North America and Europe Artificial Pancreas Systems Market Segmentation By Distribution Channel - Hospitals and E-Commerce; By Disease Indication - Diabetes Type 1 and Diabetes Type 2: http://www.futuremarketinsights.com/reports/north-america-and-europe-artificial-pancreas-systems-market

One of the largest company in North America & Europe's artificial pancreas systems markethas been identified as Illinois-based medical device manufacturer - Medtronic plc. With it, the UK-based Cellnovo is also being recognised as a prominent manufacturer of artificial pancreas systems. Other key players in the artificial pancreas systems market across North America and Europe include, Johnson & Johnson Services, Inc., Dexcom Inc., Insulet Corporation, and Tandem Diabetes Care Inc.

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Rising Diabetes Incidence Rate in North America & Europe Driving Sales of Artificial Pancreas Systems - Yahoo Finance

Science Daily

Diabetes drug may be effective against deadly form of breast cancer, study suggests Science Daily The study, 'AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program,' suggests that an inhibitor of this enzyme currently used to treat diabetes patients could be an effective therapy for this ... Diabetes drug may protect against deadly form of breast cancer ...UPI.com Diabetes Drug Fights Form Of Aggressive Breast Cancer - SFGateSFGate all 3 news articles »

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Diabetes drug may be effective against deadly form of breast cancer, study suggests - Science Daily

Nearly half of all deaths from heart disease, stroke and diabetes in the United States are associated with diets that skimp on certain foods and nutrients, such as vegetables, and exceed optimal levels of others, like salt, a new study finds.

Using available studies and clinical trials, researchers identified 10 dietary factors with the strongest evidence of a protective or harmful association with death due to "cardiometabolic" disease.

"It wasn't just too much 'bad' in the American diet; it's also not enough 'good,'" said lead author Renata Micha.

"Americans are not eating enough fruits, vegetables, nuts/seeds, whole grains, vegetable oils or fish," she said.

Micha is an assistant research professor at the Tufts University School of Nutrition Science and Policy in Boston.

RELATED: Mediterranean Diet Plus Olive Oil a Boost to Heart Health?

The researchers used data from multiple national sources to examine deaths from cardiometabolic diseases -- heart disease, stroke and type 2 diabetes -- in 2012, and the role that diet may have played.

"In the U.S. in 2012, we observed about 700,000 deaths due to those diseases," Micha said. "Nearly half of these were associated with suboptimal intakes of the 10 dietary factors combined."

Too much salt in people's diets was the leading factor, accounting for nearly 10 percent of cardiometabolic deaths, according to the analysis.

The study identifies 2,000 milligrams a day, or less than 1 teaspoon of salt, as the optimal amount. While experts don't agree on how low to go, there is broad consensus that people consume too much salt, Micha noted.

Other key factors in cardiometabolic death included low intake of nuts and seeds, seafood omega-3 fats, vegetables, fruits and whole grains, and high intake of processed meats (such as cold cuts) and sugar-sweetened beverages.

Each of these factors accounted for between 6 percent and 9 percent of deaths from heart disease, stroke and diabetes.

"Optimal" intake of foods and nutrients was based on levels associated with lower disease risk in studies and clinical trials. Micha cautioned that these levels are not conclusive. Optimal intake "could be modestly lower or higher," she explained.

Low consumption of polyunsaturated fats (found in soybean, sunflower and corn oils) accounted for just over 2 percent of cardiometabolic deaths, according to the study. High consumption of unprocessed red meats (such as beef) was responsible for less than one half of 1 percent of these deaths, the analysis showed.

The take-home message: "Eat more of the good and less of the bad," Micha said.

Vegetable intake, for example, was considered optimal at four servings per day. That would be roughly equivalent to 2 cups of cooked or 4 cups of raw veggies, she said.

Fruit intake was deemed optimal at three daily servings: "For example, one apple, one orange and half of an average-size banana," she continued.

"And eat less salt, processed meats, and sugary-sweetened beverages," she said.

