Category Archives: Stem Cell Research

Parkinsons is a progressive neurodegenerative disorder that characteristically affects the dopamine-producing neurons in the substantia nigra or the midbrain. It usually begins with stiffness, shaking, tremors, voice changes, and postural instability, all of which worsen with time, resulting in difficulty walking and talking.

Man With Parkinsons

Parkinsons is a widely common neurodegenerative disease affecting approximately 10 million people worldwide, as of 2019. And the rate of incidence increases with age, for example, it affects 1 percent of individuals over the age of 60 years in comparison to 5 percent of individuals over the age of 85 years.

Read Also: Parkinsons Disease: A Promising Treatment Thanks to Stem Cells

Parkinsons is a nervous system disorder that predominantly affects the motor function of the patient, therefore reducing the quality of life significantly. Unfortunately, Parkinson does not have a cure but there are many supportive therapeutic options available for the patients in the form of physical therapy, and medication along with a treatment option including deep brain stimulation (DBS).

DBS has shown great results but it is an invasive procedure that only produces temporary results. Hence, more research and studies need to be performed in the field of nervous system disorders to discover better therapeutic approaches.

Parkinsons and other nervous system disorders like stroke, Huntingtons, and so on are difficult to cure or treat due to the extensive damage to the neurons seen in these diseases. This is a problem because neurons are infamous for their inability to regenerate. Although stem cells that can be adapted into neurons may be recommended as a therapeutic option, they come with a problem of their own.

The new neurons do not connect with the native neurons as they do not recognize or identify them. This results in no improvement in neuronal circuitry and in the patients condition.

A recent study published in Cell Stem Cell Journal by Su-Chun Zhang, Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, and her team claim to have derived neurons from human stem cells that can be used to repair circuitry and improve neural functions.

Read Also: Antibiotics May Increase Your Risk of Having Parkinsons Disease

Zhang and her team derived dopamine-producing neurons from human embryonic stem cells and then transplanted these into the substantia nigra of the brain in animal models with Parkinsons disease.

These transplanted cells also contained on and off switches that could be stimulated externally using certain drugs or foods.

Zhang and her team found that these transplanted cells formed connections with native neurons and grew long-distance to form connections with the motor control regions in the brain to improve the motor functions usually affected by Parkinsons. The results were visible after a few months of transplantation, the time needed for the transplanted neurons to integrate into the brain.

To confirm that the improvement seen in the mice was due to the transplanted cells, the on and off switches were stimulated by the research team.

Read Also: Implants from Own Stem Cells May Offer Solution to Back Pain, Researchers Say

When the cells were turned off, the symptoms of Parkinsons reappeared indicating the proper functioning of these cells in the treatment of the neurodegenerative disorder. Furthermore, the scientists on closer look found that these cells were identified by native neurons and had been integrated into the midbrain. Moreover, the researchers believe that these switches can be used to fine-tune the treatment option for the patients.

The research team is currently applying these results to the primates model and aims to use the results from Parkison disease models for other nervous system disorders as well.

Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

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Excerpt from:
University of Wisconsin Researchers Use Stem Cells to Treat Parkinson's - Gilmore Health News

Periodontal disease, also known as gum disease, is a serious infection that affects nearly 50 percent of Americans aged 30 years and older. If left unchecked, periodontal disease can destroy the jawbone and lead to tooth loss. The disease is also associated with higher risk of diabetes and cardiovascular disease.

The current treatment for periodontal disease involves opening the infected gum flaps and adding bone grafts to strengthen the teeth. But in new research published recently in the journal Frontiers in Immunology, Forsyth Institute scientists have discovered that a specific type of molecule may stimulate stem cells to regenerate, reversing the inflammation caused by periodontal disease. This finding could lead to the development of new therapeutics to treat a variety of systemic diseases that are characterized by inflammation in the body.

For the study, Dr. Alpdogan Kantarci, his PhD student Dr. Emmanuel Albuquerque, and their team removed stem cells from previously extracted wisdom teeth and placed the stem cells onto petri dishes. The researchers then created a simulated inflammatory periodontal disease environment in the petri dishes. Next, they added two specific types of synthetic molecules called Maresin-1 and Resolvin-E1, both specialized pro-resolving lipid mediators from omega-3 fatty acids. The scientists found that Mar1 and RvE1 stimulated the stem cells to regenerate even under the inflammatory conditions.

