Category Archives: Idaho Stem Cells

Robin Bates, who has lived with multiple sclerosis for two decades, is halfway to his fundraising goal to give him a second chance at life.

HAYDEN, Idaho A second chance at life?

Robin Bates is working on it.

"You never really know what you're in for when you start out on these journeys," Bates said Friday, seated in his motorized wheelchair in his living room. "I'm a really private person, and I've had to be completely transparent and talk to people about things I'd never talk about. It's like creating a whole new you."

For 23 years, Bates, 53, of Hayden, has lived with multiple sclerosis, a disease that affects the brain and spinal cord and causes vision loss, pain, fatigue and impaired coordination.

Nearly 1 million people in the United States are affected by MS, according to the National MS Society. Bates' condition has progressed to the point where he can no longer do simple tasks, like make his own meals or even lift the kettle off the stove without help from Paula, his caregiver and wife of 23 years, as reported by our news partners, the Coeur d'Alene Press.

"There's all these things I can't do," he said. "I'm like a 50-year-old baby. Honestly, I can do nothing."

Earlier this year, Bates launched an effort to undergo a procedure that would basically reset his immune system and repurpose cells or create new MS-free stem cells, allowing him to once again have control of his mobility and possibly even walk once again. If he does nothing, he may end up in an assisted care facility where he will be away from his wife and the life he loves.

"If I can get stem cells, I don't have to take drugs," he said. "Then they do the treatment and I don't need drugs ever again, in a perfect world."

These procedures come with a hefty price tag, and it has been a challenge for Bates to make arrangements because of the advanced level of his condition, especially in the United States. This particular operation, a hematopoietic stem cell transplant, is not approved or covered in the U.S. Bates has had to seek out facilities abroad after being denied or told "no" by U.S. doctors.

"This is America, we have all the best technologies," he said. "It's kind of annoying that the place that should be able to help you, save you, turns you down. I'm the sickest person you'll ever come across and really need this technology, and they give it to healthy people."

Through the frustrations and difficulties, Bates was pleased to report he is halfway to his $50,000 fundraising goal and he is in the final approval stage with stem cell facilities in Mexico and in South Africa, where he is originally from.

He has a few options regarding time and cost $40,000 for a six-week treatment or $75,000 for a six-month treatment.

"The $40,000 place said they'll guarantee that my disease will not get worse," he said. "Six months, they'll guarantee that I'll walk out of there. If I had $75,000, I'd be there yesterday."

Bates said America does have one $25,000 option for him at facilities in Seattle and Florida, but the outcome would only halt progression for six months and would require expensive repeat procedures.

He has an online appointment with a doctor in Mexico today.

"I'm pretty confident, I think it's going to go well," Bates said.

He'll know in the next 30 to 40 days if he will be officially approved for a hematopoietic stem cell transplant. If not, he'll aim for the $75,000 procedure, even though it means he'll have to move to Cabo San Lucas for six months.

"How terrible could that be, living in paradise for six months?" he said with a grin.

Bates is optimistic about the process.

"From a physical standpoint, I have nothing, but from a mental standpoint I'm gung-ho, there's nothing that can get me down," he said. "Even on the worst days, I can take a terrible situation and find good in it. If you have a disease where you have no chance and you believe you've got no chance, you may as well just die. With me, I'm always optimistic, I always look for the good. No matter how terrible things are."

Contributions from friends, community members and strangers have also encouraged Bates, including a dear friend who offered to donate $5,000 if another $5,000 was donated. This resulted in $11,995 being raised in September.

Bates is eager to break free from MS and show others with the disease that there is hope. He is grateful to all who have supported him thus far and those who help in the future.

"Some people want to get better so they can get back to work," he said. "I want to get better so I can teach everyone with MS there's a way out of here. If you haven't got hope, what have you got?"

Info and updates: http://www.gofundme.com/f/stem-cell-transplant-to-stop-multiple-sclerosis.

The Coeur d'Alene Press is a KREM 2 news partner. For more from our partners,click here.

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North Idaho resident working on a second chance at life - KREM.com

Expertise and institutional independence are on the ballot this fall. Partisan culture wars have spread beyond specific people, ideas, and events. Now the target is public higher education itself.

American universities are no strangers to the culture wars, of course. President George W. Bush tussled with biomedical researchers over the use of embryonic stem cells. As an editorial in Nature Medicine put it in 2001, Newly inaugurated, Bush wasted no time injecting himself into the controversial debate. Later, Bush allies at Fox News lambasted professors who criticized the U.S. invasion of Iraq as insufficiently patriotic. Republican megadonors Charles and David Koch were among the most notable of those who poured millions of dollars into colleges and universities to support conservative causes, including programs that advanced free-market ideas and traditional American values.

The past quarter-century is full of right-wing attacks on higher education. But most of these attacks targeted specific events, ideas, or people. Often these controversies were triggered by the idea that white people, men, Christians, and/or conservatives are marginalized in higher education. Such culture-war flare-ups continue. Arizona State University, for instance, was plunged into controversy when white men displaying pro-police slogans were asked by other students to leave the universitys multicultural center.

