Category Archives: Genetics

ANN ARBOR, Mich. (WOOD) A new study led by researchers at the University of Michigan shows how genetics play a key role in how each persons body reacts to booster shots.

The study was a partnership with the Australian National Health and Research Center and the American Foundation for AIDS Research. Unlike the original vaccine, boosters re-expose the immune system to a virus or some portion of it to boost the bodys natural immune response. Not every body reacts the same way. The booster doses increase the number of antibodies in a persons system, but genetics dictate how well the immune receptors stick to those antibodies.

Different people vary in the amount and type of antibodies they produce, Kelly Arnold wrote in a 2021 study published in Cell Reports Medicine.

Arnold is an assistant professor of biomedical engineering at the University of Michigan and one of the leading researchers on the study.

Depending on their genetics, they also have different protein sequences in their antibodies and immune cell receptors that cause them to bind differently, Arnold said.

She says two people can have the same antibody count but have different immune responses and, theoretically, booster doses can be specifically designed to make them more effective for people depending on their genetic makeup.

That technology is not yet available, but it could be possible.

Depending on your genetic background, weve found that vaccine boosting may be more or less effective in activating certain innate immune functions, Arnold told the University of Michigan Health Lab. And in some people, where boosting the concentrations of antibodies was ineffective, being able to change the affinity of antibodies could be the more successful route.

Arnold and her research team have worked with their partners in Australia, Thailand and other places in the United States to create a computer model to determine how different genetic factors dictate immune responses.

Melissa Lemke, a Ph.D. candidate who led the 2021 study, says vaccine formulas developed for specific genetic traits is key in fighting viruses that mutate rapidly, like COVID-19, HIV or influenza.

This means that in order to protect all people to the same degree from a variety of viral mutations, we need an array of possible solutions that can be matched to any given persons health status, sex, age and genetic background, Lemke told the University of Michigan Health Lab. Computational tools like this one are going to be essential in speeding up the search for mechanisms that can be implemented to create effective vaccines for all.

Here is the original post:
Study: Genetic makeup plays key role in effectiveness of booster doses - WOODTV.com

FACULTY OF NATURAL AND AGRICULTURAL SCIENCESDEPARTMENT OF BIOCHEMISTRY, GENETICS AND MICROBIOLOGYGENETICSLECTURER (BIOINFORMATICS)

In pursuit of the ideals of excellence and diversity, the University of Pretoria wishes to invite applications for the above vacancy.

The University of Pretoria's commitment to quality makes us one of the top research Universities in the country and gives us a competitive advantage in international science and technology development.

BACKGROUND:

The incumbent is expected to be positioned in the Centre of Bioinformatics and Computational Biology, which resides within the Department of Biochemistry, Genetics and Microbiology, to provide ongoing bioinformatics services and support, which includes the development of bioinformatics tools and resources for both internal and public use. The incumbent will also have an academic mandate to teach at undergraduate and postgraduate levels in Bioinformatics and Genetics, as well as a research mandate to build an active research programme which will enhance the Departments research profile and grow capacity in postgraduate supervision.

RESPONSIBILITIES:

The incumbent will actively participate in the following areas:

MINIMUM REQUIREMENTS:

REQUIRED COMPETENCIES (SKILLS, KNOWLEDGE AND BEHAVIOURAL ATTRIBUTES):

ADDED ADVANTAGES AND PREFERENCES:

PLEASE NOTE: The Department of Biochemistry, Genetics and Microbiology (BGM) reserves the right to request and review copies of academic publications (papers/dissertation/ thesis) for suitability before a candidate is shortlisted. All shortlisted applicants will be expected to present a lecture on a given topic within the Department.

The annual remuneration package will be commensurate with the incumbents level of appointment, as determined by UP policy guidelines. UP subscribes to the BESTMED and UMVUZO medical aid schemes and contributes 50% of the applicable monthly premium.

Applicants are requested to apply online at http://www.up.ac.za, and follow the link: Careers@UP.

In applying for these posts, please attach:

CLOSING DATE: 7 April 2022

No application will be considered after the closing date, or if it does not comply with at least the minimum requirements.

ENQUIRIES:

Mrs S Mahlangu, Email: shado.mahlangu@up.ac.za for application-related and Prof F Joubert, fourie.joubert@up.ac.za for post content enquiries.

Should you not hear from the University of Pretoria by 31 May 2022, please accept that your application has been unsuccessful.

The University of Pretoria is committed to equality, employment equity and diversity.

In accordance with the Employment Equity Plan of the University and its Employment Equity goals and targets, preference may be given, but is not limited to candidates from under-represented designated groups.

All candidates who comply with the requirements for appointment are invited to apply. All candidates agree to undergo verification of personal credentials.

The University of Pretoria reserves the right to not fill the advertised positions.

The rest is here:
Lecturer, Bioinformatics, Department of Biochemistry job with UNIVERSITY OF PRETORIA | 287312 - Times Higher Education

What if we could help threatened wildlife better adapt to the intractable threats many species are facing from challenges like climate change and disease?

The United Nations has warned that about a million animal and plant species are at risk of extinction. In response, conservation breeding programs are ramping up to boost and protect populations.

