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Category Archives: Stem Cell Therapy

Stem cell treatments reaching patients

Posted: May 12, 2014 at 10:41 am

Neurosurgeon and stem cell researcher, Joseph Ciacci M.D. will soon start a clinical trial of stem cells to treat paralysis from spinal cord injury.

After many years of waiting, a flood of new regenerative-cell therapies is finally reaching patients. Hundreds of clinical trials for these experimental treatments are under way across the world.

In the United States, 774 trials with stem or other regenerative cells are open to patients or soon will be, according to clinicaltrials.gov, which lists government-approved clinical testing in this country and abroad. Of that total, 147 are taking place in California.

One of the most difficult tests involving stem cells repairing spinal-cord damage that has caused complete loss of movement and sensation below the injury site is set to begin soon at UC San Diego.

Patients in that study will get injections of fetal-derived neural stem cells in and around the injury site, along with physical therapy and immune-system drugs in case theres a reaction to the stem cells. The trial will use a device that delivers precisely targeted micro-injections of cells to the targeted areas.

The clinical trial will test safety and look for early signs of efficacy, said Dr. Joseph Ciacci, a UC San Diego neurosurgeon leading the testing.

A study published a year ago found that in rats with spinal-cord injuries, the neural stem cells significantly improved movement in the hind paws. Ciacci, who co-authored that study, saw the cells proliferate and fill in a spinal-cord cavity that had resulted from the injuries. Such results supported testing the therapy in people, he said, but he declined to say whether he expected to see any improvement in those patients.

I really dont know, because its not been done, Ciacci said.

The clinical trial is expected to start in June. Its intended for adults 18 to 65 years old who suffered their injury at least one year ago but no more than two years ago. For more information, visit utsandiego.com/ucsdspinal or call Amber Faulise at (858) 657-5175.

Another type of stem cells, mesenchymal stromal, might be described as the duct tape of regenerative cells. Generally derived from bone marrow, they are being tested for treatment of pulmonary fibrosis, multiple sclerosis, kidney transplants, liver cirrhosis, osteoarthritis of the knee, stroke and many other conditions. Worldwide, 226 trials are being conducted with these cells, including 45 in the U.S. and 12 in California, according to clinicaltrials.gov.

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Stem cell treatments reaching patients

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Knee arthritis/torn meniscus 6 months after stem cell therapy by Dr Harry Adelson – Video

Posted: May 12, 2014 at 4:41 am


Knee arthritis/torn meniscus 6 months after stem cell therapy by Dr Harry Adelson
Alan discusses his results six months after stem cell therapy by Dr Harry Adelson for treatment of his arthritic knees and torn menisci http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Knee arthritis/torn meniscus 6 months after stem cell therapy by Dr Harry Adelson - Video

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Acute torn meniscus; 5 months after stem cell therapy by Dr Harry Adelson – Video

Posted: May 10, 2014 at 4:43 am


Acute torn meniscus; 5 months after stem cell therapy by Dr Harry Adelson
At Docere Clinics, the vast majority of cases we see are for chronic pain. Occasionally, we get acute injuries and do very well with them. Here, Bryan describes his experience 5 months after...

By: Harry Adelson, N.D.

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Acute torn meniscus; 5 months after stem cell therapy by Dr Harry Adelson - Video

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Dont be fooled by quacks and fake meds

Posted: May 9, 2014 at 2:47 am

Beware of fake medicines and advertisements touting the purported miracles that stem cell therapy can do. This was the warning aired by former health secretary Esperanza Cabral at the Kapihan sa Manila at the Diamond Hotel last Monday.

Contrary to what the ads claim, she said, stem cell therapy has not been scientifically proven to cure any disease or make anyone young again. It has been successful in a very few experiments, which is the reason quack doctors are taking advantage of it to make exaggerated claims that the therapy can cure the deadliest diseases known to man.

The Food and Drug Administration (FDA) very recently issued a similar warning against it.

Stem cell therapy is the process of injecting into patients young cells taken from humans or sheep. The theory is that the young cells will rejuvenate the old cells of the patients and make them young again and cure whatever diseases they have. Although experiments are being conducted, no such results have been achieved. But that does not prevent foreign quack doctors from coming here and making all those exaggerated claims. Sadly, they are aided by some Filipino doctors.

