Category Archives: Iowa Stem Cells

The mailings promised Life Without Pain! via stem cell injections or IVs administered in a patients own home. The allure was obvious: more than 20% of U.S. adults suffer from chronic pain.

A court exhibit from a lawsuit filed by Iowa Attorney General Brenna Bird is seen on a laptop computer May 8 in Urbandale, Iowa.

The flyers invited Iowans to free dinners across the state. Afterward, sales people traveled to potential customers homes for high-pressure pitches disguised as pre-screenings, according to prosecutors. More than 250 people signed up, paying $3,200 to $20,000 each for a total of $1.5 million. For this, a nurse practitioner came to their homes to administer injections and IVs filled with stem cells derived from umbilical cords.

Yet experts and regulators have alternately labeled such treatments as ripoffs, scams or simply unproven. In some cases, studies have documented real harm.

Last fall, Iowas attorney general sued two proprietors responsible for the mailings in her state, naming a Minnesota man who hosts a Christian entrepreneurship podcast and his Florida business partner for allegedly deceiving consumers, many of them elderly.

In bringing the lawsuit, Iowa joined attorneys general in New York, North Dakota, Georgia, Nebraska, Arkansas and Washington state who have sued businesses alleging they fraudulently promoted unproven stem cell treatments.

Stem cells have long fascinated researchers because of their ability to reproduce and, in some cases, transform into other cell types. Because of this, they are thought to hold the potential for treating many diseases and injuries.

But the FDA has approved only a handful of such therapies, and only for certain forms of blood cancer and immune system disorders. Stem cells are considered experimental for most uses, despite being marketed as a treatment for everything from autism and emphysema to sports injuries.

The FDA has repeatedly warned Americans to be wary of businesses hawking unapproved, unproven and costly stem cell therapies, which occasionally have caused blindness, bacterial infections and tumors.

In a 2020 notice, the agency expressed concern about patients being misled about products that are illegally marketed, have not been shown to be safe or effective, and, in some cases, may have significant safety issues.

Dr. Jeffrey Goldberg, chair of ophthalmology at the Byers Eye Institute at Stanford University, whose work has documented vision loss in some patients treated with cells removed from patients' own bodies, processed and reinjected, lamented that people are "desperately willing to shell out large sums of money for unproven and in some cases, explicitly sort of sham, so-called therapeutics.

Since August 2017, the FDA has issued about 30 warning letters regarding the unproven treatments.

Experts, including Dr. Paul Knoepfler, a stem cell researcher at the University of California at Davis, and Leigh Turner, a bioethicist at the University of California, Irvine, are among those who have raised alarm that such federal action is too little to regulate a U.S. industry which Turner estimated in 2021 topped 2,700 clinics.

Because states can seek substantial fines against wayward operators, Turner said their legal actions offer promise.

"If you look at them collectively, they might over time start to have an impact, he said.

The FDA offers training to attorneys general pursuing such cases. Dr. Peter Marks, director of the FDAs Center for Biologics Evaluation and Research, said federal regulators partner with state law enforcers in a shared mission.

Iowa Attorney General Brenna Bird speaks during a town hall campaign event for Republican presidential candidate Nikki Haley on May 17, 2023, in Ankeny, Iowa.

That puts people like Iowa Attorney General Brenna Bird on the front lines.

Last year, Bird brought the case over mailers offering Iowans a pain-free life, naming the now dissolved Biologics Health and Summit Partners Group, which operated under the name Summit Health Centers, as defendants. The state also sued the companies' proprietors: Rylee Meek, of Prior Lake, Minnesota, and Scott Thomas, of Thonotosassa, Florida.

Neither man claims to have any medical training. Yet over a series of free dinners across Iowa, attendees listened to their presentations about how stem cells could ostensibly repair damage linked to back or joint pain. The claims came despite an FDA warning that no such product has been approved to treat any orthopedic condition.

One testimonial featured a woman quoted as saying she had multiple sclerosis, fibromyalgia, degenerative joint problems and scoliosis. It implied the treatment worked so well she was able to stop using a walker and taking opioids. Prosecutors say that left people believing stem cells are effective at treating all the conditions listed.

The company offered packages ranging from 5 million cells to up to 60 million to fix customers' ailments. Iowas lawsuit described the practices as scattershot, for-profit experimentations.

Research has shown dead cells are often injected, Knoepfler said.

The Iowa case is still in the discovery stage, with the trial set for March 2025.

Meek and Thomas did not return multiple text and email messages from The Associated Press. Nor did their attorney, Nathan Russell, though he did rebut many of the allegations in court filings, including that the promotional information was deceptive or misleading. The filing stressed that Meek and Thomas always emphasized they were not doctors.

Instead, Meek promoted himself as the $100 million man and touted his business prowess on his Kings Council podcast. His and Thomas book, Intentional Influence in Sales: The Power of Persuasion with Neuro-linguistic Programming, is described as a way to get people to think the way you want them to think, without them even realizing it.

Nearly a quarter of Americans struggle with symptoms of depression, according to the latest Centers for Disease Control and Prevention data from an October 2023 survey. That number is down from 2020 to 2021, when the COVID-19 pandemic exacerbated mental health conditions for millions of Americans.

Like other forms of mental illness, depression impacts groups of people differently depending on their unique backgrounds and experiences. While depression is among the most common forms of mental illness, some portions of the U.S. are seeing rates of depression fall faster than others.

Northwell Health partnered with Stacker to look at which groups of people are the most likely to feel depressed, using data from the CDC.

Signs someone may have depression include an inability to focus, thoughts of death or suicide, hopelessness, and low self-worth, as well as changes in appetite and sleep patterns, according to the World Health Organization.

Depression can be transitorybrought on by the loss of a loved one or other difficult life eventsor chronic, such as for those who live with bipolar disorder. The latest data on depression rates suggest some of the uptick in depression during COVID-19 may have been more of the former.

Depression has lingered at elevated levels for some communities, including young people and those who identify as part of the LGBTQ+ community.

Americans ages 18 to 29 years old report the highest levels of depression, with those 30 to 49 years old showing the next highest levels, according to the CDC. Rates of depression taper off even more as Americans clear the age of 60.

Higher reported rates of depression in young people could partially be attributed to the way each generation views mental illness. Members of Gen Z, those born between 1997 and 2012, have been more open to talking about mental illness and seeking therapy, for example, than older generations who came of age at a time when mental health disorders were heavily stigmatized in media and popular culture.

Surveys have found that discrimination is often cited as a significant source of stress; Black and Hispanic adults, specifically, report higher levels of stress from discrimination compared to their white peers.

When it comes to depression rates, a similar trend appears. Hispanic, multiracial, and Black Americans report elevated rates of depression compared to white Americans, according to the latest survey data the CDC collected in late 2023.

Furthermore, LGBTQ+ Americans have reported higher levels of stress and mental illness compared to straight, cisgender people. Transgender individuals are also more than six times as likely to attempt suicide, according to a Swedish study published in The American Journal of Psychiatryone of the only studies to compile such data for an entire country over a 10-year period.

