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Category Archives: Regenerative Medicine

Regenerative Medicine – DMOS – Des Moines Orthopedic Centers

Posted: October 12, 2018 at 11:48 am

What regenerative medicine options do you offer?

DMOS offers three types of regenerative medicine options, all commonly used to treat different musculoskeletal conditions, including arthritis, muscle strains, tendon and ligament injuries.

The injection type differs based on the patient assessment and their individualized needs.

By definition, PRP is a collection of growth factors (which are proteins that are important in the healing of injuries), that can have controlled levels of white and red blood cells, based on the healing process necessary. Laboratory studies have shown that the increased concentration of growth factors in PRP can potentially speed up the healing process. Many world-class athletes use PRP therapy to repair their sports injuries faster.

Technically, BMAC is a collection of growth factors and cells, which include stem cells. Physicians use BMAC when they believe the potential upside of containing mesenchymal stem cells (MSCs) is necessary for treatment.

This injection serves to help as a local anti-inflammatory and reset the bodys natural balance in the arthritic joint. In technical terms, APS is a denatured PRP that delivers proteins, which block arthritic pain receptors. APS may be the preferred course of treatment based on if the patient exhibits radiographic evidence of knee, hip or shoulder OA (osteoarthritis).

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Regenerative Medicine | PRP Therapy | Midwest Orthopaedics

Posted: October 12, 2018 at 11:48 am

Regenerative medicine promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells. Researchers prepare the stem cells in a lab beforehand, and are manipulated to specialize into specific types of cells, such as heart muscle cells, blood cells or nerve cells. While Stem cell therapy requires no invasive surgery, these stem cells called placental-derived mesenchymal stem cells (MSCs) are prepared beforehand, and injected directly into the area of pain or injury of your joint, muscle, ligament, or tendon. This procedures objective is simply to relieve pain, while the new stem cells stimulate your body to repair itself and heal faster, by generating healthy tissue. Stem cell therapy has recently had a major breakthrough within the medical field, particularly in the field of Orthopedics, due to the potential of these stem cells ability to allow the body to heal itself, and possibly eliminate arthritis pain and other chronic or acute pain from injuries. Benefits of Regenerative Medicine:

What is it? Platelet-rich plasma (PRP) therapy is a revolutionary procedure that uses components of the bodys own blood cells to stimulate the natural healing process in certain orthopedic conditions.The bodys first response to any soft tissue injury (ligaments and tendons) is to deliver platelet cells. Filled with healing and growth factors, the platelets jump-start the repair process. The platelets are separated from the rest of the blood cells and put through a process called centrifugation, which increases the platelets concentration. These platelets are then injected into the area needed with different concentrations of other cells to enhance the bodies healing process and decrease pain. This quick procedure can also provide effective pain relief, eliminating the need for surgery and prolonged recovery.

If you are a candidate for regenerative medicine or PRP therapy, call Midwest Orthopaedics in Shawnee Mission or Overland Park, Kansas at(913) 362-8317orrequest an appointment online.

Amniotic tissue has been used for many years to treat a variety of medical issues and has had excellent results. More recently there has been application to orthopedic issues such as arthritis and tendon/ligament healing. The amniotic membrane is a layer of the amniotic sac, which is donated after birth and does not contain fetal tissue. It is dehydrated and stored and then rehydrated at the time of injection. The process is very simple and similar to a cortisone injection. The injection can decrease inflammation and promote healing through multiple growth factors. It is safe and very effective.

Many orthopedic conditions can be treated with PRP or Amnitoic Membrane injections, including chronic pain and stiffness associated with osteoarthritis. If you have pain, limited mobility, swelling, or sports injuries, chances are regenerative medicine therapy can benefit you, and has shown promising results, treating these common conditions:

If you are a candidate for regenerative medicine therapy, call Midwest Orthopaedics in Shawnee Mission or Overland Park, Kansas at(913) 362-8317orrequest an appointment online.

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The McGowan Institute for Regenerative Medicine | UPMC

Posted: October 12, 2018 at 11:48 am

Merging Science with Technology to Treat Disease

Regenerative medicine uses clinical procedures to repair or replace damaged or diseased tissues and organs, versus some traditional therapies that just treat symptoms.

To realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs, the University of Pittsburgh School of Medicine and UPMCestablished the McGowan Institute for Regenerative Medicine. The McGowan Institute serves as a single base of operations for the Universitys leading scientists and clinical faculty working to develop tissue engineering, cellular therapies, and artificial and biohybrid organ devices.

The McGowan Institute is the most ambitious regenerative program in the nation, coupling biology, clinical science, and engineering. Success in our mission will impact patients lives, bring economic benefit, serve to train the next generation of researchers, and advance the expertise of our faculty in the basic sciences, engineering, and clinical sciences. Our efforts proudly build upon the pioneering achievements of the Thomas E. Starzl Transplantation Institute.

While there are certain select therapies based on regenerative medicine principles now in clinical use, much work lies ahead to realize the potential of this growing field. Advances in the underlying science, engineering strategies to harness this science, and successful commercial activities are all required to bring new therapies to patients.

The McGowan Institute sponsors a podcast series on regenerative medicine. Listen to some of the world's leading regenerative medicine researchers and physicians talk about their work.

Listen to the most recent podcasts.

