Category Archives: Stem Cell Treatments

T he International Cellular Medicine Society (ICMS) is an international non-profit dedicated to patient safety through strict evaluation of protocols and rigorous oversight of clinics and facilities engaged in the translation of point-of-care cell-based treatments.As a professional medical association, the ICMS represents Physiciansand Researchersfrom over 35 countries who share a mission to provide scientifically credible and medically appropriate treatments to informed patients.Join the ICMS.

The ICMS works tirelessly for the clincial translation of the field of cell-based point-of-care treatments through:

Comprehensive Medical Standards and Best Practice Guidelines for Cell Based Medicine,

Strict Evaluation and Rigorous Oversight of Stem Cell Clinics and Facilities through aGlobal Accreditation Process,

Physician Education through daily updates on the latest Research on Stem Cells, the monthly Currents In Stem Cell Medicine and the annual International Congress for Regenerative and Stem Cell Medicine.

Join the ICMSto receive the latest news and research from cell-based medicne, including the bi-monthly publication, Currents in Stem Cell Medicine.

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Stem Cells | ICMS -- Advancing Stem Cell Treatments, Stem ...

Most of the cells in your body are highly specialized. A kidney cell, for example, can multiply and create new kidney tissue, but it cant turn into a bone cell or neuron. Stem cells, on the other hand, are able to differentiate into many different cell types.

The primary function of adult stem cells, which reside throughout the body, is to maintain and repair tissues. Their innate brilliance lies in their ability to zero in on areas of damage or degeneration. Signaled by inflammation, they migrate wherever theyre needed and, taking cues from surrounding cells, facilitate healing, restoration, and regeneration.

Stem cell therapy used to involve embryonic cells, which understandably generated a lot of controversy. Todays research focuses on non-embryonic adult mesenchymal stem cellsand there is nothing controversial about using your own cells in a safe and therapeutic manner. Adult stems cells may be derived from bone marrow. However, this isnt a particularly abundant source, and cells must be cultured over several days tocreate enough for therapeutic use. Furthermore, their number and viability decline dramatically with age. More recently, fat was discovered to be a far richer, much more accessible repository of robust adult stem cells.

New technologies now make it possible to remove a few ounces of a patients fat through a mini liposuction procedure, separate out the stem cells in a special process that yields extremely high numbers of viable cells, and return them back into that persons body via an IV or injection.

Performed in a physicians office, under sedation and local anesthesia and using a sterile closed system technology so the cells never come into contact with the environment, there is minimal discomfort and risk of infection. And because the stem cells come from the patients own body, there is no risk of rejection or disease transmission.

Whitaker Wellness is proud to announce that we have partnered with the Newport Beach Stem Cell Treatment Center, allowing us to offer non-embryonic adult mesenchymal stemcell therapy to our patients.

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Adult Stem Cell Therapy, Stem Cell Therapies Future Medicine

Look and Feel Younger with Stem cell Therapy | Real Anti-aging Treatments Available Now

How Regenerative Stem Cells Prevent Aging:

Aging results from the progressive depletion of regenerative cells, so the introduction of new Stemcells has the potential of slowing down or reversing this process.

Stem Cell Anti-aging Effect

Regenerative cell therapies are among the worlds greatest collective scientific breakthrough, possessing the clear potential to revolutionize the practice of medicine and improve the quality and length of life. Townsend Letter for Doctors and Patients.

Regenerative Stem cells possess a unique anti-aging effect by improving immune function and regenerating and repairing organs damaged by stressors, like free radicals and the various toxins we are exposed to in our day to day living.

Your body uses its own regenerative cells to make you stronger, healthier and more resistant to disease. As we age, we use regenerative cells to repair damaged organs, or to replace those cells destroyed by toxins over time.

At all stages of your life, your body fights damage by using regenerative cells. When you smoke, cells head for the lungs. When you are sun burnt, they repair the skin. As late as the early 2000s, we did not know that regenerative cell replenishment was true for most organs, but today we know that every organ seems to recruit cells from the bone marrow to resuscitate itself.

Decline in Regenerative cell production with age:

Decline in stem cell production with age as we age, however, the bone marrow releases fewer cells, giving us less power to repair the damage of ageing. Treatment with adult regenerative cells reverses this process.

In healthy individuals, skin youthfulness is maintained by epidermal cells which self-renew and generate daughter cells that become new skin. Despite accumulation of aging blemishes and changes in aged skin, epidermal regenerative cells are maintained at normal levels throughout life. Therefore, skin ageing is caused by impaired regenerative cell mobilization from the bone marrow or reduced number of regenerative cells able to respond to repair signals. (6). This means that, if we increase the number of circulating regenerative cells, by mobilizing from the bone marrow, and by infusion of additional regenerative cells we should dramatically change this cell behavior.