The current rates of depression among more vulnerable groups are particularly concerning at a time when mental health professionals are struggling to meet a higher demand for mental health care services.

Story editing byShannon Luders-Manuel. Copy editing by Tim Bruns.

This story originally appeared on Northwell Health and was produced and distributed in partnership with Stacker Studio.

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Experts: Don't believe everyone who is hawking stem cells - Kearney Hub

Findings have implications for treating eye diseases as well as brain disorders

In a positive sign for future treatment of human eye diseases, researchers from Iowa State University (Ames) and Harvard Medical School (Boston) found that transplanted mouse stem cells become integrated into the retinas of Brazilian opossums.

"The research is a promising step for using cell replacements to treat diseases of the human eye like glaucoma, macular degeneration, and diabetic retinopathy," said Don Sakaguchi, a developmental neurobiologist and associate professor of zoology and genetics at Iowa State.

"The work also may have implications for treating brain disorders such as Parkinson's and Alzheimer's as well as injuries to the brain or spinal cord," said Sakaguchi, who reported on the research on November 7 at the Society of Neuroscience's annual meeting in New Orleans.

In order to be able to follow the fate of transplanted stem cells, Sakaguchi, in collaboration with Harvard scientist Michael Young, engineered mice to produce enhanced green fluorescent protein in all its cells. Stem cells isolated from embryonic brains of these transgenic mice were then transplanted by intraocular injection into the eyes of Brazilian opossum pups of various ages (from 10 days to two years). The researchers determined the fate of transplanted cells by tracking GFP in sectioned eyes at various times following transplantation.

After only one week, GFP-expressing cells had not only been incorporated into the retina, but were expressing proteins characteristic of retinal cellsneurofilament protein, calretinin, and others. The researchers also found that the younger the animal was at the time of transplantation, the more highly differentiated the stem cells became.

"Experiments by other scientists have had limited success in integrating neural stem cells into adult animals," Sakaguchi said. "Our results suggest stem cells stand a better chance if they can be transplanted into an embryo-like environment."

Opossum neonates provide that kind of environment, as the opossum's pea-sized newborns are very immature.

Seven-day-old opossum pups attached to mother's nipples

"With the newborn opossum, we essentially have access to an embryonic stage of brain development," Sakaguchi said. "This makes the opossum a good model to study cellular connections in the brain as they become established."

The researchers will next try to identify the conditions in this embryo-like environment that enhance the survival and differentiation of stem cells. With this information, researchers can try to mimic the conditions so stem cells stand a better chance for use in adult animals. In the future, the researchers would like to transplant stem cells into animals with eye or other brain disorders to see whether the cells help treat the disease.

Abstract Number 415.2 and 415.2 Incorporation and differentiation of embryonic mouse stem cells transplanted into the mammalian retina. S.J. Van Hoffelen; A.M. Benediktsson; M.A. Shatos; M.J. Young; M.H. West Greenlee; D.S. Sakaguchi, Neuroscience Program, Iowa State University, Ames, Iowa, and Schepens Eye Research Institute, Harvard Medical School, Boston, MA.

Edited by Laura DeFrancesco Managing Editor, Bioresearch Online Email: ldefrancesco@bioresearchonline.com

Click here for more news from the Society for Neuroscience Annual Meeting.

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SOCIETY FOR NEUROSCIENCE NEWS: Mouse embryonic stem cells differentiate in opossum eyes - BioProcess Online

Each year comes a new wave of common viral infections. And not many of us really understand the depths of how our body fights infections and bad bacterias off to maintain you health.

Although vitamins and a healthy lifestyle can encourage our body to combat infection. it is actually our white blood cells that do most of the work.

According to research, a human body has between 4,500 and 11,000 white blood cells per cubic millimetre of blood. White blood cells are essential for helping the immune system fight off infections. They are bigger than red blood cells, are fewer in number but have an equally effective impact.

Maintaining a healthy white blood cell count is essential for inhibiting infections. It can also encourage the body to fight off any foreign invaders. There are several medical, health, and lifestyle factors that determine how effective our white blood cells can be.

Today, we will discuss: what white blood cells are? how do they work? how to maintain healthy white blood cell levels? and how to assess if your levels are healthy?

The White Blood Cells (wbcs) or Leukocytes are the type of cells that have a nucleus and float freely in your bloodstream. Bone marrow, lymph glands, and nodes are the primary sources where WBCS gets produced. They pass directly to the bloodstream and live from several days to many years.

After this timeframe, they usually become deactivated in the spleen tissues. Their count is important for your general health and can show your doctor whether you have an infection or not.WBCS belong to the enormous cells of the human body.

Their DNA can increase the creation of antibodies according to the specific types of intruders. They are durable cells, which may attract and penetrate viruses and germs. The leukocyte population quickly reaches the infection site (alongside with platelets) and restores the balance in tissues.

There are several types of wbcs, each one serving a unique goal. Lets take a look at the leukocytes which take part in inflammatory disease conditions. They are essential parts of your immune system and can create a protection network for antigens coming from the environment.

Some of the white blood cells come from the bone marrow, while others come from the lymphatic tissues. They come in many shapes and sizes so that they can attack different threats, and offer you increased cell defense against blood infections or disorders.

They represent almost 67% of the wbcs present in the human body. The use of an electronic microscope allowed us to estimate their cell size coming up to 10-12m approximately.

They attack mainly the fungi and bacteria trying to enter and multiply in the bloodstream. The cell count of the neutrophils is always high compared to the other types giving your doctor many reasons to believe that you can deal with infections successfully.

Their life cycle varies from several hours to a few days top. They are all heading to spleen tissue, where their dissolution happens.

This type of white blood cell has the same size as the neutrophils (10-12m). Their name comes from the pink color they take under the microscope when the doctor uses a cell pigmentation method.

They belong to the wbc with low cell count (approximately 2.4%) and protect you against parasites or ease the symptoms of allergic inflammatory responses. They live only for a few days (no more than 8) and circulate in your bloodstream for less time to deal with infections and disease, getting things back to normal.

Scientists have found these white blood cells to be rare in your body, counting for less than 0.4% of the total immune system cells. They are the only ones who have two or three lobes, and their cytoplasm granules can take blue color under the microscope.

Their size is somewhere between 12 and 15m, and their main task is to release histamine to urge the inflammatory response of your body. These cells are the hardest to spot when having a blood test since their count is minimal.

The life span of basophil wbc keeps on being short, varying from a few hours to several days before getting destroyed in your spleen tissue.

One of the most valuable wbcs types existing in your body. They count for almost 30% of the total white blood cell population in your bloodstream. However, they are more apparent in the lymphatic system than in your blood.

These cells have a small nucleus that is close to the membrane and have two or three lobes. They include several types listed here:

They produce the antibodies and can also start the immune response, activating other types of lymphocytes.

Cytokines are their primary product. They activate the immune system against any infection. Furthermore, the CD4+ and CD8+ cell variations attack the cancer cells and can help to give patients increased immune system reactions and treatment for leukemia.

T-cells also include some suppressor types that prevent autoimmunity (attacking your body cells) or the overreaction against external infections.

