Category Archives: Georgia Stem Cells

Ortho Sport & Spine Physicians is proud to be one of Atlantas leading providers of stem cell therapy to be used in the treatment of lumbar and cervical spine injuries and degenerative disorders. We are an interventional spine and sports medicine practice that specializes in finding solutions to acute and chronic pain conditions with interventional spine treatments. Our dedicated team of double board certified interventional spine physicians and orthopedic specialists are committed to using the most minimally invasive methods possible to help patients with acute and chronic pain find relief from their symptoms, improved function and a better overall quality of life.

Ortho Sport & Spine Physicians offers a variety of stem cell treatments that can be used to treat chronic back pain that is caused by injury or aging. Our stem cell therapy treatments involve removing stem cells from an adult patient and returning them to that same patient in a concentrated form to the damaged area in the spine. In some cases, stem cell therapy is used in conjunction with endoscopic spine surgery. The goal of stem cell therapy in the treatment of chronic back pain is to enable the parts of the spine (vertebra, discs, etc.) that have been damaged or degenerated due to injury or age to repair themselves. There are minimal complications associated with this type of stem cell therapy that has shown great promise and effectiveness in the treatment of chronic back pain.

Our Interventional Spine Physician, Dr. Armin V. Oskouei, is a nationally recognized leader in the field of regenerative medicine and travels widely to deliver lectures on the use of stem cell therapy in combination with endoscopic spine surgery. Dr. Oskouei has participated in many clinical trials evaluating the safety and effectiveness of stem cell therapy in the use of treating injuries and degenerative disorders of the spine. He has been actively using stem cell therapy in clinical practice for many years.

If you would like to find out if you are a candidate for stem cell therapy, please contact our Atlanta Stem Cell Therapy Specialists at Ortho Sport & Spine Physicians today and schedule a consultation with one of our Interventional Spine doctors. We look forward to helping you stay active and live your best life.

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Atlanta Stem Cell Therapy | Georgia Stem Cell Treatments ...

Protect your family's future health.

Secure their stem cells today.

Bank the valuable stem cells found in

baby teeth and wisdom teeth.

Researchers at the National Institutes of Health (NIH) discovered a rich source of adult stem cells in teeth the stem cells that naturally repair your body. Scientists aredirecting stem cells so they grow into almost any type of human cell, including heart, brain, nerve, cartilage, bone, liver and insulin producing pancreatic beta cells.

AAOMS - American Association of Oral and Maxillofacial Surgeons

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Doctors recommend StemSave stem cell banking for the cryopreservation of powerful adult stem cells from deciduous teeth (baby teeth), wisdom teeth or permanent teethwith healthy dentalpulp.

Easy OnlineEnrollment

StemSave Stem Cell Banking exclusively recovers and stores non-embryonic stem cells. Dental Stem Cells are also known asDSC, DASC, DPSC, or SHED cellsand are classified as atype of adult stem cells.

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Storing Stem Cells In Teeth For Your Familys Future Health

Reversing the aging process could lead to medical treatments for many chronic conditions

Researchers have shown they can reverse the aging process for human adult stem cells, which are responsible for helping old or damaged tissues regenerate. The findings could lead to medical treatments that may repair a host of ailments that occur because of tissue damage as people age. A research group led by the Buck Institute for Research on Aging and the Georgia Institute of Technology conducted the study in cell culture, which appears in the September 1, 2011 edition of the journal Cell Cycle.

The regenerative power of tissues and organs declines as we age. The modern day stem cell hypothesis of aging suggests that living organisms are as old as are its tissue specific or adult stem cells. Therefore, an understanding of the molecules and processes that enable human adult stem cells to initiate self-renewal and to divide, proliferate and then differentiate in order to rejuvenate damaged tissue might be the key to regenerative medicine and an eventual cure for many age-related diseases A research group led by the Buck Institute for Research on Aging in collaboration with the Georgia Institute of Technology, conducted the study that pinpoints what is going wrong with the biological clock underlying the limited division of human adult stem cells as they age.

We demonstrated that we were able to reverse the process of aging for human adult stem cells by intervening with the activity of non-protein coding RNAs originated from genomic regions once dismissed as non-functional genomic junk, said Victoria Lunyak, Ph.D., associate professor at the Buck Institute for Research on Aging.