The problem is that while conservation breeding can prevent extinction, it doesnt allow threatened species to survive in the wild in the face of these difficult to mitigate threats.

So, while it is critical that we address climate change and diseases, we also need to be urgently looking at way to make it easier for species to live with the threats.

This is where Targeted Genetic Intervention (TGI) comes in.

TGI works by adapting methods that are successfully used in agriculture and medicine in which an individuals genetics are tweaked in ways that, when passed on to the wider population through breeding, can change the traits of a species to improve its survival.

Read more

Two of the most promising approaches in this toolkit include artificial selection and synthetic biology.

Artificial selection has been used for thousands of years in animal and plant breeding to produce pets, farm animals and agriculture crops with desired features.

This has led to the development of many of the animals and plants we now rely on for food or companionship like dairy cattle, rice and Golden Retrievers.

These approaches were even lauded by English naturalist Charles Darwin for their astonishing ability to generate from wolves our domesticated dogs which are as different as Chihuahuas and Great Danes.

Today, advances in genomic approaches have made artificial selection methods considerably more sophisticated than in Darwins day. We can now use genomic information to predict what traits an animal will have with an approach known as genomic selection.

Genomic selection may be a game changer for endangered wildlife because it allows for the development of informed breeding strategies that promote adaptation.

It works by first understanding and identifying what genetic features make members of a species more adapted to an environment or threat than others. This is usually done by exposing individuals in a reference population to the threat (like heat stress or infectious disease) and then measuring their response.

Read more

We then look for genes that are present in individuals that resist and survive the threat. This genetic information can be used to predict which animals in the breeding population are better adapted to survive a given threat based on their own genotype.

Over time, the use of genomic selection as a breeding strategy can increase the average ability of these individuals in the breeding population to survive by promoting adaptation in captivity.

The ability to use this sort of genomic prediction data based on discrete groups of individuals is a major advantage because it means that risky activities, like exposing a population to a disease or other infection as part of a trial, can be performed separately in laboratories away from the critical breeding populations.

Synthetic biology is newer and more controversial than artificial selection. It includes methods like transgenesis and gene editing.

While these methods frequently figure in science fiction and are sometimes feared for their unintended consequences, the real science of synthetic biology is gaining traction in the conservation community due to its many benefits.

Additionally, a recent public opinion survey conducted by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) indicates that the public are moderately-to-strongly supportive of use of synthetic biology approaches for conservation.

Read more

Synthetic biology can be used to introduce lost or novel genes and tweak specific genetic features of an organism without changing other characteristics, which often occurs with less targeted approaches like artificial selection.

Transgenesis does this by incorporating foreign DNA from a different species into the genome. Gene editing is more subtle and works by inducing the organism itself to knock out or replace targeted genes.

American Chestnut trees, corals and black-footed ferrets are just some of the species that synthetic biology methods are currently being trialled to assist with restoration. American Chestnut trees, in particular, are a great success story for the use of synthetic biology for conservation.

This species was driven to virtual extinction in North America after the introduction of the Asian Chestnut Blight fungus in the late 1800s.

Various approaches have been tested to increase resistance to this pathogen with varying degrees of success, but since the tree lacks natural resistance, the most effective approach to date has involved using transgenesis to introduce a new disease-tolerant gene from wheat.

This has produced American Chestnut trees that appear to be blight tolerant. Trial plantings of these trees in American forests may soon start, pending regulatory approval.

Read more

My research group at the University of Melbourne was recently awarded grants from the Australian Research Council (here and here) to test TGI approaches in various Australian frogs vulnerable to extinction.

Many frogs in Australia and globally are threatened by the devastating fungal disease chytridiomycosis. This disease is caused by the introduced fungus Batrachochytrium dendrobatidis and unfortunately few options exist for restoring frogs susceptible to this disease to the wild.

We are working with various institutions including Zoos Victoria and the Taronga Conservation Society to investigate if TGI approaches can be used to increase chytridiomycosis resistance in Australian frogs.

We are currently working on the iconic Southern Corroboree frog (Pseudophryne corroboree) and, in the next few years, we intend to add additional species like the Green and Golden Bell frog (Litoria aurea) and Northern Corroboree frog (Pseudophryne pengilleyi).

Its imperative that we as a community investigate the application of TGI approaches for conservation as in some cases they may be the only way to restore a species in the wild.

Read more

But with this comes the responsibility of the public, government and scientists to not only fund research on TGI, but to also make sure that it is done responsibly with careful consideration to all entities impacted and with proper evaluation of all potential risks.

Since TGI for conservation is a new concept, species modified by TGI should be evaluated to ensure that induced genetic changes increase survival and that the organisms pose no risk to the environment by occupying a different niche or position in the food chain.

Given the scale and seriousness of the challenge in conserving our wildlife, and given the established efficacy of TGI, its an approach that we cant afford to ignore.

The ideas introduced in this article are discussed in more detail in our recent article in the journal Trends in Ecology and Evolution. Dr Koschs co-authors are Anthony W. Waddle, Dr Caitlin A. Cooper, Professor Kyall R. Zenger, Professor Dorian J. Garrick, Associate Professor Lee Berger, and Professor Lee F. Skerratt.