The reason is that in countries like the Philippines where the people are suckers for miracle cures, stem cell therapyand other miracle curesis like a gold mine.

Aging millionaires looking for the fountain of youth pay a lot of money to undergo stem cell therapy. Patients with terminal illnesses like cancer, in a desperate search for a cure, also fall victim to the sales talk and word-of-mouth yarns of so-and-so being cured by the therapy.

But they get neither younger nor cured. And the quack doctors run laughing with their patients money all the way to the bank.

A friend told me that he had gone abroad to have stem cell therapy. He said he felt better and stronger after the treatment. Look at me, dont I look younger? he said.

I looked at him. He didnt look a minute younger and in fact looked the same as when I last saw him, maybe even older.

My wife said I look younger, he said. It was his wife who had convinced him to have the stem cell therapy.

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Dont be fooled by quacks and fake meds

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Unlicensed stem cell doctor slapped with charges over patient's death

Posted: May 7, 2014 at 11:55 am

Charges of syndicated estafa, illegal medical practice and murder were filed on Tuesday against Dr. Zoharina Antonia Pedrera Carandang, also known as Dr. Antonia Carandang-Park, for practicing stem cell therapy on 23-year-old cancer patient Katherine Kate Tan. The treatment was alleged to have caused the Tan's death.

The charges were filed by Kate's father Bernard Tan before the Tagaytay Municipal Fiscal's Office. Aside from Carandang, owner and operator of Tagaytay-based Green & Young Health and Wellness Center, also charged were Joy Dimaranan, Estrella Maranan, Bebot Maranan and several other employees of the wellness center.

Tan also filed on Tuesday a separate administrative complaint against Park before Tagaytay's Office of the City Administrator, GMA News TV's Quick Response Team (QRT) reported.

According to the City Administrator's Office, Park had, in the past, applied for a permit to operate a medical clinic but was denied for failing to present the necessary documents, such as a Department of Health (DOH) certification.

Park, was, however, granted a permit to operate a massage clinic in 2012.

A caretaker at the wellness center, who received the copy of the criminal and administrative complaints, said Park had left the clinic Tuesday morning.

The Fiscal's Office also sent a letter to Park requiring her to respond to the complaint within two days, otherwise an investigation based only on the evidence presented by the Tans would be pursued.

The Office of the City Administrator also prohibited the wellness clinic from operating until a reply to the administrative complaint was filed.

Alternative treatment

In a separate complaint filed last month before the National Bureau of Investigation (NBI), Tan alleged that Park was not licensed by the Professional Regulation Commission (PRC) to practice medicine in the Philippines.

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Unlicensed stem cell doctor slapped with charges over patient's death

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Knee arthritis 9 months after stem cell therapy by Dr Harry Adelson – Video

Posted: May 7, 2014 at 11:45 am


Knee arthritis 9 months after stem cell therapy by Dr Harry Adelson
Carol describes her outcome from stem cell therapy by Dr Harry Adelson for her arthritic knee http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Knee arthritis 9 months after stem cell therapy by Dr Harry Adelson - Video

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Cedars-Sinai researchers identify how heart stem cells orchestrate regeneration

Posted: May 7, 2014 at 11:44 am

PUBLIC RELEASE DATE:

6-May-2014

Contact: Sally Stewart sally.stewart@cshs.org 310-248-6566 Cedars-Sinai Medical Center

LOS ANGELES (EMBARGOED UNTIL NOON ET ON MAY 6, 2014) Investigators at the Cedars-Sinai Heart Institute whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans have identified components of those stem cells responsible for the beneficial effects.

In a series of laboratory and lab animal studies, Heart Institute researchers found that exosomes, tiny membrane-enclosed "bubbles" involved in cell-to-cell communication, convey messages that reduce cell death, promote growth of new heart muscle cells and encourage the development of healthy blood vessels.

