Category Archives: Stem Cells

A groundbreaking attempt to heal eight Parkinson's patients with their own cells could move from research to the clinic next year.

For eight Parkinson's patients seeking treatment with a new form of stem cell therapy, 2014 promises to be a milestone. If all goes well, next year the FDA will give approval to begin clinical trials. And if the patients can raise enough money, the scientists and doctors working with them will have the money to proceed.

Jeanne Loring, a stem cell scientist at The Scripps Research Institute, discusses the status of a project to treat Parkinson's patients with their own cells, turned into the kind of brain cells destroyed in Parkinson's. The project is a collaboration with Scripps Health and the Parkinson's Association of San Diego.

Scientists at The Scripps Research Institute led by Jeanne Loring have taken skin cells from all patients and grown them into artificial embryonic stem cells, called induced pluripotent stem cells. They then converted the cells into dopamine-making neurons, the kind destroyed in Parkinson's disease.

Loring discussed the project's progress on Friday morning at the 2013 World Stem Cell Summit in San Diego.

If animal studies now under way and other requirements are met, doctors at Scripps Health will perform a clinical trial. They will grow neurons until they are just short of maturity, then transplant them into the brains of the respective patients. The cells are expected to complete maturation in the brain, forming appropriate connections with their new neighbors, and begin making dopamine.

Earlier attempts to treat Parkinson's with a stem cell-like therapy mostly failed because of difficulties in quality control of the source, neural cells from aborted fetuses, Loring said. But some patients gained lasting improvement, a tantalizing hint that the trials were on the right track.

In January, a "pre-pre-IND meeting" is planned with the FDA, Loring said.

Also speaking were Ed Fitzpatrick, one of the eight patients, and Kyoto University researcher Jun Takahashi, who is independently trying the same approach in Japan.

Ed Fitzpatrick, one of eight Parkinson's patients in a program to be treated with his own cells, grown into the kind of brain cells destroyed in Parkinson's.

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Stem cells for Parkinson's getting ready for clinic

"STEM CELLS IN ORTHOPEDICS an Alternative to Surgery" http://www.CLINICell.com

By: ClinicellTech

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"STEM CELLS IN ORTHOPEDICS an Alternative to Surgery" http://www.CLINICell.com - Video

[Int. version] Marianna Tryfonidou: "We use cultivated stem cells to repair intervertebral discs"
Dr Marianna Tryfonidou is a specialist veterinary surgeon for companion animals and researcher into tissue regeneration. She works in the Orthopaedics sectio...

By: UniversiteitUtrecht

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[Int. version] Marianna Tryfonidou: "We use cultivated stem cells to repair intervertebral discs" - Video

Organ Transplants #39; Future with Stem Cells

By: Healthy living

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Organ Transplants' Future with Stem Cells - Video

Stefan Karlsson - Development of advanced cell therapies using hematopoietic stem cells
Interview wtth Stefan Karlssonl, researcher at Lund Stem Cell Center.

By: Medicinska Fakulteten, LU

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Stefan Karlsson - Development of advanced cell therapies using hematopoietic stem cells - Video

ReelLife Science 2013 Secondary School 2nd Place - St Mary #39;s College - The Future for Stem Cells
In second place in the 2013 ReelLife Science competition at Secondary level (www.reellifescience.com) under the "Stem Cells" category, we have a video produc...

By: ReelLife Science

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ReelLife Science 2013 Secondary School 2nd Place - St Mary's College - The Future for Stem Cells - Video

Product Type Please Select Specialized cell culture media Cell isolation products Antibodies Primary cells Mammalian cloning products Contract Services Cytokines Other cell culture media, reagents & supplies Software Stem cell detection kits Training & education Proficiency testing T-shirts

Cell Type Please Select B cells Brain tumor stem cells Bronchial epithelial cells CHO cells Dendritic cells Embryonic stem cells & iPS cells (Human) Embryonic stem cells & iPS cells (Mouse) Granulocytes & subsets Hematopoietic stem & progenitor cells Hybridomas Lymphocytes Mammary epithelial cells Mesenchymal stem cells Monocytes Myeloid cells Neural stem & progenitor cells Neurons Natural killer (NK) cells Other cells Prostate epithelial cells Regulatory T cells T cells

Your area of interest Please Select Cancer Cell line development Chimerism analysis Cord blood banking Embryonic stem cell & induced pluripotent stem cell research Endothelial & angiogenic cell research Hematologic malignancies Hematopoietic stem cell research HIV HLA Hybridoma generation Immunology Immunology (Mouse) Mammary cell research Mesenchymal stem cell research Neuroscience Pharmacology, toxicology & drug discovery Prostate cell research Respiratory research Semi-solid cloning Stem cell biology Transplantation