But now partisan attacks on higher education have spread beyond right-wing outrage over specific issues. Today, the very idea of public colleges and universities that operate independent of partisan control is under attack.

Leery of public higher educations autonomy from partisan government, many Republican officials seek to exert more control over state colleges and universities as a way of reducing the influence of nonpartisan institutions and professional expertise. Core principles of academic freedom are at stake. At the University of Idaho, faculty members were advised to remain neutral on the topic of abortion and proceed cautiously when discussing reproductive health. For faculty members who teach about the topics in medical or social-science classes, the guidance doesnt just urge them to avoid hot-button issues. It is a clear step toward a state-controlled curriculum.

Attacks on institutional independence extend beyond the curriculum. Florida now mandates public colleges to change their accreditor frequently, a move seen by the federal government as an accountability runaround. Virginias newly elected attorney general fired the top lawyers at the University of Virginia and George Mason University on seemingly partisan grounds. A change to governance bylaws in Georgia gives the Republican-controlled state board the authority to selectively relocate the power to grant and deny tenure from the campuses to the state board. According to the American Association of University Professors, the governance change eviscerates tenure protections in Georgia.

Harry Campbell for The Chronicle

The contemporary Republican approach to higher education is part of a broader partisan campaign to undermine independent expertise. Anti-intellectualism has deep roots in American political life, and contemporary conservative suspicion of expertise and nonpartisan institutions has been brewing for a while. Its based on ideological skepticism of government and regulation. Fox News, social media, and conspiracy theories fuel mistrust in independent expertise. Indeed, the conservative movement has worked to degrade Americans trust in just about any institution that is not explicitly aligned with the Republican Party be it government agencies, corporations, health-care providers, the media, or colleges.

Republican attempts to control higher education also seek to erase challenges to partisan narratives. The University of Floridas efforts to prevent a professor from testifying against the state in a lawsuit challenging a restrictive voting law was illustrative. Floridas voting law flows directly from the big lie, or the baseless position that the 2020 presidential election was stolen from former President Donald Trump. Academic independence, if left unchecked, could question or even threaten this partisan narrative. And that independence from partisan governance is now unacceptable to many Republican-elected officials. On top of this, Sen. Ben Sasse of Nebraska, a Republican, is set to become the next president of the University of Florida, and State Sen. Ray Rodrigues, also a Republican, will be chancellor of the State University System of Florida more evidence that party fealty counts in appointing academic leaders.

In policy terms, replacing academic independence with partisan control is consistent with the GOPs deconstruction of the administrative state. Bucking the establishment has populist appeal for politicians like Sarah Palin and former President Trump. A decade ago, under the administration of Gov. Scott Walker, a Republican, Wisconsin piloted policies that pit state government against public universities.

Attacks on institutional independence and expertise are also rooted in conservative philosophy and legal thought like constitutional originalism. Recent rulings from the Supreme Court are consistent with the goal of limiting the authority of independent expertise in American life. For example, in their majority opinion restricting the Environmental Protection Agencys authority to regulate greenhouse gasses in West Virginia v. EPA, the courts conservative majority introduced the raised eyebrow doctrine the court could strike down any regulation that raises an eyebrow. According to UCLA law professor Blake Emerson, thats very dangerous because that just depends on the ideological predilections of the judge.

As with environmental regulation at the federal level, public higher education is a front in the right-wing campaign against independent expertise in the states. Gov. Ron DeSantis of Florida, a Republican, visibly leads efforts to assert the partisan rule of higher education, but it doesnt stop in Florida. Prohibiting or limiting instruction about race and gender in the United States has become a campaign priority for Republicans nationwide. According to a database maintained by PEN America, Republicans in state legislatures across the country have introduced nearly 200 educational gag orders since the beginning of 2021. Such bills could dictate what is taught in college and university classrooms, directly challenge a cornerstone of academic freedom, and undermine academic independence.

Of course, Democrats are not immune to partisan meddling in university administration. Andrew Cuomo, former Democratic governor of New York, installed a political loyalist to head the State University of New York system, and legislation to limit tenure and assert greater state control over public higher education is circulating in Hawaii. Electing Democratic candidates is no guarantee of higher educations institutional independence. The difference, however, is that breaking independent expertise is not a central goal of the Democratic Party. It is for the Republicans.

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The Right-Wing Attempt to Control Higher Ed - The Chronicle of Higher Education

ELK CITY, Idaho--(BUSINESS WIRE)--Therapeutic Solutions International announced today granting of Emergency IND # 28685 and a May Proceed Notification from the Food and Drug Administration (FDA) for the treatment of advanced COVID-19 ARDS outside of the currently ongoing Double Blind Placebo Controlled Phase III clinical trial for the same indication. The Company previously announced treatment of 15 "no option patients under both eIND and Right to Try Law1.