"Both Maresin-1 and Resolvin-1 reprogrammed the cellular phenotype of the human stem cells, showing that even in response to inflammation, it is possible to boost capacity of the stem cells so they can become regenerative," said Dr. Kantarci, Associate Member of Staff at the Forsyth Institute.

This finding is important because it allows scientists to identify the specific protein pathways involved in inflammation. Those same protein pathways are consistent across many systemic diseases, including periodontal disease, diabetes, heart disease, dementia, and obesity.

"Now that we understand how these molecules stimulate the differentiation of stem cells in different tissues and reverse inflammation at a critical point in time, the mechanism we identified could one day be used for building complex organs" said Dr. Kantarci. "There is exciting potential for reprogramming stem cells to focus on building tissues."

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Forsyth researchers demonstrate how changing the stem cell response to inflammation may reverse periodontal disease - Science Codex

Stem Cell Manufacturing Market Report Delivering Growth Analysis with Key Trends of Top Companies (2020-2026)

A comprehensive research study on the Stem Cell Manufacturing Marketwas recently published by Market Report Expert. This is an up-to-date report, covering the current COVID-19 impact on the market. The Coronavirus (COVID-19) has affected every aspect of life globally and thus altering the global market scenario. The changes in the market conditions are drastic. The swiftly changing market scenario and initial and future assessment of the impact on Stem Cell Manufacturing market is covered in the report.The Stem Cell Manufacturing Market report is a precise and deep-dive study on the current state that aims at the major drivers, market strategies, and imposing growth of the key players. Worldwide Stem Cell Manufacturing Industry also offers a granular study of the dynamics, segmentation, revenue, share forecasts, and allows you to make superior business decisions. The report serves imperative statistics on the market stature of the prominent manufacturers and is an important source of guidance and advice for companies and individuals involved in the Stem Cell Manufacturing industry.

The Global Stem Cell Manufacturing Market poised to grow from US$ XX million in 2020 to US$ XX million by 2026 at a compound annual growth rate (CAGR) of XX% during the projection period of 2020-2026.

An Outline of the Major Key Players covered in this Report:

Thermo Fisher, Merck Group, Becton Dickinson, Bio-Rad, Miltenyi Biotec, Takara Bio, STEMCELL, Pharmicell, Osiris, Anterogen, Cellular Dynamics, MEDIPOST, Lonza, Holostem, Pluristem

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The report puts together a succinct analysis of the growth drivers influencing the current business scenario across various regions and countries. Substantial information pertaining to the industry analysis size, share, application, and statistics are summed in the report in order to present a collaborative prediction. Additionally, this report encompasses a precise competitive analysis of major market players, innovative companies, and their strategies during the projection timeline.

The latest report on the Stem Cell Manufacturing Market consists of an analysis of this industry and its type, application, and other segments. As per the report, the market is estimated to gain significant returns and register substantial y-o-y growth during the forecast period of 2020-2026.

Majortype, primarily split into

HSCsMSCsiPSCsESCsInstrumentsMediaConsumables

Major applications/end users, including

ResearchTarget IdentificationTherapyCell Banks

According to the report, the study offers details regarding the valuable estimations of the market such as market size, sales capacity, and profit projections. The report documents factors such as drivers, restraints, and opportunities that impacts the remuneration of this market.

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The research offers an analysis of the geographical landscape of the Stem Cell Manufacturing Market, which is divided into regions such as North America, Europe, Asia Pacific, South America, and the Middle East & Africa. The segment includes data about several parameters related to the regional contribution such as market share, application share, type share, key companies in respective regions, market share of key companies in regional market, growth rate and revenue of the regional market, sales, production, and consumption of the respective Stem Cell Manufacturing market.

Major Highlights of TOC Covers:

Stem Cell Manufacturing Market 2020, Stem Cell Manufacturing Market size, Stem Cell Manufacturing Market share, Stem Cell Manufacturing Market analysis, Stem Cell Manufacturing Market forecast, Stem Cell Manufacturing Market trends, Stem Cell Manufacturing Market Research report, Stem Cell Manufacturing application, Stem Cell Manufacturing Trends, Stem Cell Manufacturing Market growing CAGR, Stem Cell Manufacturing Market Competitive Landscape, Stem Cell Manufacturing Market Growth

Information related to the growth rate, revenue, sales, production, consumption, during the forecast period is included in the report. The Stem Cell Manufacturing Market report claims that the industry is projected to generate significant revenue and sales during the forecast period. The report consists of information related to the market dynamics such as challenges involved in this vertical, growth opportunities, and driving factors affecting the market.