Dr. Steven Little Receives International Young Investigator Award for Development of Novel Drug Delivery Systems

The Controlled Release Society has announced that McGowan Institute for Regenerative Medicine faculty member and University of Pittsburgh professor Steven Little, PhD, is the recipient of its 2018 Young Investigator Award. The honor annually recognizes one individual in the world, 40 years of age or younger, for outstanding contributions in the science of controlled release.

Learn more.

Dr. Stephen Badylak at the World Advanced Therapies & Regenerative Medicine Congress

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From Technology Developed at the McGowan Institute, LyGenesis Closes $3 Million Series A Financing to Advance Its Organ Regeneration Technology to the Clinic

Learn more.

Living Donor Liver Transplant: A Lifesaving Option for All Patients with Liver Failure

Learn more.

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Syracuse Regenerative Medicine – rsmmd.com

Posted: October 12, 2018 at 11:48 am

Regenerative injection therapy for tendons, ligaments, muscles and spine conditions.

About Regenerative Injection Therapies (RIT).

Regenerative injections broadly deals with the use of biologic materials to enhance the body's own repair mechanisms to help heal previously non-reparable tissues. The goal of these non-surgical procedures is to help heal the source of pain, not to simply mask it. The exact mechanism is evolving, but science points toward enhancing and stimulating healing and stabilizing factors of the local tissues.

Regenerative injection treatments offer a viable alternative for individuals considering elective orthopedic surgery or joint replacement due to arthritis or injury. Patients experience very little down time and they typically avoid the long, painful rehabilitation periods that can follow surgery. Since 2014, Regenerative Spine & Musculoskeletal Medicine has provided state of the art regenerative cellular therapies to help patients find relief from pain without invasive surgeries.

The Procedures:

Prolotherapy:

This treatment involves injecting a proliferant (usually dextrose) into weakened or injured joints, ligaments, or tendons. With a precise injection of a mild irritant solution directly on the site of injury, prolotherapy creates a mild, controlled inflammation that stimulates the bodys natural healing mechanism to lay down new tissue on the weakened area. Additional treatments repeat the process, allowing a gradual build-up of tissue to help restore strength to the area and relieve pain. Injection sessions are done 3-6 weeks apart, and usually a series of 3 injection sessions is done and then the response is assessed. The average number of treatment sessions is between 3 and 6.

Perineural Injections:

Peri-neural injections involves injecting diluted dextrose solutions superficially along the pathway of chronically inflamed nerves. They can be used for any part of the body where nerve pain exists. After the first treatment, pain relief may initially last for a period of four hours to four days. Repeated treatments (usually 6-8 sessions) are necessary, given every 1-3 weeks.

Platelet Rich Plasma Therapy (PRP):

During PRP therapy, a small vial of your own blood is drawn and placed in a centrifuge to separate the platelet-rich plasma from other blood components. This highly concentrated platelet-rich layer contains growth factors and a variety of cells. Growth factors stimulate local cells for tissue repair and remodeling. Your PRP is injected into and around the area of injury. Several injections may be done at the injured site at one time to fully treat the area. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Cell Therapy:

Stem cells(MSCs) are readily available and can be harvested from your bone marrow through a needle. Once injected into an area of injury, MSCs secrete bioactive molecules to modulate repair and offer the potential to regenerate injured cartilage, ligament, tendons, or muscle. MSCs can be thought of as the manager of your bodys innate healing potential. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Lipoaspirate (Fat) Graft:

Lipo aspirate therapy is a gentle process that uses your body's own fat tissue to cushion and support areas of injury or damage as your body heals itself. The fat is taken from the stomach, flank or thigh areas using a local anesthetic. It is especially effective for areas where there are soft tissue defects such as tears or arthritis. This type of injection is used in collaboration with PRP or bone marrow aspirate cell injections, which deliver growth factors to the injured area.

Alpha 2 Macroglobulin (A2M):

A2M is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown and progression of arthritis. A small vial of your own blood is drawn and placed in a centrifuge to separate the blood components, then is injected. A2M attaches to and removes the destructive enzymes that damage cartilage cells in the joint. The A2M is soothing to the joint and acts like a natural anti-inflammatory.

What parts of the body can benefit from regenerative treatments?

Spinal Injections:

Spinal procedures can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Epidural nerve blocks, spine ligaments, facet joint, sacroiliac joint and intervertebral disc injections with platelets/growth factors may be performed. The injection is performed in the same manner as conventional spine injections with the use of x-ray guidance to ensure accurate placement of the treatment.

Joint, tendon, ligament, muscle Injections:

Musculoskeletal injections can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Whenever appropriate the injection is performed with the use of x-ray or ultrasound guidance along with full safety and sterile precautions.

What conditions can benefit from regenerative injections?

Will insurance cover my Regenerative Injection?

Insurance companies will not pay for the cost of the Regenerative treatment. The cost of your injection can be discussed after your visit once you and the provider have decided on the most appropriate treatment option for you.

What sets Regenerative Spine & Musculoskeletal Medicine apart from others?

As the popularity of RIT grows, other medical professionals are beginning to perform these procedures, with great variation in training and background. Rene S. Melfi, M.D. is a physician specializing in non-surgical spine, orthopedic and musculoskeletal performance and function. With three national board certifications and Fellowship training in interventional spine and musculoskeletal medicine, Dr. Melfi has been performing spine and orthopedic injections since 2002. Dr. Melfi is also certified in Integrative Medicine and Acupuncture, and offers suggestions to enhance your results with recommendations for proper nutrition and supplements.