Based on my clinical experience with the JadiCells, their therapeutic effects are unparalleled in comparison to any other stem cell therapy, said Dr. James Veltmeyer, Chief Medical Officer of Therapeutic Solutions International. With the increase in COVID-19 cases, as well as the anticipated deluge of COVID-19 long hauler patients, it is imperative that we have mechanisms to provide these cells to patients who desperately need them, even if it is outside of the clinical trial. Our number one mission as a Company is to accelerate development of these cells as rapidly as possible and to save peoples lives.

Previously the Company has demonstrated superior activity of JadiCells to other stem cells, as well as identifying mechanisms of action2,3. The JadiCell is currently in Phase III for COVID-19 ARDS4, has been granted IND numbers for COPD5, and Chronic Traumatic Encephalopathy6, and is in late preclinical development for Idiopathic Pulmonary Fibrosis7.

We are thankful for the brave doctors that approach us and work with us to provide accelerated access to potentially life-saving cell therapies such as JadiCells to their patients, said Timothy Dixon, President, and CEO of Therapeutic Solutions International. We are blessed to have very positive relations with the FDA which has allowed for rapid movement through the various regulatory hurdles involved in development and commercialization of stem cell therapies.

About Therapeutic Solutions International, Inc.

Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is http://www.therapeuticsolutionsint.com.

1 Therapeutic Solutions International Successfully Treats "No Option" Patients with its JadiCell Stem Cell Therapy While Advancing Preparations for Phase III COVID-19 Clinical Trial (yahoo.com) 2 Therapeutic Solutions International Identifies and Files Patent on Novel Mechanism of Action of Its FDA Phase III Cleared JadiCell Treatment of COVID-19 and Delta Variant (prnewswire.com) 3 Therapeutic Solutions International Identifies Novel Biological Pathway Utilized by its Phase III Adult Stem Cell Product JadiCell to Stimulate Healing of Injured Lung Tissue | Business Wire 4 Therapeutic Solutions International Announces Launching of Phase III Clinical Trial for Treating COVID-19 Lung Damage Using its JadiCell Universal Donor Stem Cell Drug | BioSpace 5 Review of TSOIs COPD Therapy Moves Forward With IND Designation (copdnewstoday.com) 6 Therapeutic Solutions International Files Investigational New Drug Application (IND) with FDA for Treatment of Chronic Traumatic Encephalopathy Using Clinically Validated JadiCell Universal Donor Stem Cell (prnewswire.com) 7 Therapeutic Solutions International Develops Novel Stem Cell Based Therapy to Reduce Lung Scarring: Potential Solution to Post COVID-19 Lung Deterioration (prnewswire.com)

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Therapeutic Solutions International Granted Emergency IND by FDA for Expanded Patient Access to JadiCell Universal Donor Stem Cell for COVID-19 ARDS...

Robin and Paula Bates are determined to beat the odds, and to keep the fight at home.

HAYDEN, Idaho Hayden resident Robin Bates greets each day with a positive attitude and a grateful heart.

Keeping his chin up has been difficult lately. His secondary progressive multiple sclerosis has taken a toll on him and his wife of 23 years, Paula, who is his full-time caregiver.

Robin, 52, is facing the distressing possibility of having to move into an assisted living facility away from the love of his life, away from his friends and family, away from the home he knows, our partners at the Coeur d'Alene Press report.

As his condition deteriorates, he is running out of time.

"It's getting so much worse so much quicker," Robin said Friday. "I just started to lose the ability to use my hands. I cant even open my hands anymore."

Robin is in the process of qualifying for a hematopoietic stem cell transplant, a procedure that involves the intravenous infusion of stem cells that help reestablish blood cell production in people whose bone marrow or immune systems are not properly functioning.

It's not possible in the United States, and it's not cheap or covered by insurance.

Robin is working to raise $50,000 to cover the cost of the transplant, hospital stay, rehabilitation time, travel, lodging, food and other expenditures that will come with traveling outside of the country.

"I'm confident I'm going to get approved by Mexico, probably South Africa," said Robin, who is originally from South Africa. "Getting it done is going to be easy. It comes down to how soon I can raise the money and move forward."

Robin came to the U.S. when he was 27. He met Paula and the two were soon married.

Just three months into their marriage, he was diagnosed with multiple sclerosis, a disease that impacts the brain and spinal cord, which make up the central nervous system. It causes an array of symptoms, including numbness and tingling in the arms and legs, trouble walking, dizziness, vision problems and emotional and cognitive changes.

Robin has spent the last 13 years in a wheelchair. He's tried to participate in clinical trials, only to be told he is not able to because of his age and the advanced stage of his condition. He said he has tried countless conventional disease-modifying drugs to treat multiple sclerosis, as well as loads of alternative therapies, including diet and exercise programs.

But it keeps getting worse. Without some change of course, he fears life as he knows it will end.

"Its all going to go away if I cant stop this. I'm going to have to go to a home, my marriage will pretty much end, Robin said. "Its heartbreaking. It's frustrating. Its scary, and thats kind of where I am. If I had the money I would get the stem cell transplant tomorrow. They cant guarantee that I'm going to get better, but they can guarantee I wont get worse."