As their name implies, this type of white blood cells can kill any virus or cellular intruder comes into your bloodstream. They can attack even the ones that have no compatibility with your body proteins called MHC (Major Histocompatibility Complex).

Lymphocytes vary in size. The smaller cells can have an average size close to 7-8m while the larger ones can measure up to the range of 12-15m in diameter.

They live from several days up to many years, since they are the memory cells of your immune system, offering an acute reaction to an infectious agent penetrating your body once more.

The waste management cells of your immune system are monocytes. They are the roomiest types of white blood cells, measuring from 15 to 30m each.

Monocytes are approximately 5.3% of your wbc count, and you may find them in your bone marrow or any other lymphatic tissue. These cells help neutrophils to fight against infections, keeping the medical treatment of diseases at normal levels.

White Blood Cells are the fighters of your immune system. They work through chemical routes and can activate themselves when an antigen comes into your bloodstream. Antigens are all chemical agents, viruses, germs, or bacteria that can enter your body through your skin.

Once the invasion gets detected by one of the white blood cells, a chemical message becomes available to initiate counterattacks to the invader cells or organisms.

Our body keeps a relevant number of wbcs to circulate in your bloodstream, retaining your health to normal levels. The production of neutrophils and lymphocytes gets high when an antigen enters your body.

All types of white blood cells are present in our bone marrow tissue and wake-up every time you need to have an inflammatory reaction against potential dangers.

The wbcs count is important to determine whether you had an infection or you have already overpassed it. It can show your doctor the possibility of having cancer, according to their type and number, which varies in several disorders.

According to the University of Iowa, Hospitals & Clinics, the white blood cells range and percentage to the total count seen as normal are as follows:TypePercentageNumberNeutrophil50 60%2 188 7 800Lymphocytes20 40%875 3 300Monocytes2 9%130 860Eosinophils1 4%40 390Basophils0.5 2%10 136

Have in mind that numbers refer to the cell count per ml of your blood specimen. These are the world recognized prices that get compared to the findings from your blood. All general blood control exams include the inspection of the wbc counts since leukocytes number will alert your doctor to propose further tests and examinations.

While some of the disorders affecting the count of white blood cells are hereditary, it seems like the modern way of life can inflate them to healthy individuals. Their number or their type is the first to get affected, and you have to perform regular medical examinations and a blood test to identify them.

Any deviation from the normal count can create severe problems for your health. Not to mention, that your immune system can become vulnerable to external threats and even attack your cells to initiate an inflammatory response called an autoimmune disorder.

Lets check what the most frequent disease is that has to do with the alterations from the normal count of your white blood cells.

Even though it is not that frequent, your doctor will be equally concerned with a high wbc number, seen in your blood test. This high number of leukocytes, known as Leukocytosis, could be the response to a recent illness and germ infection.

Leukocytosis could also be an alert to check your bone marrow function and search if you have cancer or malignancy in your bloodstream or any other organ.

Even though a high white blood cell count could easily justify its present, its always a good practice to run any additional medical test to exclude any possible disease. The high wbcs count may also be a signal of autoimmune disorders.

The Lupus is the most common autoimmune disease, causing the overproduction of lymphocytes giving you a chronic clinical inflammatory condition in need of medications and special treatment.

It is one of the cancer forms often seen in children and adults. The platelets and red cells are getting replaced by white blood cells. Bone marrow overproduces the lymphocytes, which are not working properly and aggravate the body functions.

Leukemia can be either acute or chronic. It is an urgent medical condition that needs radiation therapy and chemotherapy to get better. Bone marrow transplant is another therapeutic option to restore its normal function and bring the wbc counts to the right levels.

Having a low white blood cell count patient is the usual medical condition that a doctor will face during his career. These conditions are the well-known Leukopenia (meaning lack of leukocytes).

It is a dangerous condition for your health. The bone marrow tissue cannot produce enough Neutrophils and the leukocytes removal rate is higher than ever before.

Persons suffering from neutropenia are more vulnerable to infection and inflammatory disease. Your doctor will read and view your blood test, estimating the wbc counts to offer you the right medical treatment.

The reduction of normal Lymphocytes level is another severe medical condition. White Blood Cells who usually get affected are the T-cells coming from the Lymphocytes strain.

The low leukocytes level associates with a decreased immune system response to external infections.

All these types of cells are the particles of your blood. White Blood Cells are usually bigger than red blood cells and platelets. However, their most important difference is that White Blood Cells are the only ones having a nucleus.

That is the way a doctor can distinguish the ones from the others using the electron microscope when examining your blood specimens. Red blood cells give the red color to your blood, while platelets are important to heal wounds by forming clots.

It is necessary to know that all these cells come from a common ancestor in the bone marrow (stem cells), getting differentiated as the fetus grows. The balance between the wbc counts and the platelets or red blood cell number is an essential health index for your doctor.

Several common symptoms relate to White Blood Cells disorders. Lets check each one separately:

Neutropenia usually runs silently through your body without causing any severe symptoms. However, your doctor could be suspicious of low wbcs counts when you appear to have:

A low lymphocyte count could give you symptoms like:

Since leukemia affects millions of people worldwide, there are many known and described symptoms like:

The increase of leukocytes number can cause the following symptoms:

Today doctors have a wide range of treatment for all White Blood Cells Disorders. It would be wiser to examine it according to each type of wbc disorder:

The treatment usually associates with the type of problems caused by the increased leukocyte number.

Leukemia is a severe type of cancer that needs specific treatment:

Common treatments to Neutropenia include:

There are certain drawbacks in the methods you can calculate your white blood cell levels. The nucleated red blood cells usually take part in the count, changing the real measurement of the wbc exact number.

To obtain the real wbcs count you need to follow the underscored steps:

It is an easy way to have exact measurements of your wbcs count when you have the right equipment. Have in mind that getting the right number is important for your doctor to decide the kind of treatment you are going to take.

Many drugs can affect your White Blood Cells levels. The most important of them include the following.

Most people dont feel anything when they have a high white blood cells count. However, it can make you look pale and feel tired all the time. Not to mention, that rashes and skin itches are going to occur more often than previously.

Diseases that cause high White Blood Cells count include:

White Blood Cells have a life cycle that varies from several hours to a few years. They usually come to the apoptosis stage (death) when they have reached their goal to defend your body from external intruders.

The white blood cells direct to your spleen tissue where most of them are getting deactivated and decomposed after several days.

Certain foods can increase the White Blood Cells count in your body. These include:

=> Also have a look on our foods list to boost your immune system

Vitamin C can give a natural boost to the White Blood Cells creation. Your body cannot store Vitamin C and that is why it would be wise to consume oranges and citrus daily. Have in mind that you should never exceed the 2,000 mg per day dosage to avoid problems from your stomach and intestine.

Vitamin C acts as an accelerating enzyme to all the molecular reactions that proliferate the multiplication of T-cells and Lymphocytes in your blood.

The caffeine that is the main substance in coffee beverages can increase your energy levels and improve your ability to exercise more. A recent study has shown that people who consumed coffee and had exercise experienced an increase of 73% to their wbcs counts.