The southern corroboree frog genome is being sequenced for the researchers by the Vertebrate Genomes Project.

Banner: Getty Images

Follow this link:
Using genetics to conserve wildlife - Pursuit

A world-first pilot of predictive genetic testing aiming to identify those at high risk of cardiovascular disease is under way in GP surgeries in the north of England.

The NHS pilot, called Heart, is offering genetic tests to 1,000 healthy volunteers aged between 45 and 64 years old to give more accurate predictions for their risk of heart disease and stroke.

The pilot could be the first step towards a wider rollout of predictive genetic testing on the NHS to improve screening for those at risk of a range of common diseases including breast and bowel cancer, diabetes and osteoporosis.

Prof Sir Peter Donnelly, the founder and chief executive of Genomics, the company that developed the tests, said: These are people going about their daily lives who are at high risk of cardiovascular disease who are currently invisible to the NHS. We can find these people who are actually at quite high levels of risk but not aware of it.

Genetics is an important risk factor for many common diseases, including heart disease. However, until recently it has been impossible to quantify the genetic component of risk because it is typically spread thinly over thousands of DNA regions. The advent of vast genetic databases has changed this, allowing scientists to develop algorithms that aggregate the contributions of huge numbers of genes into a polygenic risk score (PRS) for a given condition.

The participants will be recruited from those undergoing a routine NHS health check that is offered to people over 40. As part of the check, GPs use an algorithm called QRisk that combines non-genetic factors such as age, blood pressure, smoking history and cholesterol to identify those at risk. Those estimated to have a 10% chance of a heart attack or stroke in the next 10 years are advised on lifestyle changes and offered medications such as statins.

The pilot will combine the QRisk score with the genetic score to provide a more precise estimate of risk. Research suggests that in 45- to 55-year-old men, the PRS is the single most important risk factor, explaining about the same amount of the risk for heart disease as the combined effect of all the non-genetic risk factors. Overall, about 5% of people aged 45-65 are expected to be above the risk threshold for statins based on PRS and QRisk combined, but not on Qrisk alone. Applied to the number of 45-65-year-olds in England, if these extra individuals were all treated with statins about 9,500 cardiovascular events could be avoided over 10 years.

Michael Brennan, 61, who is retired and lives in Darlington, said he had no hesitation in signing up for the pilot. Im probably not alone at this time of the year in thinking about health and lifestyle, he said. He is waiting his results, but said he will be glad to find out either way. If I know, Ive got a chance of doing something about it, he said.

However, some have concerns that deploying the tests could lead to genetic fatalism, because unlike most other risk factors, genetic ones are not modifiable. There is also continued concern that the tests, which have been largely developed using genetic data from white Europeans, give less accurate results for people from other ethnic backgrounds. Donnelly said that the company had worked hard to address this issue that genetic ancestry is factored in when calculating risk scores.

However, Prof David Curtis, a geneticist and psychiatrist at University College London, said that it had not been demonstrated that the tests work equally well for those of all backgrounds. I maintain that this is a test that will work less well in people with minority ancestries and so would be expected to increase inequalities in healthcare, he said.

Prof Ahmet Fuat, the chief investigator on the pilot and a GP with a specialist interest in cardiovascular health, said genetic testing could be a game changer for primary care. Genomic testing can improve our identification of patients who need extra management, screening or treatment, and better personalise those interventions to them, he said. Common diseases like cardiovascular disease place a great deal of demand on our resources and anything that helps us use those more efficiently and effectively is incredibly valuable.

See original here:
NHS pilots genetic testing to predict risk of heart disease - The Guardian

Cervical cancer is cancer that develops in the cervix, the part of the body that connects the vaginal canal to the uterus.

The most common types of cervical cancer are not hereditary, meaning a person is not more likely to develop it if a parent or close relative has had the disease. However, some rare types of cervical cancer may have a genetic component. Changes to certain genes, such as the DICER1 gene or STK11 gene, may increase a persons risk of cervical cancer.

This article describes which types of cervical cancer may be hereditary and outlines some familial risk factors for the disease. We also list other risk factors for cervical cancer and provide information on symptoms, prevention, and outlook.

Most common types of cervical cancer are not hereditary. In fact, around 70% of cervical cancers are due to infection with human papillomavirus (HPV).

However, some very rare types of cervical cancer can be hereditary, meaning they have a genetic component. In these cases, a person may be at risk of developing such cancers if they have a genetic variant that increases their risk of developing cervical cancer or a first-degree relative with cervical cancer linked to a genetic cause.

If multiple people on one side of a persons family have cervical cancer, a doctor may recommend they have additional screening tests or more regular screening for cervical cancer.

If doctors notice a trend in cancer types among family members, they may recommend additional screening or even hereditary cancer screening. This can help discover genetic trends or risk factors for cancer.

Having a risk factor for cervical cancer does not mean that a person will develop the disease, only that they are at increased risk of doing so.

