Category Archives: Regenerative Medicine

A TE-NMI in vitro and reinnervated muscle fiber after delayed nerve repair following TE-NMI excision.

PHILADELPHIA Researchers engineered the first injectable microtissue containing motor and sensory neurons encased in protective tissue, called tissue engineered neuromuscular interfaces (TE-NMIs). The TE-NMI neurons provide a source of axons to muscles in rats who suffered nerve injuries, and babysit the muscles to prevent degeneration and loss of function, while the damaged nerve regrows, according to researchers at the Perelman School of Medicine at the University of Pennsylvania. Their findings were published in Bioactive Materials.

The TE-NMIs are comprised of nerve cells encapsulated in a protective hydrogel, and the entire microenvironment is injected in close proximity to muscles. This ship in a bottle method protects the neurons and increases the likelihood that a greater quantity of axons will connect with the muscle and maintain regenerative pathways.

Researchers severed the sciatic nerve in rats, and injected them with either a TE-NMI or a microtissue without any neurons. In the group that received TE-NMIs, researchers were able to electrically stimulate the nerve stump being babysat by the TE-NMI and record a muscle response up to five months after the tissue was implanted. No muscle response was detected in the control group.

There are hundreds of thousands of patients who undergo surgery to repair nerve injuries every year, and even if a surgeon performs a perfect procedure, they cant make axons regrow faster than about one inch per month. For nerve injuries in the upper arm or upper leg, regeneration could take years; however, the pathway leading to the muscle and the muscle itself will irreparably degenerate after six to 12 months without connections from axons, resulting in permanent loss of motor and sensory function, said senior author D. Kacy Cullen, PhD, an associate professor of Neurosurgery. By increasing the time window for a patients axons to reconnect to muscle, this research has potential to improve the extent of recovery for patients without causing further damage.

For example, patients who suffer from a brachial plexus injury a nerve root avulsion where nerves are pulled away from the spinal cord may regain elbow function, but will likely never regain function of their hand. In these cases, a neurosurgeon would typically split a healthy nerve near the hand, and reroute it to stimulate the hand muscles to restore partial function while the nerve regrows. TE-NMIs would potentially do a more thorough job, without having to damage a patients healthy nerve, researchers suggest.

Working closely with clinicians at Penns Nerve Center, we identified a potential surgical paradigm that would be most helpful to them and their patients, said first author Justin Burrell, PhD, a postdoctoral research fellow in the Department of Neurosurgery and the Institute for Translational Medicine and Therapeutics. Whats more, as we continue to test and reaffirm our findings, we will continue our partnership with the Nerve Center to ensure that our research is providing them with the technology they need to provide the best possible care for patients.

This study was primarily supported by the U.S. Department of Defense (W81XWH-16-1-0796, W81XWH-19-1-0867), the National Institutes of Health (R44-NS108869, TL1-TR001880), and the Department of Veteran Affairs (I01-BX003748).

Editors Note: Dr. Cullen is a co-founder of Axonova Medical, LLC, and Innervace, Inc., which are both University of Pennsylvania (Penn) spinout companies focused on the translation of advanced regenerative therapies to treat nervous system disorders. Dr. Cullens laboratory at Penn receives sponsored research funding from Axonova Medical. Penn and Dr. Cullen each own equity interests in both companies, have received license-related financial consideration and may receive additional financial consideration in the future related to the licensing of certain Penn intellectual property to these companies.

Penn Medicineis one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and theUniversity of Pennsylvania Health System, which together form a $9.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $546 million awarded in the 2021 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals byU.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 52,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2021, Penn Medicine provided more than $619 million to benefit our community.

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Penn Researchers Develop Injectable Microtissue to Preserve Muscle Function in Rats with Severed Sciatic Nerves - Penn Medicine

The Regenerative Medicine (Bone and Joint) Market research provides a clear understanding of the markets major geographies, and also the key segments and sub-segments. The study focuses on the state of regional development, including sales volume, cost, and growth volume. The report also gives detailed company descriptions of leading players in the Regenerative Medicine (Bone and Joint) industry that are included in Regenerative Medicine (Bone and Joint) Market. The research investigates all of the segments based on various parameters such as market dominance, volume, and CAGR. On the fact that it is based, revenue, and sales in the Regenerative Medicine (Bone and Joint) market, the analysts have also thoroughly examined different regions such as North America, Europe, and the Asia Pacific. For this report on the Regenerative Medicine (Bone and Joint) market, the researchers employed extensive mixed research approaches and technologies.

The analysts have segmented the global market based on raw material, type, application, sales, and region. The study also analyzes the present landscape of the ever-evolving business sector and the present and future of the market. It covers important insights pertaining to established companies operating in the global Regenerative Medicine (Bone and Joint) market. The report provides in-depth information by market segment to help you monitor performance and make important decisions for growth and profitability. The report also proposes significant data regarding marketing channel development trends and market position.