However, the direct relation of coffee consumption with the production of the white blood cells is not yet evaluated in double-blind trials with controlled with placebo groups.

Low White Blood Cells count doesnt necessarily mean you have any kind of underlying cancer. It is more probable that you suffer from chronic infections or spleen inefficiency that can cause low wbcs levels to occur.

Your doctor is the only competent person to differ-diagnose your low wbcs levels and find the origin of this deficiency.

The only type of cancer that associates with low white blood cells are myeloid leukemia that is extremely rare. It affects your bone marrow and may get better with a transplant from a healthy donor.

A low White Blood Cells level can make you feel tired. It happens because the wbc high count can remove red blood cells from your bloodstream. Removing the red blood cells means that less oxygen gets to your muscles and that is the main reason for feeling constantly tired and exhausted.

Many people who suffer from wbcs deficiencies can benefit from blood transplants rich in platelets and red blood cells that can increase the oxygenation of their tissues.

Stress can lower your White Blood Cells count since it is the chronic mental condition that can increase cortisol production in your body. It is proven that cortisol can lower the production of white blood cells in your bone marrow, lymphatic tissues, and spleen.

In this way, people who suffer from chronic stress and dont receive any treatment for it can place themselves at severe risk. The low White Blood Cells count can make them vulnerable to infections.

It is vital to deal with anxiety and stress to restore your wbcs levels and immune system health to normal.

You can find the production of White Blood Cells in several different organs in the human body:

The human body can physically live without white blood cells. However, without them the body will become very sick as it will be open to infection and be seen as an easy target by bad bacteria and pathogens. The majority of the blood is made up of red blood cells and platelets, meaning the human body can continue to live but may develop life threatening infections due to lack of WBCS.

Leukopenia, also known as low white blood cell count, causes fatigue. Your body will become easily tired when you are experiencing leukopenia as your bodys defense and immune system becomes weak.

The reason for white blood cells being called white, is due to their physical appearance. After separating them from the red blood cells, the cells are indeed white in colour. The same goes for red blood cells, they are red in appearance.

The immune system has its safeguards that are the White Blood Cells. They are necessary to give you the health levels you need to function well in a world full of threats for your body.

Following a healthy lifestyle that includes organic foods, supplements and lots of workouts can give you the immune system function you always wanted.

Checking your White Blood Cells count regularly could be useful for your doctor to evaluate your general health levels.

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White Blood Cells (WBCs) - Definition, Function, and Ranges

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Click to view a previous story about Carly's battle.

October 30th brought a second challenge to Vinton-Shellsburg Kindergarten teacher, Carly Meyer. After battling her first round of leukemia, she suffered another relapse with a second diagnosis of leukemia.

"I thought I was done with these updates... but should have known 2020 wasnt done messing stuff up yet!" Carly shared. "For those of you who don't know, I was diagnosed with Acute Myeloid Leukemia in August 2019 and completed chemo treatments in December 2019, but unfortunately my lab results on October 30, showed some "blasts", which are the cancerous cells in my blood." She explained back in November that her lab results also showed that my WBC's the infection fighting cells, were very low.

At the beginning of November, she had another bone marrow biopsy which Wes, her husband believes is her 6th. She was then admitted to the University of Iowa Hospital for a month long stay.

Carly finished up her 5 days of chemotherapy on November 11th with only a couple of side effects (fatigue and loss of appetite) which are a couple of the more common side effects with chemotherapy treatments. Unfortunately, she suffered from dehydration as well and this caused her to pass out a couple of times, and one of the falls caused her to hit her head. This of course triggered a trip for a CT Scan just to make sure she was alright, fortunately, she didn't have any side effects from the fall.

"It is fairly common for leukemia patients to spike fevers and to get random bugs because we are neutropenic and our body cant fight off simple things they normally would," Carly explained. She did come down with an infection during this time but it was able to be pinpointed and treated right away. On Thanksgiving, she was able to return home 10 days earlier from her hospital stay than had been anticipated,

Her journey continues to beat cancer with a trip back to the hospital at the end of December, to begin preparation for her bone marrow transplant. "My hero of a brother started getting shots December 30 to prep and will be donating his Stem Cells on Monday, January 4th." Carly explained how the process works. Her brother Kyle was hooked up to a machine she said it is similar to donating blood/plasma and that the procedure lasts for about 5 hours. Fortunately, her brother Kyle was a 100% perfect match to be her donor.

The stem cells were then put into her IV Powerline over about 30 minutes while they closely monitored Carly for any side effects. "Then its just a waiting game after that," she said.

After the transplant, Carly's immune system was down to zero. Unfortunately, it is common for SCT patients to spike fevers and even get an infection after transplant.

New Year, New Me has never rang more true than this year Carly said.

She is hoping to be home at the end of the week. She said that this last stay has been "extremely exhausting mentally and physically." Developing mucositis, extreme sores and pain in her mouth, it has made it very hard to eat or drink anything. Mucositis is very common after receiving the strong chemo that she received just before her bone marrow transplant. She is slowly recovering from this.

She said that she is excited to be coming home with her husband and fur-baby Maverick if all goes well, by the end of the week.

"I am so lucky to have an amazing support system (especially my husband) to get me through this tough time," she said.

Please keep the couple in your prayers as Carly continues to heal.

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Cancer requires more tutoring, with Meyer continuing to Teaching Cancer a lesson - News - vintontoday.com

Article In Brief

Scientists identified several cellular abnormalities in the developing cortex from fetal tissues carrying the mutant gene implicated in Huntington's disease. The findings suggest that the disease alters human development at an early age.

Teams of French researchers have found cellular changes that alter cortical development in the brains of human fetuses who carry the mutant huntingtin gene (mHTT) implicated in Huntington's disease (HD).

The finding adds a new wrinkle to the puzzle of HD as many people who carry the mutation can live healthy lives for four decades or longer before the onset of symptoms.

No one knows why, but this is a common thread in other late-onset genetically-driven neurodegenerative conditions like Alzheimer's and Parkinson's disease, the researchers said. And a growing number of researchers believe that it is best to treat people with the HD mutation as early as possible.Now, findings from this study, published online July 16 in Science, beg the question: How early?

The researchers, led by Sandrine Humbert, PhD, research director of INSERM (the French National Institute for Health and Medical Research) and group leader at the Grenoble Institut des Neurosciences, and Alexandra Durr, MD, PhD, professor at Sorbonne University and team leader of the Paris Brain Institute at Pitie-Salptrire Hospital, had access to fetal tissue from families that terminated their pregnancy in the context of a prenatal test. The developing fetus carried the mHTT.

Other mouse and neuroimaging studies with pre-manifest mutation carriers have suggested that the mutation might affect neurodevelopment but this is the first time that scientists have looked to the human fetus to know for sure.

Dr. Durr works with people undergoing genetic testing and counseling for Huntington's disease. Her team was able to collect cortical tissue from four HD mutation carriers when the pregnancies were terminated at around 13-weeks' gestation and tissue from four healthy controls.

This age is an opportune time to assess the tissue, the study authors noted, because at this stage the cortical neurons that project to the striatumthose that become dysfunctional and die during the course of the diseaseare being born from progenitor cells at the ventricular zone.