Your procedure at Regenerative Spine & Musculoskeletal Medicine is carefully chosen based on review of the latest evidence based medicine. Image guidance with x-ray or ultrasound is used, when appropriate, to confirm accurate placement of cellular therapy to optimize your results.

Call today for your appointment and a premier experience in Regenerative Injection therapy in Central New York 315-701-4000.

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Regenerative Medicine – directorthocare.com

Posted: October 12, 2018 at 11:47 am

Regenerative medicine is a game-changer in the world of medicine. Treatments include: Stem Cell Therapy, PRP (Platelet Rich Plasma) Therapy and Amniotic Stem Cell Therapy (Amnion). Each custom treatment option may help to heal damaged tissues and organs, offering solutions and hope for people whose conditions have proven beyond repair previously.

I didnt know anything about PRP when I went to my appointment with Dr. Hall. I was able to do some research before I had anything done. The stem cells come from my own bone marrow. Stem cell treatment is fairly new, but shows positive results. I decided that it was something that could help me. I trust Dr. Hall. Dr. Hall removed the stem cells from my hip and injected them into my knees while I was in surgery under anesthesia.

I was in physical therapy after the surgery. Now Im back in the gym three days a week, exercising on the elliptical machine, weight training and in yoga classes. I walk five miles four or five days a week.

In six weeks, I was at 133 degrees range of motion, which was only 4 degrees behind my good leg. I attribute my advanced recovery to the outstanding hands of the DOC surgeon, the PRP/stem cell therapy, and Mike at ATI Physical Therapy.I attribute my advanced recovery to the outstanding hands of the DOC surgeon, the PRP/stem cell therapy, and Mike at ATI Physical Therapy.

If you are reading this testimonial and questioning whether the extra money spent on the PRP and stem cell therapy are worth it, I would highly recommend that you take out a loan if necessary in order to benefit from this healing therapy.

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Regenerative Medicine Florida Musculoskeletal Institute

Posted: October 12, 2018 at 11:47 am

Stem Cell Injections

The use of amniotic fluid and stem cells in medicine is much older and more widespread than people might think. It has been used to diagnose prenatal conditions for more than 70 years, and to treat injury, pain and scarring for nearly a century. What makes this therapy so exciting is the wealth of research and real-life application that supports its usefulness in not only relieving pain and assisting healing, but also in regenerating damaged soft tissues, including ligaments, tendons and cartilage. What this means to patients is the genuine possibility of healing injured tissues, making amniotic fluid/stem cell injection a revolutionary approach to managing, and even healing, ligament damage, tendonitis and osteoarthritis.

FMI utilizes NuCel bioactive amniotic suspension (HCT/P) to treat and repair soft tissue and to assist in certain types of orthopaedic surgery. NuCels more than 17,000 applications have proven it safe and effective at reducing pain, inflammation and scarring, and assisting in healing.

NuCel is derived from amniotic membranes from consenting donors, not from fetal tissue. NuCel contains concentrated multipotential stem cells, which are cells with the ability to make more of themselves, and growth factors, which are the naturally-occurring agents that can stimulate cell migration to injury sites to actively repair tissues. These agents are combined with all-natural hyaluronic acid and proteins to assist in delivery and support healing and healthy cell regeneration. NuCel is fully regulated by the FDA and has been used in thousands of patients without a single reported rejection, allergic response or other adverse reaction.

NuCel is not presently covered by insurance, which may cause some patients to be concerned about cost. But because NuCel has the potential to actually heal injuries and pain conditions, it can delay and even prevent the need for surgery, making it a preferred option for some patients.

FMIs Dr. Carl Ollivierre is not only a provider of NuCel, but also a patient who has successfully used it to treat his own posterior tibial tendinitis. Dr. Ollivierre provides NuCel injections at both FMI locations.

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Regenerative Medicine Florida Musculoskeletal Institute

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RMI | National Institutes of Health (NIH)

Posted: October 12, 2018 at 11:47 am

Background

Regenerative medicine is an emerging area of science that holds great promise for treating and even curing a variety of injuries and diseases. Regenerative medicine includes using stem cells and other technologiessuch as engineered biomaterials and gene editingto repair or replace damaged cells, tissues, or organs. Stem cell-based approaches are under development in labs around the world, and some have already moved into clinical trials. Such progress notwithstanding, much work remains to be done toward the development of safe and effective regenerative medicine products and to realize the full potential of this field.

The 21st Century Cures Act, passed in December 2016, established the Regenerative Medicine Innovation Project (RMIP) to accelerate the field by supporting clinical research on adult stem cells while promoting the highest standards for carrying out scientific research and protecting patient safety. In recognition of the integral role of the Food and Drug Administration (FDA) in the successful development of this field, NIH is leading the RMIP in coordination with FDA.

The 21st Century Cures Act authorizes $30 million in federal awards over four years (20172020) for the RMIP. Importantly, the Act requires award recipients to match the federal funds provided with at least an equal amount of non-federal funds.This matching requirement will amplify the federal investment and could help stimulate collaboration and develop key partnerships across the public and private sectors.

Congress allocated $2 million for the RMIP in FY 2017. To make optimal use of these funds, researchers were invited to submit applications for competitive revisions to support clinical studies involving adult stem cells. Eight awards were issued in September 2017.

On December 6-7, 2017, the NIH and FDA hosted a public Regenerative Medicine Innovation Workshop that brought together key stakeholders to explore the state of regenerative medicine clinical research involving adult stem cells with a focus on approaches to the development of safe and effective products. Video recordings from each session are available. The deliberations at this workshop were instrumental in helping to identify some of the major needs, opportunities, and challenges in the regenerative medicine field.

