Category Archives: Molecular Genetics

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biology

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The data accumulated by scientists of the early 20th century provided compelling evidence that chromosomes are the carriers of genes. But the nature of the genes themselves remained a mystery, as did the mechanism by which they exert their influence. Molecular geneticsthe study

the early 20th century when molecular geneticists began conducting research using model organisms such as Drosophila melanogaster (also called the vinegar fly or fruit fly) that provided a more comprehensive view of the complexities of genetic transmission. For example, molecular genetics studies demonstrated that two alleles can be codominant (characteristics

Although overlapping with biochemical techniques, molecular genetics techniques are deeply involved with the direct study of DNA. This field has been revolutionized by the invention of recombinant DNA technology. The DNA of any gene of interest from a donor organism (such as a

Molecular genetics is the study of the molecular structure of DNA, its cellular activities (including its replication), and its influence in determining the overall makeup of an organism. Molecular genetics relies heavily on genetic engineering (recombinant DNA technology), which can be used to

comparative embryology, and molecular genetics. Studies of the molecular structure of genes and of the geographic distribution of flora and fauna are also useful. The fossil record is often used to determine the phylogeny of groups containing hard body parts; it is also used to date divergence times of

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Molecular genetics | biology | Britannica.com

Research in the Department of Molecular Reproduction, Development and Genetics is diverse, ranging from bacterial and human genetics to signal transduction, mammalian reproduction, developmental biology, cancer and stem cell biology. The underlying theme is molecular level studies of cellular functioning in normal and pathological conditions. We approach this in a variety of ways, using model systems such as Drosophila, Caenorhabditis elegans, as well as transgenic, knockout and humanized mouse models.

Research in the department is supported by a number of grants funded by national and international agencies. The department receives support from University Grants Commission (UGC)-Special Assistance Programme (since 2002), Department of Science and Technology under the Fund for Improvement of S&T Infrastructure in Higher Educational Institutions (FIST) programmme (since 2002) and is recognized by the Indian Council of Medical Research (ICMR) as an Advanced Center for Cellular and Molecular Reproduction (since 2001). In addition, core support from the Indian Institute of Science and the Department of Biotechnology under the Grant-In-Aid Programme is also available.

A broad spectrum of research interests combined with excellent facilities and interactive and supportive atmosphere provides an environment in which there is a vigorous exchange of ideas among researchers. Our former students have established themselves as independent investigators in premier institutions both in India and abroad, and many of them are pursuing post-doctoral fellowships in leading Universities and Research Institutes around the world. We welcome post-doctoral fellows in the department and try to ensure their career progression during and after their stay. We also host a number of project trainees and students from institutions in India and around the world who participate in ongoing research projects and then move on to pursue PhD programmes in India and elsewhere.

We extend a warm welcome to MRDG!

Sandhya S. Visweswariah, Professor and Chair, MRDG, IISc

Originally posted here:
Molecular Reproduction, Development and Genetics at IISc

operates within the Division of Biological Sciences. Its faculty investigate molecular aspects of biological phenomena that operate on a cellular scale. The Department currently represents research on a wide range of biological problems and systems - its internationally recognized strengths include:

- invertebrate and vertebrate development - plant development and plant pathogen interactions- molecular biology - immunology - microbiology - cellular structure and function - yeast genetics

The department administers the Cell and Molecular Biology Graduate program in the Molecular Biosciences Graduate Training Program Cluster. The cluster combines five programs: Cell and Molecular Biology (CMB), Biochemistry and Molecular Biology (BMB), Human Genetics (HG), Genetics, Genomics & Systems Biology (GGSB), and Development, Regeneration, and Stem Cell Biology (DRSB). MGCB also plays key roles in the undergraduate biology curricula at the University.

Prof. Heng-Chi Lee is featured in the Faculty Spotlight.

Mike Rust was featured in an article that was also picked up by NOVA. https://www.uchicagomedicine.org/forefront/biological-sciences-articles/2018/november/twitter-use-influenced-by-social-schedules https://www.pbs.org/wgbh/nova/article/track-social-jet-lag-twitter

Please welcome David Pincus, who joined the Department of MGCB as an Assistant Professor October 1, 2018.

David Pincus from the Whitehead Institute at MIT has accepted an offer to start as an Assistant Professor in Molecular Genetics and Cell Biology and in the Institute for the Physics of Evolving Matter. He studies protein homeostasis.