Email Robin at robinmbates@hotmail.com or visit https://bit.ly/3z9YYcz to donate.

The Coeur d'Alene Press is a KREM 2 news partner. For more from our partners,click here.

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Hayden resident family determined to keep the fight against multiple sclerosis at home - KREM.com

Not Smart But Clever? The Return of Dumbphones (Maria)

The author writes, Five years ago, Przemek Olejniczak, a psychologist, swapped his smartphone for a Nokia 3310, initially because of the longer-lasting battery. However, he soon realized that there were other benefits. Before, I would always be stuck to the phone, checking anything and everything, browsing Facebook or the news, or other facts I didnt need to know, he says. Now I have more time for my family and me. A huge benefit is that Im not addicted to liking, sharing, commenting, or describing my life to other people. Now I have more privacy. Tech expert Prof Sandra Wachter, a senior research fellow in artificial intelligence at Oxford University, says it is understandable that some of us are looking for simpler mobile phones. One can reasonably say that nowadays a smart phones ability to connect calls and send short messages is almost a side feature, she explains.

From Nature: Researchers are right to be concerned. The selection of embryos on the basis of these predictions is not yet supported by science. Moreover, the societal implications of using complex genetic tests to choose embryos has not yet been fully considered. Some scientists are completely opposed to the practice, whereas others recognize that, as more data accrue, there might be benefits, but realize that it must be carefully regulated. A study published in Nature Medicine1 on 21 March that explains some of the methodology behind the determination of what are called polygenic risk scores draws attention to the practice but does not allay scientists fears.

The author writes, With Idaho poised to enact one of the most restrictive abortion laws in the country, Oregon is shoring up access to abortion. Idahos measure would disallow abortion after six weeks and let family members of rapists sue abortion providers. According to the New York Times, a similar law in Texas resulted in a 60 percent drop in abortions in Texas and as much as an 800 percent increase in demand for abortions in clinics in neighboring states. Oregon is getting ready for a similar wave, and a possible end to Roe v. Wade, by passing legislation to fund support for those hardest hit by an end to reproductive health care, according to Christel Allen, executive director of Pro-Choice Oregon.

From Euronews: Rescue workers have found no survivors in the wreckage of China Eastern flight 5735, which crashed on Monday. The Boeing 737-800 aircraft went down in the remote Chinese mountainside with 123 passengers and nine crew members on board. The plane crashed outside the city of Wuzhou in the Guangxi region while flying from Kunming to Guangzhou. According to the Chinese Foreign Ministry, all the passengers are believed to be Chinese. The cause of the plane crash has not yet been revealed.

The author writes, Were 3D printing these cells into a very specific structure that mimics human anatomy, which we think is our best shot at stimulating sperm production. If successful, this could open the door to new fertility treatments for couples who currently have no other options. For the recent study, the researchers performed a biopsy to collect stem cells from the testicles of a patient living with NOA. The cells were then grown and 3D printed onto a petri dish into a hollow tubular structure that resembles the sperm-producing seminiferous tubules.

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Not Smart But Clever? The Return of 'Dumbphones' - WhoWhatWhy

ELK CITY, Idaho, Aug. 11, 2021 /PRNewswire/ --Therapeutic Solutions International, Inc., (OTC Markets: TSOI), reported today new data and a patent filing describing the superior ability of JadiCell adult stem cells to other stem cell types in terms of stimulating production of new brain cells in an animal model of inflammation. The process of producing new brain cells is termed "neurogenesis" and is an active area of research for the Company.

"We saw that increasing doses of double stranded RNA, which mimics viral induced inflammation, was associated with decreased neurogenesis, which is to be expected. Shockingly, out of the stem cells tested, only the JadiCells were capable of stimulating neurogenesis under conditions of inflammation" stated Dr. James Veltmeyer, Chief Medical Officer of the Company. "These data suggest the possibility that JadiCells may be useful not only for patients with acute COVID-19, which we will test in our upcoming clinical trial, but may also have the potential to fight the long-term consequence of this infection."

"We are eager to explore collaborations with other neurological companies. One interesting thing about the filed patent was the embodiment of combining JadiCells with various existing drugs such as oxytocin, human chorionic growth hormone, and SSRIs" said Famela Ramos, Vice President of Business Development for the Company.

In previous studies the Company has demonstrated the superior activity of JadiCell to other types of stem cells including bone marrow, adipose, cord blood, and placenta. Furthermore, the JadiCell was shown to be 100% effective in saving the lives of COVID-19 patients under the age of 85 in a double-blind placebo controlled clinical trial with patients in the ICU on a ventilator. In patients over the age of 85 the survival rate was 91%1.

"Given we are getting closer to starting our Phase I/II CTE2 and our Phase III COVID trial, the validation that our cells are more potent than other adult stem cells for the brain is very promising" said Timothy Dixon, President and CEO of the Company and co-inventor. "We are enthusiastic about the success of the JadiCells because of the following characteristics: a) long history of safety data; b) what appears to be superior efficacy data as compared to other stem cells in preclinical models; c) low cost of production; and d) promising human data."