Input from the workshop and other sources informed the development of the next round of funding opportunity announcements (FOAs) published in August 2018. These FOAs solicit new investigator-initiated projects, which may either involve a clinical trial or entail late stage Investigational New Drug (IND)- or Investigational Device Exemption (IDE)-enabling clinical research. Applicants who have questions about these opportunities may consult our Frequently Asked Questions, and those with additional questions are encouraged to either consult the relevant program officer listed in the FOA, or write to RMIP@nih.gov.

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Regenerative Medicine Conferences | Tissue Science …

Posted: October 6, 2018 at 11:42 pm

About the Conference

Conference Series llc LTDinvites all participants to attend 11thInternational Conference on Tissue Engineering & Regenerative Medicinewhich is going to be held during October 18-20, 2018 at Rome, Italy mainly focuses on two key topics viz.Tissue EngineeringandRegenerative Medicine with basic theme Redefining Health Care through Regenerative Medicine.

Regenerative Medicine -2018 provides an ideal environment to discuss on recent strategies in tissue engineering and regenerative medicine for disease remediation and tissue repair.

11thInternational Conference on Tissue Engineering & Regenerative Medicinemainlyfocuses on Stem Cell Research and Tissue Engineering.Stem cell Researchincludes stem cell treatment for various disease and conditions includeDiabetes, Rheumatoid arthritis, Parkinson's disease, Alzheimer's disease, Osteoarthritis, Stroke and traumatic brain injury repair, Learning disability due to congenital disorder, Spinal cord injury repair,Heart infarction, Anti-cancer treatments, Baldness reversal, Replace missing teeth, Repair hearing, Restore vision and repair damage to the cornea, Amyotrophic lateral sclerosis, Crohn's disease, Wound healing, Male infertility due to absence of spermatogonial stem cells etc.,Tissue Engineeringincludes Bone tissue engineering, soft tissues, tissue imaging, tissue implant, cartilage and skin defects are a special focus along with applying basic science and engineering principles from diverse areas towards solving clinically relevant biomedical problems.

Conference Series llc LTDis a Worlds leading Event Organizer that organizes 1000+ Global Events inclusive of 300+ Conferences, 500+ Upcoming and Previous Symposiums and Workshops in USA, Europe & Asia with support from 1000 more scientific societies and publishes 700+ Open access journals which contains over 30000 eminent personalities, reputed scientists as editorial board members.

Targeted Audience:

Major Sessions:

Scaffolds Cord Blood & Regenerative Medicine Bone and Cartilage Tissue Engineering Stem Cells-Tools to Battle Cancer Novel Approaches in Guided Tissue Regeneration Clinical Medicine Clinical Trials with Stem Cells Biomaterials and Bioengineering Tissue Biomarkers Regeneration and Therapeutics Rejuvenation Immunotherapy Stem Cell Treatment for Diabetes Applications of Tissue Engineering and Regenerative Medicine Bioreactors in Tissue Engineering Biochips and Tissue Chips Cancer Stem Cells Tissue Regeneration Advances in Stem Cell Materials and Designs for Tissue Engineering Tissue Engineering and 3D Printing Whole Organ Engineering and Approaches Stem Cell Engineering (SCE)

Scaffolds

Scaffoldsare one of the three most important elements constituting the basic concept ofregenerative medicine, and are included in the core technology of regenerative medicine. Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field oftissue engineering(TE) aims to regenerate damagedtissuesby combining cells from the body with highly porous scaffoldbiomaterials, which act as templates fortissue regeneration, to guide the growth of new tissue. Scaffolds has a prominent role in tissue regeneration the designs, fabrication, 3D models, surface ligands andmolecular architecture, nanoparticle-cell interactions and porous of the scaffolds are been used in the field in attempts to regenerate different tissues and organs in the body. The worldstem cell marketwas approximately 2.715 billion dollars in 2010, and with a growth rate of 16.8% annually, a market of 6.877 billion dollars will be formed in 2016. From 2017, the expected annual growth rate is 10.6%, which would expand the market to 11.38 billion dollars by 2021.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

ISSCR 2018 Annual Meeting, June 20-23, 2018 Melbourne, Australia;Generating Diverse Cells and Networks in the Nervous System, Gordon Conference, July 29-August 3, 2018 Newport, RI, USA;6thCambridge International Stem Cell Symposium, September 19-21, 2018 Cambridge, UK;Modeling Cell-Cell Interactions Governing Tissue Repair & Disease, Gordon Conference, August 19-24, 2018 Waterville Valley, NH, USA;27thInternational Conference On Oncology Research & Cancer Stem CellsMay 10-12, 2018 Frankfurt, Germany;10thAnnual Conference On Stem Cell And Regenerative MedicineAugust 13-14, 2018 London, UK;7thInternational Conference And Exhibition On Cell And Gene TherapyMarch 15-17, 2018 London, UK.