There are two main genetic risk factors for cervical cancer: DICER1 syndrome and Peutz-Jeghers syndrome (PJS).

DICER1 syndrome is a rare genetic condition causing changes in the DICER1 gene. It is a risk factor for hereditary cancer types in children and young adults.

Having DICER1 gene variations may increase the risk of a rare type of cervical cancer called cervical embryonal rhabdomyosarcoma (ERMS) and other sarcomas of the cervix.

While many problems that stem from the DICER1 gene appear in childhood, about 33% of cervical ERMS cases occur in people over the age of 20.

PJS is a genetic condition that causes changes in a tumor-suppressing gene called STK11. The condition causes noncancerous growths called polyps to appear in the gastrointestinal tract. It also increases the risk of some cancer types, including cervical cancer.

PJS may have an association with some more rare cancer types, such as minimal deviation adenocarcinoma (MDA). This cancer type accounts for around 13% of cervical adenocarcinomas, a less common type of cervical cancer.

There are a number of other important risk factors for cervical cancer besides genetics. These include:

There are many types of HPV infection. Some do not increase the risk of cervical cancer, while others may cause changes in the cervix that could develop into cervical cancer over time. Two types of HPV, HPV 16 and 18, cause approximately 70% of cervical cancers.

Doctors recommend regular screening tests to check for HPV infections in anyone between 2565 years of age with a cervix.

Having several sexual partners or having sex with someone who has many sexual partners may be a risk factor for cervical cancer. A person with a higher number of sexual partners may have a greater chance of exposure to HPV, the major cause of most cervical cancers.

Taking oral contraceptives for extended lengths of time may be a risk factor for cervical cancer. According to the American Cancer Society (ACS), the risk may increase the longer a person takes the pill but decreases when they stop. Once a person has stopped taking the pill for many years, their risk level returns to normal.

Autoimmune diseases can make it difficult for the body to fight off infections and illness. Therefore, having an autoimmune disorder may be a risk factor for cancer, including cervical cancer.

Smoking and tobacco use increases the risk of cancer developing anywhere in the body, including the cervix.

Tobacco smoke contains at least 70 cancer-causing chemicals. Quitting tobacco use can reduce a persons risk of developing cancer and other chronic diseases.

Anyone having trouble quitting smoking should speak with a doctor for information and advice.

People from low income areas may lack sufficient access to medical care that reduces their risk of cervical cancer. This may include difficulty getting regular screening for HPV and cervical cancer and difficulty accessing vaccines and medications for sexually transmitted infections (STIs).

People with early stage cervical cancers typically do not notice any signs or symptoms. However, a doctor may still be able to detect early stage cervical cancer through screening tests. This is why regular cervical screening is so important.

Signs and symptoms of cervical cancer usually only occur once cancer has grown in size or has spread to nearby tissues. At this stage, the most common symptoms are:

The above signs and symptoms can also be due to conditions other than cervical cancer. However, anyone who experiences one or more of these symptoms should contact a doctor for a cervical exam.

Below are some preventive measures people can take to help reduce their risk of developing cervical cancer.

Getting an HPV vaccine may protect against the types of HPV associated with cancers of the cervix, vagina, and vulva.

The Centers for Disease Control and Prevention (CDC) recommends the HPV vaccine for everyone up to age 26. People aged 2745 years should speak with a doctor about their risk of contracting new HPV infections and the potential benefits of receiving a vaccination.

Doctors may recommend screening for cervical cancer using cervical exams, Pap smear tests, and HPV tests every 35 years.

Regular screening can help detect precancerous cervical cells. These are abnormal cervical cells that are not yet cancerous but have the potential to become cancerous if left untreated. Detecting and treating these cells can help prevent cervical cancer in some cases.

Regular screening also helps to detect early stage cervical cancers. Treating cervical cancer in its early stages can help improve a persons outlook.

In some cases, changing certain sexual behaviors may help reduce the risk of HPV. Potential changes include:

There is no guarantee that making the above changes will prevent cervical cancer, but they may reduce a persons risk.

No matter how long a person has smoked, quitting smoking and tobacco use may help reduce their risk of cancer, including cancer of the cervix.

Thanks to regular screening, doctors can detect and treat cervical precancer and cancer earlier. Advances in treatments are also improving the outlook for people with the disease.

According to the ACS, the 5-year relative survival rate for cervical cancer from 20102016 across all disease stages was 66%. During the same period, the 5-year relative survival rate for localized cervical cancers that had not spread to nearby tissues or lymph nodes was 92%. The difference in these statistics emphasizes the importance of early detection and treatment of cervical precancer and cancer.

The most common types of cervical cancer are not hereditary. HPV causes most cases of cervical cancer. A person typically acquires HPV through sexual contact with someone who carries the virus.

However, some very rare forms of cervical cancer may have a genetic component. Changes to the DICER1 gene or STK11 gene may increase a persons risk of developing the disease. Anyone with a family history of cervical cancer related to genetics should speak with a doctor about screening.

Regular screening for cervical cancer can help doctors detect and treat precancerous cervical cells, which may help prevent the cells from developing into cancer. Regular screening also allows doctors to detect early stage cervical cancer. This is important since treating cancer in its early stages is associated with better outcomes.