Leading players of Regenerative Medicine (Bone and Joint) Market including

Anika Therapeutics, Inc, Arthrex, Inc., Baxter International, Inc., CONMED Corporation, Johnson & Johnson, Medtronic, Plc, Smith & Nephew plc, Stryker Corporation, Zimmer Holdings, Inc., Aziyo Biologics, and Ortho Regenerative Technologies Inc.

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Main Region Coverage: Production, Demand, and Forecasts by Country:

North America (USA, Canada, and Mexico)

Europe (Germany, France, UK, Russia, Italy, and other European countries)

Asia Pacific (China, Japan, Korea, India, Southeast Asia, and Australia)

South America (Brazil, Argentina, Colombia, and other South America)

The Middle East and Africa (Saudi Arabia, UAE, Egypt, South Africa, and other the Middle East and Africa)

Key Questions Answers in Regenerative Medicine (Bone and Joint) Market Report:

Which Manufacturing Morden Development Technology prefer for Regenerative Medicine (Bone and Joint)?

Who Are the current Key Players in This Regenerative Medicine (Bone and Joint) Industry with Their (Company Profile, Product Information, and Contact Information)?

What is the current as well as future market status of Regenerative Medicine (Bone and Joint)?

Who are the key stakeholders in the market?

What Are Industry Dynamics, Challenges, and Opportunities of Regenerative Medicine (Bone and Joint) Market?

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What Was the worldwide Market Status of Regenerative Medicine (Bone and Joint) Market with Capacity, Production Value, Cost, and profit?

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In the end, The Regenerative Medicine (Bone and Joint) Market Trend for Advancement is examined, along with marketing channels. Finally, the viability of new capital investments is evaluated, and research findings are presented. The Regenerative Medicine (Bone and Joint) Market Report also includes information on market share and production growth for each product in the Regenerative Medicine (Bone and Joint) market.

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Orthopedic Regenerative Medicine Market Analysis 2022, Size, Share, Trend and Growth in Future Scope 2022-2028 | Baxter International, Anika...

Frontiers in Stem Cell and Regenerative Medicine Research informs on multidisciplinary areas relevant to stem cell research and their application in regenerative medicine. The series is vital reading for researchers seeking updates in stem cell therapeutics and regenerative medicine.

The tenth volume of Frontiers in Stem Cell and Regenerative Medicine Researchpresents important recent developments in this fast-growing field.

Volume 10 includes 5 chapters on these topics:

-Novel drugs and their stem cell-based targets forosteoporosis: challenges and proceedings

-The role ofcancer stem cellsin disease progression and therapy resistance

-Stem cells fromhuman exfoliated deciduous teethin tissue regeneration

-The fate oftoxicological studies: from animal models to stem cell-based methods

-Effect of material properties on differentiation ofmesenchymal stem cells

Audience: Pharmaceutical scientists, biomedical researchers, stem cell biologists, pre-clinical and clinical researchers, life science, researchers, and healthcare professionals in regenerative medicine

About the Editors:

Prof. Atta-ur-Rahman, Ph.D. in Organic Chemistry from Cambridge University (1968) has 1,232 international publications (45 international patents and 341 books). He received the following awards: Fellow Royal Society (FRS) London (2006), UNESCO Science Prize (1999), Honorary Life Fellow Kings College, Cambridge University (2007), Academician (Foreign Member) Chinese Academy of Sciences (2015), Highest Civil Award for Foreigners of China (Friendship Award, 2014), High Civil Award Austria ("Grosse Goldene Ehrenzeischen am Bande") (2007), Foreign Fellow Chinese Chemical Society (2013), Sc.D. Cambridge University (UK) (1 987), TWAS (Italy) Prize (2009). He was the President of Network of Academies of Sciences of Islamic Countries (NASIC), Vice President TWAS (Italy), Foreign Fellow Korean Academy of Science & Technology, President Pakistan Academy of Sciences (2003-2006) and (2011 2014). He was the Federal Minister for Science and Technology of Pakistan (2000 2002), Federal Minister of Education (2002) and Chairman Higher Education Commission/ Federal Minister (2002-2008), Coordinator General of COMSTECH (OIC Ministerial Committee) (1996-2012), and the Editor-in-Chief of Current Medicinal Chemistry.

Dr. Shazia Anium is the Professor of the Chemistry Department and the Director of Cholistan Institute of Desert Studies, the Islamic University of Bahawalpur, Pakistan. She is experienced medicinal and natural product chemist. She has authored and co-authored more than 116 research papers (Impact Factor: 208) and a US patent. She has edited 09 books and has published 03 chapters in international books. She has accomplished the synthesis of several naturally occurring aminoglycosides that can be used as antibiotics. Dozen of students have completed their MS degrees under her supervision and couple of others are pursing for their MS/PhD degrees. As recognition of her contributions to science, she has been awarded with 03 International awards like Fellowship from Islamic World Academy of Sciences, Postdoctoral fellowship from Ministry of Culture and Education, Spain and a Young Chemist Award from Third World Academy of Sciences, Italy. She also has several national awards on her credit.