The study also found that poor diet was associated with a larger proportion of deaths at younger versus older ages, among people with lower versus higher levels of education, and among minorities versus whites.

Dr. Ashkan Afshin is acting assistant professor of global health at the University of Washington's Institute for Health Metrics and Evaluation.

"I commend the current study's authors for exploring sociodemographic factors, like ethnicity and education, and their role in the relationship of diet with cardiometabolic disease," said Afshin, who was not involved in the study.

"This is an area that deserves more attention so that we may fully understand the connection between diet and health," he said.

The study doesn't prove that improving your diet reduces risk of death from heart disease, stroke and diabetes, but suggests that dietary changes may have an impact.

"It is important to know which dietary habits affect health the most so that people can make healthy changes in how they eat and how they feed their families," Afshin said.

The study was published March 7 in theJournal of the American Medical Association.

In an accompanying journal editorial, researchers from Johns Hopkins University urged caution in interpreting the findings.

According to Noel Mueller and Dr. Lawrence Appel, the results may be biased by the number of dietary factors included, the interaction of dietary factors and the authors' "strong assumption" that evidence from observational studies implies a cause-and-effect relationship.

Still, the editorialists concluded that the likely benefits of an improved diet "are substantial and justify policies designed to improve diet quality."

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Poor Diet Tied to Half of US Deaths From Heart Disease, Diabetes - Everyday Health (blog)

Medical News Today

Early periods associated with risk of gestational diabetes Science Daily "A large proportion of women who develop diabetes during pregnancy are overweight or obese, and encouraging those with an early start of puberty to control their weight before pregnancy may help to lower their risk of gestational diabetes," she said. Early period may indicate risk of diabetes during pregnancyMedical News Today Early Periods May Increase Women's Risk of Gestational DiabetesNDTV Early period may up gestational diabetes riskThe Tribune TheHealthSite all 20 news articles »

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Early periods associated with risk of gestational diabetes - Science Daily

White Sox pitching prospect Dylan Covey is among the many players in spring training who have no idea where they will head when the teams pack up for the regular season.

A Rule 5 draft pick in December, Covey would have to make the big-league roster out of spring training or be put on waivers and offered back to the Athletics, per major-league rules.

But at 25, Covey already is a pro at dealing with the unpredictable.

His biggest life-altering twist came in 2010 after the Brewers drafted the right-hander 14th overall one spot behind Chris Sale out of his California high school. Covey was nearing the signing deadline when a blood test from a team physical revealed he had Type 1 diabetes.

That gave him just days to figure out how to proceed.

Covey said the Brewers offered him the slot value of $1.7 million, less than what he asked for before the diagnosis, but he and his family decided to turn it down. He instead attended the University of San Diego, closer to home and his physician, while he learned to manage his disease.

"Maybe not financially speaking, but as far as my health, which is obviously more important, I think it was the right decision," Covey said. "I had all of the resources there. I'm sure the Brewers would have been great with it too, but just being so unfamiliar with it all, it was really a comfort thing. I didn't know what to expect."

When the Sox asked about Covey this offseason, he told them the diabetes "is not even an issue anymore." He knows how to eat and has an insulin pump to manage it, and he said his body is "like a normal person's now."

It took a while to get there.

The first year and a half after his diagnosis were "really tough," he said. Covey learned about counting carbohydrates and taking insulin. He lost weight before the diagnosis, and after putting it back on, he worked to turn it into muscle.

Meanwhile, he pitched 34 1/3 innings as a freshman at San Diego, though in retrospect he said he should have redshirted.

"Learning to do that at first is tough because you don't really think about how many carbohydrates you're eating every time you take a bite of food," said Covey, who is 6-foot-2 and weighs 195 pounds. "It was definitely an adjustment period I had to go through."

After three seasons at San Diego, the A's drafted Covey in the fourth round in 2013, and he signed for $370,000. He worked his way to Double A in 2016 and had a 1.84 ERA in six starts before an oblique injury. He returned to pitch in the Arizona Fall League, going 4-0 with a 4.74 ERA, before the Sox picked him up at the winter meetings in December.