Related Associations and Societies:

Europe:EuroStemCell (European Consortium for Stem Cell Research);German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);Norwegian Center for Stem Cell Research (NCSCR);

USA:California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS);International Society for Stem Cell Research (ISSCR);

Asia:

The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;Stem Cell Society Singapore (SCSS);

Tissue Regeneration

In the field of biology, regeneration is the progression of renewal, regeneration, and growth that makes it possible for genomes, cells, organ regeneration to natural changes or events that cause damage or disturbance. This study is carried out as craniofacial tissue engineering, in-situ tissue regeneration, adipose-derived stem cells for regenerative medicine which is also a breakthrough in cell culture technology. The study is not stopped with the regeneration of tissue where it is further carried out in relation with cell signalling, morphogenetic proteins. Most of the neurological disorders occurred accidental having a scope of recovery by replacement or repair of intervertebral discs repair, spinal fusion, and many more advancements. The global market for tissue engineering and regeneration products such as scaffolds, tissue implants, biomimetic materials reached $55.9 billion in 2010 and it is expected to reach $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%. It grows to $135 billion by 2024.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

ISSCR 2018 Annual Meeting, June 20-23, 2018 Melbourne, Australia;Generating Diverse Cells and Networks in the Nervous System, Gordon Conference, July 29-August 3, 2018 Newport, RI, USA;6thCambridge International Stem Cell Symposium, September 19-21, 2018 Cambridge, UK;Modeling Cell-Cell Interactions Governing Tissue Repair & Disease, Gordon Conference, August 19-24, 2018 Waterville Valley, NH, USA;27thInternational Conference On Oncology Research & Cancer Stem CellsMay 10-12, 2018 Frankfurt, Germany;10thAnnual Conference On Stem Cell And Regenerative MedicineAugust 13-14, 2018 London, UK;7thInternational Conference And Exhibition On Cell And Gene TherapyMarch 15-17, 2018 London, UK.

Related Associations and Societies:

Europe:EuroStemCell (European Consortium for Stem Cell Research);German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);Norwegian Center for Stem Cell Research (NCSCR);

USA:California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS);International Society for Stem Cell Research (ISSCR);

Asia:

The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;Stem Cell Society Singapore (SCSS);

Advances in Stem Cell

Since the beginning of there has been a effective research in the field of stem cell biology, recent advances in the field of stem cell research mainly focused in the translation of scientific insights into new therapies. It represents a new strategy for organ and tissue repair in several pathologies. Additional treatment strategies are urgently needed due to donor organ shortage that costs many lives every year and results in lifelong immunosuppression. Stem cells are characterized by the ability to renew themselves and differentiating into a various range of specialized cell types. Stem cells have potential to treat various diseases, genetic bone marrow disorders and the treatment of malignant. Being all other stem cell applications highly experimental, Moreover, there is a growing body of evidence showing that administration of stem cells leads to the successful regeneration of tissues or organ.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

10thWorld Congress And Expo On Cell & Stem Cell ResearchMarch 19-21, 2018 New York, USA;Generating Diverse Cells and Networks in the Nervous System, Gordon Conference, July 29-August 3, 2018 Newport, RI, USA;11thWorld Congress On Cell & Tissue ScienceMay 14-15, 2018 Tokyo, Japan;11thInternational Conference And Exhibition On Metabolomics & Systems BiologyMay 16-18, 2018 Tokyo, Japan;World Congress On Cell And Structural BiologyMay 28-29, 2018 Osaka, Japan;13thInternational Conference On Metabolomics And Systems BiologyJune 11-12, 2018 London, UK;10thGlobal Summit On Immunology And Cell BiologyMay 28-29, 2018 Osaka, Japan;World Congress On Stem Cell Biology And BiobankingAugust 20-21, 2018 Tokyo, Japan;2nd Annual Summit On Cell MetabolismSeptember 19 - 20, 2018 Philadelphia, USA.

Related Associations and Societies:

Europe:German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);ScanBalt Stem Cell Research Network;EuroStemCell (European Consortium for Stem Cell Research);Norwegian Center for Stem Cell Research (NCSCR);British Association of Tissue Banks.

USA:Regenerative Medicine Foundation;American association of tissue banks;California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS).

Asia:

Asia Pacific Association of Surgical Tissue Banking;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;The New South Wales Stem Cell Network;Korean Society for Stem Cell Research.

Materials and Designs for Tissue Engineering

Tissue engineering of musculoskeletal tissues, particularly bone and cartilage, is a rapidly advancing field. In bone, technology has centered on bone graft substitute materials and the development of biodegradable scaffolds. Recently, tissue engineering strategies have included cell and gene therapy. The availability of growth factors and the expanding knowledge base concerning the bone regeneration with modern techniques like recombinant signalling molecules, solid free form fabrication of scaffolds, synthetic cartilage, Electrochemical deposition, spinal fusion and ossification are new generated techniques for tissue-engineering applications. The worldwide market for bone and cartilage repairs strategies is estimated about $300 million. During the last 10/15 years, the scientific community witnessed and reported the appearance of several sources of stem cells with both osteo and chondrogenic potential.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

2nd Annual Summit On Cell Signaling And Cancer TherapySeptember 19 - 20, 2018 Philadelphia, USA;2ndAnnual Summit On Cell Therapy And Regenerative MedicineOctober 03-04, 2018 Atlanta, USA;Cellular Therapies2018 San Francisco, USA;4thInternational Conference On Central Nervous System Disorders & TherapeuticsNovember 12-14, 2018 Edinburgh, Scotland;10thGlobal Summit On Immunology And Cell BiologyMay 28-29, 2018 Osaka, Japan;World Congress On Stem Cell Biology And BiobankingAugust 20-21, 2018 Tokyo, Japan;2nd Annual Summit On Cell MetabolismSeptember 19 - 20, 2018 Philadelphia, USA.