About Therapeutic Solutions International, Inc.Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is http://www.therapeuticsolutionsint.com, and our public forum is https://board.therapeuticsolutionsint.com/

1Therapeutic Solutions International Receives FDA Clearance to Initiate Phase III Pivotal Registration Trial for JadiCell Universal Donor COVID-19 Therapy2 Therapeutic Solutions International Completes FDA Requested Studies to Initiate JadiCell Chronic Traumatic Encephalopathy (CTE) Clinical Trial

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SOURCE Therapeutic Solutions International

therapeuticsolutionsint.com

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Therapeutic Solutions International Reports Superior Neurogenesis Induction in Animal Model of Viral Induced Cognitive Dysfunction Compared to other...

A 47-year-old bodybuilder has claimed that "thinking himself young" is the key to his success.

Kris Gethin claims he has the biology of someone half his age and he believes it's due to his healthy lifestyle.

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Gethin, who grew up on a Welsh farm, was never into fitness growing up.

However, after becoming more active in his teens, he took things to another level when he studied international health and fitness in the mid-90s.

This got him interested in building muscle and performance which prompted him to leave his hometown of Wales for America in 1999.

Since then, he has worked as a personal trainer all over the world, including India and Australia, before returning to America where he currently lives in Boise, Idaho.

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While his initial focus was on building muscle and improving performance, Gethins current drive is on delaying and even reversing his biological clock.

And after seeing the effect that Alzheimer's had on his grandfather John Morgan before he died at the age of 92 in 2019, he was determined to remain healthy and independent for as long as possible.

He told The Sun: My grandfather passed away a couple of years ago.

For the last few months he had quite bad Alzheimer's and I saw the effect that it had on my mother, his daughters, and myself.

I want to live to be over 100 years old, but I dont want to have Alzheimer's, back problems, eye problems anything of the sort.

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Im trying to live in the present and I dont want to have regrets. Ive met a lot of older people who have a lot of regrets and I dont want to have any.

I want to be hiking up Snowden in my 90s."

Gethin further revealed that he wants to stay healthy for his family and those who depend on him:

Im very close to my family and Im closer to them now even though I live so far away. It's all about quality rather than quantity. I want that to continue," he told The Sun.

I dont want to be in a retirement village, I dont want to be on a zimmer frame, I want to be independent.

Im going to do everything I can to make sure that happens.

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I love weight training, running, swimming, and mountain biking. I dont want to watch from the sidelines. I want to be part of it."

And as for his secret to looking so young? Gethin told The Sun: I believe that having a young mindset is key. I set my intentions every morning and think of myself as a 25-year-old which is my biological age.

Gethin said he also keeps young by adopting a shotgun approach," which means that he only eats grass-fed, organic, wild-caught meat.

He is also in bed by 7: 30 pm every night and has various youth-boosting drugs injected into his body every six weeks.

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He also drinks hydrogen-rich water every day because it is high in antioxidants, he claimed.

He goes into an infrared sauna every day followed by a three-minute ice bath which he claimed improves his mental stability.

In addition to this, he recently had 600 million stem cells injected at a Colombian clinic.

His extreme regime may not be for everyone, but Gethin said that it is never too late for people to turn things around.

He told The Sun: Its never too late to turn it around. My father is in his 70s and he goes mountain biking every weekend.

When people ask me what the key to staying young is, I say maybe its their perception that tells them they are too old or maybe thats the life they live.

I think its all intention I believe that you can think yourself young. I dont feel 47 and I think you can set that intention.

Kris assessment of life is supported by 888casino.com who says that a positive mentality is the key to getting the most out of life.

A spokesman for888casion.comsaid: "Kris exemplifies the mindset and actions that are key to success and happiness.

"Pushing yourself in your chosen field and making the most of every opportunity are very admirable qualities. We share this mindset at888casino.comand encourage everyone to enjoy themselves while staying within their limits."

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Link:
Bodybuilder, 47, looks half his age & claims the trick to his youthful appearance & strength is thinking h... - The US Sun

ELK CITY, Idaho, April 26, 2021 /PRNewswire/ --Therapeutic Solutions International, Inc., (OTC Markets: TSOI), announced today new data demonstrating an unexpected synergy between its inducible pluripotent stem cell (StemVacs-V iPSC) derived immunotherapy product with low dose cyclophosphamide in evoking potent immune mediated cancer regression.

In a series of experiments, the Company demonstrated that its previously announced stem cell derived tumor endothelial-like cell vaccine1 enabled non-toxic doses of cyclophosphamide, an established chemotherapeutic agent, to induce significant reduction of established lung cancers, brain cancers, and skin cancers in animal models. Furthermore, it was demonstrated that reduction of tumors was associated with increased infiltration of immune cells.

"Previous companies, such as Batu Biologics, have demonstrated the clinical safety of using the immune system to selectively kill the blood vessels that feed cancer2, which was validated by FDA clearance3 to initiate clinical trials," said Dr. James Veltmeyer, Chief Medical Officer of the Company. "As a physician who sees firsthand the suffering of cancer patients caused by current chemotherapy protocols, the thought of leveraging the patient's own immune system to allow for increased efficacy with reduced toxicity is extremely exciting."