It has been a more difficult journey than Covey could have imagined as a teenager.

"Who knows what would have happened if I had signed in 2010," Covey said. "It has been a little bit longer of a path, but I'm happy for the situation I am in right now with the White Sox."

The Sox are giving Covey a shot to show what he can do this spring.

He gave up two earned runs on three hits in his first one-inning appearance against the Rockies last month, an outing pitching coach Don Cooper chalked up to "anxiousness."

But he pitched two scoreless innings on 16 pitches in his start against the Padres on Friday, and he's scheduled to start again Saturday.

"He had a nice outing the other night, got nothing but ground balls," Cooper said. "He's a two-seam guy, so he's real strong with his sinker, arm-side, down and in to righties, down and away to lefties. ... I told him, now we're on the move, and now we've got to see if he can carry it into the next one."

The Sox rotation is full, barring a trade, but the club could keep Covey as a long reliever or spot starter. They also could try to strike a trade with the A's if they like what they see this spring.

Covey said he is staying focused amid the "little bit of pressure."

"If I don't make the team, I go back to the situation I was in before," Covey said. "I've just got to go out and do my best every time, and hopefully my actions prove to them that I'm worth the pick they used to get me."

Intention to start: Pitching prospect Reynaldo Lopez has made it known he hopes to remain a starter when he reaches the majors, and manager Rick Renteria reiterated Monday the Sox are sticking with that plan for now.

Renteria said he was happy with how Lopez located in his second start Sunday, when he allowed one earned run on three hits with a walk and three strikeouts in three innings.

"First inning was a little rough, but obviously he settled down and did a nice job," Renteria said. "He was commanding all of his pitches and looked very good."

WBC update: Sox minor-leaguer Alex Katz pitched a scoreless inning in Team Israel's 2-1, 10-inning victory over South Korea to open the World Baseball Classic. Katz hit one batter and had one strikeout in the seventh.

ckane@chicagotribune.com

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With diabetes under control, pitcher Dylan Covey tries to stick with White Sox - Chicago Tribune

When pregnant mothers have diabetes, their children may have altered fat cells that make metabolic diseases in adulthood more likely, a small Danish study suggests.

Babies of mothers with diabetes may be exposed to high blood sugar levels in the womb, a condition known as fetal hyperglycemia.

"Fetal hyperglycemia affects fat stem cells and these defects can be detected several years later," said lead study author Ninna Schioler Hansen of the University of Copenhagen in Denmark.

In lab tests, adult offspring of women who had diabetes during pregnancy appeared to have larger fat cells and more leptin, a protein made by fat cells that influences hunger.

"If (high blood sugar) or diabetes is present during pregnancy, our study supports the importance of aiming at normal blood glucose levels to reduce the negative impact on the cells of the unborn baby," Hansen added by email

"Women who are lean and fit before pregnancy have a reduced risk of developing gestational diabetes during pregnancy," Hansen said.

Hansen's team studied 206 adults, including some whose mothers had diabetes before pregnancy, others whose mothers developed a condition known as gestational diabetes during pregnancy, and a control group with mothers who didn't have diabetes at all.

Adult offspring of women with diabetes in pregnancy showed "fundamental changes" in the size of their fat cells, their ability to store fat as well as the way their bodies produced the hormone leptin, which influences appetite regulation in the brain, Hansen said.

It's possible that differences between adults with and without mothers who had diabetes during pregnancy might be explained by other factors that happened during fetal development, the authors note in the Journal of Clinical Endocrinology and Metabolism.

Even so, the results offer clues to explain the increased diabetes risk among children born to mothers with diabetes, said Dr. Joachim Dudenhausen, an obstetrics and gynecology researcher at Weill Cornell Medicine in New York who wasn't involved in the study.

Changes induced by hyperglycemia in the mother "can be responsible for diabetes of the child in later life," Dudenhausen said by email.