Popular product lines Please Select AggreWell ALDECOUNT ALDEFLUOR CFU-Hill Medium ClonaCell CollagenCult EasySep EpiCult EPO-ELISA ES-Cult MammoCult MegaCult MesenCult MethoCult mFreSR mTeSR1 & TeSR2 MyeloCult NeuroCult PneumaCult-ALI Primary cells ProstaCult RoboSep RosetteSep SepMate StemAdhere STEMdiff StemSep StemSpan STEMvision TeSR-E8

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Stemcell Technologies - Official Site

Thinking of stem cells for your arthritis?
http://www.stemcellsarthritistreatment.com Thinking of stem cells for your arthritis. Think Arthritis Treatment Center. The Experts. http://youtu.be/aqX0dtsWuEk.

By: Nathan Wei

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Thinking of stem cells for your arthritis? - Video

News Update Wednesday, 30 January 2013 15:32

"Now I can touch my mouth. Now I can put my finger in my ear. Now I can open my hands, I can lift them up. I can work on my computer. I can type. I can do many things with my hands."

Gabi Iordache, SCI Stem Cell Patient

What sort of gains can be had by Spinal Cord Injury patients receiving adult stem cell therapies? Let the patients tell you themselves. This month we're releasing a video containing eight StemCellsChina interviewees discussing the improvements they saw in their conditions following adult stem cell transplants.

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Patients here have all had between one and six cycles of treatment. They all had incomplete injuries. While not every patient sees the full spectrum of improvements discussed here, this video is intended to give an idea of what real patients have found through today's process.

We'd like to thank all the patients for their courage in sharing their stories with us. Most of the patients featured in this video have patient experience interviews here at StemCellsChina. If you're interested in their stories, check out our StemCellsChina SCI Channel at Vimeo.

If you'd like to learn more about options available today, send us an inquiry!

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China Stem Cells

home stem cell research all about stem cells what are stem cells?

Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources:

Both types are generally characterized by their potency, or potential to differentiate into different cell types (such as skin, muscle, bone, etc.).

Adult or somatic stem cells exist throughout the body after embryonic development and are found inside of different types of tissue. These stem cells have been found in tissues such as the brain, bone marrow, blood, blood vessels, skeletal muscles, skin, and the liver. They remain in a quiescent or non-dividing state for years until activated by disease or tissue injury.

Adult stem cells can divide or self-renew indefinitely, enabling them to generate a range of cell types from the originating organ or even regenerate the entire original organ. It is generally thought that adult stem cells are limited in their ability to differentiate based on their tissue of origin, but there is some evidence to suggest that they can differentiate to become other cell types.

Embryonic stem cells are derived from a four- or five-day-old human embryo that is in the blastocyst phase of development. The embryos are usually extras that have been created in IVF (in vitro fertilization) clinics where several eggs are fertilized in a test tube, but only one is implanted into a woman.

Sexual reproduction begins when a male's sperm fertilizes a female's ovum (egg) to form a single cell called a zygote. The single zygote cell then begins a series of divisions, forming 2, 4, 8, 16 cells, etc. After four to six days - before implantation in the uterus - this mass of cells is called a blastocyst. The blastocyst consists of an inner cell mass (embryoblast) and an outer cell mass (trophoblast). The outer cell mass becomes part of the placenta, and the inner cell mass is the group of cells that will differentiate to become all the structures of an adult organism. This latter mass is the source of embryonic stem cells - totipotent cells (cells with total potential to develop into any cell in the body).

In a normal pregnancy, the blastocyst stage continues until implantation of the embryo in the uterus, at which point the embryo is referred to as a fetus. This usually occurs by the end of the 10th week of gestation after all major organs of the body have been created.

However, when extracting embryonic stem cells, the blastocyst stage signals when to isolate stem cells by placing the "inner cell mass" of the blastocyst into a culture dish containing a nutrient-rich broth. Lacking the necessary stimulation to differentiate, they begin to divide and replicate while maintaining their ability to become any cell type in the human body. Eventually, these undifferentiated cells can be stimulated to create specialized cells.

Stem cells are either extracted from adult tissue or from a dividing zygote in a culture dish. Once extracted, scientists place the cells in a controlled culture that prohibits them from further specializing or differentiating but usually allows them to divide and replicate. The process of growing large numbers of embryonic stem cells has been easier than growing large numbers of adult stem cells, but progress is being made for both cell types.

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What are Stem Cells? - Medical News Today