Read the original post:
Cervical cancer: Is it genetic? - Medical News Today

The MarketandResearch.biz latest research, titled Global Reproductive Genetics Market from 2021 to 2027, gives a complete overview of the industry, featuring product descriptions, market segmentation based on several parameters, and current market conditions. The research provides a detailed analysis of the global Reproductive Genetics market, including market dynamics, the size of the market, market value, and market growth over the projected period, both on a compound and yearly basis.

The research focuses on new business organizations that have been mentioned in the global Reproductive Genetics market report. The companys overview, geographical position, product variety, and recent developments are all taken into account while analyzing the corporate profiles.

DOWNLOAD FREE SAMPLE REPORT: https://www.marketandresearch.biz/sample-request/213803

The market analysis includes the following important players:

The significant regions featured in the study are as follows:

Based on its type, the product can be divided into various market segments:

Market segmentation based on application is categorized as

ACCESS FULL REPORT: https://www.marketandresearch.biz/report/213803/global-reproductive-genetics-market-growth-status-and-outlook-2021-2027

The study investigates current and future market circumstances for the coming years of 2021-2027, gaining insight and information on the various segments linked to the global Reproductive Genetics market. It also includes information on strategic relationships. This research also includes SWOT analysis, a financial concept study, and a rate of return analysis.

In this report, the market development plans for this market are projected. The market research examines the global Reproductive Genetics market in terms of a variety of factors, including market growth drivers and constraints.

Customization of the Report:

This report can be customized to meet the clients requirements. Please connect with our sales team (sales@marketandresearch.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

Contact UsMark StoneHead of Business DevelopmentPhone: +1-201-465-4211Email: sales@marketandresearch.bizWeb: http://www.marketandresearch.biz

Here is the original post:
Global Reproductive Genetics Market Size 2021 Review, Growth Strategy, Developing Technologies and Forecast by 2027 Discovery Sports Media -...

Predictive Genetic Testing And Consumer (Wellness) Genomics Market report focused on the comprehensive analysis of current and future prospects of the Predictive Genetic Testing And Consumer (Wellness) Genomics industry. This report is a consolidation of primary and secondary research, which provides market size, share, dynamics, and forecast for various segments and sub-segments considering the macro and micro environmental factors. An in-depth analysis of past trends, future trends, demographics, technological advancements, and regulatory requirements for the Predictive Genetic Testing And Consumer (Wellness) Genomics market has been done in order to calculate the growth rates for each segment and sub-segments.

Get Sample Copy (Including FULL TOC, Graphs and Tables) of this report: https://www.a2zmarketresearch.com/sample-request/365659

Top Key Vendors of this Market are:

Myriad Genetics, Inc, BGI, Illumina, Inc, Pathway Genomics, WeGene, Quest Diagnostics, Helix, Gene by Gene, ARUP Laboratories, Laboratory Corporation of America, 23andMe, Inc, Genesis Genetics, Color Genomics Inc., Thermo Fisher.

Global Predictive Genetic Testing And Consumer (Wellness) Genomics Market Segmentation:

Market Segmentation: By Type

Predictive Testing, Consumer Genomics, Wellness Genomics

Market Segmentation: By Application

Clinic, Direct to Consumer, Hospital

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Predictive Genetic Testing And Consumer (Wellness) Genomics market. This report is a consolidation of primary and secondary research, which provides market size, share, dynamics, and forecast for various segments and sub-segments considering the macro and micro environmental factors. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market.

The report provides insights on the following pointers:

Market Penetration: Comprehensive information on the product portfolios of the top players in the Predictive Genetic Testing And Consumer (Wellness) Genomics market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Market Development: Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Predictive Genetic Testing And Consumer (Wellness) Genomics market.

Get Special Pricing on this Premium Report: https://www.a2zmarketresearch.com/discount/365659

The influence of the latest government guidelines is also analysed in detail in the report. It studies the Predictive Genetic Testing And Consumer (Wellness) Genomics markets trajectory between forecast periods. The cost analysis of the Global Predictive Genetic Testing And Consumer (Wellness) Genomics Market has been performed while keeping in view manufacturing expenses, labour cost, and raw materials and their market concentration rate, suppliers, and price trend.

Reasons for buying this report:

Table of Contents

Global Predictive Genetic Testing And Consumer (Wellness) Genomics Market Research Report 2021 2028

Chapter 1 Predictive Genetic Testing And Consumer (Wellness) Genomics Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Predictive Genetic Testing And Consumer (Wellness) Genomics Market Forecast

Buy Exclusive Report: https://www.a2zmarketresearch.com/checkout

If you have any special requirements, please let us know and we will offer you the report as you want.

About A2Z Market Research:

The A2Z Market Research library provides syndication reports from market researchers around the world. Ready-to-buy syndication Market research studies will help you find the most relevant business intelligence.

Our Research Analyst Provides business insights and market research reports for large and small businesses.