Related Associations and Societies:

Europe:European Association of Tissue Banks;Norwegian Center for Stem Cell Research (NCSCR);ScanBalt Stem Cell Research Network;Danish Stem Cell Society (DASCS);Stem Cell Network North Rhine-Westphalia.

USA:American association of tissue banks;International Society for Stem Cell Research (ISSCR);Adult Stem Cell Research Network (ASCR);California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF)

Asia:

Korean Society for Stem Cell Research;Stem Cell Society Singapore (SCSS);Japanese Society for Regenerative Medicine;Australian Society for Stem Cell Research (ASSCR);Taiwan Society for Stem Cell Research;

Tissue Engineering and 3D Printing

Aims to fabricate of multifunctional scaffolds that meet the mechanical, structural, and nutritional requirements based on optimized models. Computer-aided three-dimensional (3D) printing technology is driving major innovations in many areas, such as engineering, manufacturing, art, education and medicine. It is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation. Recently, it has shown a great promise in tissue fabrication with structural control from micro- to macro-scale by using a layer-by-layer approach. It involves additional complexities, such as choice of materials, cell types, growth and differentiation factors, and technical challenges related to the sensitivities of living cells and the construction of tissues. It has been already used for the generation and transplantation of several tissues, including multi-layered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures. Other applications involve developing the high-throughput 3D-bioprinted tissue models for analysis, drug discovery, and pharmacological medicine. This track will cover several approaches that have advanced the field of 3D technology through novel fabrication methods of tissue engineering constructs.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

11thWorld Congress On Cell & Tissue ScienceMay 14-15, 2018 Tokyo, Japan;11thInternational Conference And Exhibition On Metabolomics & Systems BiologyMay 16-18, 2018 Tokyo, Japan;World Congress On Cell And Structural BiologyMay 28-29, 2018 Osaka, Japan;13thInternational Conference On Metabolomics And Systems BiologyJune 11-12, 2018 London, UK;10thGlobal Summit On Immunology And Cell BiologyMay 28-29, 2018 Osaka, Japan;6thCambridge International Stem Cell Symposium, September 19-21, 2018 Cambridge, UK

Related Associations and Societies:

Europe:The Swiss Stem Cell Network;Danish Stem Cell Society (DASCS);Stem Cell Network North Rhine-Westphalia.EuroStemCell (European Consortium for Stem Cell Research);German Stem Cell Network (GSCN);ScanBalt Stem Cell Research Network;European Calcified Tissue Society;European Association of Tissue Banks.

USA:Adult Stem Cell Research Network (ASCR);International Society for Stem Cell Research (ISSCR); California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);American association of tissue banks;Tissue Engineering International & Regenerative Medicine Society (TERMIS).

Asia:

Asia Pacific Association of Surgical Tissue Banking;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;The New South Wales Stem Cell Network;Korean Society for Stem Cell Research.

Whole Organ Engineering and Approaches

Guided tissue regeneration is defined as procedures attempting to regenerate lost periodontal structures through differential tissue responses. Guided bone regeneration typically refers to ridge augmentation or bone regenerative procedures it typically refers to regeneration of periodontal therapy. The recent advancements and innovations in biomedical and regenerative tissue engineering techniques include the novel approach of guided tissue regeneration.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

Europe:Stem Cell Network North Rhine-Westphalia;German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);Norwegian Center for Stem Cell Research (NCSCR);European Tissue Repair Society;Spanish Association of Tissue Bank.

USA:International Society for Stem Cell Research (ISSCR);Tissue Engineering International & Regenerative Medicine Society (TERMIS);Adult Stem Cell Research Network (ASCR);California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);Regenerative Medicine Foundation.

Asia:

Japanese Society for Regenerative Medicine;Australian Society for Stem Cell Research (ASSCR);The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Taiwan Society for Stem Cell Research;Stem Cell Society Singapore (SCSS);

Stem Cell Engineering (SCE)

Stem cell engineering (SCE) was to gather information on the worldwide status and trends of research and development in field SCE, that is, the engineers and engineering approaches in the stem cell field, both in basic research and translation of research into clinical applications and commercial products. The study of Stem Cells Engineering is facilitated and managed by the World Technology Evaluation Center (WTEC). This will provide a support for the generation of future economic growth and new markets. The process involved site visits in both Europe and Asia, and it also included several different workshops.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

Modeling Cell-Cell Interactions Governing Tissue Repair & Disease, Gordon Conference, August 19-24, 2018 Waterville Valley, NH, USA;27thInternational Conference On Oncology Research & Cancer Stem CellsMay 10-12, 2018 Frankfurt, Germany;10thAnnual Conference On Stem Cell And Regenerative MedicineAugust 13-14, 2018 London, UK;7thInternational Conference And Exhibition On Cell And Gene TherapyMarch 15-17, 2018London, UK;10thWorld Congress And Expo On Cell & Stem Cell ResearchMarch 19-21, 2018 New York, USA.

Related Associations and Societies:

Europe:Danish Stem Cell Society (DASCS);Stem Cell Network North Rhine-Westphalia;German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);Spanish Association of Tissue Bank;European Calcified Tissue Society;European Association of Tissue Banks.

USA:Adult Stem Cell Research Network (ASCR);California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS);International Society for Stem Cell Research (ISSCR);Regenerative Medicine Foundation.