Thirteen weeks gestation is the time point when you need a lot of cells to be generated, Dr. Humbert explained. At this stage in development cells are massively cycling. The implications for the fetal brain with an HD mutation is that there is a shift to differentiate early and, as a result, you generate fewer neurons, at least at this specific time point during development.

The scientists identified several cellular abnormalities in the developing cortex, including mislocalization of the mutant huntingtin protein and other junction proteins that keep the neuroepithelium sealed. They observed abnormal ciliogenesis and changes in mitosis and cell-cycle progression, which correlated with defects in the balance between renewal and differentiation of progenitors.

In neuroprogenitor cells, this balance is tightly regulated to provide the right amount of neurons along the development of the cortex. Fewer proliferating cells and more progenitors prematurely began to differentiate in the tissues of HD carrierssubtle findings that are changing the landscape of the cortex.

Huntington's definitely has a neurodevelopmental component in addition to a neurodegenerative disease, Dr. Humbert explained. Studies in mice have found similar cellular abnormalities.

These data are supported by similar findings in mice that show mutant HTT impairs neuroprogenitor cell division, migration, and maturation, and that these changes result in a thinner cortex. Additional studies have revealed that early exposure to mutant HTT is enough to trigger signs of HD when the mice grow up. Neuroimaging studies with pre-symptomatic mutation carriers, even children, have shown smaller intracranial volume in HD mutation carriers.

What is also intriguing is that these events occurred even though the fetuses had small pathological expansions39, 40, and 42 repeats that would typically cause an adult onset of HD.

The findings trigger a number of questions: Why aren't there any obvious clinical problems until mid-life? Do these early developmental changes set the stage for symptoms decades down the road? Are other brain cells compensating for the changes and it takes 40-plus years for symptoms to develop?

Dr. Humbert and her colleagues said that the defects we observed likely render the cortico-striatal circuitry more vulnerable to the later dysfunctions characteristic of HD. The path to degeneration is complex, however, and weaves together both pathogenic and compensatory mechanisms.

They cited a recent pair of studies in Neurology by Peg Nopoulos, MD, and her colleagues at the University of Iowa, Carver College of Medicine that looked at children who are HD mutation carriers. They showed initial striatal enlargement with hyper-connectivity between the striatum and the cerebellum. Over time, the striatum decreases and the connections weaken. Although the cerebellar connections initially may help compensate for the abnormally developed striatum, it is the loss of these connections that may ultimately lead to motor abnormalities. Again, it will be decades before any obvious motor signs develop.

Once there are disease-modifying therapies, we know we should treat as early as possible or differently in pre-manifest compared to symptomatic stages of the disease, or it may not be sufficient, said Dr. Humbert.

She said she is now interested in understanding how these early defects contribute to adult pathology, and how their compensation could be regulated during the silent symptom-free period. This should give access to new molecules of interest, either as treatments or biomarkers, she added.

It is a beautiful paper, said Christopher A. Ross, MD, PhD, director of neurobiology and professor of psychiatry and behavioral sciences at Johns Hopkins Medicine. The concept fits with ideas people have had. Their study is groundbreaking.

It's unclear how these cell-cycle abnormalities alter normal development, said Dr. Ross. I have been doing pre-manifest genetic testing for years, and my belief is that asymptomatic people who are far from their predicted onset but test positive are clinically completely normal.

These data are very interesting, said Sarah Tabrizi, MD, PhD, professor of clinical neurology at University College London Institute of Neurology. There has been debate in the HD field regarding the existence of a neurodevelopmental deficit, and evidence is accruing that this may be the case based on differentiating HD induced pluripotent stem cell systems, mouse development, and now these studies of early human development.

We recently found that HD gene carriers ~24 years before predicted disease onset had essentially completely normal brains including normal cortico-striatal connectivity on advanced neuroimaging, apart from a slightly smaller striatum, which we hypothesized resulted in selective vulnerability of the striatum to subsequent neurodegeneration in HD (Lancet Neurology 2020). Importantly, our HD gene carriers performed as well as matched controls on a range of stringent cognitive and motor assessments.

This all suggests that we need to treat as early as possible with disease-modifying therapies to enable us to delay or prevent symptom onset, Dr. Tabrizi said, and means that there is still great potential for therapies to potentially prevent the neurodegeneration occurring if we treat early enough. We need to understand more about the very earliest manifestations of neurodegeneration and then intervene at the optimal stage.

Dr. Ross believes that the brain figures out a workaround of these developmental alterations but agrees that it may leave the brain more vulnerable later in life. He added, These findings are conceptually very important, though not necessarily with immediate implications for patients or those who are asymptomatic but test positive.

He said that this finding represents a paradigm shift that will lead scientists to look for developmental abnormalities in other neurodegenerative diseases.

It is important to emphasize how the Huntington gene (HTT) affects the brain in the context of a lifetime trajectory, added Dr. Nopoulos, the Paul W. Penningroth professor of psychiatry and chair in the department of psychiatry at University of Iowa Carver College of Medicine. This gene is vital for brain development. Our group has shown that HTT drives brain development and that repeats in HTT are beneficial, and the higher the repeat, the higher the IQ. For individuals with repeats in the range of 39-42, like those in the fetal tissue study, HTT likely contributed to the development of a cerebellar-striatal-cortical circuit that was initially advantageous (which is why they are found to be asymptomatic in the Tabrizi study), but later in life, vulnerable to degeneration. Therefore, although the findings in the fetal tissue study are reported as abnormalities, they are more likely to be evidence of differences since the changes are not pathologic until much later in life.

However, she added, everything about HTT is on a spectrumthe classic dose effect of repeats on the age of onset is a good example where greater repeats result in earlier onset. The same is likely true for development.

Human brain development is prolonged, lasting until roughly age 30, she continued. Those with repeats in the low mutant range (36-42) will have a chance for full brain development before the vulnerable cerebellar-striatal-cortical circuit begins to degenerate and disease manifests. However, in those with longer repeats (above 50), the vulnerable brain circuit may begin to degenerate before full brain maturation is complete.

In this range of repeats, the ultimate effect of mHTT on brain development may be detrimental. These considerations are vitally important when considering when to intervene with preventive therapies such as gene knock-down drugs. In those with low mutant repeats, knocking down the gene early in life (before age 30) may be detrimental to brain development, yet in those with high repeats, rescue may need to be much earlier (adolescence).

Drs. Humbert, Durr, Ross, and Nopoulos had no relevant disclosures.

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Huntington's Disease Alters Human Development in the Fetal... : Neurology Today - LWW Journals

It now seems apparent that COVID-19 will dominate American life for months to come, quite possibly through the national election in November.

That means the disease, and efforts to respond to it, will likewise dominate the 2020 campaign and make it largely about something it has never been about before.

That something is science.

It is hard to think of a time when hard science biology, virology, epidemiology has been so much the core of our political conflict. Issues from evolution to stem cells to vaccination have long been a part of our political conversation, but not at the forefront of presidential elections.

This virus crisis has largely taken over the political conversation. Americans are all learning new, polysyllabic vocabulary and complex truths about threats they cannot see.

