Category Archives: Stem Cell Therapy

Autologous and Adult Stem Cells Transplant in Mexico
http://www.mexicohealth.com The video shows a top stem cell specialist in Mexico explaining why autologous stem cell treatment is a better choice than adult stem cell transplant. The doctor goes on to caution about risks of reaction in case of adult stem cells transplant. In some cases, the reaction could kill. Autologous, on the other hand, is a safe proposition. The doctor has been in the profession since 1978 and has treated over 40 patients with acute degenerative disorders like, multiple sclerosis. To read the transcript of the video about autologous and adult stem cell transplant in Mexico, click the link above. Related Searches: Autologous stem cell transplant mexico, Hematopoietic stem cell transplantation mexico, Stem Cell Transplantation in Adults mexico, Stem cell treatment ms mexico, stem cell treatment glaucoma mexico, stem cell therapy brain disorders mexico, stem cell therapy brain injury mexico, stem cell treatment spinal cord MX,From:mexicohealthViews:2 0ratingsTime:03:08More inPeople Blogs

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PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version).mp4
PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version) Please contact Pearly @ +65 9338 9541 for more detailsFrom:PurtierPearlyViews:1 0ratingsTime:08:01More inPeople Blogs

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PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version).mp4 - Video

Embryonic stem cells

When he was only 43, Peter Harrison had a severe heart attack that left him suffering from the symptoms of a damaged heart: shortness of breath, chest pain and increased risk of another heart attack. An otherwise healthy commercial real estate agent from Key Biscayne, Harrison was in and out of the hospital for 20 years treating his heart condition until last year when doctors at the University of Miami Miller School of Medicine injected his heart with stem cells as part of a study.

Three weeks later, he was hiking the steep hills of the U.S. Virgin Islands, keeping up with his wife.

"There was no chest pain and I was not out of breath -- it was quite a revelation," he said. "I was hoping that the damaged part of my heart would come back to life, and the indication is that it has."

The study, which was funded by the National Institutes of Health and published in the Journal of the American Medical Association this week, found that stem cell injections into the heart muscle reduced scar tissue by one third, built up healthy heart tissue and remodeled the spherical shape of the damaged heart to look more like a football-shaped healthy heart.

Dr. Joshua Hare, the director of the UM Interdisciplinary Stem Cell Institute and the lead author of the study, said the stem cells -- cells that are not fully formed and have the potential to become different kinds of cells -- internalize information from their "milieu" to know what to become.

"We think the cells respond to environmental cues to determine how they divide and differentiate," he said. The stem cells used in this study were taken from bone marrow and have a "limited repertoire" of possibility, meaning they are more easily transformed into bone or muscle than blood or brain.

Half of the 30 men enrolled in this small pilot study at UM and Johns Hopkins University received injections of their own stem cells, while the other half got stem cells from a third party donor. Harrison was in the group that got donated stem cells. There are no compatibility requirements for stem cell donors as there is with blood and bone marrow, and one donor can provide enough stem cells for "many, many people," Hare said.

"This is an elegant treatment in that it doesn't transgress any ethical boundaries," Hare said, alluding to the controversy surrounding the use of stem cells from human embryos. "You don't need to create a donor bank, it's easy to implement and relatively inexpensive."

Stem cell therapy, a growing area of research, drew attention earlier this year when the Nobel Prize in Medicine went to John B. Gurdon of the University of Cambridge in England and Shinya Yamanaka of Kyoto University in Japan for their work in turning mature cells back into "pluripotent" stem cells that have the potential to become other types of cells. Hare said the UM study was essentially the opposite -- rather than reduce mature cells to stem cells, these injections of stem cells differentiated into healthy heart tissue.

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In University of Miami study, stem cell injections repair damaged heart

Public release date: 6-Nov-2012 [ | E-mail | Share ]

Contact: Jill Scoggins jill.scoggins@louisville.edu 502-852-7461 University of Louisville

LOS ANGELES Marked sustained improvement in all patients with zero adverse effects.

For a phase I clinical trial, these results are the Holy Grail. Yet researchers from the University of Louisville and Brigham and Women's Hospital today reported just such almost-never-attained data.

In a Late-Breaking Clinical Trial session at the American Heart Association Scientific Sessions 2012 meeting, Roberto Bolli, M.D., of the University of Louisville and Piero Anversa, M.D., of Brigham and Women's Hospital, Boston, presented data from their groundbreaking research in the use of autologous adult stem cells with patients who had previous heart attacks.