Congratulations to Mike Rust who recently published in Nature Communications and in eLife. See also a commentary in UChicago News.

Congratulations to a CMB student Cody Hernandez in Jonathan Staley's lab who received a 2018 HHMI/Gilliam Award.

Congratulations to Jean Greenberg who was awarded a 2018 Fellow of the American Society of Plant Biologists.

Congratulations to CMB student DeQuantarius Speed of Jean Greenberg's lab who received 2017 Howard Hughes Medical Institute Gilliam Fellowship.

(News archives)

Administrative Information (on-campus-only)

MGCB THURSDAY EVENTS: WINTER/SPRING 2019

All seminars are on Thursdays at 4pm in CLSC 101 (*unless indicated).

1/10/19 JOURNAL CLUB - Desai, *CLSC 119

1/17/19 Arshad Desai, Ludwig Cancer Research

1/24/19 JOURNAL CLUB - Kuhlman, *CLSC 119

1/31/19Thomas Kuhlman, University of Illinois Urbana/Champaign

2/7/19Sandy Simon, Rockefeller University

2/14/19 MGCB Student Talks, University of Chicago

2/21/19 JOURNAL CLUB - Blythe, *CLSC 119

2/28/19 Shelby Blythe, Northwestern University

3/6/19 SPECIAL SEMINAR Alex Ruthenburg, University of Chicago, *NOTE DAY: Wednesday, 4:00pm, CLSC 101

3/7/19 JOURNAL CLUB - Griffin, *CLSC 119

3/14/19 Erik Griffin, Dartmouth College

4/2/19 SPECIAL SEMINAR Guy Tanentzapf, University of British Columbia

4/11/19 JOURNAL CLUB - Rosenblatt, *CLSC 119

4/18/19 Jody Rosenblatt, Huntsman Cancer Institute, University of Utah

5/2/19 JOURNAL CLUB - Haselkorn, *CLSC 119

5/8/19 Haselkorn Scientific Seminar

5/9/19 Haselkorn Lecture: David Baker, Institute for Protein Design, University of Washington, *BSLC 109

5/30/19 JOURNAL CLUB - Shi, *CLSC 119

6/6/19 Songhai Shi, Memorial Sloan Kettering Cancer Center

6/14/19SPECIAL SEMINAREric Wieschaus, Princeton University

For more information about MGCB Thursdays CLICK HERE.

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Molecular Genetics and Cell Biology

Each quarter, UCLA undergraduate science students showcase the research they have done. We would like to invite you to see our students in action and to share your professional expertise during theWinter 2019 MIMG/MCDB Undergraduate ResearchPoster Symposium.

Date: Friday March 15th, 2019

Time: 2:00 4:00 PM

Location:

Good Weather: Molecular Sciences Bldg.Patio

Poor Weather: Life Sciences Bldg.rm2320

Program Overview: Showcases and celebrates undergraduate student research and allows students to present their work to the campus and broader community. Studentswillpresent the results of their work conducted thisyear in thefollowinglaboratory programs:

MIMG 103BL AdvancedResearchAnalysis inVirology:Characterizationand Genomic Analysis ofNovelBacteriophages

MIMG 109BL AdvancedResearchAnalysis in Microbiology: Agricultural Impacts on Soil Microbial Communities

MCDB 150L Research Immersion Laboratory in Plant-Microbe Ecology: Plant Growth Promotion in Diverse Soils

Your Role: Give studentsan opportunity to share their research and to practice and strengthen their public speaking skills.Your role is to listen to student poster talks and provide students with feedback on their work and presentations.

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Department of Microbiology, Immunology and Molecular Genetics

The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.

The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.

Students may also be interested in the combined degree program inMedicine, Doctor of / Doctor of Philosophy (MD/PhD).

See video Explore Graduate Programs at the Faculty of Medicine

Molecular GeneticsMSc, MD/PhD, Ph

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Molecular Genetics - University of Toronto

The OCME Molecular Genetics Laboratory the only such laboratory based in a medical examiners office nationwide helps medical examiners investigate sudden unexpected natural deaths in apparently healthy individuals. The laboratory provides postmortem molecular diagnostic testing to search for gene changes that explain sudden deaths, and to alert surviving family members so that loved ones at high risk for inherited disease can be tested and treated.