Adult stem cells are important because they help keep human tissues healthy by replacing cells that have gotten old or damaged. Theyre also multipotent, which means that an adult stem cell can grow and replace any number of body cells in the tissue or organ they belong to. However, just as the cells in the liver, or any other organ, can get damaged over time, adult stem cells undergo age-related damage. And when this happens, the body cant replace damaged tissue as well as it once could, leading to a host of diseases and conditions. But if scientists can find a way to keep these adult stem cells young, they could possibly use these cells to repair damaged heart tissue after a heart attack; heal wounds; correct metabolic syndromes; produce insulin for patients with type 1 diabetes; cure arthritis and osteoporosis and regenerate bone.

The team began by hypothesizing that DNA damage in the genome of adult stem cells would look very different from age-related damage occurring in regular body cells. They thought so because body cells are known to experience a shortening of the caps found at the ends of chromosomes, known as telomeres. But adult stem cells are known to maintain their telomeres. Much of the damage in aging is widely thought to be a result of losing telomeres. So there must be different mechanisms at play that are key to explaining how aging occurs in these adult stem cells, they thought.

Researchers used adult stem cells from humans and combined experimental techniques with computational approaches to study the changes in the genome associated with aging. They compared freshly isolated human adult stem cells from young individuals, which can self-renew, to cells from the same individuals that were subjected to prolonged passaging in culture. This accelerated model of adult stem cell aging exhausts the regenerative capacity of the adult stem cells. Researchers looked at the changes in genomic sites that accumulate DNA damage in both groups.

We found the majority of DNA damage and associated chromatin changes that occurred with adult stem cell aging were due to parts of the genome known as retrotransposons, said King Jordan, Ph.D., associate professor in the School of Biology at Georgia Tech.

Retroransposons were previously thought to be non-functional and were even labeled as junk DNA, but accumulating evidence indicates these elements play an important role in genome regulation, he added.

While the young adult stem cells were able to suppress transcriptional activity of these genomic elements and deal with the damage to the DNA, older adult stem cells were not able to scavenge this transcription. New discovery suggests that this event is deleterious for the regenerative ability of stem cells and triggers a process known as cellular senescence.

By suppressing the accumulation of toxic transcripts from retrotransposons, we were able to reverse the process of human adult stem cell aging in culture, said Lunyak.

Furthermore, by rewinding the cellular clock in this way, we were not only able to rejuvenate aged human stem cells, but to our surprise we were able to reset them to an earlier developmental stage, by up-regulating the pluripotency factors the proteins that are critically involved in the self-renewal of undifferentiated embryonic stem cells. she said.

Next the team plans to use further analysis to validate the extent to which the rejuvenated stem cells may be suitable for clinical tissue regenerative applications.

The study was conducted by a team with members from the Buck Institute for Research on Aging, the Georgia Institute of Technology, the University of California, San Diego, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, International Computer Science Institute, Applied Biosystems and Tel-Aviv University.

Citation: Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal. Cell Cycle, Volume 10, Issue 17, September 1, 2011

About the Buck Institute for Research on Aging The Buck Institute is the first freestanding institute in the United States that is devoted solely to basic research on aging and age-associated disease. The Institute is an independent nonprofit organization dedicated to extending the healthspan, the healthy years of each individuals life. Buck Institute scientists work in an innovative, interdisciplinary setting to understand the mechanisms of aging and to discover new ways of detecting, preventing and treating conditions such as Alzheimers and Parkinsons disease, cancer, cardiovascular disease and stroke. Collaborative research at the Institute is supported by new developments in genomics, proteomics and bioinformatics technology. For more information: http://www.thebuck.org.

About the Georgia Institute of Technology The Georgia Institute of Technology is one of the world's premier research universities. Ranked seventh amongU.S. News & World Report's top public universities, Georgia Tech has more than 20,000 students enrolled in its Colleges of Architecture, Computing, Engineering, Liberal Arts, Management and Sciences and is among the nation's top producers of women and minority engineers.The Institute offers research opportunities to both undergraduate and graduate students and is home to more than 100 interdisciplinary units plus the Georgia Tech Research Institute. For more information: http://www.gatech.edu.

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Scientists Turn Back the Clock on Adult Stem Cells Aging ...