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Stem Cell Manufacturing Market Business Growth, Size and Comprehensive Research Study Forecast to 2026| Thermo Fisher, Merck Group, Becton Dickinson -...

DetailsCategory: DNA RNA and CellsPublished on Thursday, 08 October 2020 15:15Hits: 58

NEW YORK, NY, USA and PARIS, France I October 08, 2020 I Cytovia Therapeutics ("Cytovia"), an emerging biopharmaceutical company, announces today that it has entered a research and licensing agreement with Inserm to develop NK engager bi-specific antibodies and iPSC CAR NK cell therapy targeting CD38, a key marker of multiple myeloma. The licensing agreement has been negotiated and signed by Inserm Transfert, the private subsidiary of Inserm, on behalf of Inserm (the French National Institute of Health and Medical Research) and its academic partners. Cytovia is licensing Inserm's CD38 antibody and Chimeric Antigen Receptor (CAR) patent and applying its proprietary NK engager bispecific antibody and iPSC CAR NK technology platforms. The research agreement will include evaluation of the therapeutic candidates at Hpital Saint-Louis Research Institute (Inserm Unit 976) under the leadership of Professors Armand Bensussan and Jean-Christophe Bories.

Dr Daniel Teper, Cytovia's Chairman and CEO commented: "We are delighted to partner with one of the top centers of excellence in the world for research and treatment in hematology. CD38 is a validated target and Natural Killer cells have significant cytotoxicity to Myeloma cells. We are looking forward to bringing promising new options to address the unmet needs of patients with Multiple Myeloma and aim for a cure."

Professor Armand Bensussan, Director of The Immuno-Oncology Research Institute at Hpital Saint-Louis added: "We have demonstrated the selectivity of our novel CD38 antibody in killing myeloma cells but not normal cells such as NK, T, and B cells. The activation of NK cells through NKp46 may enhance the efficacy of the bispecific antibody in patients not responsive to CD38 monoclonal antibody therapy. CD38 CAR NK is a promising approach forrelapsed/refractory patients and an alternative to CAR T therapies."

About Multiple MyelomaMultiple Myeloma is a currently incurable cancer, affecting a type of white blood cell known as plasma cells. It leads to an accumulation of tumor cells in the bone marrow, rapidly outnumbering healthy blood cells. Instead of producing beneficial antibodies, cancerous cells release abnormal proteins causing several complications. While symptoms are not always present, the majority of patients are diagnosed due to symptoms such as bone pain or fracture, low red blood cell counts, fatigue, high calcium levels, kidney problems, and infections. According to the World Cancer Research Fund, Multiple Myeloma is the second most common blood cancer, with nearly 160,000 new annual cases worldwide, including close to 50,000 in Europe. 32,000 in the US, and 30,000 in Eastern Asia. Over 95% of cases are diagnosed late, with a 5-year survival rate of 51%. Initial treatment comprises of a combination of different therapies, including biological and targeted therapies, corticosteroids, and chemotherapy, with the option for bone marrow transplants for eligible patients. Immunotherapy and cell therapy are the most promising new treatment option for Multiple Myeloma, with the potential for long term cancer remission.

About CAR NK cellsChimeric Antigen Receptors (CAR) are fusion proteins that combine an extracellular antigen recognition domain with an intracellular co-stimulatory signaling domain. Natural Killer (NK) cells are modified genetically to allow insertion of a CAR. CAR-NK cell therapy has demonstrated initial clinical relevance without the limitations of CAR-T, such as Cytokine Release Syndrome, neurotoxicity or Graft vs Host Disease (GVHD). Induced Pluripotent Stem Cells (iPSC) - derived CAR-NKs are naturally allogeneic, available off-the-shelf and may be able to be administered on an outpatient basis. Recent innovative developments with the iPSC, an innovative technology, allow large quantities of homogeneous genetically modified CAR NK cells to be produced from a master cell bank, and thus hold promise to expand access to cell therapy for many patients.