Keywords

Osteoporosis, cancer stem cells, therapy resistance, human exfoliated deciduous teeth in tissue regeneration, animal models, differentiation of mesenchymal stem cells.

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Boundaries in stem cell and reformative medicine research - EurekAlert

VANCOUVER, BC, March 22, 2022 /PRNewswire/ -- The global cell expansion market is estimated to reach value of USD 39.74 Billion by 2027, according to a current analysis by Emergen Research. Cell expansion is witnessing a surge in demand owing to an increase in automated solutions. Automation in the production of gene therapies and cell therapies products reduces the cost of production and decreases workforce.

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The emergence of cell-based therapy is expected to further growth of cell expansion market. Advancement in tissue engineering and regenerative medicine have provided growth opportunity for cell expansion market. Demand for regenerative medicine is growing rapidly to develop clinical therapies for repair, maintenance, replacement, and enhancement of biological function. Cell expansion is an important part of regenerative medicine as it provides a better understanding of neurodegenerative diseases. Thus, increase in the adoption of regenerative medicine drives the growth of cell expansion market.

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Lack of skilled professionals and high cost of the operations are expected to restrain growth of cell expansion market. Risk of contamination during the cell expansion procedure is also expected to hinder its adoption by the consumers.

Key Highlights of Report

In June 2019, Demcon acquired a share in Scinus Cell Expansion Company. Scinus is involved in developing equipment for stem cell therapy. The company is working on a technology that is cheaper, more reproducible, and less labor-intensive than the existing technology.

The instruments segment is forecast to register a faster rate during the forecast period owing to automation in bioreactors. Emergence of automation enables the tracking of processes and allows for effective time usage of skilled professionals.

Growing genetic disorders are driving the demand for embryonic stem cells. Research is being undertaken to use embryonic stem cells for eradication of genetic diseases. An increase in chronic diseases all across the globe is fueling the revenue growth of the segment.

Increase in incidence of cancer has propelled the research by biopharmaceutical companies in cell-based research. There are several funds allocated by public and private companies for cancer and cell-based research.

The market in Asia Pacific is expected to register the fastest rate owing to the increasing amount of research activities in developing nations. Several companies in the region are investing in developing advanced therapeutic tools, which is encouraging the adoption of cell expansion technology in the region.

Key companies include Danaher Corporation, Thermo Fisher Scientific, Inc., Corning Incorporated, Lonza, Merck KGAA, Terumo Corporation, Stemcell Technologies, Inc., Cellexus, Becton, Dickinson and Company, and Himedia Laboratories.

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For the purpose of this report, Emergen Research has segmented global cell expansion market based on product, cell type, application, end-user, and region:

Product Outlook (Revenue, USD Million; 20172027)

Cell Type Outlook (Revenue, USD Million; 20172027)

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Application Outlook (Revenue, USD Million; 20172027)

End-User Outlook (Revenue, USD Million; 20172027)

Regional Outlook (Revenue, USD Million; 20172027)

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Cell Expansion Market To Reach Value Of USD 39.74 Billion By 2027 | Increase In The Adoption Of Regenerative Medicine Drives The Growth Of Market,...

According to The Insight Partners new market research study on Cryopreservation Equipment Market Forecast to 2028 COVID-19 Impact and Global Analysis by Type, Cryogen Type, Application, and End User, the market is expected to reach US$ 11,255.02 million by 2028 from US$ 5,798.82 million in 2021; it is estimated to grow at a CAGR of 9.9% from 2021 to 2028.

Cryopreservation plays an important part in the field of regenerative medicine as it facilitates stable and secure storage of cells and other related components for a prolonged time. Regenerative medicine enables replacing diseased or damaged cells, tissues, and organs by retrieving their normal function through stem cell therapy. Owing to the advancements in the medical technology, stem cell therapy is now being considered as an alternative to traditional drug therapies in the treatment of a wide range of chronic diseases, including diabetes and neurodegenerative diseases. Moreover, the US Food and Drug Administration (FDA) has approved blood-forming stem cells. The blood-forming stem cells are also known as hematopoietic progenitor cells that are derived from umbilical cord blood. The growing approvals for stem cell and gene therapies are eventually leading to the high demand for cryopreservation equipment.

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Prominent players operating in the cryopreservation equipment market include Thermo Fisher Scientific Inc., Gold Sim Cellular Science LLC, Brooks Automation, Inc, Avantor, Inc., Hamilton Company, PHC Holdings Corporation, General Electric Company, Cryoport Systems, LLC., Antech Group Inc., Cryofab, BioLife Solutions, and ZhongkeMeiling Cryogenics Company Limited.