The company helps clients build business policies and grow in that market area. A2Z Market Research is not only interested in industry reports dealing with telecommunications, healthcare, pharmaceuticals, financial services, energy, technology, real estate, logistics, F & B, media, etc. but also your company data, country profiles, trends, information and analysis on the sector of your interest.

Contact Us:

Roger Smith

1887 WHITNEY MESA DR HENDERSON, NV 89014

[emailprotected]

+1 775 237 4147

Related Report:

Pharmaceutical Customer Relationship Management (CRM) Software Market by Product, Applications, Geographic and Key Players: Adjetter, Medismo Technologies, Actis Sales Technologies

Go here to see the original:
Predictive Genetic Testing And Consumer (Wellness) Genomics Market Research Report and Forecast to 2028 Myriad Genetics, Inc, BGI Industrial IT -...

A2Z Market Research announces the release ofPreimplantation Genetics Diagnosis Marketresearch report. The market is predictable to grow at a healthy pace in the coming years. Preimplantation Genetics Diagnosis Market 2021 research report presents analysis of market size, share, and growth, trends, cost structure, statistical and comprehensive data of the global market.

.

Get Sample Copy (Including FULL TOC, Graphs and Tables) of this report: https://www.a2zmarketresearch.com/sample-request/619333

Top Key Vendors of this Market are:

Reprogenetics, Genesis Genetics, PerkinElmer, Natera, Laboratory Corporation of America Holdings, Quest Diagnostics Incorporated, Illumina, Reproductive Genetics Innovations, Genea Limited.

As analytics have become an inherent part of every business activity and role, form a central role in the decision-making process of companies these days is mentioned in this report. In the next few years, the demand for the market is expected to substantially rise globally, enabling healthy growth of the Preimplantation Genetics Diagnosis Market is also detailed in the report. This report highlights the manufacturing cost structure includes the cost of the materials, labor cost, depreciation cost, and the cost of manufacturing procedures. Price analysis and analysis of equipment suppliers are also done by the analysts in the report.

This research report represents a 360-degree overview of the competitive landscape of the Preimplantation Genetics Diagnosis Market. Furthermore, it offers massive data relating to recent trends, technological advancements, tools, and methodologies. The research report analyzes the Employee Protection Software Market in a detailed and concise manner for better insights into the businesses.

The report, with the assistance of nitty-gritty business profiles, project practicality analysis, SWOT examination, and a few different insights about the key organizations working in the Preimplantation Genetics Diagnosis Market, exhibits a point-by-point scientific record of the markets competitive scenario. The report likewise displays a review of the effect of recent developments in the market on markets future development prospects.

Global Preimplantation Genetics Diagnosis Market Segmentation:

Market Segmentation: By Type

Chromosomal Abnormalities, Gender Selection, X-Linked Diseases, Aneuploidy, Single Gene Disorders, Others

Market Segmentation: By Application

Hospitals, Clinics, Others

Geographic analysis:

The global Preimplantation Genetics Diagnosis market has been spread across North America, Europe, Asia-Pacific, the Middle East and Africa, and the rest of the world.

Get Special Pricing on this Premium Report: https://www.a2zmarketresearch.com/discount/619333

COVID-19 Impact Analysis

The pandemic of COVID-19 has emerged in lockdown across regions, line limitations, and breakdown of transportation organizations. Furthermore, the financial vulnerability Preimplantation Genetics Diagnosis Market is a lot higher than past flare-ups like the extreme intense respiratory condition (SARS), avian influenza, pig influenza, bird influenza, and Ebola, inferable from the rising number of contaminated individuals and the vulnerability about the finish of the crisis. With the rapid rising cases, the worldwide Preimplantation Genetics Diagnosis refreshments market is getting influenced from multiple points of view.

The accessibility of the labor force is by all accounts disturbing the inventory network of the worldwide Preimplantation Genetics Diagnosis drinks market as the lockdown and the spread of the infection are pushing individuals to remain inside. The presentation of the Preimplantation Genetics Diagnosis makers and the transportation of the products are associated. If the assembling movement is stopped, transportation and, likewise, the store network additionally stops. The stacking and dumping of the items, i.e., crude materials and results (fixings), which require a ton of labor, is likewise vigorously affected because of the pandemic. From the assembling plant entryway to the stockroom or from the distribution center to the end clients, i.e., application ventures, the whole Preimplantation Genetics Diagnosis inventory network is seriously compromised because of the episode.

The research provides answers to the following key questions:

Buy Exclusive Report: https://www.a2zmarketresearch.com/checkout

If you have any special requirements, please let us know and we will offer you the report as you want.

About A2Z Market Research:

The A2Z Market Research library provides syndication reports from market researchers around the world. Ready-to-buy syndication Market research studies will help you find the most relevant business intelligence.

Our Research Analyst Provides business insights and market research reports for large and small businesses.

The company helps clients build business policies and grow in that market area. A2Z Market Research is not only interested in industry reports dealing with telecommunications, healthcare, pharmaceuticals, financial services, energy, technology, real estate, logistics, F & B, media, etc. but also your company data, country profiles, trends, information and analysis on the sector of your interest.