It has been postulated that regenerative cell exhaustion from the bone marrow is partly responsible for the process of cardiovascular ageing and the resulting diseases such as angina, heart attack, stroke and senile dementia. It has now been proven that cell damage in the bone marrow, from aging, is responsible for coronary artery disease and resultant cardiac muscle damage. (1, 2,4). This means that cardiac disease can be prevented by regenerative cell therapy.

As aging progresses, there is a decline in the brains capacity to produce new neurons. The underlying cause of the declining neurogenesis is unknown, but is presumably related to age-related changes that occur during normal aging of the brain. It is exacerbated by age-related neurodegenerative diseases such as Alzheimers and Parkinsons diseases. (5).

References: 1. Spyridopoulos I et al. Arteriosclerosis, Thrombosis & Vascular Biology. 28(5):968-974, May 2008. 2. Jos J. Fuster, Vicente Andrs.Circulation Research. 2006;99:1167.2006 American Heart Association, Inc.Reviews.Telomere Biology and Cardiovascular Disease. 3. Ignacio Flores, Roberta Benetti and Maria A Blasco. Telomerase regulation and regenerative cell behaviour. Current Opinion in Cell Biology 2006, 18:254260. 4. Frederick M. Rauscher et al.Aging, Progenitor Cell Exhaustion, and Atherosclerosis. Circulation, The American Heart Association. 5. TL Limke, MS Rao, Neural regenerative cell therapy in the aging brain: pitfalls and possibilities. J Hematother Regenerative Cell Res (2003) 12: 615-23. 6. Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann C.Human skin regenerative cells and the ageing process. Exp Gerontol. 2008 Sep 9.

The most powerful solution:

According to the American Academy of Anti-aging Medicine, regenerative cells appear to be our most powerful tool in Regenerative Medicine at this time. Previous dogma concerning adult regenerative cells taught that our tissues did not have regenerative cells and the cells present at birth just declined in quantity and quality until there was nothing left. It was also believed that hematopoietic regenerative cells lacked plasticity and could not transform to other tissues.

Current medical literature proves that adult regenerative cells exist in most tissues including brain, heart, muscles and liver and adult regenerative cells have plasticity to potentially transform and repair all tissues and organs.

Current literature also shows that regenerative cell supplementation of an age-damaged bone marrow regenerative cell population can result in rejuvenation and the increase in longevity of that regenerative cell source. (1 )

Reference: 1. Ignacio Flores, Roberta Benetti and Maria A Blasco. Telomerase regulation and regenerative cell behaviour. Current Opinion in Cell Biology 2006, 18:254260.

Specific age-related conditions can be treated:

Osteoarthritis responds well to joint infusions of regenerative cells as shown in phase III trials in the USA. Early Alzheimers disease can be reversed and Parkinsons disease has shown excellent improvement when treated in the early stages. Emotional and cognitive improvement occurs, which you will notice as your memory improves, concentration ability increases and your ability to handle complex tasks, as you did before, is regained. An increase in energy levels and a resistance to disease develops as your cardiovascular, nervous and immune systems are boosted by the regenerative cell infusion. You will find that you will have higher levels of energy than before.

The Beauty Response from StemCells real stem cell anti-aging

The most evident beauty response in regenerative cell treated patients is the appearance of the facial skin a few weeks after therapy it glows. You will notice a smoothness and improvement in color along with a look of youthfulness.

Grey hair has been noted to regain its original color and bald spots have filled in. The rest of your skin will show an improvement in color and age-related pigmentation marks, less bruising and an increase in elasticity and tone.

Overall improvements:

You can expect improvements after regenerative cell therapy, including but not limited to:

1. Physical improvements such as:

Less head/neck aches

Decreased soreness in neck, arms and legs

Reduced stiffness in joints

Far less tiredness or fatigue

2. Aesthetic improvements such as:

The skin on the face and hands becomes tighter

Fewer wrinkles

Looking younger general younger appearance

Change in color of hair from grey to black/normal

Hair thickens

3. Mental and Emotional improvements.

4. Improvements in Energy Levels.

5. Improvement in the Overall Quality of Life.

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anti-aging stem cell therapy | Stem Cells 21

As living proof that stem cell therapy can repair damaged heart muscle, Noel Zuniga leapt onto a treadmill for a brisk run and followed with a set of weighted push ups inside the cardiac rehabilitation room at University of Miami Hospital Friday.

Zuniga, 44, did not lose his breath or feel fatigued.

Two years ago, he barely survived what cardiologists call a widow maker heart attack, a complete blockage of a major coronary artery. Few expected Zuniga to recover this well without a heart transplant.

But last year, when he could hardly run and felt fatigued just walking in the mall with his wife, Zuniga enrolled in a clinical study at the University of Miami Health Systems Interdisciplinary Stem Cell Institute.

UHealth doctors had saved his life in 2013 shipping off at a moments notice to Panama to implant a special catheter with a pump into his heart, staving off massive organ failure after the heart attack. Now they held out the hope of helping Zunigas heart recover much of the function it had lost.