They report that after two years, all patients receiving the stem cell therapy show improvement in heart function, with an overall 12.9 absolute unit increase in left ventricular ejection fraction (LVEF), a standard measure of heart function that shows the amount of blood ejected from the left ventricle during a heartbeat. No adverse effects resulting from the therapy were seen. Moreover, MRIs performed on nine patients in the trial showed evidence of myocardial regeneration new heart tissue replacing former dead tissue killed by heart attack.

"The trial shows the feasibility of isolating and expanding autologous stem cells from virtually every patient," said Bolli, who is the Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology and director of the Institute for Molecular Cardiology in the Department of Medicine at UofL. "The results suggest that this therapy has a potent, beneficial effect on cardiac function that warrants further study."

"In all patients, cells with high regenerative reserve were obtained and employed therapeutically," said Anversa, professor of Anaesthesia and Medicine at Brigham and Women's Hospital and Harvard Medical School. "Our efforts to carefully characterize the phenotype and growth properties of the cardiac stem cells may have contributed to these initial positive results."

The trial called SCIPIO for Stem Cell Infusion in Patients with Ischemic CardiOmyopathy was a randomized open-label trial of cardiac stem cells (CSCs) in patients who were diagnosed with heart failure following a myocardial infarction and had a LVEF of 40 percent or lower; the normal LVEF is 50 percent or higher.

The investigators harvested the CSCs, referred to as "c-kit positive" cells because they express the c-kit protein on their surface, from 33 patients during coronary artery bypass surgery. The stem cells were purified and processed in Anversa's lab in Boston so that they could multiply. Once an adequate number of stem cells was produced about one million for each patient Bolli's team in Louisville reintroduced them into the region of the patient's heart that had been scarred by the heart attack.

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2 years out, patients receiving stem cell therapy show sustained heart function improvement

ScienceDaily (Nov. 6, 2012) For a phase I clinical trial, these results are the Holy Grail. Yet researchers from the University of Louisville and Brigham and Women's Hospital reported just such almost-never-attained data.

In a Late-Breaking Clinical Trial session on Nov. 6 at the American Heart Association Scientific Sessions 2012 meeting, Roberto Bolli, M.D., of the University of Louisville and Piero Anversa, M.D., of Brigham and Women's Hospital, Boston, presented data from their groundbreaking research in the use of autologous adult stem cells with patients who had previous heart attacks.

They report that after two years, all patients receiving the stem cell therapy show improvement in heart function, with an overall 12.9 absolute unit increase in left ventricular ejection fraction (LVEF), a standard measure of heart function that shows the amount of blood ejected from the left ventricle during a heartbeat. No adverse effects resulting from the therapy were seen. Moreover, MRIs performed on nine patients in the trial showed evidence of myocardial regeneration -- new heart tissue replacing former dead tissue killed by heart attack.

"The trial shows the feasibility of isolating and expanding autologous stem cells from virtually every patient," said Bolli, who is the Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology and director of the Institute for Molecular Cardiology in the Department of Medicine at UofL. "The results suggest that this therapy has a potent, beneficial effect on cardiac function that warrants further study."

"In all patients, cells with high regenerative reserve were obtained and employed therapeutically," said Anversa, professor of Anaesthesia and Medicine at Brigham and Women's Hospital and Harvard Medical School. "Our efforts to carefully characterize the phenotype and growth properties of the cardiac stem cells may have contributed to these initial positive results."

The trial -- called SCIPIO for Stem Cell Infusion in Patients with Ischemic CardiOmyopathy -- was a randomized open-label trial of cardiac stem cells (CSCs) in patients who were diagnosed with heart failure following a myocardial infarction and had a LVEF of 40 percent or lower; the normal LVEF is 50 percent or higher.

The investigators harvested the CSCs, referred to as "c-kit positive" cells because they express the c-kit protein on their surface, from 33 patients during coronary artery bypass surgery. The stem cells were purified and processed in Anversa's lab in Boston so that they could multiply. Once an adequate number of stem cells was produced -- about one million for each patient -- Bolli's team in Louisville reintroduced them into the region of the patient's heart that had been scarred by the heart attack.

The researchers reported that in the 20 patients receiving CSCs, LVEF increased from 29 percent to 36 percent at four months following infusion. None of the 13 control patients in the trial received CSCs and this group showed, on average, no improvement.

The beneficial effect of the CSCs persisted and became progressively greater at the one- and two-year mark following infusion. At the one-year mark following infusion, LVEF increased by 8.1 percent, and at the two-year mark, by 12.9 percent.

Nine patients in the trial were able to undergo magnetic resonance imaging of their hearts that showed a profound reduction in the size of the infarct, that area of the heart that is dead tissue as a result of the heart attack, and an increase in viable tissue.

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Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests

Washington, November 6 (ANI)

Administering to patients stem cells derived from their own bone marrow either three or seven days after a heart attack is safe but does not improve heart function six months later, according to a clinical trial.