"From a business perspective, one of the significant hurdles preventing advancement in cancer therapeutics is lack of interdisciplinary collaboration," said Famela Ramos, Vice President of Business Development. "The demonstration that our immunotherapy possesses ability to potentiate anticancer activities of existing therapeutics, thus allowing for utilization of lower doses while retaining efficacy, is a game changer in my opinion."

"The idea that killing tumor blood vessels weakens cancer, and thus allows for lower doses of chemotherapy to be effective is very attractive. This concept has been validated in clinical trials which involved combinations of chemotherapy with the antiangiogenic activities of the monoclonal antibody drug Avastin," said Timothy Dixon, President and CEO of the Company. "Based on side-to-side comparisons, our stem cell based immunotherapy appears substantially more efficacious in inducing immune mediated "choking" of the tumor blood supply and demands deeper investigation."

About Therapeutic Solutions International, Inc.Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is http://www.therapeuticsolutionsint.com, and our public forum is https://board.therapeuticsolutionsint.com/

1Therapeutic Solutions International Demonstrates Potent and Selective Destruction of Tumor Blood Vessels by Leveraging Pre-Existing Natural Anti-Xenogeneic Antibodies (prnewswire.com)2Safety of targeting tumor endothelial cell antigens | Journal of Translational Medicine | Full Text (biomedcentral.com)3Batu Biologics Receives FDA Clearance for First Multi-Pronged Immunotherapy Targeting the Blood Vessels That Feed Cancer | BioSpace

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SOURCE Therapeutic Solutions International

therapeuticsolutionsint.com

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Therapeutic Solutions International Reports Regression of Established Tumors by Combining its Cancer Blood Vessel Targeting Immunotherapy with Low...

ELK CITY, Idaho, Feb. 22, 2021 /PRNewswire/ --Therapeutic Solutions International, Inc., (OTC Markets: TSOI), reported today novel data and filing of a patent application demonstrating that StemVacs cells carrying proprietary sequences from the cancer-specific antigen Brother of the Regulator of Imprinted Sites (BORIS), were able to elicit the generation of T cells capable of selectively killing cancer stem cells.

In contrast to other markers associated with cancer, BORIS is not simply a "flag" that is recognized by the immune system, but it is essential for cancer to be cancer. Dr. Thomas Ichim, Board Member of the Company, published that gene silencing of BORIS resulted in the death of cancer cells.1 National Institutes of Health Scientist Dr. Dmitri Loukinov, as well as other collaborators, published with Dr. Ichim that DNA immunization with BORIS resulted in suppression of aggressive breast cancer,2 as well as induction of T cells capable of killing glioma, leukemia, and mastocytoma.3

"Despite living in what is called the Golden Age of Immunotherapy, the majority of cancers still do not undergo substantial responses to current treatments," said Dr. James Veltmeyer, Chief Medical Officer of the Company and co-inventor of the patent application. "What is impressive about the StemVacs approach is that it can generate personalized T cells that selectively seek and destroy cancer stem cells. It is the cancer stem cells that are the 'roots' of the cancer. They are resistant to chemotherapy and radiotherapy and to my knowledge the only possible way of eliminating cancer stem cells is through immunotherapy."

"Having worked in the area of cellular therapy and vaccine development, the possibility of using an allogeneic dendritic cell-based approach to ex vivo generate cancer stem cell killing T effector cells is tantalizing," said Feng Lin, MD, Ph.D., Chief Scientific Officer of the Company. "I look forward to continuation of these studies and eventual clinical utilization."

Researchers believe current cancer treatments sometimes fail because they don't destroy the cancer stem cells. Think of cancer as a weed: the stem cells are the root while the remaining majority of the cells are the part of the weed above ground. If you remove only the leaves but not the root, the weed will grow back. The same is true for cancer: if you do not kill the cancer stem cells, the cancer is likely to return.4

"Cellular therapy is the future of medicine," said Famela Ramos, Vice President of Business Development of the Company and co-inventor of the patent. "This demonstration that StemVacs can generate "patient specific" killer cells that can be reinfused in patients offers a new area of product development for us, as well as an ability to implement a two-punch attack on the tumor."

"At Therapeutic Solutions International we are focused on researching, patenting, and implementing the most innovative and potentially effective immunotherapies we can develop," said Timothy Dixon, President and CEO of the Company and co-inventor of the patent. "The ability to generate tailor-made killer T cells that appear to selectively target cancer stem cells provides yet another complementary cellular immunotherapy in our growing armamentarium against this terrible disease."