The best prevention is for women to start pregnancy at a normal weight and gain a healthy amount of weight while they're growing their babies.

Women who start out at a normal healthy weight should gain 25 to 35 pounds during pregnancy, while women who are overweight to start should gain no more than 25 pounds, according to the U.S. Centers for Disease Control and Prevention.

"One of the highest risk factors for gestational diabetes is being overweight before and during pregnancy," Dudenhausen said.

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Diabetes in pregnancy tied to altered fat cells in adult offspring - Fox News

Most people can think of one person they know who suffers from diabetes, and yet not everyone knows about the disease.

The University of Nebraska-Lincolns College Diabetes Network is setting out to bring awareness to the disease and to promote a supporting environment for diabetics. College Diabetes Network is a nationally Recognized Student Organization that got its start at UNL after Haley Schepers, president and founder of UNLs chapter, decided to bring it here in December 2016. The club was approved in January 2017.

Type 1 diabetes is a disease in which the pancreas stops working, affecting the production of insulin, a hormone that breaks down sugars in the body. Diabetics must use insulin shots or pumps to regulate their blood sugar levels all day every day. Type 1 is an autoimmune disease that has no known cause or cure, although has some hopethere is a cure.

Schepers and the vice president of UNLs College Diabetes Network Ansley Alberts have similar stories about why theyre dedicated to diabetes. Both have younger siblings who were diagnosed at a young age with Type 1 diabetes. Schepers sister was diagnosed at age 12, and Alberts brother was diagnosed at age 11.

Its a complete life cycle change, so being a sister to someone with diabetes is really about being a support system, Alberts said. Its always on your mind.

Now, both students are making it their goal to raise awareness about Type 1 diabetes and to change the culture on campus. They want the club to be a place where students with diabetes can talk to each other. This is especially important for freshmen who have never lived alone with the disease.

Schepers said she hopes the group can get upperclassmen to mentor underclassmen on how to live with diabetes in college. This includes learning how to handle the drinking culture as well as eating in the dining hall and regulating their blood pressure.

Students are given this freedom and they dont know what to do with it, Schepers said, Theyre thrown into this crazy culture and theyre not regulating it, and people around them dont know how to help them.

Jacinta Benton, a member of College Diabetes Network, said the group has supported her by being a place where she can have personal interactions with others who have Type 1 diabetes. Benton was diagnosed with the disease last year when she was a freshman.

Benton said she quickly learned to take diabetes one day at a time. She said she hopes students will be educated on the science behind diabetes. Benton also said she thinks its important for UNL students to know what to do in a situation when a diabetics blood pressure is too low or too high.

Students should know how to check a students blood pressure and when to give more sugar if its at dangerous levels, she said.

Benton said that reaching out to other people with diabetes helps you learn specific accommodations you can get in college.

I would recommend to people who get diagnosed to do your research and reach out to people early, she said. If you do it early, later on in your life its simpler - not easier - but simpler.

Schepers said she hopes the group can get the word out about College Diabetes Network and attract new members. She said in the future she wants students who get diagnosed to get sent straight to College Diabetes Network so they can help with the transition.

The club accepts students who have diabetes, students who know someone who has it or students who just want to help the cause. Schepers said to go to their Facebook page CDN-Lincoln to learn more about meeting times and upcoming events like an awareness campaign and their first annual Walk to Cure Diabetes on April 2 with a fraternity on campus, Delta Tau Delta.

Schepers said there is also a GoFundMe page for the event if someone cannot attend but would like to help.

We are very close to a cure for Type 1 right now, Alberts said. I think that cure can come in my brothers lifetime.

news@dailynebraskan.com

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UNL's new College Diabetes Network hopes to raise awareness, connect students - Daily Nebraskan

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Diabetes Smackdown seminar - Kozi Radio

Of all the photos taken over 20 years of my daughter Laurens diabetes life, the one that haunts me is the one in which she and we had no idea Type 1 diabetes was trying to kill her.