Contact Us:

Roger Smith

1887 WHITNEY MESA DR HENDERSON, NV 89014

[emailprotected]

+1 775 237 4147

Related Report:

Mini Fridge Market 2021 and Analysis to 2027 Videocon Industries, Electrolux, Samsung Electronics, LG Electronics

Read the original post:
Preimplantation Genetics Diagnosis Market to Witness Robust Expansion by 2029 | Reprogenetics, Genesis Genetics, PerkinElmer Industrial IT -...

From a distance, the canids of Galveston Island, Texas, look almost like coyotes, prowling around the beach at night, eyes gleaming in the dark.

But look closer and oddities appear. The animals bodies seem slightly out of proportion, with overly long legs, unusually broad heads and sharply pointed snouts. And then there is their fur, distinctly reddish in hue, with white patches on their muzzles.

The Galveston Island canids are not conventional coyotes at least, not entirely. They carry a ghostly genetic legacy: DNA from red wolves, which were declared extinct in the wild in 1980.

For years, these genes have been hiding in plain sight, tucked away in the seemingly unremarkable animals that scavenged for food behind housing developments and roamed the grounds of the local airport.

Their discovery, which came after a determined local resident persuaded scientists to take a closer look at the canids, could help revive a captive breeding program for red wolves and restore the rich genetic variation that once existed in the wild population.

It doesnt seem to be lost any longer, said Bridgett vonHoldt, an evolutionary biologist at Princeton University, referring to the genetic diversity that once characterized red wolves. We might have a chance to bring it back.

They Just Didnt Look Right

Ron Wooten, a Galveston resident, never paid close attention to the local coyotes until they ran off with his dog one night in 2008. A pack took him and carried him off, recalled Wooten, an outreach specialist at the US Army Corps of Engineers.

He found the pack, and what remained of his dog, in a nearby field. He was horrified, and he blamed himself for his dogs death. But as his flashlight swept over the coyotes red muzzles, he found himself fascinated.

Determined to learn more, he posted a message on Facebook asking his neighbors to alert him if they spotted the animals. Eventually, a friend came through: There was a pack near her apartment building.

Wooten raced over with his camera, snapping photographs as he watched a group of pups chasing each other. They were just beautiful, he said.

But when he looked more carefully at the photos, he began to wonder whether the so-called coyotes were really coyotes at all. They just didnt look right, he said. I thought at first that they must have bred with Marmaduke or something because they had superlong legs, superlong noses.

Wooten, a former fisheries biologist, started reading up on the local wildlife and stumbled across the history of red wolves. Once abundant in the southeastern United States, the wolves had dwindled in number during the 20th century a result of habitat loss, hunting and other threats.

In the 1970s, the US Fish and Wildlife Service made a last-ditch effort to save the species, traveling along the Gulf Coast and trapping all the red wolves it could find. Scientists selected some of the animals for a breeding program, in hopes of maintaining the red wolf in captivity.

Wooten became convinced that the creatures that had taken his dog were actually red wolf-coyote hybrids, if not actual red wolves.

Eager to prove his hypothesis, he began looking for dead canids by the side of the road. I was thinking that if these are red wolves, then the only way theyre going to be able to tell is with genetics, he recalled.

He soon found two dead animals, collected a small patch of skin from each and tucked them away in his freezer while he tried, for years, to pique scientists interest.

Sometimes they wouldnt respond, he said. Sometimes theyd say, Yeah, thats a neat animal. Nothing we can do about it. And, Theyre extinct. Its not a red wolf.

Genetic Secrets

Eventually, in 2016, Wootens photos made their way to vonHoldt, an expert on canid genetics.

The animals in Wootens photos immediately struck her. They just had a special look, she said. And I bit. The whole thing hook, line and sinker.

She asked him to send his specimens, but there was a glitch: By then, he had lost one. So he packed up the skin tissue he could find and threw in the scalpel he had used to prepare the other sample, hoping that the scientists could extract DNA from it.

It was just a really kind of lovely chaos, vonHoldt said. (The scientists did manage to pull DNA from the scalpel, but Wooten later found the second sample and mailed that, too.)

VonHoldt and her colleagues extracted DNA from the skin samples and compared it to DNA from coyotes, red wolves, gray wolves and eastern wolves. Although the two Galveston Island canids were mostly coyote, they had significant red wolf ancestry; roughly 30 per cent of their genetic material was from the wolves, they found.

It was a real validation, I think, to the people on the ground the naturalists and the photographers on the ground saying, We have something special here, said Kristin Brzeski, a conservation geneticist who was a postdoctoral fellow in vonHoldts lab at the time. And they do.

Wooten was thrilled. It blew me away, he said.

Even more remarkable, some of the genetic variants, or alleles, the Galveston animals carried were not present in any of the other North American canids the researchers analyzed, including the contemporary red wolves. The scientists theorize that these alleles were passed down from the wild red wolves that used to roam the region.

They harbor ancestral genetic variation, this ghost variation, which we thought was extinct from the landscape, vonHoldt said. So theres a sense of reviving what we thought was gone.

The researchers suspect that some red wolves evaded the U.S. Fish & Wildlife Service dragnet back in the 1970s. There was surely a little slippery one that got away, or a couple, vonHoldt said.