Market players are launching new and innovative products and services to maintain their position in the cryopreservation equipment market. In May 2021, Stirling Ultracold has been acquired by BioLife Solutions, Inc for cell and gene therapies and the broader biopharma market. In return for all of Stirlings outstanding shares, BioLife issued 6,646,870 shares of ordinary stock.

The COVID-19 pandemic has had a mixed impact on the cryopreservation equipment market. Restricted access to family planning services as well as diverted focus of people due to economic uncertainties and recession, and disturbed work-life balance have led to rise in egg and embryo freezing activities at fertility clinics during the pandemic. As a result, the rising use of cryopreservation equipment is boosting the market growth. Furthermore, supply chain disruption caused due to congestion of ports and disturbances in other transport means has substantially affected the distribution of cryopreservation equipment and other accessories.

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Based on type, the cryopreservation equipment market is segmented into freezers, sample preparation systems, and accessories. In 2020, the freezers segment held the largest share of the market, and it is expected to register the highest CAGR during 20212028. In ultracold freezers, liquid nitrogen is used for the successful preservation of more complex biological structures by virtually seizing all biological activities.

Following are a few instances of stem cell and gene therapies approved by the FDA and other regulatory bodies.

In February 2021, Bristol Myers Squibb (Juno Therapeutics, Inc.) received an FDA approval for Breyanzi, a CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy. The CAR-T cell therapy is used for treating relapsed or refractory large B-cell lymphoma in adults.In March 2021, Novartis AG received approval from the Health Sciences Authority of Singapore for the commercialization of the first CAR-T therapy named Kymriah, which is claimed as a one-time treatment procedure run individually for each patient. The therapy was approved under the new cell, tissue, and gene therapy products (CTGTP) regulatory framework.In July 2020, Kite, a Gilead Company, received an approval from the US FDA for its Tecartus (formerly known as KTE-X19) CAR-T cell therapy. The therapy is designed for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL).In May 2019, Vericel Corporation received an approval for its MACI (autologous cultured chondrocytes on porcine collagen membrane).In December 2017, Spark Therapeutics received an approval from the US FDA for Luxturna. It is a one-time gene therapy product for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy.

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Cryopreservation Equipment Market revenue to cross USD 11255.02 million by 2028 says, The Insight Partners - Digital Journal

AVITA Medical

Funds will support completion of the ongoing pivotal clinical trial

VALENCIA, Calif. and MELBOURNE, Australia, March 21, 2022 (GLOBE NEWSWIRE) -- AVITA Medical, Inc. (NASDAQ: RCEL, ASX: AVH), a regenerative medicine company that is developing and commercializing a technology platform that enables point-of-care autologous skin restoration for multiple unmet needs, announced today that the Biomedical Advanced Research and Development Authority (BARDA) has modified its existing contract with the Company to support AVITA Medicals clinical trial in soft tissue reconstruction. BARDA is a part of the Office of the Assistant Secretary for Preparedness and Response (ASPR) at the U.S. Department of Health and Human Services (HHS).

We are extremely pleased that BARDA is supporting advanced treatment options for soft tissue reconstruction, said Dr. Mike Perry, Chief Executive Officer of AVITA Medical. The RECELL System has already proven itself as a safe and effective tool for those with burns, and we are committed to expanding its use to include all acute wounds. We are pleased BARDA recognizes the potential it holds for a broader group of patients experiencing trauma. BARDA has been an outstanding partner, and we are excited to continue our work to expand the indication for the RECELL System with their support.

Soft tissue reconstruction is of particular concern to BARDA and AVITA Medical, as skin grafting, the current standard of care for soft tissue reconstruction, requires the harvesting of donor skin which can result in an additional wound to the patient. Significant pain, delayed healing, risk of infection, the need for multiple procedures, discoloration and scarring are associated with donor site wounds. While skin grafting is commonly associated with burn treatment, in 2017, approximately 80% of acute wounds that required skin grafting were non-burn related injuries accounting for more than 200,000 procedures in the U.S.i

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AVITA Medical is currently completing a pivotal trial for the use of the RECELL System for soft tissue reconstruction. Currently, the RECELL System is indicated in the U.S. for treatment of acute thermal burns. The clinical trial will compare the clinical performance of conventional autografting to that of widely meshed autografting with the RECELL System on acute non-burn full-thickness skin defects, with the goal of demonstrating that less donor skin is needed without compromising healing outcomes. Topline data from the trial will be shared later this year.

AVITA Medical has had a long-term positive relationship with BARDA since September 2015 and was of fundamental importance to the Company being able to achieve premarket approval for the RECELL System in late 2018.