We got Noel through the worst part, but it left such extensive damage that his outlook for the future was not very bright, said Robert Hendel, a UHealth cardiologist who cared for Zuniga after the attack.

In short, said Joshua Hare, a physician and director of the UHealth stem cell institute, He was left with a big scar on the front wall of his heart.

His outlook for the future was not very bright.

Robert Hendel. UHealth cardiologist

Hare said the scar threatened to cause Zunigas heart to remodel its shape from one resembling a football to one that looks more like a basketball, which then causes congestive heart failure and a condition called sudden cardiac death.

There's nothing we have available in all of medicine to fix that, he said, other than a heart transplant.

In June 2014, as part of the clinical study, UHealth doctors injected human stem cells from a donors bone marrow directly into the scar tissue of Zunigas heart.

Within about two months, Zuniga said, I felt a huge difference, and then it just started getting better and better and better, month after month after month.

On Friday, Zuniga and his wife, Diana, who now live in Virginia with their three children, returned to Miami to thank the UHealth team that saved his life and then helped him regain his old form.

Its as if nothing ever happened, said Zuniga, a Naval Criminal Investigative Service agent who was in charge of the U.S. Embassy in Panama when he suffered the heart attack.

The Zunigas said they want others to hear their story, especially about the power of stem cells to restore damaged tissue. Stem cells cells with the ability to divide into many different cell types are influenced by their immediate environment, which determines how they will grow.

Prior clinical studies, including one led by Hare, have demonstrated that stem cell therapy can reduce scar tissue in the heart by 35 to 50 percent, he said, calling it an enormous achievement.

UHealths Interdisciplinary Stem Cell Institute has conducted six clinical studies on the ability of stem cells to repair heart damage.

The current clinical study, which Hare also is leading, will help determine the ideal dosage of human stem cells needed to repair damaged heart tissue.

Still unknown, however, is whether human stem cell therapy helps patients live longer.

That study has yet to be done, Hare said, though he noted that several studies are under way and that he expects they will produce results in two to three years.

Zuniga doesnt need to wait, however, to know that human stem cell therapy has improved the quality of his life.

He has pushed himself hard in the gym. I wanted to put these stem cells to the test, he said, to see if they worked. And he has high hopes for the future of regenerative medicine.

I think there will come a time in the future, he said, where you will rarely hear of someone getting a heart transplant.

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After Miami stem cell therapy, NCIS agent back to old form ...

by Leigh Matthews on November 18, 2013

A new encapsulation technique has been developed using seaweed and a hydrogel scaffold to increase the effectiveness of stem cell therapy in healing heart tissue after a heart attack.

Publishing the results in the Journal of the American Heart Association, Dr. W. Robert Taylor, professor of medicine at Emory and Georgia Tech and director of Emorys cardiology division, noted that while advances had been made in saving the lives of those suffering myocardial infarction (heart attack), those who did survive often suffered from heart failure due to the tissue damage caused by the attack. [click to continue]

by Leigh Matthews on November 11, 2013

Recovery after a traumatic brain injury is notoriously difficult and complicated, with many people experiencing permanent cognitive deficits as the brain is unable to fully heal. However, new research from the University of South Florida suggests that stem cells may be able to build a sort of bridge between the damaged region of the brain and a healthy area of brain where neural stem cells are still active. Could this biobridge be the key to helping the brain help itself? [click to continue]

by Leigh Matthews on November 4, 2013

A team of stem cell scientists at Boston Childrens Hospital have developed a new way of using induced pluripotent adult stem cells that offers benefits for disease modelling. The re-specification technique turns iPSCs into haematopoietic stem cells and progenitor cells, thereby making them more relevant for the study of diseases of the blood, in contrast to skin cells or other partially differentiated stem cells ordinarily used in such research. [click to continue]

by Leigh Matthews on October 28, 2013

It sounds like science fiction but it just became science fact: Stem cell scientists have used specialised magnets to pull stem cells from a rats brain, without apparent harm to the animal. The potential for this nanotechnology is enormous as it could be used to harvest brain stem cells from patients with Parkinsons disease, Huntingtons, multiple sclerosis, even autism in order to carry out research and devise new treatments, and all without drastically invasive surgery. [click to continue]

by Leigh Matthews on October 21, 2013

Stem cell treatment for spinal cord injury has been the focus of clinical trials in Switzerland for around a year but up until now the novel therapy remained unavailable in the US. However, late last month the US Food and Drug Administration approved a clinical trial request made by StemCells Inc. to investigate the spinal cord stem cell therapy, with plans to enroll twelve patients in the trial. [click to continue]

by Leigh Matthews on October 14, 2013

The US Food and Drug Administration has issued approval for a stem cell patent filed by Cellular Dynamics International. The patent covers a new method of stem cell creation that could change the way researchers carry out their work, as well as how stem cells may be used clinically to treat illnesses.

