Category Archives: Ohio Stem Cells

Earlier this year, Ohio State researchers found that pretreating adult stem cells with an anti-angina drug allows them to better adapt to the harsh environment of their transplantation site. Scientists are studying whether transplanted cells eliminate or slow the tissue deterioration that would lead to heart failure.

In research published in the Journal of Pharmacology and Experimental Therapeutics, adult stem cells from the bone marrow of rats were pretreated with the drug trimetazidine, or TMZ. The stem cells were then grown under low oxygen conditions to mimic their native and destination environments, and then exposed to stressful conditions that exist in the damaged heart tissue. The pretreated stem cells provided a substantially better therapeutic effect in restoring heart function.

Transplanted stem cells can repair many types of damaged tissue, including heart tissue, says Dr. Periannan Kuppusamy, associate director of the Ohio State Medical Centers Dorothy M. Davis Heart and Lung Research Institute. However, most of the stem cells transplanted in the heart die within a few days due to lack of oxygen and nutrients.

Stem cell-based cardiac therapy is an experimental procedure in which stem cells are transplanted to the damaged region of the heart in patients who have suffered a heart attack. Funding from the National Institutes of Health supported Kuppusamys research.

In early 2008, OSU Medical Centers Richard M. Ross Heart Hospital began collaborating with Arteriocyte, a biotechnology company created at Case Western Reserve University, to develop stem-cell therapies for human use.

The biggest challenge is that heart muscle doesnt typically regenerate, says Dr. Vincent Pompili, Ohio States director of cardiovascular cell-based therapies, who previously served at University Hospitals Case Medical Center. These studies are allowing us to study individual disease processes and identify ways to accelerate the bodys healing mechanisms.

Two recent Phase I trials offer a glimpse into the potential of stem-cell therapy. The first infused a very low dose of umbilical cord blood stem cells into patients with chronic ischemia, a condition characterized by a constant lack of blood and oxygen supply to the heart. After receiving the stem cells, a significant number of trial participants saw improved blood flow to the heart. According to Pompili, this resulted from the stem cells ability to help the body repair itself.

The second study examined the effect of human umbilical cord blood stem cells in genetically-engineered mice experiencing a chronic lack of blood flow to one of their limbs. One month after stem cell infusion, researchers noted nearly normal blood flow in the mice limbs.

Although this research is still in its early stages, it holds great promise as a potential therapy for patients suffering from a chronic lack of blood flow to and from the heart, adds Pompili, who also serves as Ohio States section director of interventional cardiology. Ohio States partnership with biotechnology companies illustrates our commitment to offering stem cell therapies in cardiovascular medicine.

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Ohio State Researches Stem Cells for Cardiac Treatment ...

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Ohio Stem Cell Therapy | Stem Cell Treatments

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CINCINNATI (AP) A Roman Catholic diocese in Ohio is discouraging its 113 schools from participating in the ice bucket challenge to benefit the ALS Association, saying the groups funding of embryonic stem cell research is in direct conflict with Catholic teaching.

Jim Rigg, superintendent of Catholic schools for the Archdiocese of Cincinnati, told the schools in a letter Tuesday to immediately cease any plans to raise funds for the association or to instead direct donations to another organization that combats ALS, a progressive neurodegenerative disease also known as Lou Gehrigs disease that causes paralysis and almost certain death.

The Catholic Church relates the use of embryonic stem cells in research to abortion and says it violates the sanctity of human life. The use of adult stem cells in research is not forbidden by Catholic teaching.

We certainly appreciate the compassion that has caused people all over the country, certainly including many Catholics, to be interacting and engaging in a fun way to support ALS research, diocese spokesman Dan Adriacco said Thursday. But its a well-established moral principle that not only the ends be good, but the means must be good, too.

The diocese said schools could participate in the ice bucket challenge, but any money raised should be directed to groups like the John Paul II Medical Research Institute in Iowa City, Iowa, which conducts pro-life driven research, according to its website.

Carrie Munk, a spokeswoman for the ALS Association, said her group largely funds adult stem-cell research but does fund one study involving embryonic stem cells using money from one specific donor.

She said all donors to the ALS Association can stipulate where their money goes and can ask that it not pay for embryonic stem cell research.

The group hasnt heard of any other Catholic dioceses in the country recommending against donating to the group, Munk said.

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Ohio Catholic Diocese Discourages ALS Ice Bucket Challenge