And that is likely to bring out all of the culture's ambivalence about science.

Trust in science

Last summer, a Pew Research Center survey found that 86% of Americans expressed "a fair amount or a great deal of faith" that scientists act in their best interests.

But the survey's co-author told NPR, "It tends to be kind of soft support." In fact, only 48% were willing to say that medical doctors "make fair and accurate research statements and recommendations all or most of the time." And only 32% were willing to say as much for "medical research scientists."

A YouGov poll in April 2017 found an even less sanguine attitude, as reported in Scientific American. That measure found only 35% of Americans had "a lot of confidence" in scientists. A plurality (45%) had "a little," while those with "none at all" had grown substantially since YouGov polled the same question in 2013.

Little wonder then that political figures such as Texas Lt. Gov. Dan Patrick, a Republican, and media personalities such as Fox News' Tucker Carlson pounce on the difference between various projections of deaths from COVID-19.

They interpret lower death totals (thus far) as evidence that the threat was overblown, even though public health experts consider it proof that shutdowns and social distancing are working and note that the threat is not over.

Rejecting expertise

Scientific experts, like experts in general, have fared poorly in the populist atmosphere of the past decade in Europe and the United States.

"Voters say they reject expertise because experts, whom they think of as indistinguishable from governing elites, have failed them," writes Tom Nichols, a professor of national security affairs at the U.S. Naval War College.

Nichols published a book in 2017 called The Death of Expertise: The Campaign Against Established Knowledge and Why It Matters. Summing up his argument for Politico, Nichols observed that Americans have always had a healthy skepticism about "eggheads" of various kinds.

He says that skepticism renewed itself in the "social and political traumas" of the 1960s and 1970s. But since then, he argues, "Globalization and technological advances have created a gulf between people with enough knowledge and education to cope with these changes and people who feel threatened and left behind in the new world of the 21st century."

Lacking "scientific merit"

The plain fact is that for many, science is a source of wisdom but by no means the only one. There can be a "balancing" of science with religious teaching or humanistic ethics or what people may regard as their own common sense.

That is why so many Americans may identify with President Trump's overeagerness about potential drug therapies for COVID-19 that have worked on other diseases.

Trump's hopefulness for the antimalarial hydroxychloroquine, for example, was apparently not shared by one of the administration's own leading vaccine scientists, Richard Bright. Bright tried to limit broad use of the drug because its application lacked "scientific merit." As a result, he says, he was removed as director of the Biomedical Advanced Research and Development Authority.

In a statement released by his attorneys last week, Bright sounded the alarm: "To combat this deadly virus, science, not politics or cronyism, has to lead the way."

Also this past week, the president stood at the podium of the White House briefing room and cast doubt on the survival of the coronavirus in the fall. He then deferred to his top scientific adviser on the question.

"We will have the virus in the fall," said Dr. Anthony Fauci of the National Institutes of Health.

Trump also insisted the head of the Centers for Disease Control and Prevention had been misquoted about the difficulties of managing COVID-19 in the fall. Dr. Robert Redfield took the lectern to say he had not been misquoted.

But all this was prelude to the Thursday night stunner, when the president extended his embrace of "game-changer" therapy ideas to raising the question of whether injecting a disinfectant (which can kill the coronavirus on a surface) into a person could kill the virus (in reality, doing so would be toxic).

This prompted such immediate blowback from scientists, hospital personnel and even the makers of Lysol that the president later insisted he had made the comment sarcastically. And the next evening's briefing was cut off at just 22 minutes, with the president taking no questions.

A long-term struggle

The crisis is spreading through the body politic even as it spreads through the human population. It will stress both in myriad ways. Americans' conflicted relationship with science will play a role in how they deal with that stress.

For the moment, most are accepting the scientific approach of social distancing in service of a greater good. But there are rejections of stay-at-home orders in street protests and in some statehouses.

Saturday night, Trump repeated a line used to argue for reopening the country sooner rather than later: "Remember, the Cure can't be worse than the problem itself." He added, "Be careful, be safe, use common sense!"

The struggle has been joined, and it will likely outlast both this one campaign season and this one pandemic.

The rest is here:
Science Becomes A Dividing Issue In Year Of Election And Pandemic - Iowa Public Radio

Nearly two weeks ago, Alessandro Laurenzi, a biologist working as a consultant in Bologna, Italy, was mowing the grass in his garden when a friend stopped him and said the mower reeked of fuel. I couldnt smell anything at all, he tells The Scientist. That was in the morning. A few hours later, he went to have lunch and realized he couldnt smell the food he was about to eat and when he took a bite, he couldnt taste it either. Within a few days, he developed symptoms of COVID-19 and called his doctor to ask if he could get tested. Because his symptoms were mild, Laurenzi says, his doctor said no.

Laurenzi had heard anecdotally that many COVID-19 patients in Italy suffered from a loss of smell, so he started reading all the scientific papers he could find to see if his anosmia and ageusia would ever abate. One of the papers, a review published March 13, mentioned that SARS-CoV-2, like other coronaviruses such as SARS-CoV and MERS-CoV, could target the central nervous system, possibly infecting neurons in the nasal passage and disrupting the senses of smell and taste.

Some of the purely respiratory symptoms that you might attribute to the disease, the inability to get air into the lungs, might actually be defects in respiration controlled by the nervous system.

Matthew Anderson, Beth Israel Deaconess Medical Center

Reading this, Laurenzi immediately reached out to the corresponding author, Abdul Mannan Baig, a researcher at Aga Khan University in Pakistan, and asked if his symptoms were reversible. The evidence, Mannan told Laurenzi and reiterated to The Scientist, indicates they will abate, possibly because the loss of sense is caused by inflammation in the area as the body fights the virus, so those symptoms could disappear in seven to 14 days. Lets hope so, Laurenzi tells The Scientist.

Documenting such peculiar symptoms is important, Mannan tells The Scientist, because the loss of smell and taste could be an early warning sign of SARS-CoV-2 infection. Based on the literature, British ear, nose, and throat doctors have now called for adults who lost those senses to quarantine themselves in an attempt to tamp down the spread of the disease, The New York Times reports. The symptoms, Mannan adds, also suggest that the virus has the ability to invade the central nervous system, which could cause neurological damage and possibly play a role in patients dying from COVID-19.

This is something to keep a careful eye on, says Matthew Anderson, a neuropathologist at Beth Israel Deaconess Medical Center in Boston. Theres been some intriguing observations in previous studies on viruses, including coronaviruses, to show that they have the capacity to enter the nervous system. Its important that this be considered for SARS-CoV-2 and for people to do the experiments, including autopsies, to look for signs of this damage.

Because COVID-19 has symptoms similar to the flu, much of the attention could get diverted towards the pulmonary aspect of SARS-CoV-2, while neural involvement may remain covert, Mannan says. When a patient begins to exhibit severe neurological symptoms, such as a loss of involuntary breathing, it may be too late to prevent fatalities.

In a review article first published February 27, Yan-Chao Li of Jilin University in China and colleagues argue that if SARS-CoV-2 infects nerve cells, particularly neurons in the medulla oblongata, which is part of the brain stem that serves as the control center for the heart and the lungs, the damage could contribute to acute respiratory failure of patients with COVID-19.