AllCells features B cells, T cells, Natural Killer (NK) cells, and Dendritic cells from the Lymphoid Progenitor family. Subsets of the above listed cell types are available upon request. These products are sourced from both healthy and diseased donors. Tissue types include normal peripheral blood, mobilized peripheral blood, cord blood, and bone marrow.

See below for the AllCells lymphoid cells inventory.

The following healthy Lymphoid cell types are available from AllCells:

Lymphoid cells from diseased patients are available from the following disease types:

By their appearance under the light microscope, there are two broad categories of lymphocytes, namely the large granular lymphocytes and the small lymphocytes. Functionally distinct subsets of lymphocytes correlate with their appearance. Most, but not all, large granular lymphocytes are more commonly known as the natural killer cells (NK cells). The small lymphocytes are the T cells and B cells. Lymphocytes play an important and integral role in the body's defenses.

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Lymphoid Cells, Lymphoid Stem Cells - AllCells.com

The tooth is nature's 'safe' for your family's unique stem cells

While stem cells can be found in most tissues of the body, they are usually buried deep, are few in number and are similar in appearance to surrounding cells. With the discovery of stem cells in teeth, an accessible and available source of stem cells has been identified.

The tooth is nature's "safe" for these valuable stem cells, and there is an abundance of these cells in baby teeth, wisdom teeth and permanent teeth - Tooth Eligibility Criteria. The stem cells contained within teeth are capable of replicating themselves and can be readily recovered at the time of a planned dental procedure.

Living stem cells found within extracted teeth were routinely discarded every day, but now, with the knowledge from recent medical research, StemSave gives you the opportunity to save these cells for future use in developing medical treatments for your family.

Aside from being the most convenient stem cells to access, dental stem cells have significant medical benefits in the development of new medical therapies. Using one's own stem cells for medical treatment means a much lower risk of rejection by the body and decreases the need for powerful drugs that weaken the immune system, both of which are negative but typical realities that come into play when tissues or cells from a donor are used to treat patients.

Further, the stem cells from teeth have been observed in research studies to be among the most powerful stem cells in the human body. Stem cells from teeth replicate at a faster rate and for a longer period of time than do stem cells harvested from other tissues of the body.

Stem cells in the human body age over time and their regenerative abilities slow down later in life. The earlier in life that your family's stem cells are secured, the more valuable they will be when they are needed most.

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Using Stem Cells in Teeth for Future Use in Developing ...

Bone marrow contains a population of rare progenitor cells known as Mesenchymal Stem Cells (MSC) capable of replication as undifferentiated cells or differentiating into bone, cartilage, fat, muscle, tendon and marrow stroma. Due to the nature of mesenchymal stem cells (MSCs), they can play a vital role in several different types of research applications including cell differentiation and gene regulation, gene therapy and transplantation, and cell-based screening assays in drug discovery.

Cell Differentiation and Gene RegulationThe commitment of MSCs to a particular lineage is regulated by various signals from the cells' environment. Thus, there are many entry points into the process which can be exploited by researchers to help elucidate gene regulation and/or function. siRNA can be used to decrease the expression of a protein and allow one to better determine the function of the protein and pathways involved. Using stem cells allows one to study protein function and regulation at different stages in differentiation.

Gene Therapy and Transplantation Mesenchymal stem cells have the potential to treat a wide range of diseases. Compared to other types of stem cells, MSCs have the ability to take up and keep introduced genes, a phenomenon that could be exploited for the delivery of beneficial molecules to targeted locations.

Cell-based Screening AssaysMesenchymal stem cells can be used in a variety of screening applications, from screening biomolecules against known targets or identifying potential targets through siRNA screening. Due to MSCs' ability to self-renew (replicate and proliferate without differentiation), one can easily obtain large cell numbers for running these types of assays. As some drug targets may only be expressed at certain time points during lineage differentiation, cell lines can yield inconsistent results as test models; however, primary stem cells will allow for identification of small molecules through the different stages of the differentiation process.

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Human Mesenchymal Stem Cells & Media

It is a summer of anticipation for Bostons stem cell medicine biotechnology start-up Asymmetrex. The company has key milestone studies underway for continued development of its unique portfolio of adult tissue stem cell biotechnologies for regenerative medicine and drug development.