Asia:

Australian Society for Stem Cell Research (ASSCR);The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;Stem Cell Society Singapore (SCSS);

Cord Blood Stem Cells and Regenerative Medicine

Recently, cord blood stems cells are developed in the treatment of different diseases, including a broad range of cancers, blood disorders, and genetic diseases. In a cord blood transplant, stem cells are infused in to a patients bloodstream for healing and repairing damaged cells and tissue. In a successful transplant, new healthy immune system has been created. The natural power and purity of newborn's cord blood are responsible for healthy development during gestation. Cord blood applications have developed beyond transplant medicine into the areas of regenerative medicine including brain injuries, autism, Cardiac Problems, and Autoimmune Deficiencies. The latest research in routine transplantation of cord blood are reviewed followed by the critical role of cord blood stem cells in regenerative medicine research and novel approaches using cord blood as a source of whole blood for transfusion.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

11thWorld Congress On Cell & Tissue ScienceMay 14-15, 2018 Tokyo, Japan;11thInternational Conference And Exhibition On Metabolomics & Systems BiologyMay 16-18, 2018 Tokyo, Japan;World Congress On Cell And Structural BiologyMay 28-29, 2018 Osaka, Japan;13thInternational Conference On Metabolomics And Systems BiologyJune 11-12, 2018 London, UK;10thGlobal Summit On Immunology And Cell BiologyMay 28-29, 2018 Osaka, Japan;World Congress On Stem Cell Biology And BiobankingAugust 20-21, 2018 Tokyo, Japan;2ndAnnual Summit On Cell MetabolismSeptember 19 - 20, 2018 Philadelphia, USA.

Related Associations and Societies:

Europe:EuroStemCell (European Consortium for Stem Cell Research);German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);British Association of Tissue Banks;British Association for Tissue Banking;European Tissue Repair Society;Spanish Association of Tissue Bank;European Calcified Tissue Society;European Association of Tissue Banks;

USA:California Institute for Regenerative Medicine (CIRM);New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS);International Society for Stem Cell Research (ISSCR).

Asia:

The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;Stem Cell Society Singapore (SCSS).

Bone and Cartilage Tissue Engineering

This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have been also aiming at replacing lost or severely damaged tissues or organs. Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for organ transplantation with soft tissues. Although significant progress has been made in the tissue engineering field, many challenges remain and further development in this area will require on-going interactions and collaborations among the scientists from multiple disciplines, and in partnership with the regulatory and the funding agencies. As a result of the medical and market potential, there is significant academic and corporate interest in this technology.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

2ndAnnual Summit On Cell Signaling And Cancer TherapySeptember 19 - 20, 2018 Philadelphia, USA;2ndAnnual Summit On Cell Therapy And Regenerative MedicineOctober 03-04, 2018 Atlanta, USA;Cellular Therapies2018 San Francisco, USA;4thInternational Conference On Central Nervous System Disorders & TherapeuticsNovember 12-14, 2018 Edinburgh, Scotland

Related Associations and Societies:

Europe:EuroStemCell (European Consortium for Stem Cell Research);German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);Norwegian Center for Stem Cell Research (NCSCR);ScanBalt Stem Cell Research Network;

USA:California Institute for Regenerative Medicine (CIRM);American Association of tissue banks;New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS);

Asia:Asia Pacific Association of Surgical Tissue Banking;The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;

Cancer Stem Cells

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease.

RelatedRegenerative Medicine Conferences|Stem Cell Conferences|Stem Cell Congress|Tissue Science Conferences|EuropeConferences

2ndAnnual Summit On Cell Signaling And Cancer TherapySeptember 19 - 20, 2018 Philadelphia, USA;2ndAnnual Summit On Cell Therapy And Regenerative MedicineOctober 03-04, 2018 Atlanta, USA;Cellular Therapies2018 San Francisco, USA;4thInternational Conference On Central Nervous System Disorders & TherapeuticsNovember 12-14, 2018 Edinburgh, Scotland

Related Associations and Societies:

Europe:EuroStemCell (European Consortium for Stem Cell Research);German Stem Cell Network (GSCN);German Society for Stem Cell Research (GSZ);Stem Cell Network North Rhine-Westphalia (NRW);Norwegian Center for Stem Cell Research (NCSCR);ScanBalt Stem Cell Research Network;

USA:California Institute for Regenerative Medicine (CIRM);American Association of tissue banks;New York Stem Cell Foundation (NYSCF);Tissue Engineering International & Regenerative Medicine Society (TERMIS);

Asia:Asia Pacific Association of Surgical Tissue Banking;The New South Wales Stem Cell Network;Korean Society for Stem Cell Research;Japanese Society for Regenerative Medicine;Taiwan Society for Stem Cell Research;

Market Analysis Report

Tissue Engineeringis an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. Regenerative medicine is not one discipline. It can be defined as a therapeutic intervention which replaces or regenerates human cells, tissues or organs, to restore or establish normal function and deploys small molecule drugs, biologics, medical devices and cell-based therapies

Currently, it has emerged as a rapidly diversifying field with the potential to address the worldwide organ shortage issue and comprises of tissue regeneration and organ replacement. Regenerative medicine could potentially save public health bodies money by reducing the need for long-term care and reducing associated disorders, with potential benefits for the world economy as a whole. The global tissue engineering and regeneration market reached $17 billion in 2013. This market is expected to grow to nearly $20.8 billion in 2014 and $56.9 billion in 2019, a compound annual growth rate (CAGR) of 22.3%. On the basis of geography, Europe holds the second place in the global market in the field of regenerative medicine & tissue engineering. In Europe countries like the UK, France and Germany are possessing good market shares in the field of regenerative medicine and tissue engineering. Spain and Italy are the emerging market trends for tissue engineering in Europe.