The epidemiological evidence supports the hypothesis that neurons in the medulla can become infected with SARS-CoV-2 and contribute to a patients breathing problems and potential death. Li and colleagues explain that the time it takes for COVID-19 to progress from first symptoms to difficulty breathing is typically five days; patients are then admitted to the hospital roughly two days later, and a day after that put into intensive care. The latency period is enough for the virus to enter and destroy the medullary neurons, they write.

SARS-CoV-2 enters human cells using a receptor called ACE2. Researchers have reported that ACE2 regulates cardiovascular function, and according to a search of protein databases, many human cell types express ACE2, including lung, heart, kidney, intestine, and brain tissue, Mannan says. There are also multiple ways that the virus could invade the central nervous system, he explains. It might circulate through the blood and then attack ACE2 receptors in the endothelia that lines blood capillaries in the brain, breaching the blood-brain barrier and invading neurons through that route. A breached blood-brain barrier could also cause brain swelling, compressing the brain stem and affecting respiration, Mannan says. The cells innervating the lungs could also become infected, making involuntary respiration more difficult.

Evidence from experiments in mice also suggest that the virus might target the nervous system through the olfactory bulb. In a 2008 study, immunologist Stanley Perlman of the University of Iowa and colleagues showed that SARS-CoVthe virus that caused the SARS outbreak that killed more than 770 people in 2003entered the brains of transgenic mice expressing human ACE2 through neurons in the nose. The virus then rapidly spread to connecting nerve cells. The extensive nerve damage was the major cause of death, the team reported, even though low levels of the virus were detected in the animals lungs.

Although this has not been demonstrated, SARS-CoV-2 could potentially enter the nervous system through the olfactory bulb, as SARS-CoV does in mice.

Death of the animal likely results from dysfunction and/or death of infected neurons, especially those located in cardiorespiratory centers in the medulla, the team wrote. A study with the MERS virus in mice expressing ACE2 showed a similar result, Perlman tells The Scientist. The brain certainly can be readily infected in mice, he notes. Whether this occurs in humans to any great extent is really unknown, but not very likely at this point, given how much larger rodents olfactory bulbs are relative to the overall size of their brains compared with humans and the paucity of evidence in humans.

Still, he says, the fact that COVID-19 patients have lost their sense of smell or taste is interesting because, if the virus infects the nose, it would use the exact same neurons as in the mouse studies to enter the brain. If taking this path, SARS-CoV-2 could work its way up to the olfactory mucosa, which consists of epithelium cells, blood vessels, and the axons from olfactory neurons. This area is connected to the olfactory bulb, via small, sieve-like, tiny openings called the cribriform plate that is located at the base of the frontal lobes of the brain, Mannan explains. Because the brains frontal lobes are close to the olfactory bulb where neurons may be infected, the tissue deeper in the brain could be endangered too.

Infection of the brainstem could cause changes that would affect involuntary respiration, which suggests some of the purely respiratory symptoms that you might attribute to the disease, the inability to get air into the lungs, might actually be defects in respiration controlled by the nervous system, Anderson says.

Mannan emphasizes that the neurological data on SARS-CoV-2, though preliminary, could be important for doctors deciding how to treat patients. Asking about neurological symptomsloss of taste or smell, twitching, seizurescould factor into who might go into acute respiratory failure, or at least who might suffer from it soonest, and allow for more efficient triaging of patients, with a close eye kept on those with neurological symptoms. It is important to screen the patients for neurological signs early and late in the course of COVID-19, he says, as this could be life-saving in our fight against COVID-19 pandemic.

Anderson and Perlman add that postmortem examinations of the brains of patients who died from COVID-19 are essential to understanding the role nerve damage might play in the progression of the disease. Few, if any, autopsies of these patients are being done because of fear of contracting the disease, and if the autopsies are being done, its not likely that examiners are looking at the brain, only the lungs. Theyre just not thinking that the brain could be the site of the problem, Anderson says, and so thats the really important aspect of these reviews, getting that idea out there.

Ashley Yeager is an associate editor atThe Scientist. Email her atayeager@the-scientist.com. Follow her on Twitter@AshleyJYeager.

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Lost Smell and Taste Hint COVID-19 Can Target the Nervous System - The Scientist

Stem Cell Treatment for Cartilage Regeneration Posted at 28 Mar by invigo

Cartilage degeneration is a common disease or condition known as osteoarthritis. As the term indicates, it occurs when the cartilage between the joints degenerates, or breaks down with the passing of time. The cartilage is vital to the joint as it acts as a cushion for impact and movement. When this cushion wears down, the joints are subject to pain and stiffness. However, there are treatments that can help with this condition. Here are some notes to better understand cartilage degeneration and what you as a patient can do to get pain relief and regain joint function.

Although there is no specific cause for cartilage degeneration, your risk of suffering from it increases with age and use. Another contributing factor is genetics certain genes may cause an inadequate production of collagen, an essential component of cartilage. Misshapen bones may also increase your risk for osteoarthritis as they put pressure on the joint that the joint is not designed to handle.

Then there are environmental and lifestyle factors that can contribute to cartilage degeneration. Being overweight, for instance, adds extra pressure to the joints. Excessive exercise, especially if it is repetitive on the same joint, can increase wear and tear of joints. Inflammatory conditions like rheumatoid arthritis also increase the risk of cartilage damage.

There are a number of symptoms that can result from cartilage degeneration. Depending on which joint is affected, you may experience:

Household chores may become more difficult due to stiffness of fingers. If your hips or knees are affected, you should take extra caution when getting out of bed or going up and down the stairs. Stiffness of the lower limbs and weakness of the hip can increase your risk of falling and sustaining a serious injury.

There are great advances being made with stem cell technology, which is a viable and effective treatment option if you are looking for relief from joint pain cause by cartilage degeneration.

At our facility in Cedar Rapids, Iowa, we offer stem cell treatment for those who are suffering and in need. Healthy cells from unaffected areas of your body (we harvest stem cells from adipose tissue in the abdomen or love-handles) can be used to repair, heal and regenerate areas injured or damaged tissue, ligaments or cartilage. Through a natural process called differentiation, the stem cells can adapt and change into any cell in the human body. A major advantage of using stem cell treatment is the ability to avoid risky and painful surgery with long recovery times.

So, if you are tired of the pain caused by cartilage degeneration/osteoarthritis, and would like to regain a pain-free and active lifestyle, we encourage you to come into our office to discuss your treatment options. Our clinic director, Dr. Sunny Kim can give you a comprehensive consultation. And in the case that stem cell therapy is not suitable for you, we will be glad to find you another course of action for recovery. Call us at (319) 774-8143.

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Stem Cell Treatment for Cartilage Regeneration ...

After several Mennonite children suffered fatal cardiac arrests and there were no answers to why, a team of UI doctors set out to discover an unknown genetic mutation that caused these deaths.

After several children died from sudden cardiac arrests, a team of doctors discovered a genetic mutation to be the cause of their fatal heart arrhythmias a disorder of the movement of the heart that disturbs its typical contracting rhythm.