Finding ways to create a large volume of stem cells for transplantation or to facilitate multiple laboratory experiments has proven difficult for a variety of reasons but newer techniques allow scientists to control the cells differentiation and proliferation much more carefully than in previous years. [click to continue]

by Leigh Matthews on October 7, 2013

Ottawa Hospital is the site of Canadas new national public cord blood bank which launched this week and started receiving donations of umbilical cord blood. The new service will collect stem cells from cord blood that would otherwise have been discarded as medical waste. [click to continue]

by Leigh Matthews on September 30, 2013

Being a stem cell scientist may sound glamorous but the reality is that youre not going to be making headline news every day, if ever. Like any scientific profession, stem cell science involves hard work, day in and day out, for years, with the possibility that no major breakthroughs will ever happen. However, smaller successes that dont make national news but which earn you respect amongst your peers are something to strive for and there is the added bonus of this being a growing area of research that tends to attract substantial funding worldwide. [click to continue]

by Leigh Matthews on September 24, 2013

Scientists at the University of Buffalo have uncovered an interesting role played by stem cells in atherosclerosis development that could revolutionize cardiovascular medicine and the prevention of heart attacks and strokes.

Publishing their findings in PLoS One, Thomas R., Cimato and colleagues revealed that the animal research done previously by researchers at Columbia University also extends to human subjects. < ?php include 'includes/sctLeader.php';?>

In their paper they describe how so-called bad cholesterol, low density lipoprotein, stimulates stem cells to be released from bone marrow, with an associated increase in the development of atherosclerotic plaques. Researchers have previously noted an increased risk of heart disease in patients receiving donor stem cells so is this tied to the same mechanism? [click to continue]

by Leigh Matthews on September 16, 2013

Whenever a patient receives an organ transplant there is a risk that their body will reject the foreign tissue, which is why transplant patients are usually given immunosuppressant medications to calm down the immune systems response, at least initially. Patients may also have immune system ablation prior to a transplant in order to reduce the likelihood of the donor organ being rejected. [click to continue]

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Stem Cell Treatment Stem Cell Therapy

Stem cell transplants are procedures that restore blood-forming stem cells in people who have had theirs destroyed by the very high doses of chemotherapy or radiation therapy that are used to treat certain cancers.

Blood-forming stem cells are important because they grow into different types of blood cells. The main types of blood cells are:

You need all three types of blood cells to be healthy.

In a stem cell transplant, you receive healthy blood-forming stem cells through a needle in your vein. Once they enter your bloodstream, the stem cells travel to the bone marrow, where they take the place of the cells that were destroyed by treatment. The blood-forming stem cells that are used in transplants can come from the bone marrow, bloodstream, or umbilical cord. Transplants can be:

To reduce possible side effects and improve the chances that an allogeneic transplant will work, the donors blood-forming stem cells must match yours in certain ways. To learn more about how blood-forming stem cells are matched, see Blood-Forming Stem Cell Transplants.

Stem cell transplants do not usually work against cancer directly. Instead, they help you recover your ability to produce stem cells after treatment with very high doses of radiation therapy, chemotherapy, or both.

However, in multiple myeloma and some types of leukemia, the stem cell transplant may work against cancer directly. This happens because of an effect called graft-versus-tumor that can occur after allogeneic transplants. Graft-versus-tumor occurs when white blood cells from your donor (the graft) attack any cancer cells that remain in your body (the tumor) after high-dose treatments. This effect improves the success of the treatments.

Stem cell transplants are most often used to help people with leukemia and lymphoma. They may also be used for neuroblastoma and multiple myeloma.

Stem cell transplants for other types of cancer are being studied in clinical trials, which are research studies involving people. To find a study that may be an option for you, see Find a Clinical Trial.

The high doses of cancer treatment that you have before a stem cell transplant can cause problems such as bleeding and an increased risk of infection. Talk with your doctor or nurse about other side effects that you might have and how serious they might be. For more information about side effects and how to manage them, see the section on side effects.

If you have an allogeneic transplant, you might develop a serious problem called graft-versus-host disease. Graft-versus-host disease can occur when white blood cells from your donor (the graft) recognize cells in your body (the host) as foreign and attack them. This problem can cause damage to your skin, liver, intestines, and many other organs. It can occur a few weeks after the transplant or much later. Graft-versus-host disease can be treated with steroids or other drugs that suppress your immune system.

The closer your donors blood-forming stem cells match yours, the less likely you are to have graft-versus-host disease. Your doctor may also try to prevent it by giving you drugs to suppress your immune system.

Stem cells transplants are complicated procedures that are very expensive. Most insurance plans cover some of the costs of transplants for certain types of cancer. Talk with your health plan about which services it will pay for. Talking with the business office where you go for treatment may help you understand all the costs involved.

To learn about groups that may be able to provide financial help, go to the National Cancer Institute database, Organizations that Offer Support Services and search "financial assistance." Or call toll-free 1-800-4-CANCER (1-800-422-6237) for information about groups that may be able to help.