"Exosomes were first described in the mid-1980s, but we only now are beginning to appreciate their potential as therapeutic agents. We have found that exosomes and the cargo they contain are crucial mediators of stem cell-based heart regeneration, and we believe this might lead to an even more refined therapy using the 'active ingredient' instead of the entire stem cell," said Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute and a pioneer in developing investigational cardiac stem cell treatments.

"The concept of exosome therapy is interesting because it could potentially shift our strategy from living-cell transplantation to the use of a non-living agent," he added. "Stem cells must be carefully preserved to keep them alive and functioning until the time of transplant, and there are some risks involved in cell transplantation. In contrast, exosome therapy may be safer and simpler and based on a product with a longer shelf life."

In lab experiments, the researchers isolated exosomes from specialized human cardiac stem cells and found that exosomes alone had the same beneficial effects as stem cells. Exosomes also produced the same post-heart attack benefits in mice, decreasing scar size, increasing healthy heart tissue and reducing levels of chemicals that lead to inflammation. Even when exosomes were injected in mice after heart attack scars were well-established, and traditionally viewed as "irreversible," they brought about multiple structural and functional benefits.

Exosomes transport small pieces of genetic material, called microRNAs, that enable cells to communicate with neighboring cells to change their behavior. The researchers pinpointed one such microRNA one that is especially plentiful in cardiac stem cell exosomes as responsible for some of the benefits. It is likely, they believe, that this and other microRNAs in the exosomes work together to produce the regenerative effects.

"The exosomes appear to contain the signaling information needed to regenerate healthy heart tissue, they are naturally able to permeate cells, and they have a coating that protects their payloads from degradation as they shuttle from cell to cell," said Marbn, senior author of an article in the May 6, 2014 Stem Cell Reports. "Injecting exosomes derived from specialized cardiac stem cells may be an attractive alternative to the transplantation of living cells."

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Cedars-Sinai researchers identify how heart stem cells orchestrate regeneration

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OMICS Groups Cell Science & Stem Cell Research Congress to Explore the Recent Developments

Posted: May 7, 2014 at 11:44 am

Valencia, spain (PRWEB) May 07, 2014

Cell Science International Conference is being organized to broaden the scope of the research in the field of Tumorogenesis, Recombinant DNA technology, Cancer cell development and signaling pathway, Evolution of cancer, Genetic engineering and Gene therapy, Tumor suppressor genes, Tissue Engineering, Stem cell treatment, Bioinformatics and Computational biology, Bio Ethics and Patent Rights.

Eminent speakers including Stewart Sell, University of Albany, USA, Sudhakar Akul Yakkanti, SRI International, USA, and Diana Anderson, University of Bradford, UK will be joining their peers at Cell Science-2014, an International Conference 2014 to share their upcoming researches and experience in the field of Cell Science.

James L Sharely, Director of The Adult Stem Cell Technology Centre, LLC, USA organizes a symposium on Stem Cell DNA Segregation and Genetic Fidelity. Ornella Parolini, President, International Placenta Stem Cell Research (IPLASS) holds another symposium on Fetal-derived Stem cells: Characteristics and Applications during Cell Science-2014.

The GID Group, Inc. that manufactures and distributes versatile tissue processing system, sterile disposable canister like GID 700 and GID SVF-1 exhibits its products and services during the conference.

The Organizing Committee welcomes you to attend Cell Science-2014 which includes Ornella Parolini, IPLASS (International Placenta Stem Cell Society), Italy; Sudhakar A Yakkanti, Stanford Research Institute (SRI) International, USA; Stewart Sell, University of Albany, USA; Valles Marti, University of Valencia, Spain; LilianSoraya, University of Valencia, Spain; James L. Sherley, The Adult Stem Cell Technology Center, LLC, USA; Diana Anderson, University of Bradford, UK; Shiaw-Yih (Phoebus) Lin, Anderson Cancer Center The University of Texas, USA; Behjatolah Monzavi Karbassi, University of Arkansas for Medical Sciences, USA.

Cell Science-2014 official partners include The Adult Stem Cell Technology Center, LLC USA and the International Placenta Stem Cell Research (IPLASS).

The three day conference will be hosting significant sessions like Keynote forum, speaker Sessions, Poster sessions, awards and Exclussive session on Successful Postdoctoral Fellowship training.