Our Molecular Genetics Laboratory assists with approximately 500 investigations per year, and focuses on cardiac deaths in infants, children and young adults, sickle cell disease, and pulmonary thromboembolisms. The laboratory also provides genetic counseling, with an in-house certified genetic counselor who interprets test results for families and, when needed, refers surviving loved ones to clinical care partners in New York City.

The laboratory began as part of the Forensic Biology Department in 2003, and today stands as its own unit with approximately 10 professionals.

The Molecular Genetics Laboratory has been awarded nearly $2 million in grants from the National Institute of Justice since 2012, and its experts regularly publish articles in leading journals. The laboratory is also a member of Human Genetics in NYC, a group composed of some of the region's leading hospitals, universities, and scientific institutions dedicated to research, collaboration and public education around molecular genetics.

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Molecular Genetics - OCME - nyc.gov

There is a world of opportunity for our graduates. With a degree from the Department of Molecular Genetics at the University of Toronto, our students have the competitive edge over other graduates because of the reputation of excellence that is associated with our Department.

One traditional career path that our Ph.D. graduates take is to become a Professor at an academic institution or a Scientist at a research institute. To do this, our Ph.D. graduates embark on post-doctoral studies at another university or research institution. Typically, this involves 2 to 4 years of scientific investigation under the tutelage of a senior investigator (i.e. a Professor or Senior Scientist) to further demonstrate their scientific independence. Upon authoring additional prominent scientific works, our alumni place themselves in very competitive positions to land much sought after jobs at respected institutions around the world. A Ph.D. from our department, in combination with a few solid publications, has facilitated the placement of our alumni who are interested in post-doctoral work in the best labs in the best institutions in the world. A small sample of our alumni who have followed the path of becoming prominent Professors includeBrenda Andrewsat the University of Toronto,Ian Chin-Sangat Queens University;Zhigang Heat Harvard Medical School;Nevan Kroganat UCSF;Cecilia Moensat the Fred Hutchinson Cancer Research Center;Steven Schererat the Hospital for Sick Children; andTerry Yamaguchiat the National Institutes of Health National Cancer Institute, to name but a few.

Our graduate program also gives our M.Sc. and Ph.D. alumni a competitive edge in pursuing many other career paths that include dentistry, genetic counselling, law, medicine, teaching, and becoming a research associate. In addition, many of our graduates have become involved in the development, establishment and operation of several biotechnological enterprises. These are but a few of the potential career paths that our graduate program may help prepare our graduates for.

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Graduate Molecular Genetics - University of Toronto

Overview

The Division of Molecular Genetics and the Leibel Laboratory focus on the genetics of obesity and non-insulin dependent diabetes (diabetes mellitus type 2). The laboratory has mapped, cloned, and identified mutations in the obese, diabetes, and fatty genes in humans, rats, and mice, and focuses on defining the physiological basis by which signaling networks regulate body size and composition. The laboratory is also the Molecular Biology Core laboratory of the New York Obesity Research Center and the Columbia Diabetes Research Center.

Members of the lab are experts in the use of naturally occurring and transgenic rodent models to identify candidate molecules, and in vetting these candidates in large numbers of human subjects using high throughput methods (SNP detection, copy number analysis, and high throughput sequencing).

The division also co-administers research activities for the Naomi Berrie Diabetes Center, making this a division that operates across many scientific and administrative areas of the university.

Programs and centers include:

The Division of Molecular Genetics provides opportunities for graduate students to receive training and mentorships leading to a doctorate degree. Interested students who have been accepted into the Columbia University Graduate School of Arts and Sciences can rotate through our laboratories before deciding whether to consider their research projects in our labs under the mentorship of our faculty.

Frontiers in Diabetes Research provides fellowship awards to post docs and awards to research scholars based on a competitive application process. Award recipients receive awards for one year, with the opportunity to continued research support for a second year. This program includes an annual topic-specific research symposium.

Russell Berrie Obesity Research Initiative (Leibel and Zuker) provides awards to senior investigators for research projects in the area of neuroscience of ingestive behavior and body weight regulation. Additional awards are made for and feasibility studies. There is a competitive application process each year. Awards may be made for one year, with the opportunity for a second year of funding.

The Molecular Genetics Fellowship is a non-ACGME accredited program that provides opportunities for postdoctoral training in the genetic basis for monogenic or complex medical and physiological phenotypes using both human and animal models. Areas of special interest are obesity, types 1 and 2 diabetes, MODY, breast cancer, pulmonary hypertension, congenital heart disease, cardiomyopathies, inherited arrhythmias, congenital diaphragmatic hernias, oral clefts, and spinal muscular atrophy.