When you need an allogeneic stem cell transplant, you will need to go to a hospital that has a specialized transplant center. The National Marrow Donor Program maintains a list of transplant centers in the United States that can help you find a transplant center.

Unless you live near a transplant center, you may need to travel from home for your treatment. You might need to stay in the hospital during your transplant, you may be able to have it as an outpatient, or you may need to be in the hospital only part of the time. When you are not in the hospital, you will need to stay in a hotel or apartment nearby. Many transplant centers can assist with finding nearby housing.

A stem cell transplant can take a few months to complete. The process begins with treatment of high doses of chemotherapy, radiation therapy, or a combination of the two. This treatment goes on for a week or two. Once you have finished, you will have a few days to rest.

Next, you will receive the blood-forming stem cells. The stem cells will be given to you through an IV catheter. This process is like receiving a blood transfusion. It takes 1 to 5 hours to receive all the stem cells.

After receiving the stem cells, you begin the recovery phase. During this time, you wait for the blood cells you received to start making new blood cells.

Even after your blood counts return to normal, it takes much longer for your immune system to fully recoverseveral months for autologous transplants and 1 to 2 years for allogeneic or syngeneic transplants.

Stem cell transplants affect people in different ways. How you feel depends on:

Since people respond to stem cell transplants in different ways, your doctor or nurses cannot know for sure how the procedure will make you feel.

Doctors will follow the progress of the new blood cells by checking your blood counts often. As the newly transplanted stem cells produce blood cells, your blood counts will go up.

The high-dose treatments that you have before a stem cell transplant can cause side effects that make it hard to eat, such as mouth sores and nausea. Tell your doctor or nurse if you have trouble eating while you are receiving treatment. You might also find it helpful to speak with a dietitian. For more information about coping with eating problems see the booklet Eating Hints or the section on side effects.

Whether or not you can work during a stem cell transplant may depend on the type of job you have. The process of a stem cell transplant, with the high-dose treatments, the transplant, and recovery, can take weeks or months. You will be in and out of the hospital during this time. Even when you are not in the hospital, sometimes you will need to stay near it, rather than staying in your own home. So, if your job allows, you may want to arrange to work remotely part-time.

Many employers are required by law to change your work schedule to meet your needs during cancer treatment. Talk with your employer about ways to adjust your work during treatment. You can learn more about these laws by talking with a social worker.

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Types of Treatment: Stem Cell Transplant - National Cancer ...

In a typical stem cell transplant for cancer very high doses of chemo are used, often along with radiation therapy, to try to destroy all the cancer cells. This treatment also kills the stem cells in the bone marrow. Soon after treatment, stem cells are given to replace those that were destroyed. These stem cells are given into a vein, much like a blood transfusion. Over time they settle in the bone marrow and begin to grow and make healthy blood cells. This process is called engraftment.

There are 3 basic types of transplants. They are named based on who gives the stem cells.

These stem cells come from you alone. In this type of transplant, your stem cells are taken before you get cancer treatment that destroys them. Your stem cells are removed, or harvested, from either your bone marrow or your blood and then frozen. To find out more about that process, please see the section Whats it like to donate stem cells? After you get high doses of chemo and/or radiation the stem cells are thawed and given back to you.

One advantage of autologous stem cell transplant is that you are getting your own cells back. When you donate your own stem cells you dont have to worry about the graft attacking your body (graft-versus-host disease) or about getting a new infection from another person. But there can still be graft failure, and autologous transplants cant produce the graft-versus-cancer" effect.

This kind of transplant is mainly used to treat certain leukemias, lymphomas, and multiple myeloma. Its sometimes used for other cancers, like testicular cancer and neuroblastoma, and certain cancers in children. Doctors are looking at how autologous transplants might be used to treat other diseases, too, like systemic sclerosis, multiple sclerosis, Crohn disease, and systemic lupus erythematosis.

A possible disadvantage of an autologous transplant is that cancer cells may be picked up along with the stem cells and then put back into your body later. Another disadvantage is that your immune system is still the same as before when your stem cells engraft. The cancer cells were able to grow despite your immune cells before, and may be able to do so again.

To prevent this, doctors may give you anti-cancer drugs or treat your stem cells in other ways to reduce the number of cancer cells that may be present. Some centers treat the stem cells to try to remove any cancer cells before they are given back to the patient. This is sometimes called purging. It isnt clear that this really helps, as it has not yet been proven to reduce the risk of cancer coming back (recurrence).

A possible downside of purging is that some normal stem cells can be lost during this process, causing the patient to take longer to begin making normal blood cells, and have unsafe levels of white blood cells or platelets for a longer time. This could increase the risk of infections or bleeding problems.

One popular method now is to give the stem cells without treating them. Then, after transplant, the patient gets a medicine to get rid of cancer cells that may be in the body. This is called in vivo purging. Rituximab (Rituxan), a monoclonal antibody drug, may be used for this in certain lymphomas and leukemias, and other drugs are being tested. The need to remove cancer cells from transplants or transplant patients and the best way to do it is being researched.