In addition to this, Soraya L Valles, University of Valencia, Spain organized a pre-conference workshop on NeuroSceince at Salon de Grados, Faculty of Medicine Valencia, Spain on February 25th, 2014 thus promulgating this pragmatic conference.

OMICS Publishing Group hosts 350 Open Access, Online ScientificJournals and hosts more than 100 Scientific Conferences worldwide. With 30,000 strong editorial board members drawn from academics, research and industries, OMICS Group Journals will publish the best papers presented in Cell Science- 2014.

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OMICS Groups Cell Science & Stem Cell Research Congress to Explore the Recent Developments

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Questions and Answers

Posted: May 5, 2014 at 2:43 pm

FAITH Stem Cell Research and Human Cloning by: FR. GAMMY TULABING I would like to share with you this article from the United States Conference of Catholic Bishops.

Questions and Answers

What is a stem cell?

A stem cell is a relatively unspecia-lized cell that, when it divides, can do two things: make another cell like itself, or make any of a number of cells with more specialized functions. For example, just one kind of stem cell in our blood can make new red blood cells, or white blood cells, or other kindsdepending on what the body needs. These cells are like the stem of a plant that spreads out in different directions as it grows.

Is the Catholic Church opposed to all stem cell research?

Not at all. Most stem cell research uses cells obtained from adult tissue, umbilical cord blood, and other sources that pose no moral problem. Useful stem cells have been found in bone marrow, blood, muscle, fat, nerves, and even in the pulp of baby teeth. Some of these cells are already being used to treat people with a wide variety of diseases.

Why is the Church opposed to stem cell research using the embryo?

Because harvesting these stem cells kills the living human embryo. The church opposes the direct destruction of innocent human life for any purpose, including research.

If some human embryos will remain in frozen storage and ultimately be discarded anyway, why is it wrong to try to get some good out of them?

In the end, we will all die anyway, but that gives no one a right to kill us. In any case, these embryos will not die because they are inherently unable to survive, but because others are choosing to hand them over for destructive research instead of letting them implant in their mothers womb. One wrong choice does not justify an additional wrong choice to kill them for research, much less a choice to make tax payers support such destruction. The idea of experimenting on human beings because they may die anyway also poses a grave threat to convicted prisoners, terminally ill patients, and others.

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Questions and Answers

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3 stem cell procedures recognized in PH FDA

Posted: May 4, 2014 at 8:54 am

The Food and Drug Administration (FDA) yesterday reiterated that stem cell procedures in the Philippines are allowed only for three specific procedures while others remain unrecognized by the agency and are therefore illegal.

In an advisory posted on its website, Dr. Kenneth Hartigan-Go, FDA acting director, emphasized that only the following uses of stem cell therapy are recognized by the FDA Hematopoietic Transplantation (involving the blood cells to treat disorders of the blood and immune systems), Corneal Resurfacing with limbal stem cells (to treat the transparent, front part of the eye), and skin regeneration (for burns) with epidermal stem cells. All hospitals and health facilities are likewise warned that Republic Act 9711 or the FDA Act, otherwise prohibits the manufacture, importation, exportation, sale, offering for sale, distribution, transfer, non-consumer use, promotion, advertising, or sponsorship of any health product that is unregistered. The use of Human cells, Tissues, and Cellular and tissue-based products (HCT/Ps) without the authorization or permission by the FDA is considered illegal in the country, Go said.

In August 2013, the FDA issued a circular asking hospitals and other facilities offering stem cell procedures to register for accreditation. However, as of May 2, the FDA said not one stem cell or HCT product that applied for registration has been registered by the FDA for compassionate or clinical trial use or for general use.

What we are doing now is we are strengthening quality assurancethey must have scientific proof. But there is no one who is applying for compassionate use because if we ask them about ethical clearance, they have no ethical review system, the FDA chief added.

Go warned all hospitals and health facilities to stop manufacturing or selling unregistered products.

The warning also covers unlicensed practitioners from other countries and tourists who visit the country for leisure or medical needs. (Jenny F. Manongdo)

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3 stem cell procedures recognized in PH FDA

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