At some point, the red wolves or their descendants bred with local coyotes and not just in Texas. In 2018, the same year vonHoldts team published its findings, another group documented high levels of red wolf ancestry in wild canids in Louisiana.

The findings could help scientists understand the genetic variation that once existed in wild red wolves and even resurrect it.

We can start actually understanding what was the historical red wolf and think about reconstructing that animal, said Brzeski, who is now at Michigan Technological University.

In the late 1980s, some of the red wolves from the captive breeding program were released in North Carolina. But that experimental population has plummeted in recent years; officials estimate that fewer than 20 of the animals now patrol the Carolina coast. And all the red wolves alive today are descended from about a dozen animals, an extremely low level of genetic diversity that could further imperil the species.

Hybrid Help

The hybrids raise new conservation possibilities. For instance, scientists might be able to restore genetic diversity by carefully breeding red wolves to hybrids with high levels of red wolf ancestry. Or they could use artificial reproductive technologies or gene-editing techniques to insert the ghost alleles back into red wolves, vonHoldt said.

The findings also come as some scientists have begun rethinking the value of interspecies hybrids. Oftentimes, hybridization is viewed as a real threat to the integrity of a species, which it can be, Brzeski said.

One reason that the red wolf populations declined in the wild is because the animals frequently interbred with coyotes. But, she added, here we have these hybrids that are now potentially going to be the lifeline for the highly endangered red wolves.

The discovery of hybrids in both Texas and Louisiana also suggests that scientists and officials may want to refocus their red wolf conservation efforts on those areas, said Lisette Waits, a conservation geneticist at the University of Idaho and co-author of the 2018 paper on the Louisiana hybrids.

In addition to studying the hybrids, it might make sense to reintroduce captive-bred red wolves to those regions, where animals with red wolf genes still roam the landscape. It could completely change the direction of the red wolf recovery program, Waits said.

Brzeski, vonHoldt and their collaborators are now studying the hybrids in both Texas and Louisiana as part of the new Gulf Coast Canine Project.

They are using GPS collars and wildlife cameras to learn more about the canids movements and behaviors, collecting fecal samples to analyze their diets, using genetic analysis to trace pack relatedness and collecting tissue samples from animals with the most red wolf ancestry. One goal, vonHoldt said, is to create a biobank set of specimens that could be used to help increase the genetic health of the captive red wolf population.

They are also hoping to learn more about how these red wolf alleles have persisted, especially in animals that live close to humans in a popular tourist destination. The island setting, which keeps the canids relatively reproductively isolated, is probably part of the explanation, but so is the lack of persecution, Brzeski said, noting that the animals were not commonly hunted.

Indeed, Wooten is not the only local resident who has taken an interest in the animals. The research team works closely with Josh Henderson, the animal services supervisor at the Galveston Police Department, and there is considerable community support for the canids.

Steve Parker, a lawyer who grew up in the area, remembers hearing childhood stories about his relatives trapping red wolves. The Galveston canids have helped him connect with the older generations, many of whom have passed away. Id like to see something and maybe be able to touch something that was special to them, he said.

Wooten, for his part, dreams of setting up an educational center devoted to teaching the public about the unique animals. The possibilities of what these animals hold down here is pretty valuable, he said. And thats the reason I pursued it, I think. I think God was thumping me on the head and saying, Hey, I got animals here. Take care of em.

This article originally appeared in The New York Times.

See the rest here:
The ghost wolves of Galveston island - The Indian Express

press release: For the fall semester, WN@TL goes hybrid both with Zoom and with in-person presentations. The zoom registration link is still go.wisc.edu/240r59. Starting September 15, you can also watch a live web stream at biotech.wisc.edu/webcams

On January 5, Jenyne Loarcaof the Department of Horticulture will use carrots to help us see more clearly the origins, the genetics, and the roles crops play in our lives and on our lands. Jenynes talk is entitled Genetic Diversity Matters: A Field Exploration of 695 Carrot Varieties."

Description: In this talk we'll explore humans' connection with preserving plant life. An impressive 70% of the food we eat is derivedfrom plants, and most plants are grown from seeds. As humans, we've had a deep connection with seeds throughout ourhistory. Humans have been saving and cultivating seeds for tens of thousands of years.

The first large-scale institutionalized practice of seed saving began with the first seed library only 125 years ago. TheU.S. gene bank carries seed from 695 rainbow carrot varieties, collected from 60 countries all around the world.Weused this diverse collection to study traits that are important to carrot growers and to determine the genetic basis ofthese traits.

Using carrots as a case-study, we will explore why the genetic diversity in this carrot collection isfoundational for vegetable breeders to create new varieties of carrot that are farmer-friendly and fun to eat.

We will explore the idea of seed as a genetic resource and seed-saving as genetic conservation work. We will discussthe importance of seed saving, the role that gardeners and researchers play in preserving genetic diversity, and theimportance of genetic diversity to climate resilience and our uncertain future.

Explore More: https://www.nature.com/articles/ng.3565

Here is the original post:
Wednesday Nite at the Lab - Isthmus