The results of the trial, called Transplantation In Myocardial Infarction Evaluation (TIME), mirror a previous, related study, LateTIME, which found that such cells (called autologous stem cells) given two to three weeks after a heart attack did not improve heart function.

Both TIME and LateTIME were conducted by the Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the NIH's National Heart, Lung, and Blood Institute.

"This study was extremely valuable even though it did not provide a demonstrated health benefit after six months," said Sonia Skarlatos, Ph.D., deputy director of NHLBI's Division of Cardiovascular Sciences and member of the CCTRN.

"Heart stem cell therapy research is still in its infancy, and results from early trials have varied greatly due to differences in the numbers of stem cells injected, the delivery methods used, and the compositions of the study populations. With TIME and LateTIME, we have established both safety and baseline results in two large studies that followed the same procedures for growing and then administering stem cells. This standard will inform the next steps in research on the use of stem cells to repair damaged hearts," she stated.

Fellow CCTRN member Jay Travese, M.D., of the Minneapolis Heart Institute added, "With this baseline now set, we can start to adjust some of the components of the protocol to grow and administer stem cell to find cases where the procedure may improve function."

"For example, this therapy may work better in different population groups, or we might need to use new cell types or new methods of delivery," he noted.

Skarlatos said that another advantage of the TIME study is that CCTRN is storing samples of the stem cells taken from the participants. Investigators can examine the relationship between people who showed significant improvement during the study and the characteristics of their stem cells. Such a comparison may offer insights on the cell traits that are associated with clinical improvement.

The findings will be presented at the American Heart Association (AHA) 2012 Scientific Sessions in Los Angeles and will appear concurrently in the Journal of the American Medical Association.

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Stem cell therapy may not improve recovery after heart attack

Public release date: 6-Nov-2012 [ | E-mail | Share ]

Contact: Steve Goodyear sgoodyear@mhif.org 952-807-8365 Minneapolis Heart Institute Foundation

MINNEAPOLIS, MN November 6, 2012 Administering autologous stem cells obtained from bone marrow either 3 or 7 days following a heart attack did not improve heart function six months later, reports a new clinical trial supported by the National Institutes of Health. The results of this trial, called TIME (Transplantation In Myocardial Infarction Evaluation), were presented by Jay Traverse, MD of the Minneapolis Heart Institute Foundation Tuesday, Nov. 6, at the 2012 Scientific Sessions of the American Heart Association in Los Angeles.

The results of this trial mirror a previous, related study (LateTIME) which found that autologous bone marrow stem cell therapy given 2-3 weeks after a heart attack did not improve cardiac recovery. Both TIME and LateTIME were carried out by the Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the NIH's National Heart, Lung, and Blood Institute.

"The data presented by TIME do much to advance stem cell therapy research," said Jay Traverse, MD of the Minneapolis Heart Institute Foundation and Principal Investigator of this study. "While this study did not provide a demonstrated cardiac benefit after six months, we still learned a great deal. Together, TIME and Late TIME have shown that stem cell therapy is safe, and they have set a baseline in terms of quantity of stem cells, type of stem cells, and severity of heart attack."

TIME enrolled 120 volunteers (avg. age 57) between July 2008 and February 2011; the participants all had moderate to severe impairment in their left ventricle and had undergone coronary stent placement as treatment for the heart attack. The participants were randomly assigned to one of four groups: day 3 stem cell, day 3 placebo (inactive cells), day 7 stem cell, or day 7 placebo. The CCTRN researchers developed a method of processing and purifying the stem cells from the bone marrow of each volunteer to ensure everyone received a uniform dose (150 million stem cells).

Heart improvement was assessed six months after stem cell therapy by measuring the percentage of blood that gets pumped out of the left ventricle during each contraction (left-ventricular ejection fraction, or LVEF). The study found no significant differences between the change in LVEF readings at the six month follow-up in either the Day 3 or Day 7 stem cell groups compared with placebo or with each other; every group showed about a 3 percent improvement in LVEF. However, the researchers found that younger patients randomized to Day 7 had greater improvement in their LVEF compared to their placebo counterparts

"The lack of six-month improvement seen for TIME and, prior to that, LateTIME, does not mean stem cell therapy is not a viable post-heart attack strategy," said Traverse. "Because we have this data we can start to address some parameters; for example this therapy may work better in younger people, or maybe we need to use cells from healthy volunteers (allogeneic) since their cells may provide greater therapeutic benefit. There will also be upcoming studies using novel cell types which we look forward to using in future clinical trials."

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Stem cell therapy using patient's own cells after heart attack does not enhance cardiac recovery