Its her formal kindergarten picture, taken in 1997, when, sans Internet, youd have your school picture taken and six weeks later it would be sent home. In my daughters picture shes gaunt and pale in a way that I somehow didnt notice in daily living. Her cute dresss shoulder seam sits almost at her elbow. Shed grown so thin, her clothes were almost falling off of her.

I didnt understand what was happening.

Id been semi-nonchalantly rationalizing her symptoms (excessive, nearly unquenchable thirst = it was a particularly warm fall; everyone was thirsty). Bed-wetting (shed just started school, stress perhaps?) Weight loss. (She was growing taller. Her dad was thin. Id been thin almost all my life). When I finally brought her to the doctor and they made the diagnosis, I realized it had all been right there before me.

After my daughters diagnosis I was so absorbed with her care that I hardly reflected on what it had been like before the diagnosis. Six weeks later, my heart nearly broke when her school picture arrived in the mail. It was taken two days before her Type 1 diabetes diagnosis.

I will always harbor a tiny bit of guilt for not seeing my daughters suffering before her diagnosis.I was reminded of Laurens kindergarten picture when I read that after a months-long trial, a Canadian judge has found Emil and Rodica Radita guilty of first-degree murder in the death of their 15 year old son, Alex, who had Type 1 diabetes. The Raditas denied their son the insulin therapy he needed to survive, and were both sentenced to life in prison.

The Washington Post reports:

An emergency worker detailed thedisturbing scene upon discovering the teen in his parents bedroom on the night of his death, May 7, 2013.

She described him as emaciated to the point where he appeared mummified. His face had no visible flesh left as she could see every bone in his face, court records of the workers account stated. He had black, necrotic sores on his face and his left jaw had open sores so deep she could see his jaw bone. There was nothing left of his stomach as he was just so extraordinarily skinny. She estimated his waistline to be approximately three inches. He was dressed in a diaper and t-shirt. His eyes were open. He was not breathing.

An autopsy foundthecause of death to bebacterial sepsis, brought on by starvation and neglect.

Every parent should be horrified by this story letting a child in your care die of a treatable disease because of religion? And for the diabetes-parent, it goes much deeper because weve been with our children through many high blood sugar experiences. Weve smelled the sickly-sweet poison of ketones on our kids breath. We know first-hand just how evil diabetes can be to a body, even when care is present. We understand this because we are so intimate with the disease. The cruelty of Alexandru Raditas murder, then, the years of his unthinkable suffering and horror, shreds our hearts in a kind of personal way because we spend our lives making sure that never happens to our children.

Court records state that the Raditas took Alex, who was diagnosed with Type 1 diabetes in 2000, to the hospital in 2003 and told the doctor he had only been sick for a couple of weeks when he got a viral infection and began vomiting. The doctor could not reconcile this information to the physical state Alex was then in. He asked Mrs. Radita directly whether she understood that Alex had diabetes. She did not respond.

In 2004, Alex was placed in foster care where he thrived, learning the basics of his diabetes care like matching the food he ate with a dose of insulin, and understanding the importance of constant oversight and care.

But in 2005 he was sent back to his parents. Four years later the Raditas moved to Alberta, where Alex was reportedly homeschooled, and isolated from anyone who could see his sickly condition and interfere on his behalf. Alex lived and died alone, a prosecutor said.

The Raditas withheld simple shots of insulin from their son, shots which take only 10 seconds to administer, and which enable a person with diabetes to live a full, healthy, and happy life. Instead they chose to let him sink into what had to have been one of the most horrifying and painful deaths imaginable.

When I look at that photo of my daughter, suffering greatly and me not knowing yet, I flash back to something someone said after her diagnosis that bothered me then.

Im glad she has you for a mom.

How I wish Alex had been mine, or the child of one of the thousands and thousands of D-parents I know who would turn their lives upside down to make his better.

The image of Alex Radita is a screenshot from the Calgary Heralds report.

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A Diabetes Mom's Thoughts on the Horrific Murder of Alex Radita - A Sweet Life (blog)