About Therapeutic Solutions International, Inc.Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is http://www.therapeuticsolutionsint.com, and our public forum is https://board.therapeuticsolutionsint.com/

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1 Selective apoptosis of breast cancer cells by siRNA targeting of BORIS - PubMed (nih.gov)2 DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice (nih.gov)3 Elicitation of T Cell Responses to Histologically Unrelated Tumors by Immunization with the Novel Cancer-Testis Antigen, Brother of the Regulator of Imprinted Sites | The Journal of Immunology (jimmunol.org)4 Cancer Stem Cell Research | University of Michigan Rogel Cancer Center

SOURCE Therapeutic Solutions International

therapeuticsolutionsint.com

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Therapeutic Solutions International Uses StemVacs Platform to Generate Personalized Adoptive T Cell Therapy Targeting Cancer Stem Cells - PRNewswire

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At some time in the kitchen, you've likely seen cooking oil smoke and burn. Watching that smoke billow is an unpleasant sight and smell, forcing you to turn on the exhaust fan and rush to open the windows. But how does it affect the oil's taste and quality? Is smoking oil really such a bad thing? (Beware of these cooking mistakes that can make food toxic.)

We spoke with top chefs and registered dietitian nutritionists about what the smoke point of oils means, how overheating oil can alter nutrients, and the potentially harmful impacts of burning and smoking oil.

The smoke point of an oil refers to the temperature at which it begins to smokeand also degrade in both quality and taste. Typically, the odor of an oil becomes at least somewhat foul once it begins smoking.

"Food can taste burnt if the oil it has been cooked in has started to smoke," says Lisa Andrews, RD, a registered dietitian in Cincinnati.

An oil's smoke point affects what you're able to accomplish with it. For instance, peanut oil has a smoke point of 450 F, which makes it suitable for deep-frying, according to the U.S. Department of Agriculture (USDA). Extra-virgin olive oil, on the other hand, has a smoke point of 405 F; that lower number makes this oil better suited for roasting and baking, says the Institute of Food Technologists.

Smoke points most often become an issue with higher-temperature cooking, such as sauting, pan searing, stir frying, and pan frying, says Michele Redmond, a chef and dietitian in Scottsdale, Arizona. "It's important to know the smoke point of an oil because it alters the taste of foodand not in a good way," she adds. "Knowing some basic smoke point ranges can make you a more efficient, flavor-sensitive cook." (Get the scoop on the healthiest cooking oils.)

Curious about what happens to an oil once it begins to smoke? A lot. "Oil smokes when direct heat applied to it reacts with oxygen enough to burn and create smoke," says Redmond.

Know, however, that a smoke point of an oil isn't an exact science. Consider, instead, a smoke point as a range of temperatures. "A single type of oil can have multiple smoke points, depending on the seed variety, processing, fatty acid profile, exposure to air and light, and the amount of trace carbohydrates, minerals, proteins, and aromatic compounds," says Redmond.

Unfortunately, there's no easy way to tell from an oils fat content whether it has a higher smoke point. A high smoke point oil can be loaded with good-for-you mono- and polyunsaturated fats, or it can depend on saturated fats. Palm oil, with nearly 7 grams saturated fat, 5 grams monounsaturated fat, and 1 gram polyunsaturated fat per tablespoon, has a high smoke point of 450 F, per the USDA database. The same amount of refined avocado oil, on the other hand, which has a smoke point of up to 500 F, contains just under 2 grams saturated fat, 10 grams monounsaturated fat, and 2 grams polyunsaturated fat. The lower levels of saturated fat and high amounts of monounsaturated fat makes avocado a much more nutritious pick if you need something to fry with.

Then there are also high-oleic oils to consider (oleic refers to omega-9 fatty acids, a type of monounsaturated fat). One popular example is sunflower oil. "Cooking oils high in oleic acids are less sensitive to heat because they are made using plants bred to have more monounsaturated fats and fewer omega-6 polyunsaturated fats," says Redmond. "For example, traditional sunflower oil is about 20 percent oleic acid, versus 80 percent in high-oleic acid sunflower oil. This makes it more stable for cooking at high heats and gives it a longer shelf life."

Now, what can happen when oil gets too hot? Let's investigate.

Foods readily absorb oil, so anything sitting in smoking oil can absorb acrid and burnt flavors. "The No. 1 reason we choose certain foods is because of taste," says Lexi Endicott, RD, a registered dietitian in Boise, Idaho. "And foods cooked in burnt oil may taste bitter, burnt, or rancid."

Gallery: The 10 Healthiest Cooking Oils, According to Food Experts (The Healthy)

"Olive and sesame oils have low smoke points," adds Andrews. "When used in high heat, they will break down and impart an off taste to your food. Avocado and sunflower oil, on the other hand, can tolerate higher temperatures and would be better suited for deep frying or roasting vegetables on high heat."

"If you leave an oil smoking in your pan for too long, you risk it hitting its flash point of catching on fire," says Redmond. Plus, the clean-up is not fun. As oil thickens, which happens when it catches on fire, says Redmond, it gets sticky and harder to scrub away.

Just as overly grilled BBQ food poses a carcinogenic risk, the same goes for overly heated oil.