This project has been funded in whole or in part with Federal funds from the Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority, under Contract No. HHSO100201500028C

ABOUT AVITA MEDICAL, INC.AVITA Medical is a regenerative medicine company with a technology platform positioned to address unmet medical needs in burns, chronic wounds, and aesthetics indications. AVITA Medicals patented and proprietary collection and application technology provides innovative treatment solutions derived from the regenerative properties of a patients own skin. The medical devices work by preparing a RES REGENERATIVE EPIDERMAL SUSPENSION, an autologous suspension comprised of the patients skin cells necessary to regenerate natural healthy epidermis. This autologous suspension is then sprayed onto the areas of the patient requiring treatment.

AVITA Medicals first U.S. product, the RECELL System, was approved by the U.S. Food and Drug Administration (FDA) in September 2018 and a new ease-of-use design was approved in 2022. The RECELL System is indicated for use in the treatment of acute thermal burns. The RECELL System is used to prepare Spray-On Skin Cells using a small amount of a patients own skin, providing a new way to treat severe burns, while significantly reducing the amount of donor skin required. The RECELL System is designed to be used at the point of care alone or in combination with autografts depending on the depth of the burn injury. Compelling data from randomized, controlled clinical trials conducted at major U.S. burn centers and real-world use in more than 10,000 patients globally reinforce that the RECELL System is a significant advancement over the current standard of care for burn patients and offers benefits in clinical outcomes and cost savings. Healthcare professionals should read the INSTRUCTIONS FOR USE - RECELL Autologous Cell Harvesting Device (https://recellsystem.com/) for a full description of indications for use and important safety information including contraindications, warnings, and precautions.

In international markets, our products are marketed under the RECELL System brand to promote skin healing in a wide range of applications including burns, chronic wounds, and aesthetics. The RECELL System is TGA-registered in Australia and received CE-mark approval in Europe. To learn more, visit http://www.avitamedical.com.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This press release includes forward-looking statements. These forward-looking statements generally can be identified by the use of words such as anticipate, expect, intend, could, may, will, believe, estimate, look forward, forecast, goal, target, project, continue, outlook, guidance, future, other words of similar meaning and the use of future dates. Forward-looking statements in this press release include, but are not limited to, statements concerning, among other things, our ongoing clinical trials and product development activities, regulatory approval of our products, the potential for future growth in our business, and our ability to achieve our key strategic, operational and financial goal. Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Each forward-looking statement contained in this press release is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statement. Applicable risks and uncertainties include, among others, the timing of regulatory approvals of our products; physician acceptance, endorsement, and use of our products; failure to achieve the anticipated benefits from approval of our products; the effect of regulatory actions; product liability claims; risks associated with international operations and expansion; and other business effects, including the effects of industry, economic or political conditions outside of the companys control. Investors should not place considerable reliance on the forward-looking statements contained in this press release. Investors are encouraged to read our publicly available filings for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this release, and we undertake no obligation to update or revise any of these statements.

This press release was authorized by the review committee of AVITA Medical, Inc.

FOR FURTHER INFORMATION:

i 2017 Procedural Data. 2019 DR/Decision Resources, LLC

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AVITA Medical Announces Modification of BARDA Contract to Advance Development of RECELL System in Soft Tissue Reconstruction - Yahoo Finance

TheGlobal Cell Therapy Marketwas worth USD7.8 billion in 2021, according to a new analysis released by Maximize Market Research, and is expected to rise to USD 20.2 billion by 2027, with a CAGR of 14.5% percent over the forecast period. From the markets perspective, its ever-changing trends, industrial environment, existing market features, and the current short-term and long-term influence on the market

the research will aid decision-makers in developing the outline and strategies for organisations by region.

The implantation of a human cell to replace or repair damaged tissue or cells is known as cellular therapy. Therapy typically consists of live cells that are safely injected, implanted, or grafted into the patients body to have a therapeutic effect. T-cell and stem cell treatment are two types of cell therapy that are used to combat cancer via cell mediated immunity or to repair damaged tissues. For patients with long-term ailments, cell therapy has become a popular treatment option.

Cell Therapy Market Scope and Dynamics:

The Maximize Market Research report contains a detailed study of factors that will drive and restrain the growth of the Cell Therapy Market Globally. Significant advances in cell therapy, a growing emphasis on regenerative medicine, increased R&D activities in the life sciences sector to develop advanced cellular therapies, and the rising prevalence of cancer, musculoskeletal disorders, cardiovascular diseases, autoimmune disorders, and neurological diseases are all driving the global cell therapy market revenue growth.

Other significant factors driving global market revenue growth include increased awareness and commercialization of stem cell therapies, an increase in the number of clinical trials of new cell therapies, an increase in the use of human cells in cell therapy research and development, and an increase in cellular therapy manufacturing under Good Manufacturing Practices (GMP) supervision. Increased government investments in the healthcare industry, as well as increased collaborations between pharmaceutical and biotechnology behemoths and leading research institutes for the development of advanced cellular therapies for cancer, cardiovascular disease, and other severe chronic diseases, are expected to boost global cell therapy market revenue growth in the coming years.