About CytoviaCytovia Therapeutics Inc is an emerging biotechnology company that aims to accelerate patient access to transformational immunotherapies, addressing several of the most challenging unmet medical needs in cancer and severe acute infectious diseases. Cytovia focuses on Natural Killer (NK) cell biology and is leveraging multiple advanced patented technologies, including an induced pluripotent stem cell (iPSC) platform for CAR (Chimeric Antigen Receptors) NK cell therapy, next-generation precision gene-editing to enhance targeting of NK cells, and NK engager multi-functional antibodies. Our initial product portfolio focuses on both hematological malignancies such as multiple myeloma and solid tumors including hepatocellular carcinoma and glioblastoma. The company partners with the University of California San Francisco (UCSF), the New York Stem Cell Foundation (NYSCF), the Hebrew University of Jerusalem, and CytoImmune Therapeutics. Learn more at http://www.cytoviatx.com

About InsermFounded in 1964, the French National Institute of Health and Medical Research (Inserm) is a public science and technology institute, jointly supervised by the French Ministry of National Education, Higher Education and Research, and the Ministry of Social Affairs, Health and Womens Rights. Inserm is the only French public research institute to focus entirely on human health and position itself on the pathway from the research laboratory to the patients bedside. The mission of its scientists is to study all diseases, from the most common to the rarest. With an initial 2020 budget of 927.28 million, Inserm supports nearly 350 laboratories throughout France, with a team of nearly 14,000 researchers, engineers, technicians, and post-doctoral students. http://www.inserm.fr

SOURCE: Cytovia Therapeutics

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Cytovia Therapeutics partners with Inserm to develop selective CD38 NK therapeutics and offer new treatment options for Multiple Myeloma patients |...

Proposition 14 is on the California ballot to continue funding stem cell research by borrowing up to $5.5 billion through bonds.

CALIFORNIA, USA California Proposition 14 is a vote to approve $5.5 billion dollars for stem cell research and research facilities in the state. In 2004, California voters approved Proposition 71. It gave legal protection to stem cell research that was hoping to find new medical treatments or cures for everything from Parkinsons to cancer. Proposition 71 also approved spending more than $3 billion to use for stem cell research and to build research facilities. Since 2004, most of the funding has been spent.

Proposition 14 would help to continue the funding of the existing research program with an additional $5.5 billion. The total estimated cost of the bond is an additional $260 million per year for the next 30 years. The total cost to pay off the bond is estimated to be $7.8 billion ($5.5 billion in bonds + $2.3 billion in interest).

Proposition 14 does offer a chance for the state to make back some money, a unique property compared to most state bonds. If the research leads to new inventions that earn revenue, the state will get a portion of the profits.

So far thats only raised about $350,000 or about 0.01% of the bond money weve already spent on stem cell work since 2004.

Find more background about this proposition as well as opinions from both sides on the California Voter Guide or on your local voter guide.

What is the full name for Prop 14?

The California Stem Cell Research, Treatments, and Cures Initiative of 2020

What does a YES vote on Prop 14 mean?

A yes vote approves $5.5 billion dollars for stem cell research and research facilities. The money will come from a bond.

What does a NO vote on Prop 14 mean?

A no vote means that the states existing stem cell program would start to wind down.

Original filing for Prop 14

Visit link:
CA Prop 14: Stem cell research - CBS News 8

Cellnest was designed and manufactured by Fujifilm Corporation.

Fujifilm sold cellnest through other company channels previously. However, Fujifilm Irvine Scientific is best placed to sell these products since they are complementary to our portfolio of cell culture media for primary cells. We joined Fujifilm in 2018 and synergies such as this are part of the Fujifilm life science strategy, said Lori Serles, spokesperson, Fujifilm Irvine Scientific.

Attachment substrates mimic the extracellular matrix (ECM), a complex and dynamic environment in which cells reside in vivo, in cell culture and allow for the adhesion, expansion, and potential differentiation of stem cells.

Unlike animal-derived components, which can introduce unpredictability in results, the chemically defined, animal component-free formula of cellnest provides consistent results to researchers and can smooth the regulatory path to commercialization, claims Fujifilm Irvine Scientific.

Serles expanded on how those aspects, highlighting that natural and undefined components present regulatory and production concerns.

There is considerable quantitative and qualitative variability in the composition of serum and serumderived products such as HSA. Levels of key growth factors, hormone, etc. can vary widely.