Boston, MA (PRWEB) July 29, 2015

Asymmetrex, LLC founder and director James L. Sherley says the company is making good progress in evaluating the full range of capabilities of its unique cache of technologies for identifying, quantifying, and producing adult tissue stem cells. Adult tissue stem cells perform the day-to-day renewal and repair of normal tissues and organs. This property makes them the essential therapeutic factor in regenerative medicine treatments developed to restore diseased or injured tissues. The essential role of adult tissue stem cells in maintaining normal tissues also makes them important determinants of drug safety.

Despite the widely understood importance of adult tissue stem cells for advancing biomedicine, in the past, implementation of this knowledge has been largely unachievable because of long-standing technology barriers. In many cases, adult tissue stem cells have been difficult to identify, impossible to count, and difficult to produce in therapeutic quantities. These significant technical challenges have limited regenerative medicine treatments to only a few tissue stem cell types and essentially precluded evaluation of drug candidate effects on critical tissue stem cell types.

Says Sherley, Asymmetrex seeks to catalyze a new era of stem cell biomedicine. The company plans to achieve catalysis by reaching a tipping point for the widespread use of its patented technologies for identifying, counting, and producing adult tissue stem cells from many different human tissues. In addition, because Asymmetrexs technologies are based on universal tissue stem cell principles, they also have application for animal research and veterinary medicine.

Director Sherley notes two studies that the company is pursuing this summer that will be completed by early fall and one that will continue until next April, or longer if needed. For its development of adult tissue stem cell production technologies, Asymmetrex is conducting a series of standard pharmaceutical analyses of mature liver cell properties for cells produced from the companys expanded human liver stem cells. Asymmetrex has a patented technology for producing human liver stem cells in pound quantities. Establishing that the expanded liver stem cells can be used to make similarly large quantities of differentiated cells with mature liver functions is an important milestone. This achievement would advance the tissue stem cell expansion technology to applications for pharmaceutical drug evaluations and liver cell transplantation therapies for liver failure patients.

The second summer study is an evaluation of a new technology developed with partner AlphaSTAR Corporation. AlphaSTEM technology is a proprietary human cell culture-computer simulation technology that can estimate and monitor tissue stem cell number, viability, and function for many different human tissues. AlphaSTEM technology could be used to estimate stem cell dose and determine stem cell quality for regenerative medicine stem cell transplantation therapies. Neither of these capabilities currently exists.

A major commercialization thrust of the two partner companies is the use of AlphaSTEM technology to identify tissue stem cell-toxic drug candidates before expensive pre-clinical animal studies and clinical trials. Estimates indicate that, with widespread adoption, the technology could save the U.S. pharmaceutical industry as much as $4 billion each year by preventing expensive testing of drug candidates that would ultimately fail because of toxicity against tissue stem cells. The current study is an evaluation of a panel of known stem cell-activating, stem cell-toxic, and neutral agents designed to begin estimating the predictive power of AlphaSTEM technology.

The third, year-long or greater, study might also yield new developments as soon as the end of the summer. Asymmetrexs most recent patent (U.S. 9,081,008) is for a unique set of biomarkers with sufficient specificity to enable counting of adult tissue stem cells for the first time. In April, the company launched a crowdsourcing campaign to engage investigators worldwide in evaluating its most specific biomarker called H2A.Z asymmetry for counting adult tissue stem cells that are the focus of their research or clinical studies. H2A.Z is a chromosome factor involved in selective gene regulation. In functioning adult tissue stem cells reported to date, it displays a unique pattern that can be used to identify and count tissue stem cells.

Director Sherley is scheduled to discuss the cellular basis of Asymmetrexs biomarkers for counting tissue stem cells and give an update on the progress of the H2A.Z asymmetry crowdsourcing campaign at the 8th International Epigenetics, Stem Cells, Sequencing & SNiPs-2015 Meeting from August 24-25 in Boston. The outcomes from the two summer studies will be reported at BioPharm America 2015, September 15-17, in Boston.

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Asymmetrex Plans to Report Results From Adult Stem Cell ...

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The L7 PBMC Priming-Recovery Kit is supplied with PBMC priming and recovery media, enhancers, and a detailed protocol for PBMC reprogramming utilizing episomal vector technology.

To learn more about the L7 System, click hereor listen to the archived stem cell webinar.

Listen to the archived pluripotent stem cellwebinar.