Ian Law, pediatric cardiologist at the University of Iowa Hospitals and Clinics, said a Mennonite family moved to Iowa in 2013 just before one of the children died suddenly of cardiac arrests.

Doctors ran further tests and found other Mennonite children to be at a similar risk for heart problems, Law said, and had been so for years. Ultimately, the cardiac arrests were the result of genetically inherited heart arrhythmias.

We determined that the children had inherited gene mutations and the mother and father both had one good copy and one bad copy, causing their children to have different combinations of the gene, Law said.

One bad copy plus one good copy would give a child more of a predisposition to the heart defects but not make them at risk, two bad copies would mean they are indeed at risk of the fatal mutation, while two good copies would mean they bear no trace of the gene, Law said.

As of right now, Law said, there is no cure for the recently discovered genetic mutation, but physicians can prophylactically place pacemaking devices or beta blockers in children who test positive for the gene before they have an episode.

In a letter written to Law at UIHC, the mother of the children affected said that the family was thankful for the doctors putting in implantable cardioverter defibrillators the children, and understands that they need to pay more attention to how the kids take medications daily and watch their activity when sick because most of the cardiac episodes occurred when they were feeling under the weather.

[We are] glad to know if we can do a blood test to find out if the children and grandchildren will be affected I still have a hard time fully believing we can totally rely on these tests, the letter said.

The new genetic mutation is unnamed at the moment, because it had not been discovered or identified before now, Law said. Moving forward, precaution against it can now be taken.

Knowledge is power, so ideally what will happen is that we genetically test those who want to get married and counsel them, whether or not they have any trace of the mutated gene, Law said.

RELATED: Labs from UI, Texas share credit for simultaneous genetic discovery

Hannah Bombei, a genetic counselor in pediatric cardiology at the Stead Family Childrens Hospital, defined genetic arrhythmias as an abnormal heart rhythm which can stem from a variety of causes.

You can think about this like a factory assembly line. The genetic code is the blueprint to make certain products such as calcium, potassium, or sodium channels in the heart muscle cells, Bombei said. If the blueprints arent correct due to a genetic mutation, the resulting products wont be produced and/or function properly.

In the future, Bombei said doctors hope to move toward more personalized medicine. This means they would determine the most effective treatment based on the particular underlying genetic cause of an anomaly in a patients heart.

UI pediatric cardiology Professor Emerita Dianne Atkins said there are multiple mutations similar to this one which has been found only in Mennonite families, and that by the doctors discovered it they were anxious and then moved on to figure out why it happened.

Now that we have found this specific mutation it is very likely that we will continue to find it other communities and families, Atkins said.

RELATED: UI researchers find potential link between DNA changes and suicidal behavior

Its hard to pinpoint how many people are affected by arrhythmias, Atkins said, because the condition presents very differently in different people and doctors only know about those who show symptoms. Some are extremely rare, she said, and others are more common.

This mutation differs from others because doctors can discover who is at risk and who isnt, Atkins added, so treatment can begin before a fatal event.

Atkins said this discovery was important as a collaboration because doctors agreed that they were all helping patients with unclearly defined abnormalities and had to work together to find answers.

Law said they had to work to define the mutation itself, as well as keep track of who carried and showed symptoms of it.

Persistence, curiosity and teamwork is key, Law said. If we didnt have a community working together, these people and those in similar positions, would have continued to die.

Here is the original post:
UI doctors discover new genetic mutation that causes fatal heart arrhythmias - UI The Daily Iowan

Having written for various publications for the past 30 years, I have for the most part avoided extending predictions or trends beyond the coming year or two.

But as we close out the decade and move into the new, Ive taken some time to reflect on the past 10 years and look ahead to what I believe are exciting things to come.

Making predictions might be best summarized by being either naive or foolish. Perhaps today, you get a bit of both. But I believe these technological advancements will significantly impact our lives during the next decade.

AI is growing at a pace perhaps not previously seen in human history.

Not only will AI impact the obvious areas predictive analytics and computer-assisted living devices in the home and workplace but even more critically in the field of medicine.

Humans, by 2030, will be helped through computer-assisted living.

Just as contact lenses can monitor diabetic insulin levels, AI will lead to a host of invasive and non-invasive sensors to collect and interpret tens of thousands of human body data points. The information can be shared against a database of millions of other patients to detect anomalies (while never compromising individual privacy).

The shared economy taking root in health care will enable AI to make determinations faster and more mobile.

AI will detect potential issues long before the patient feels sick. And it also will enable providers to create custom treatment plans specific to each patient and his or her symptoms based on the best outcome of treatment by aggregating the non-identifiable data of millions of other individuals.

Lab-grown meat is a dangerous prediction, being both from Iowa and personally loving a quality steak.

That said, with a population that could reach almost 9 billion by 2030, lab-grown meat (from the stem cells of real animals) has the chance to:

Reduce the environmental impact of raising animals.

Reduce the energy input required to raise a pound of fresh meat.

Use tiny spaces to grow significantly large quantities that can feed the world especially calorie-rich food products in countries where raising animals is not a viable option.

The U.S. could be a laggard in this regard, but lab-grown meat has the potential to play a significant role in feeding the world.

The smartphone, or the smart device we carry, will become the go-to for all things technology.

During the next 10 years, we will continue to see the mass deployment of thousands, if not tens of thousands, of micro-satellites that will enable individuals to be as connected to the web as if they were at their desktop at the office regardless of world locale.

The phone will continue to play a less and less significant role in the device. Added features will help run the household, collect volumes of health-related data points and, coupled with AI, suggest products, services and appointments based on complex algorithms.

By 2030, we will indeed have a significant time-saving device at our disposal. Think Siri and Alexa to a power of 10.

Higher education will see a considerable shift in delivery during the upcoming decade.

Some futurists predict as many as 50% of all higher education schools could close, merge or reinvent themselves before 2030. While I believe this prediction is high, I see higher education undergoing the most radical reinvention it has endured since its modern-day existence.

School debt is not sustainable. And some large countries are reporting wages for new graduates to be marginally better than the monthly earnings of unskilled labor.

The upcoming decade will press higher education to deliver knowledge and skills that are immediately transferable to the workplace, and job-training programs will continue to expand. Four-year brick and mortars will continue to be challenged by three-year online programs and, in some cases, 2.5-year programs.

Open-source education will gain increased value with employers by 2030. The cost will put downward pressure on the amount of time necessary to obtain an undergraduate, graduate and terminal degree.

Finally, be prepared to say goodbye to dozens of Fortune 500 companies.

The staying power of a Fortune 500 company has never been shorter. We are in a period of massive disruption.

A dozen or more of the top 100 companies in 2030 have yet to form as a company. And some of the names we trust and hold dear will quietly work their way into obsolescence.

Change is constant, and these predictions highlight the speed at which businesses, organizations and people are expected to change.

Todd Link is Senior Vice President of Risk Management and Remote Delivery at Dupaco Community Credit Union in Dubuque.

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What will the US look like in 2030? | Articles - telegraphherald.com