Doing 2 autologous transplants in a row is known as a tandem transplant or a double autologous transplant. In this type of transplant, the patient gets 2 courses of high-dose chemo, each followed by a transplant of their own stem cells. All of the stem cells needed are collected before the first high-dose chemo treatment, and half of them are used for each transplant. Most often both courses of chemo are given within 6 months, with the second one given after the patient recovers from the first one.

Tandem transplants are most often used to treat multiple myeloma and advanced testicular cancer, but doctors do not always agree that these are really better than a single transplant for certain cancers. Because this involves 2 transplants, the risk of serious outcomes is higher than for a single transplant. Tandem transplants are still being studied to find out when they might be best used.

Sometimes an autologous transplant followed by an allogeneic transplant might also be called a tandem transplant (see Mini-transplants in the section Allogeneic stem cell transplants).

In the most common type of allogeneic transplant, the stem cells come from a donor whose tissue type closely matches the patients. (This is discussed later under HLA matching in the section called Donor matching for allogeneic transplant.) The best donor is a close family member, usually a brother or sister. If you do not have a good match in your family, a donor might be found in the general public through a national registry. This is sometimes called a MUD (matched unrelated donor) transplant. Transplants with a MUD are usually riskier than those with a relative who is a good match.

Blood taken from the placenta and umbilical cord of newborns is a newer source of stem cells for allogeneic transplant. Called cord blood, this small volume of blood has a high number of stem cells that tend to multiply quickly. But the number of stem cells in a unit of cord blood is often too low for large adults, so this source of stem cells is limited to small adults and children. Doctors are now looking at different ways to use cord blood for transplant in larger adults, such as using cord blood from 2 donors.

Pros of allogeneic stem cell transplant: The donor stem cells make their own immune cells, which could help destroy any cancer cells that remain after high-dose treatment. This is called the graft-versus-cancer effect. Other advantages are that the donor can often be asked to donate more stem cells or even white blood cells if needed, and stem cells from healthy donors are free of cancer cells.

Cons to allogeneic stem cell transplants: The transplant, also known as the graft, might not take that is, the donor cells could die or be destroyed by the patients body before settling in the bone marrow. Another risk is that the immune cells from the donor may not just attack the cancer cells they could attack healthy cells in the patients body. This is called graft-versus-host disease (described in the section called Problems that may come up shortly after transplant). There is also a very small risk of certain infections from the donor cells, even though donors are tested before they donate. A higher risk comes from infections you have had, and which your immune system has under control. These infections often surface after allogeneic transplant because your immune system is held in check (suppressed) by medicines called immunosuppressive drugs. These infections can cause serious problems and even death.

Allogeneic transplant is most often used to treat certain types of leukemia, lymphomas, multiple myeloma, myelodysplastic syndrome, and other bone marrow disorders such as aplastic anemia.

For some people, age or certain health conditions make it more risky to wipe out all of their bone marrow before a transplant. For those people, doctors can use a type of allogeneic transplant thats sometimes called a mini-transplant. Compared with a standard allogeneic transplant, this one uses less chemo and/or radiation to get the patient ready for the transplant. Your doctor might refer to it as a non-myeloablative transplant or mention reduced-intensity conditioning (RIC). The idea here is to kill some of the cancer cells along with some of the bone marrow, and suppress the immune system just enough to allow donor stem cells to settle in the bone marrow.

Unlike the standard allogeneic transplant, cells from both the donor and the patient exist together in the patients body for some time after a mini-transplant. But slowly, over the course of months, the donor cells take over the bone marrow and replace the patients own bone marrow cells. These new cells can then develop an immune response to the cancer and help kill off the patients cancer cells the graft-versus-cancer effect.

One advantage of a mini-transplant is the lower doses of chemotherapy (chemo) and/or radiation. And because the stem cells arent all killed, blood cell counts dont drop as low while waiting for the new stem cells to start making normal blood cells. This makes it especially useful in older patients and those with other health problems who arent strong enough for a standard allogeneic stem cell transplant. Rarely, it may be used in patients who have already had a transplant.

Mini-transplants treat some diseases better than others. They may not work well for patients with a lot of cancer in their body or those with fast-growing cancers. Also, although side effects from chemo and radiation may be less than those from a standard allogeneic transplant, the risk of graft-versus-host disease is not.

This procedure has only been used since the late 1990s and long-term patient outcomes are not yet clear. There are lower risks of some complications, but the cancer may be more likely to relapse (come back). Ways to improve outcomes are still being studied.

Studies have looked at using an allogeneic mini-transplant after an autologous transplant. This is another type of tandem transplant (see Tandem transplants under Autologous transplant) being tested in certain types of cancer, such as multiple myeloma. The autologous transplant can help decrease the amount of cancer present so that the lower doses of chemo given before the mini-transplant can work better. And the recipient still gets the benefit of the graft-versus-cancer effect of the allogeneic transplant.