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Regenerative Medicine | NC Ortho

Posted: September 14, 2018 at 6:40 pm

Regenerative Medicine what is it?

Regenerative medicine is a field of medicine at the intersection of molecular biology and tissue engineering and is a viable non-surgical option for many patients. Its goal is to heal or replace tissues that were possibly previously determined beyond repair through trauma, disease, or congenital issues. Certain cells (such as stem cells) in the body rejuvenate, or possess a natural ability to heal. They have the ability to become other types of cells, such as fat cells (adipocytes), cartilage cells (chondrocytes), bone cells (osteoblasts), and muscle cells (myocytes). By regenerating these cells or their growth factors, we are able to encourage healing in damaged areas that otherwise have lost these characteristics. These cells can be used for issues such as tendonitis and arthritis. Stem cell therapies and tissue engineering/biomaterials are just two exciting areas of regenerative medicine that the surgeons at the North Carolina Orthopaedic Clinic (NCOC) utilizes.

Stem cells are harvested from your own bone marrow or fat and are a natural, safe option to accelerate healing and repair damage. The harvested stem cells are then processed in the operating room or in-office to remove unnecessary products in preparation to be reinjected into the patient. The overall procedures take about 45-60 minutes, but the portion of active time involving the patient (harvesting and re-injecting) is much shorter, about 15 minutes. The rest of the time is spent processing the cells.

There is typically minimal pain associated with these procedures as sites are numbed in office before harvesting begins. After the procedure, the healing process begins. Some patients notice that initially the pain is the same as before the procedure, or perhaps a little worse for a few days following the procedure due to being sore, with improvement starting 2-4 weeks after the procedure and continuing from there. Depending on the location of the injection, you may be placed in a boot for a few days to allow the injection site to calm down. Physical therapy is often used in conjunction with stem cell therapies for the best results.

Regenerative medicine is an important aspect of managing both acute and chronic orthopaedic problems. NCOC is on the forefront of innovation in using both traditional and regenerative medicine to treat numerous knee, shoulder, elbow, hand, and foot and ankle concerns. NCOC offers both in-office procedures to help prevent or delay surgery and intra-operative techniques to help expedite and reinforce healing.

In the office, NCOC performs Lipogems to help stimulate healing in chronically painful areas. This procedure utilizes a patients own harvested abdominal adipose (fat) tissue that is then spun down into stem cells and injected back into the patient to stimulate healing. This procedure is done as a same-day, sterile, in-office environment without need for sedation. Lipogems is similar to PRP injections, but different in that PRP uses plasma (blood products) while Lipogems uses a patients own stem cells. Dr. Parekh has used this technique to successfully treat problems ranging from knee arthritis, to plantar fasciitis to osteoarthritis, delaying or eliminating the need for surgery. You can watch such a procedure being performed at: https://youtu.be/vZbk5rb8eIc

In the operating room, NCOC has multiple techniques to promote successful healing post-operatively. One such technique is bone marrow harvest concentrate (BMAC), where a patients bone marrow is aspirated from the calcaneus (heel), tibia (shin), or iliac crest (pelvis) bone, and then spun down into a stem cell concentrate. Again, as this is the patients own tissue, this is considered an autograft. This concentrate is often mixed with other materials and then reinjected into the body to promote healing in procedures such as spine fusions, midfoot and ankle fusions and enhance fracture healing.

Finally, at times, the surgeons at NCOC may use engineered tissues in the operating room to close a difficult wound, thereby eliminating or lessening the chance of a skin graft or infection.

The goal of regenerative medicine as a technique in orthopedics is to promote tissue regeneration resulting in quality patient outcomes. NCOC is committed to using every technique available to us to successfully alleviate patients concerns. Contact our office at 919-471-9622 to schedule an appointment to discuss your options.

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Regenerative Medicine | NC Ortho

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CTI – CRO Specializing in Clinical Research and Consulting

Posted: August 23, 2018 at 2:44 am

CTI Clinical Trial and Consulting Services (CTI), a global, privately held, full-service contract research organization announces the acquisition of Eurotrials, a full-service contract research organization, with more than 20 years of experience, and strong local expertise in Europe and Latin America.

We see our collaboration with Sernova on this trial in the growing field of regenerative medicine as having the potential to impact many people with diabetes, said Tim Schroeder, CEO of CTI. It is a great opportunity for CTI to collaborate with the experienced team at Sernova and allows us to continue our work in cell therapy, currently representing approximately 40% of CTIs active research programs.

Paul Ritter is a finalist in the Chief Legal Officer category, and Kevin Schwarz is a finalist in the Chief Operating Officer category.

"We are privileged to have such strong leaders on our team," remarks Tim Schroeder, CEO of CTI. "Both Paul and Kevin haveplayed crucial roles in the growth and success of our company over the last 15 years, and we are thrilled to see this well-deserved recognition from the community."

CTI is extremely happy to partner with Bexion on the development of this novel therapy in patients who desperately need alternative treatments, stated William Aronstein, PhD, MD, FACP, Vice President, Medical Affairs at CTI. They are an innovative organization with very strong regional ties the drug was initially developed and licensed at a local hospital, early funding has predominantly come from the region, and the management and board have strong local connections.

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CTI - CRO Specializing in Clinical Research and Consulting

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