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Molecular Genetics | Department of Pediatrics

OverviewDescription

Molecular geneticists identify genes associated with specific functions, diseases, and disorders. They identify genetic mutations on a molecular level and establish genotypes to better understand the nature of genetic makeup. Some molecular geneticists work to develop new diagnostic tests based on DNA analysis.

The most common activity undertaken by molecular geneticists is identifying the causes of congenital disease and determining what roles environmental conditions play in their development. Their hope is to devise ways to minimize or even eliminate the presence of these disorders in humans.

Molecular geneticists use cutting edge equipment and techniques to gather, replicate, and analyze DNA. After testing is complete, they produce reports summarizing their findings and share them with colleagues. By gathering enough information, geneticists can form new understandings and methods for addressing genetic diseases and disorders.

Given the abundance of information coming from the Human Genome Project, opportunities in the field of molecular genetics will continue to expand. As genetic testing becomes more commonplace, more molecular geneticists will be needed to conduct and evaluate tests and their results.

Molecular geneticists work in laboratories associated with hospitals, universities, and medical research centers. They typically work with a team of assistants and related specialists. Their work demands familiarity with sophisticated equipment and methods, about which they are expected to continue learning throughout their careers.

Molecular geneticists are most frequently employed by hospitals, though universities and government agencies are also common employers. There is limited employment by private corporations.

A typical Salary Range for this career is $35,620 - $101,030 annually.

The Median Income for this career is about $65,080 annually.

A Bachelor's degree is the minimum expected of molecular geneticists. The best opportunities are available to those who obtain at least a Ph.D. or M.D. One's Bachelor's and Master's degrees should be in genetics or molecular biology, complemented by courses in biochemistry, biomedical science, and biotechnology.

Experience is a key factor in job opportunities. Those with significant experience in laboratory settings will have a competitive edge.

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Genomic Career: Molecular Geneticist ($35,620-$101,030)

Faculty and Staff Search Select a member name TYPE IN NAMEAljohani, Hashim MusallamBeucler, Matthew Bridges, James Cartwright, Iain L.Casey, Anthony MichaelCastleberry, Mark AndrewChoi, Edmund MChristensen, Collin JordanCole, Brenda SColeman, Anna Walsworthcong, Xinyu Czepnik, Magdalena Davidson, Sean Deacon, Patrick Dean, Gary EDeepe, George SamuelFenker, Daniel Fischesser, Demetria MarieFreeman, MacKenzie ReneeGebelein, Brian Phd Gipson, Gregory Goebel, Erich JGruenstein, Eric IanHall, Daniel PHassett, Daniel JHerr, Andrew B.Hildeman, David Holokai, Loryn LeilaniHong, Christian Huang, Taosheng Hui, David YKappes, Emily ChristineKattamuri, Chandramohan Kolb, Ellen MarieKovall, Rhett A.Lawder, John JamesLerner, Grigoriy YevgenyevichLieberman, Michael ALingrel, Jerry BLuo, Fucheng Luo, Yu Manoharan, Palanikumar Martin, Kendall ElizabethMcCoy, Jason CMenon, Anil GMillay, Douglas Miller, William Miser, Jaimie LynnMolkentin, Jeffrey Monaco, John J.Moquin, Kelli Muglia, Louis Ozbudak, Ertugrul Panchanathan, Ravichandran Panmanee, Warunya Pradhan, Suman Puga, Alvaro Rance, Mark A.Rosevear, Paul R.Rosile, Sarah MarieRothenberg, Marc E.Sadayappan, Sakthivel Saelinger, Catharine BSawtell, Nancy Schoch, Emma CarolynShull, Gary EdwardSmall, Jason TSmith, Haley E.Spearman, Paul WStambrook, Peter JStottmann, Rolf Stringer, James RStuessel, Kory NicholasThompson, Richard LThompson, Thomas B.Vest, Katherine ElizabethWaxman, Joshua Way, Sing_Sing Webb, Jordan Weiss, Alison A.Wells, Susanne Whitlow, Thomas JWieczorek, David FWolfe, Erin AshleyWolfkiel, Patrick RWright, Zoe Yarawsky, Alexander EYuan, Zhenyu Yurick, Lawrence JamesZavros, Yana Zhang, Yu

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Molecular Genetics, Biochemistry & Microbiology