This is a special kind of allogeneic transplant that can only be used when the recipient has an identical sibling (twin or triplet) who can donate someone who will have the same tissue type. An advantage of syngeneic stem cell transplant is that graft-versus-host disease will not be a problem. There are no cancer cells in the transplant, either, as there would be in an autologous transplant.

A disadvantage is that because the new immune system is so much like the recipients immune system, there is no graft-versus-cancer effect, either. Every effort must be made to destroy all the cancer cells before the transplant is done to help keep the cancer from relapsing (coming back).

Some centers are doing half-match (haploidentical) transplants for people who dont have closely matching family members. This technique is most often used in children, usually with a parent as the donor, though a child can also donate to a parent. Half of the HLA factors will match perfectly, and the other half typically dont match at all, so the procedure requires a special way to get rid of a certain white blood cells that can cause graft-versus-host disease. Its still rarely done, but its being studied in a few centers in the United States. Researchers are continuing to learn new ways to make haploidentical transplants more successful.

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Types of stem cell transplants for treating cancer

Located in beautiful Phoenix, Arizona, we are the originalStem Cell Rejuvenation Center.We havebeenperformingstem cell therapies for over 10years and all of ourprocedures are done on site atour clinic herein Phoenix. Itis our top priority to provide you a safe, clean,sterile and friendly environment.Our Treatment Center is located just 8 minutes from the Phoenix Sky Harbor International Airport and many hotels provide shuttle service to and from our clinic making it ideal for out-of-town visitors. We provide stem cell therapy for a variety of conditions byusing our revolutionarytechnology and treatments to isolate and reinfuse stem cells from a patient's own adipose stroma or fat (also called the Stromal Vascular Fraction (SVF)). We combine the best of technology, nature, and medicine to help improve the quality of our patients' lives. Stem cell therapy is offered to those who are qualified candidates and whom desire treatment.

We are aStem Cell Therapy and Treatment Center, founded in the U.S.A., and performing all therapies within the United States. Neither our patients nor the stem cells that we harvest are transported outside the United States. We use less than minimally manipulated technology to provide Autologous Stem Cell and PRP therapies originally initiated during the 1990's.

To see if you are a candidate, please fill-out this form and provide as much detail as possible.

Our Integrative staff and Physicians use a variety of modalities including Anti-aging and Eclectic medicine. These approaches are usedto treat many injuries and conditions. Below are some links toa journal database maintained by theNIH thatrelate to current research on stem cells and particular conditions......

Degenerative and Debilitating Conditions:

Autoimmune Conditions:

Viral Conditions:

Musculoskeletal Injuries:

Cosmetic and Dermatological:

Please note that although we have supplied links to the research journals above on the use of stem cells for specific conditions, we are not saying that any of these studies would relate to your particular condition, nor that it would even be an effective treatment. Our Autologous Stem Cell Therapy is not an FDA approved treatment for any condition. We provide stem cell therapy (less than manipulated) as a service and as a practice of medicine only. We do not use collagenase in our clinic. Please see the bottom of the FAQ page for more information. Thesejournal articlesare for educational purposes only and are not intended to be used to sell or promote our therapy.

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Stem Cell Rejuvenation Center

At The Stem Cell Treatment Institute advanced stem cell procedures are performed in compliance with Global Good Manufacturing Practice (GMP) standards, thus guaranteeing the highest level of quality and safety for our patients.

Stem Cell and Cancer RetroVirus solutions are often more effective than most of the traditional medical procedures being practiced today and can now be obtained without international flights.

We offer Stem Cell and Cancer RetroVirus treatments with enhanced, manipulated, and activated stem cells. These expanded and activated stem cells have been found to provide better results than non-manipulated stem cell applications. Manipulation or amplification of the stem cells is done in a nearby lab, where care is taken to coordinate transportation and timing in order to retain the cells quality and viability. Then transfer factors are added to activate cells. These expanded and activated cells provide superior results and cell recovery has been found to occur twice as fast as with non-manipulated stem cell applications.

We currently have available treatments with stem cells utilizing a patient's own bone marrow, adipose (fat cells) or younger sources, like placenta stem cells.

Treatments are available in the following areas: Macular Degeneration, Breast Cancer, , Spinal Cord Injury, Arthritis, Parkinsons Disease, Autoimmune disease, Cerebral Palsy, Diabetes, Heart Failure, Multiple Sclerosis, Alzheimers Disease, and Stroke, just to mention a few.

Cancer RetroVirus Vaccine Treatment

The RetroVirus Cancer Vaccine is more of a process used to teach your body to attack the cancer, at the tumor, anywhere else it is in the body now, and set up protection in case it tries to come back.

How do we do this? First we remove cancer cells and stem cells from the patient. We then use the cancer cells to program the stem cells and turn them into RetroVirus immune system cells specifically programed against your cancer. By returning these educated cells back to the body the body's immune system is educated by the process and responds by eliminating the targeted tumor and other locations the cancer may have spread to called metastases.

