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Category Archives: Gene therapy

Hair Trigger: How a Cell’s Primary Cilium Functions as a Molecular Antenna

Posted: June 30, 2010 at 8:25 am

It turns out that not all the hairlike cilia projecting from the surfaces of many cells in the human body are equal--there are the myriad ones for sweeping, swimming and other functions, and then there is the until recently mysterious primary cilium.

Nearly all human cells contain these numerous microscopic projections. The more abundant variety of cilia are motile; they act like oars, paddling in coordinated waves to help propel cells through fluid, or to sweep material across cellular surfaces (as in the respiratory system, where millions of cilia lining the airways help to expel mucus, dead cells and other bodily debris). By contrast, cells also contain a single, nonmotile cilium known as the primary cilium. Its presence on cells has been known for more than a century, but many believed it was a functionless evolutionary remnant.

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Cell - Biology - Cell biology - Cilium - Human body

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Hair Trigger: How a Cell's Primary Cilium Functions as a Molecular Antenna

Posted: June 30, 2010 at 8:23 am

It turns out that not all the hairlike cilia projecting from the surfaces of many cells in the human body are equal--there are the myriad ones for sweeping, swimming and other functions, and then there is the until recently mysterious primary cilium.

Nearly all human cells contain these numerous microscopic projections. The more abundant variety of cilia are motile; they act like oars, paddling in coordinated waves to help propel cells through fluid, or to sweep material across cellular surfaces (as in the respiratory system, where millions of cilia lining the airways help to expel mucus, dead cells and other bodily debris). By contrast, cells also contain a single, nonmotile cilium known as the primary cilium. Its presence on cells has been known for more than a century, but many believed it was a functionless evolutionary remnant.

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Cell - Biology - Cell biology - Cilium - Human body

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A genome story: 10th anniversary commentary by Francis Collins

Posted: June 29, 2010 at 8:22 am

For those of you who like stories with simple plots and tidy endings, I must confess the tale of the Human Genome Project isn't one of those. The story didn't reach its conclusion when we unveiled the first draft of the human genetic blueprint at the White House on June 26, 2000. Nor did it end on April 14, 2003, with the completion of a finished, reference sequence. [More]

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Human Genome Project - White House - Biology - genetic - Francis Collins

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A genome story: 10th anniversary commentary by Francis Collins

Posted: June 29, 2010 at 8:20 am

For those of you who like stories with simple plots and tidy endings, I must confess the tale of the Human Genome Project isn't one of those. The story didn't reach its conclusion when we unveiled the first draft of the human genetic blueprint at the White House on June 26, 2000. Nor did it end on April 14, 2003, with the completion of a finished, reference sequence. [More]

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Human Genome Project - White House - Biology - genetic - Francis Collins

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Vaccines Derived from Patients’ Tumor Cells Are Individualizing Cancer Treatment

Posted: June 26, 2010 at 8:22 am

The first discovery of a cancer gene marker--the BRAF oncogene for melanoma and colorectal malignancies--back in 2002 changed the way many researchers thought about cancer treatment. Rather than approach the disease based on what region of the body it stemmed from, scientists began to identify cancers in terms of their genetic signatures. Researchers now recognize more than 200 kinds of cancer--all genetically unique. [More]

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Cancer - Health - Conditions and Diseases - Colorectal cancer - Management of cancer

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Vaccines Derived from Patients' Tumor Cells Are Individualizing Cancer Treatment

Posted: June 26, 2010 at 8:21 am

The first discovery of a cancer gene marker--the BRAF oncogene for melanoma and colorectal malignancies--back in 2002 changed the way many researchers thought about cancer treatment. Rather than approach the disease based on what region of the body it stemmed from, scientists began to identify cancers in terms of their genetic signatures. Researchers now recognize more than 200 kinds of cancer--all genetically unique. [More]

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Cancer - Health - Conditions and Diseases - Colorectal cancer - Management of cancer

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Cancer Therapy Goes Viral: Progress Is Made Tackling Tumors with Viruses

Posted: June 24, 2010 at 8:25 am

The adapted virus that immunized hundreds of millions of people against smallpox has now been enlisted in the war on cancer. Vaccinia poxvirus joins a herpesvirus and a host of other pathogens on a growing list of engineered viruses entering late-stage human testing against cancer. [More]

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Cancer - Smallpox - Virus - Vaccinia - Health

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Cancer Therapy Goes Viral: Progress Is Made Tackling Tumors with Viruses

Posted: June 24, 2010 at 8:24 am

The adapted virus that immunized hundreds of millions of people against smallpox has now been enlisted in the war on cancer. Vaccinia poxvirus joins a herpesvirus and a host of other pathogens on a growing list of engineered viruses entering late-stage human testing against cancer. [More]

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Cancer - Smallpox - Virus - Vaccinia - Health

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Large-Scale Autism Study Reveals Disorder’s Genetic Complexity

Posted: June 12, 2010 at 8:22 am

The vast array of behaviors that are seen in autism spectrum disorder seems to cover an even deeper range of genetic complexity just below the surface. And the largest genetic study of autistic children and their parents to date has located a host of new variations in autistic individuals. [More]

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Autism spectrum - Autism - Health - Mental health - Disorders

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Large-Scale Autism Study Reveals Disorder's Genetic Complexity

Posted: June 12, 2010 at 8:21 am

The vast array of behaviors that are seen in autism spectrum disorder seems to cover an even deeper range of genetic complexity just below the surface. And the largest genetic study of autistic children and their parents to date has located a host of new variations in autistic individuals. [More]

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Autism spectrum - Autism - Health - Mental health - Disorders

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