The Impact of COVID-19 on the Cell Therapy Market:

The COVID-19 pandemic has impacted the majority of biopharmaceutical companies, but several cellular treatment development companies have seen a significant negative impact, which can be related to logistical issues as well as the manufacturing models used in this field. Furthermore, large and reliable funding is required to ensure successful commercial translation of cell-based medicines, a factor that was negatively impacted in 2020, affecting market growth even more.

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Cell Therapy Market Region Insights:

Regional analysis is another highly comprehensive part of the research and analysis study of the global Cell Therapy Market presented in the report. The global cell treatment market is dominated by North America. In 2020, North America held a total market share of 14.5%percent, as new institutions and institutes invest in R&D to propel cell therapy forward. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Harvard Stem Cell Institute, and Yale Steam Cell Center are among the main universities in the United States that are involved in new research in cell regenerative technologies. During the forecasted period, Asia Pacific is expected to increase at a significant rate of 14.5%percent. China, South Korea, and Japan are spending extensively in regenerative medicine and stem cell therapies. Certain government-funded institutes are devoted to R&D with the goal of pushing the market forward.

What does the report include?

The study on the Global Cell Therapy Market includes qualitative characteristics such as drivers, constraints, and opportunities.The research looks at the current and future rivals in the Global Cell Therapy Market, as well as their product development strategies.The study examines the market in both qualitative and quantitative terms, and it is separated into three segments: component, deployment type, organisation size, and industry. Furthermore, the report provides comparable statistics for the key regions.For each of the above-mentioned segments, actual market sizes and predictions have been presented.

Cell Therapy Market Segmentation:

Global Cell Therapy Market, by Therapy Type:

AutologousAllogeneic

Global Cell Therapy Market, by Cell Type:

T-CellStem Cell

Global Cell Therapy Market, by Application:

MalignanciesMusculoskeletal DisorderAutoimmune DisorderDermatologyOthers

Global Cell Therapy Market, by End User:

Hospitals and clinicsAcademics and Research Institutes

By Region:

North AmericaEuropeAsia PacificSouth AmericaMiddle East and Africa

Key Players in Cell Therapy Market:

Kolon TissueGene Inc.Anterogen Co. Ltd.JCR Pharmaceuticals Co., Ltd.Castle Creek Biosciences, Inc.The Future of Biotechnology, MEDIPOSTOsiris Therapeutics, Inc.PHARMICELL Co., LtdTameika Cell Technologies, Inc.Cells for CellsNuVasive, Inc.Vericel CorporationCelgene CorporationThermo Fisher Scientific Inc.Merck KGaADanaher CorporationBecton, Dickinson, and CompanyLonza GroupSartorius AGTerumo BCTFresenius Medical Care AG & Co. KGaA

To Get a Detailed Report Summary and Research Scope of Cell Therapy MarketClick here @https://www.maximizemarketresearch.com/market-report/cell-therapy-market/126471/

About Maximize Market Research:

Maximize Market Research, a global market study firm with a dedicated team of specialists and data, has conducted thorough research on the Cell Therapy Market. Maximize Market Research is well-positioned to assess and predict market size while also taking into account the competitive landscape of the various industries. Maximize Market Research has a strong unified team of industry professionals and analysts across sectors to guarantee that the whole industry ecosystem, as well as current developments, new trends, and futuristic the technology effect of uniquely particular industries is taken into consideration.

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Cell Therapy Market is Expected to Grow by USD 20.2 Billion Progressing at a CAGR of 14.5% By Forecast 2027 - Digital Journal

Visiongain Ltd

Visiongain has published a new report on Viral Vectors and Plasmid DNA Manufacturing Market 2021-2031. Forecasts by Vector Type (Adenovirus, Retrovirus, Plasmid DNA, AAV, Lentivirus, Others), Application (Antisense & RNAi, Gene Therapy, Cell Therapy, Vaccinology), Disease (Oncology, Genetic Disorders, Infectious Diseases, Others), End-Use (Pharma and Biopharma Companies, Research Institutes), Region (North America, Europe, Asia Pacific, Latin America, Middle East, and Africa), PLUS COVID-19 Recovery Scenarios

Global viral vectors and plasmid DNA manufacturing market size is estimated to be valued at US$420.7million in 2020 and is anticipated to reach US$2,381.5 million in 2031 while growing at a CAGR of17.4% during the forecast period from 2021 to 2031.