Several companies are currently preparing RetroVirus Investigational New Drug (IND) applications to submit to the FDA in order to begin US-based clinical trials of this process.

You don't have to wait!

Treatments are available now in the following areas: Prostate Cancer RetroVirus, Breast Cancer RetroVirus, Colon Cancer RetroVirus, just to mention a few.

Not sure what to do! Want a personal consultation with one of our doctors? To begin the consultation and review process now, just click here >>>, give us your contact information and we will get right back to you. It's easy and FREE!

At The Stem Cell Treatment Institute our doctors use advanced stem cell procedures to treat a wide range of conditions. Our Health Department Permit, a COFEPRIS, is on a Presidential level.

Stem Cells can come from the patient?s fat or bone marrow, but stem cell treatment from donor placenta or umbilical cord blood is also available. Donor characteristics (i.e., age, health) play a key role in treatment success. Your individual situation will be considered and suitable options will be discussed.

In some countries (US and Europe) requlations limit access to these advanced stem cell applications or stored cells are used limiting the effectiveness. Fortunately our doctors and lab are experienced in providing the highest level of quality stem cell treatment.

Depending on budget, condition, age and other factors the best solution can be determined. Sometimes cells are placed directly into an organ, other times a simple IV with cells harvested from your own bone marrow will do just fine. We can help you make this decision.

No international flights required! Patients fly to the San Diego International Airport, are taken to the clinics for extraction and treatments.

Understanding Stem Cell Treatment Let's face it, your body is at war against infection, disease, aging, and sometimes itself. Your immune system is the first line of defense. Anything that it can?t deal with will do some damage. Your Stem Cells are the crews that repair this damage. If your condition or disease has become chronic this means that your damage crews can not handle the job, they need help. We have found that additional stem cells can be added to your troops to help in the repair process. Stem cells can be stimulated with powerful "homing" mechanisms which enable them to hone in on areas of the body that are in need of repair. These cells can be taken from your body and manipulated, then can be put back in.

Our experienced International Medical and Scientific Board of Advisors will review all the medical data provided and prepare a recommendation regarding stem cell therapy options. Each patient is provided a personal phone consultation with one of our doctors and gets a personalized treatment plan based on the their medical history and current condition.

To contact our stem cell expert team, and begin the consultation and review process now, click here >>>

Breast Cancer Testimonials

Prostate Cancer Testimonial

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Our team and their associates have evaluated thousands of stem cell treatment candidates over the past 25 years. They have treated over 1,000 patients.

Located in the heart of the stem cell research capital of the world, San Diego, California, we work hand in hand with top research centers. Even though some stem cell research is being conducted in the U.S., most stem cell implementation must take place outside of the country. We are strategically located to take advantage of both. No international flights required!

It is believed that by the practical application of stem cells, the need for liver, kidney and heart transplants can be reduced dramatically. In addition, a cure for diabetes, nerve restoration and the extension of ones life expectancy by more than 50 years are on the horizon.

To begin the consultation and review process now, just click here >>>,

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Stem Cell Treatment - The Stem Cell Treatment Institute

Formerly Orthopedic Stem Cell Institute We put the power of your own body to work for you.

Our team of board certified, fellowship-trained orthopedic and spine surgeons work with patients from around the world using the newest and most advanced technology to treat orthopedic injuries and bone and joint pain, as well as relieving symptoms and improving the lives of patients with a multitude of illnesses.

The Premier Stem Cell Institute is a leading research and treatment facility in Colorado providing the most innovative and proven techniques and therapies using the bodys natural healing power of stem cells.

A stem cell is a basic cell constantly produced by your body to heal injuries, build new skin, even grow your hair. However, your body wont refix a chronic injury or illness by continuing to attack it with new stem cells unless those cells are extracted and reintroduced into your body via stem cell therapies.

We are a leading research and treatment facility providing the most innovative and proven techniques and therapies using the bodys natural healing power of stem cells. Our services are performed by fellowship-trained surgeons using the most state-of-the-art equipment and technology in the field.All stem cell treatments are not alike. AtPremier Stem Cell Institute, we extract your stem cells from your bone marrow because they are higher quality and result in better outcomes than stem cells from fat (adipose). We treat each patient with the utmost respect and our concierge service makes you feel incredibly well cared for from the first phone call to follow up visits.

They're very personable, they're very helpful..nice people. Bottom line is there's no pain where there was a lot of pain before.

Jon Hoffman, Former NFL Player

I used to dread doing simple things like putting on a coat, a seat belt or reaching for things. I can now do those things without nearly as much difficulty. I want to thank everyone at the clinic for performing the procedure on me. They are making peoples' lives much more enjoyable.

Bob Hyland, Former NFL Player

It's amazing! You're awake the whole time, it's virtually painless, and within an hour you're walking out.

Don Horn, Former NFL Player

of Patients are 70% Better Within 1 Year!

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Stem Cell Therapy - Premier Stem Cell Institute