The components in media and the culture system affect attachment, growth, differentiation, phenotype etc. Ultimately that produces variability in in the culture system. While that might not be critical in early research, for translational and clinical research reliable results are necessary.

Regulatory bodies want to mitigate risk. Using a defined substrate in the culture system reduces the risk of variability in the end treatment/efficacy of the therapy. It also reduces risk of adventitious agents entering the process, she told BioPharma-Reporter.

What type of cell or gene therapy research will the use of this substrate help advance?

"Cellnest will contribute to advancing cell therapies involving human mesenchymal stem cells (hMSC).The cell and gene therapy market is maturing and the number of therapies progressing to clinical research phases is increasing rapidly. By providing defined and chemically defined products that can contribute to reliable, consistent results in culture systems, we are supporting this maturation.More therapeutic uses for hMSCs are being discovered, including new clinical trials for the treatment of coronavirus-induced disease, said Serles.

Cellnest is compatible with any adherent cell type that binds to the Arg-Gly-Asp (RGD) domain, an amino acid sequence within the extracellular matrix protein fibronectin that mediates cell attachment, said the producer.

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Fujifilm Irvine Scientific takes on distribution of substrate that supports cell therapy research - BioPharma-Reporter.com

DUBLIN, Sept. 30, 2020 /PRNewswire/ -- The "Global Regenerative Medicine Partnering Terms and Agreements 2014 to 2020" report has been added to ResearchAndMarkets.com's offering.

The Global Regenerative Medicine Partnering Terms and Agreements 2014-2020 report provides comprehensive understanding and unprecedented access to the regenerative medicine including cell therapy, organ regeneration, stem cells and tissue regeneration partnering deals and agreements entered into by the worlds leading healthcare companies.

The report provides a detailed understanding and analysis of how and why companies enter Regenerative Medicine partnering deals. These deals tend to be multicomponent, starting with collaborative R&D, and proceed to commercialization of outcomes.

This report provides details of the latest Regenerative Medicine agreements announced in the life sciences since 2014.

The report takes the reader through a comprehensive review Regenerative Medicine deal trends, key players, top deal values, as well as deal financials, allowing the understanding of how, why and under what terms, companies are entering Regenerative Medicine partnering deals.

The report presents financial deal term values for Regenerative Medicine deals, listing by headline value, upfront payments, milestone payments and royalties, enabling readers to analyse and benchmark the financial value of deals.

The middle section of the report explores the leading dealmakers in the Regenerative Medicine partnering field; both the leading deal values and most active Regenerative Medicine dealmaker companies are reported allowing the reader to see who is succeeding in this dynamic dealmaking market.

One of the key highlights of the report is that over 1100 online deal records of actual Regenerative Medicine deals, as disclosed by the deal parties, are included towards the end of the report in a directory format - by company A-Z, stage of development, deal type, therapy focus, and technology type - that is easy to reference. Each deal record in the report links via Weblink to an online version of the deal.

In addition, where available, records include contract documents as submitted to the Securities Exchange Commission by companies and their partners. Whilst many companies will be seeking details of the payment clauses, the devil is in the detail in terms of how payments are triggered - contract documents provide this insight where press releases and databases do not.

A comprehensive series of appendices is provided organized by Regenerative Medicine partnering company A-Z, stage of development, deal type, and therapy focus. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each deal on demand.

The report also includes numerous tables and figures that illustrate the trends and activities in Regenerative Medicine partnering and dealmaking since 2014.

In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of Regenerative Medicine technologies and products.

Key benefits

Global Regenerative Medicine Partnering Terms and Agreements 2014-2020 provides the reader with the following key benefits:

In Global Regenerative Medicine Partnering Terms and Agreements 2014-2020, the available deals are listed by:

Key Topics Covered:

Executive Summary

Chapter 1 - Introduction

Chapter 2 - Trends in Regenerative Medicine dealmaking2.1. Introduction2.2. Regenerative Medicine partnering over the years2.3. Most active Regenerative Medicine dealmakers2.4. Regenerative Medicine partnering by deal type2.5. Regenerative Medicine partnering by therapy area2.6. Deal terms for Regenerative Medicine partnering2.6.1 Regenerative Medicine partnering headline values2.6.2 Regenerative Medicine deal upfront payments72.6.3 Regenerative Medicine deal milestone payments2.6.4 Regenerative Medicine royalty rates