Download Exclusive Sample of Report @ https://www.visiongain.com/report/viral-vectors-manufacturing-market-2021/#download_sampe_div

COVID-19 Impact on the Viral Vectors and Plasmid DNA Manufacturing Market

Due to increases in the therapies in progress, the dosages provided, & the patient populations targeted, viral vector production capacity has become increasingly reduced in recent years. The condition is aggravated by COVID-19. The number of companies developing innovative medicines such as cell, gene, & tissue-based therapies surpassed 1,000 in the first half of 2020, according to the ARM (Alliance for Regenerative Medicine). Since 2015, that represents an upsurge of almost 50%. Increases in clinical trial activity have corresponded to the emergence of successful advanced therapy companies.

Market Drivers

A Robust Pipeline for Gene Therapy and Viral Vectors

Almost 400 Embryonic cell and gene therapies address a broad variety of diseases. The overlapping areas of biomedical science with common therapeutic targets that target DNA or RNA within or outside the body are cell and gene therapy. To optimize functioning or tackle the disease, all techniques aim to alter genetic material. Specifically, gene therapy uses genetic material, or DNA, to cure an inherited or acquired disorder by modifying a patient's cells. The injection or transplantation of whole cells into a recipient for the treatment of an inherited or acquired disorder is cell therapy.

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Increasing Capacities by Manufacturers Owing to Rising Demand

There is a growing need for realistic production methods for viral vectors that can be quickly standardized and scaled since cell and gene therapies have the ability to progress rapidly from clinical trials through commercialization. Brammer Bio and Pall Biotech are both designing and applying state-of-the-art solutions designed to speed up process growth and scale-up for the manufacture of viral vectors through ongoing efforts. While biological drug substances with lower molecular weight are often generated through fermentation, larger recombinant proteins, and monoclonal antibodies (mAbs) are usually manufactured using well-established platform processes, accounting for the largest fraction of biologics on the market today. Consequently, manufacturing equipment has been built for the production ofmAbs, and this room is well serviced by suppliers of equipment.

Market Opportunities

The rise in the Development of Allogeneic and Autologous Cell Therapy

The more commercially appealing development of allogeneic cell therapy currently dominates over the production of autologous cell therapy, while clinical research in support of patient-specific therapy is convincing. There are opportunities for both autologous and allogeneic cell therapies to be developed, which differ greatly in their production requirements, patient administration paths, and cost structures.

In an autologous transplant, the patient's own stem cells are used for transplantation purposes for the treatment of many diseases such as cancer. The stem cells are obtained from either bone marrow or blood and are then frozen for harvest purposes. High doses of chemo or radiation therapy damage different cells of the body. Thus, after these therapies during cancer treatment, the thawed stem cells are reintroduced into the patient's body to restore the damaged cells. As the patient's own cells are used during autologous stem cell transplantation, there would be no risk of transplant rejection. This type of transplant is mainly utilized for the treatment of types of leukemia, lymphomas, and multiple myeloma. It is occasionally used to treat cancers in children and follicular lymphoma.

Competitive Landscape

Some of the major companies operating in the global Viral Vectors and Plasmid DNA Manufacturing market are Merck KGaA, Lonza, FUJIFILM Diosynth Biotechnologies U.S.A., Inc., Cobra Biologics Ltd., Brammer Bio, Waisman Biomanufacturing, Genezen, YPOSKESI, Advanced BioScience Laboratories, Inc. (ABL, Inc.), Novasep Holding S.A.S, ATVIO Biotech Ltd, Vigene Biosciences, Inc., Cytiva, CEVEC Pharmaceuticals GmbH, Batavia Biosciences B.V, Biovian Oy, Wuxi AppTec Co., Ltd., VGXI, Inc., Paragon Bioservices, Inc., MiltenyiBiotec GmbH, SIRION Biotech GmbH, Virovek Incorporation, BioNTech IMFS GmbH, VIVEbiotech S.L., Creative Biogene, Vibalogics GmbH, Cell and Gene Therapy Catapult, BlueBird Bio, Addgene, Inc., Aldevron, L.L.C., Audentes Therapeutics, and BioMarin Pharmaceutical.

Find quantitative and qualitative analyses with independent predictions. Receive information that only our report contains, staying informed with this invaluable business intelligence.

To access the data contained in this document please email contactus@visiongain.com

Information found nowhere elseWith this new and exclusive report, you are less likely to fall behind in knowledge or miss out on opportunities. See how our work could benefit your investment, research, analyses, and decisions. Visiongain's study is for everybody needing commercial analyses for the Viral Vectors and Plasmid DNA Manufacturing market and leading companies. You will get the most recent data, opportunities, trends, and predictions.