L7 hiPSC Reprogramming and hPSC Culture System In 2011 Lonza began development on a clinical grade master cell bank. During development it was determined thatexisting commercialproductsdid not provide the optimal xeno-free, defined conditionsfor human induced pluripotent stem cell (hiPSC) generation and human pluripotent stem cell (hPSC) culture so theL7 hiPSC Reprogramming and hPSC Culture System was created. Efficient and reliable reprogramming of human somatic cells towards hiPSCs has never been easier!

Stem Cell Transfection using Nucleofector Technology Transfection ofstem cells is typically a very difficult task using non-viral methods. With the Nucleofector Technology stem cells can be consistently transfected at high efficiency for various applications, comprising those that require co-transfection of several substrates:

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Stem Cells - Lonza

Stem Cell Training, Inc., a subsidiary of Global Stem Cells Group, announces plans to conduct the first stem cell training course in Romania Nov. 27-28, 2015. The training class will be held in Bucharest and lead by Cosmetic Surgeon Morad Iancu, M.D.

MIAMI (PRWEB) June 03, 2015

Global Stem Cells Group and its subsidiary Stem Cell Training, Inc. have announced plans to conduct Romanias first ever stem cells harvesting and reintegration course Nov. 27-28, 2015. Through an alliance with Miami-based Stem Cell Training, Inc., Cosmetic Surgeon Morad Iancu, M.D. will conduct the Adipose and Bone Marrow Stem Cell Training Course for medical professionals in Bucharest.

Iancu is a reconstructive plastic surgery specialist practicing in Bucharest and Tel Aviv, Israel, and a popular celebrity doctor in Eastern Europe.

The Adipose and Bone Marrow Stem Cell Training Course was developed for physicians and high-level practitioners to learn the process of isolating and re-integrating adipose- and bone marrow-derived stem cells through an intensive, hands-on training session. The objective is to arm participating physicians with clinical protocols and state-of-the-art regenerative medicine techniques so that they can bring regenerative medicine therapies to their patients in-office. Iancu will focus the training session on stem cell treatments in cosmetic applications.

Global Stem Cells Groups Stem Cell Training, Inc. courses have been extended to approximately 35 countries, allowing a global community of physicians to learn how to apply these new stem cell technologies.

For more information, visit the Stem Cell Training, Inc. website, email info(at)stemcelltraining(dot)net, or call 305-224-1858.

About Global Stem Cells Group:

Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions.

With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine.

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Global Stem Cells Group Announces First Stem Cell Training ...

Stem cell treatments are not a new phenomenon. The first knownbone marrow stem cell transplant took place back in 1959 on victims of radiation poisoning whose own bone marrow cells had been damaged.For over 50 years now Hematopoietic "blood" stem cell transplants have proven their benefits and effectiveness for various medical conditions.The Regen Centeris dedicated to providing patients & families with the safest and most effective cell enrichedmedical therapiesfor manydegenerative & chronic conditions affecting: Kidney, Liver, Spinal,Endocrine, Pancreatic, Neurological,Spinal and Orthopedic. Other treatments include radiation free cancer immunotherapiesfor: Lymphomas Leukemia Myelodysplastic disorders Myeloproliferative disorders Multiple Myeloma Amyloidosis,tissue and organ failure regeneration. Currentapplications of expandedneural cell and Hematopoietic cell transplantsinclude: Adult autologous transplants have helped thousands of men and women regain their health to get more out of life by eliminating eliminate pain or dysfunction in vital organs. Our clinical medical teamare experts in regenerative medicine andare fully licensed to perform medicine in Kingdom of Thailand. Ourcell banking and expansion laboratories in Bangkok allow us to provide a fully integrative environment that is results oriented using proprietary multi-stage treatment protocols. Our facilities use safe,modern medical techniques and equipment by trained medical personnel. Other related medical solutions include: Cancer Immunotherapy using NK T-Cells Oncology Lymphology Intestinal Diseases DNA and Genetic Testing Markers Bio-Identical Hormone Replacement Chronic inflammatory diseases Developmental Biology Comprehensive Age and Gender Based Annual Exams for preventative medicine,Blood Labs & Modern Radiology department (MRI,CT-Scan,Ultrasound)

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Effective Hematopoietic Mesenchymal Stem Cell Therapies