"As an oil passes its smoke point, the part of the oil's triglyceride structure is broken apart from the fatty acidsand free fatty acids, aldehydes, and polar compounds are released," says Endicott. "As the glycerol continues to heat, it is further broken down to acrolein, an irritating compound to the eyes and throat. Increased acrolein exposure may increase cancer risk, as it disrupts normal RNA [ribonucleic acid] and DNA [deoxyribonucleic acid] function." That increases the likelihood of cell mutations that can lead to tumor growth.

Another reason why cooking food in smoking oil is a no go? "The higher the temperature that an oil is cooked at, the increased likelihood of free radical production," says Endicott. "Free radicals are known to alter cellular function, which may lead to increased cancer risk."

Bottom line: It's better to not overheat cooking oils. "Healthy fat is incredibly healthy for the health of our cells and cell membranes," says Isabel Smith, MS, RD, a registered dietitian in New York City. "We want the fat we're consuming to be high quality and not burnt!"

That doesn't mean your cancer risk increases the second your pan starts smoking. "A smoking oil doesn't mean it immediately oxidizes or becomes less stable," notes Redmond. "The amount of time an oil smokesand other variables, including the type of fatty acidscan slow these processes. For example, oils high in monounsaturated fats and antioxidants can maintain stability well."

Those same factors that may impact your cancer risk may also affect your risk of heart disease. "Consumption of polar compounds, aldehydes, and oxidized fats may also increase heart disease risk," says Endicott. "Oxidized fats cause damage to the endothelial lining of blood vessel, which over time can decrease vascular function and therefore damage proper blood flow." (Find out the food rules of an anti-inflammatory diet.)

Here's a rough guide to smoke points from the cooking tools company, Anova:

To avoid problems when an oil reaches its smoke point, here's what you can do to decrease your risk.

"Choose oils that best fit the needs of your cooking application," advises Endicott. You already know that oils with higher smoke pointsavocado and peanut oilare better suited for roasting and sauteing. Unrefined coconut oil is best used for baking and stovetop cooking.

And some oils simply aren't meant to be heated at all. "Flavor-infused oils or expensive artisan oils are better reserved for finishing," says Endicott. These include unrefined walnut, pecan, or pumpkin oils. You can use them to drizzle flavor on top of just-out-of-the-oven butternut squash, or they can also be swirled onto freshly made dip.

You might need to experiment, too. "Sometimes, you won't know the smoke point of an oil until you try cooking with it," says Endicott. "If you notice an off smell or flavor, or feel a burning sensation in your eyes, your oil has likely exceeded its smoke point." An oil will often turn clear just before it begins to smoke.

Match your cooking oil to your technique to limit smoke at high heats. Oils with smoke points at or above 350 F pair well with the high temperatures needed for direct-heat techniques like sauting, pan searing, stir frying, and pan frying.

Like life, almost nothing in the kitchen is clear cut. "In some cases, you may desire an oil that begins to smoke just before cooking," says Redmond. "Cook's Illustrated tested how a fast pan sear of meat develops better flavors and texturesand cooks faster when added to a just-smoking pan. It's a bit contrarian, but this is how chefs cook."

It may seem like your supermarket shelves are filled with more cooking oil options than you've ever seen before. Vegetable, canola, and extra virgin olive oils (EVOO) are like culinary dinosaurs next to the seemingly modern avocado or flaxseed oil. With so many choices, and so many trends in the health food community, it's hard to know which is the healthiest cooking oil to put in your cart.

"There are 'health halos' associated with some cooking oils and opposite perceptions about others, not all of which are warranted," says Kris Sollid, RD, senior director of nutrition communications of the International Food Information Council (IFIC). A health halo is the impression that a specific food is really good for you despite a lack of factual information to back up the idea.

"Where these beliefs stem from is anyone's guess, but I wouldn't rule out connotations of an oil's food source, which may, in part, be influenced by the more exotic regions of the world that some of these foods are native to," Sollid adds.

With this in mind, which healthiest cooking oil should you reach for when prepping a meal? Our food experts weigh in with multiple options for every palette. (Beware of the cooking mistakes that could make your food toxic.)

When you'd like your oil to add a little flavor to your food, olive oil is one of the most recommended options. But it's important to keep in mind that its smoke point is lower than that of canola oil, so consider how you'll be using it first and at what temperature.

"Olive oil varieties have a lower smoke point but provide bigger flavor, so they are best suited for direct consumption in things like oil and vinegar salad dressings and in lower temperature cooking techniques like sauting, pan frying, and baking," says Sollid.

He also notes that olive oil is known for its high MUFA content, but also provides a small amount of ALA, the plant form of an especially beneficial type of polyunsaturated (PUFA) omega-3 fat. (Learn more about the different types of healthy fats.)

One thing to remember, just because an oil is deemed "healthy" doesn't make it a health food. "Cooking oils are calorie denseone tablespoon contains about 120 calories and one cup contains about 1,900 calories," says Sollid. "Therefore, advice focuses on using them, even the healthiest varieties, in moderate quantities. A little goes a long way."

The post What Nutritionists Need You to Know About Smoke Point and Cooking Oils appeared first on The Healthy.

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