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Do you have any custom requirements we can help you with? Any need for a specific country, geo region, market segment or specific company information? Contact us today, we can discuss your needs and see how we can help: catherine.walker@visiongain.com

About Visiongain

Visiongain is one of the fastest growing and most innovative, independent, market intelligence around, the company publishes hundreds of market research reports which it adds to its extensive portfolio each year. These reports offer in-depth analysis across 18 industries worldwide. The reports cover a 10-year forecast, are hundreds of pages long, with in depth market analysis and valuable competitive intelligence data. Visiongain works across a range of vertical markets, which currently can influence one another, these markets include automotive, aviation, chemicals, cyber, defense, energy, food & drink, materials, packaging, pharmaceutical and utilities sectors. Our customized and syndicated market research reports mean that you can have a bespoke piece of market intelligence customized to your very own business needs.

Contact:

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Global Viral Vectors and Plasmid DNA Manufacturing Market is anticipated to reach US$2,381.5 Million in 2031: Visiongain Research Inc - Yahoo Finance

Exhibit features live presentations and interactive content highlighting innovative allograft biologics for bone healing and joint reconstruction

CHICAGO, March 22, 2022 /PRNewswire/ -- LifeNet Health, the world leader in allograft biologics, is showcasing its comprehensive portfolio of advanced biomaterials for fractures, fusions, and joint repair and reconstruction at the 2022 AAOS Annual Meeting (Booth #3445) March 23-25 in Chicago.

Its featured solutions include:

"Having the right biologics can be critical to ensuring patients heal successfully," said Daniel Osborne, LifeNet Health Vice President of Global Marketing and Commercial Strategy. "Our combination of proprietary technologies and clinical insight allows us to offer better biologics, and we look forward to sharing data at AAOS that illustrates how our solutions provide efficiency in the OR and efficacy for patients."

LifeNet Health's presence at AAOS will highlight the robust clinical and technical data behind its solutions, such as recent studies that show ViviGen supports outcomes equivalent to autograft1,2 and superior to mesenchymal stem cell (MSC)-based grafts in even high-risk foot and ankle procedures.

Live Presentations In-Person or OnlineIn addition to its exhibit hall and digital presence, LifeNet Health's Medical Science Liaison Elena Gianulis, PhD, will lead live, in-booth presentations on two of the most-advanced osteobiologics solutions available, ViviGen and PliaFX Prime.

The first presentation explores the growing body of evidence showing ViviGen supports healing in trauma, extremity and spine procedures. The second session will focus on how the unique technology of PliaFX Prime 100% bone moldable, demineralized fibers supports effective outcomes while providing exceptional value to hospitals. Dr. Gianulis' talks will take place March 23 and 24 at 10:10 a.m. and 3:10 p.m. CST. They also will be streamed live to LifeNet Health's online showcase.

Learn more about LifeNet Health's activities at AAOS, as well as its portfolio of solutions for sports medicine, trauma, extremity and spine procedures, at http://www.LifeNetHealth.org/AAOS2021.

About LifeNet HealthLifeNet Health helps save lives, restore health, and give hope to thousands each year. It is the world's most trusted provider of transplant solutions from organ procurement to bio-implants and cellular therapies and a leader in regenerative medicine, while always honoring the donors and healthcare professionals who enable healing. For more information about LifeNet Health, go to http://www.lifenethealth.org.

SOURCE LifeNet Health

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LifeNet Health features best-in-class orthobiologic solutions at AAOS Annual Meeting - PR Newswire

By Dr. Greg Pursley ~ PC Wellness Centers

Thursday, January 20, 2022

If your joints and spine function properly, do they hurt? No. Pain occurs from damage. If there is no damage, there is no pain.

Heres how it works. Pain develops from damage. Damage comes from improper function. Improper function comes from imbalance in the joint and muscle. When the joint or spine stops functioning properly, either from a one-time injury that didnt heal correctly, or a repetitive trauma, it starts to get damaged which leads to inflammation, called arthritis, and if not corrected will lead to degenerative arthritis.

Arthritis stands for joint (Arth) and inflammation (Itis). Inflammation occurs in the body for two reasons. It causes irritation in the tissue, so you stay off it and floods the area with healing properties. Degenerative Arthritis occurs due to three factors: 1) How bad is it working? (Function) 2) How much you are using it? (Pressure) 3) How long it has been happening? (Time)

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Simply put, if there is a joint in your body that is not working properly, you are using it a lot, and if it has been happening for a long time it will turn into degenerative arthritis. If you restore the proper function of that joint the degenerative arthritis will stop.

This leads to two treatment options. The first option is focusing on improving the function by healing the tissue and improving joint mobility and muscle balance with therapy. This option should be used if you would like to return to doing the things that the pain has stopped you from doing.

The other option is symptom reduction through medications, steroid injections and surgery. This option should be used for pain relief but does not offer any functional improvements or restoring proper use.

The clinicians at PC Medical Centers are experts in helping the body restore the function and eliminate the need for meds or surgery in the future by using regenerative medicine, joint mobility, and therapy at the same time.

See more here:
Can regenerative medicine help prevent joint and spine surgery? - Southeast Missourian