Chapter 3 - Leading Regenerative Medicine deals3.1. Introduction3.2. Top Regenerative Medicine deals by value

Chapter 4 - Most active Regenerative Medicine dealmakers4.1. Introduction4.2. Most active Regenerative Medicine dealmakers4.3. Most active Regenerative Medicine partnering company profiles

Chapter 5 - Regenerative Medicine contracts dealmaking directory5.1. Introduction5.2. Regenerative Medicine contracts dealmaking directory

Chapter 6 - Regenerative Medicine dealmaking by technology type

Chapter 7 - Partnering resource center7.1. Online partnering7.2. Partnering events7.3. Further reading on dealmaking

AppendicesAppendix 1 - Regenerative Medicine deals by company A-ZAppendix 2 - Regenerative Medicine deals by stage of developmentAppendix 3 - Regenerative Medicine deals by deal typeAppendix 4 - Regenerative Medicine deals by therapy area

For more information about this report visit https://www.researchandmarkets.com/r/dcq9uu

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Global Regenerative Medicine Partnering Report 2014-2020: Access to Cell Therapy, Organ Regeneration, Stem Cells and Tissue Regeneration Partnering...

Global Adipose Derived Stem Cell Therapy Market 2020 by Company, Type and Application, Forecast to 2025 is the latest addition to the database of MarketsandResearch.biz which exhibits an easily comprehensible description of the global market. The report provides proficient and in-depth research on the market, focusing on the market landscape and its growth prospects over the coming years from 2020 to 2025. The report emphasizes market share, market demographics, size as well as valuation and voluminous growth rate. The research also includes a discussion of the key vendors operating in this global Adipose Derived Stem Cell Therapy market. The study shares details such as current trends of the market in conjunction with the geographical landscape, demand scope, remuneration scale, and growth graph of this vertical have also been included in this report.

The report covers an in-depth analysis of the key trends and emerging drivers of the market as well as market characteristics, competitive landscape, market size and growth, regional breakdown, and strategies for this market. The research analyzes revenue growth, product range, and pricing factors related to the global Adipose Derived Stem Cell Therapy market. The report sheds light on the competition matrix and shares a versatile understanding of various vital details comprising new product related developments that are adequately addressed and invested by leading players in the global market. Details about the competitive landscape, ensuring robust growth in the global market has been given in the report.

NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

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The major players covered in the market are: AlloCure, Mesoblast, Cellleris, Antria, Intrexon, Celgene Corporation, Tissue Genesis, Cytori Therapeutics, Corestem, Pluristem Therapeutics, Cyagen, BioRestorative Therapies, Lonza, Pluristem Therapeutics, Celltex Therapeutics Corporation, iXCells Biotechnologies

Scope of Market Report:

This report provides an analysis of the supply chain, import, and export control, and future influence on the industry. Detailed analysis of the market status, competition pattern, advantages, and disadvantages of enterprise products, industry development trends (2020-2025), regional industrial layout characteristics, industrial policy has also been included. From raw materials to end-users of this industry are analyzed, as well as the trends of product circulation and sales channels are presented.

On the basis of regional segmentation, the market is bifurcated into major regions of North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.), Middle East & Africa (Saudi Arabia, Egypt, Nigeria and South Africa). The regional analysis further covers country-wise bifurcation of the market and key players.

On the basis of product type, we research the production, revenue, price, market share, and growth rate, primarily split into: Autologous Stem Cells, Allogeneic Stem Cells

For the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Adipose Derived Stem Cell Therapy market report for each application, including: Therapeutic Application, Research Application

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Global Adipose Derived Stem Cell Therapy Market 2020 Industry Analysis, Growth Factors, Share, Opportunities and Forecast to 2025 - The Daily...

Fort Collins, Colorado The STEM CELL BANKING Market is growing at a rapid pace and contributes significantly to the global economy in terms of turnover, growth rate, sales, market share and size. The STEM CELL BANKING Market Report is a comprehensive research paper that provides readers with valuable information to understand the basics of the STEM CELL BANKING Report. The report describes business strategies, market needs, dominant market players and a futuristic view of the market.

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Global STEM CELL BANKING Market to reach USD 11.2 billion by 2025. Global STEM CELL BANKING Market valued approximately USD 5.4 billion in 2016 is anticipated to grow with a healthy growth rate of more than 8.4% over the forecast period 2017-2025.

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Industry STEM CELL BANKING Study provides an in-depth analysis of key market drivers, opportunities, challenges and their impact on market performance. The report also highlights technological advancements and product developments that drive market needs.

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The market is geographically spread across several key geographic regions and the report includes regional analysis as well as production, consumption, revenue and market share in these regions for the 2020-2027 forecast period. Regions include North America, Latin America, Europe, Asia Pacific, the Middle East, and Africa.

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Researchers at Cima and the Clinica Universidad de Navarra (Spain) have led an international study identifying the cardiac cells responsible for repairing the damage to this organ after infarction. These "restorative" cells are a subpopulation of cardiac fibroblasts that play a fundamental role in the creation of the collagen scar needed to avoid the rupture of the ventricular wall. The research also reveals the molecular mechanisms involved in the activation of these cells and the regulation of their function.

This finding, in which basic and clinical researchers have participated, will permit the identification of new therapeutic targets and the development of targeted therapies which will control the healing process of the heart after infarction.

The study has been published in the latest issue of the journal Circulation, the leading scientific journal of the American Heart Association.Characterization of the reparative cardiac fibroblasts

Cardiac fibroblasts are one of the fundamental components of the heart. These cells play an essential role in maintaining the structure and mechanism of this vital organ. "Recent studies have shown that fibroblasts do not respond homogeneously to heart injury. Therefore the object of our study was to determine their heterogeneity during the remodeling of the injured ventricle and to understand the mechanisms that regulate the function of these cells", said Dr Felipe Prsper, a researcher at Cima and the Clinica Universidad de Navarra, the leader of the study.

"Using single-cell transcription analysis techniques (single-cell RNA-seq), we identified a subpopulation within the cardiac fibroblasts, which we have named Reparative Cardiac Fibroblasts (RCF) due to their role after the cardiac injury. We have found that, when a patient has a heart attack, these RCF are activated and offer a fibrotic response due to which a collagen scar is generated to avoid the rupture of the cardiac tissue", stated Dr Prsper, who is also a member of the Red de Terapia Celular (TerCel) and the Instituto de Investigacin Sanitaria de Navarra (IdiSNA).

CTHRC1, a protein related to collagen and essential for the regenerative process

In the detailed molecular study, the researchers have found that the RCF have a unique transcriptional profile, that is to say, a specific information pattern for the expression of the genes involved in their cardiac function. "Among the main differential markers of the transcriptome of these cells, we have identified the CTHRC1 protein (Collagen Triple Helix Repeat Containing 1), a molecule with a fundamental role in the fibrotic response after myocardial infarction. Specifically, this protein participates in the collagen synthesis of the extracellular cardiac matrix and is crucial for the process of ventricular remodeling", in the words of Adrin Ruiz-Villalba, a researcher on the Regenerative Medicine Program at Cima and first author of the article.

These results "suggest that the RCF activates the healing scar process of the cardiac lesion by secreting the CTHRC1 protein. Thus, this molecule may be considered as a biomarker associated with the physiological condition of the injured heart and a potential therapeutic target for patients who have suffered a heart attack or have dilated cardiomyopathy", stated Ruiz-Villalba, who is also a researcher at IdiSNA. In addition to Cima and the Clinica Universidad de Navarra, basic and clinical researchers from the United States, Belgium and Austria have taken part in this research.

This work falls within the framework of the Cell Therapy and Regenerative Medicine research line being carried out at Cima and the Clinica Universidad de Navarra, aimed at understanding the regenerative potential of stem cells and their therapeutic application in different diseases such as cardiovascular ones. Specifically, this study is linked to the BRAV? project, an international research project combining bioengineering and cardiac stem cells to restore the function of an infarcted heart. BRAV? is an H2020 funded program by the European Union (H2020-SC1-BHC-07-2019-874827).

Reference: Ruiz-Villalba A, Romero JP, Hernandez SC, et al.Single-Cell RNA-seq Analysis Reveals a Crucial Role for Collagen Triple Helix Repeat Containing 1 (CTHRC1) Cardiac Fibroblasts after Myocardial Infarction. Circ, 2020. doi:10.1161/CIRCULATIONAHA.119.044557

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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