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Category Archives: Stem Cells
A $6 Billion Question: Progress of the California Stem Cell Agency
Posted: August 18, 2013 at 3:01 am
The headlines march like legions across the
Internet and throughout the world.
Internet and throughout the world.
But then there is this extraordinarily
rare headline that sounds a harshly different note:
rare headline that sounds a harshly different note:
All these headlines go to address, in
one form or another, a request/question posed last month by an
anonymous reader of the California Stem Cell Report. The comment came
on an item about the California stem cell agency's $70 million plan
to establish a network of “Alpha” stem cell clinics in
California.
one form or another, a request/question posed last month by an
anonymous reader of the California Stem Cell Report. The comment came
on an item about the California stem cell agency's $70 million plan
to establish a network of “Alpha” stem cell clinics in
California.
The reader said,
“It would be nice to have an overall
update on how much as been spent on California's stem cell research
project and what progress has been made.”
On the surface, the answer is easy. The
agency has given away $1.8 billion. The agency says it has made
tremendous progress and expects to make even more with the about $600
million it has left. The prestigious Institute of Medicine has said the
agency has “achieved many notable results.”
agency has given away $1.8 billion. The agency says it has made
tremendous progress and expects to make even more with the about $600
million it has left. The prestigious Institute of Medicine has said the
agency has “achieved many notable results.”
However, no thorough, rigorous
evaluation has been made of the details of the agency's scientific
contributions, specific grant awards or its impact on the field of
regenerative medicine. No one has attempted to genuinely assess
whether the work of the agency is or will be worth the roughly $6
billion(including interest) that California taxpayers will have paid
for the agency's ambitious efforts.
evaluation has been made of the details of the agency's scientific
contributions, specific grant awards or its impact on the field of
regenerative medicine. No one has attempted to genuinely assess
whether the work of the agency is or will be worth the roughly $6
billion(including interest) that California taxpayers will have paid
for the agency's ambitious efforts.
Then there is the question of “progress
towards what?” Is the progress to be measured against the promises
of the 2004 ballot campaign that resulted in creation of the stem
cell agency or more modest goals that eschew the hype of the
campaign?
towards what?” Is the progress to be measured against the promises
of the 2004 ballot campaign that resulted in creation of the stem
cell agency or more modest goals that eschew the hype of the
campaign?
The stem cell agency is burdened in a way that most science is not. The 2004 campaign
created a sort of contract with voters. They were led to
believe nine years ago that the cures for diseases that the campaign said afflict nearly
one-half of all California families were, in fact, right around the corner. Few,
if any California stem cell researchers were publicly warning that a
hard and long, long slog remained before therapies reached patients.
created a sort of contract with voters. They were led to
believe nine years ago that the cures for diseases that the campaign said afflict nearly
one-half of all California families were, in fact, right around the corner. Few,
if any California stem cell researchers were publicly warning that a
hard and long, long slog remained before therapies reached patients.
Last week, however, Simon Roach of the
British newspapers, The Guardian and Observer, shed some light on the
early, rosy promises of stem cell science compared to the world as it exists
today.
British newspapers, The Guardian and Observer, shed some light on the
early, rosy promises of stem cell science compared to the world as it exists
today.
He wrote that in 1998,
“(B)iomedical engineer Professor
Michael Sefton declared that within 10 years, scientists would have
grown an entire heart, fit for transplant. 'We're shooting big,' he
said. 'Our vision is that we'll be able to pop out a damaged heart
and replace it as easily as you would replace a carburetor in a car.'“Fifteen years on, however, we've had
some liver cells, eye cells, even a lab-grown
burger, but no whole human organs. We could be forgiven for
asking: where's our heart? It does seem strange that a field stoking
so much excitement could be so far off the mark. Speaking last week
about the vision that he and his colleagues outlined in 1998, Sefton
said they had been 'hopelessly naïve.' As time plodded on and an
understanding of the biological complexity increased, the task seemed
bigger and bigger. Even now, a cacophony of headlines later, we are
not much further ahead.
“Chris Mason is a professor of
regenerative medicine at University College London and believes that
concentrating on organ regeneration is missing a trick. 'These organs
are immensely complex,' he said. 'They've got nerves, blood vessels,
in the case of the liver, a bile system – there are huge degrees of
complexity. These things take a long time to grow in humans, let
alone in the lab without all the natural cues that occur in the
growing embryo.'"
The final paragraph in Roach's article
said,
said,
“There's a tension in medical
research between the glory of the big discovery and the
assiduous commitment to real application. 'We're hoping the scope and
possibilities of this project will catch the public's imagination,'
Sefton concluded in 1998. It did, but perhaps the public's
imagination isn't always what science should be vying for.”
Little doubt exists that the California
stem cell agency has made a significant contribution to stem cell
science, although the size of that contribution – beyond dollars –
remains to be measured. For now, the key for the agency and the
public is to focus on activities that will generate the greatest value over the
next few years and advance the science that has already been financed
by the agency.
stem cell agency has made a significant contribution to stem cell
science, although the size of that contribution – beyond dollars –
remains to be measured. For now, the key for the agency and the
public is to focus on activities that will generate the greatest value over the
next few years and advance the science that has already been financed
by the agency.
As the $700,000 Institute of Medicine
report said,
report said,
“The challenge of moving its research
programs closer to the clinic and California’s large biotechnology
sector is certainly on CIRM’s agenda, but substantial achievements
in this arena remain to be made.”
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/O78NzUdZE88/a-6-billion-question-progress-of.html
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Duane Roth: Ecumenical Innovator for San Diego and Biotech
Posted: August 18, 2013 at 3:01 am
The Xconomy news service today carried
a sterling look at the contributions that Duane Roth, co-vice
chairman of the California stem cell agency, made before his untimely
death as the result of a bicycle accident.
a sterling look at the contributions that Duane Roth, co-vice
chairman of the California stem cell agency, made before his untimely
death as the result of a bicycle accident.
Reporter Bruce Bigelow pulled together
a host of comments concerning Roth's involvement in the San Diego
community, ranging from biotech to action sports companies. The
headline on the piece read, “The Connector Who Wired up a Regional
Innovation Economy.”
a host of comments concerning Roth's involvement in the San Diego
community, ranging from biotech to action sports companies. The
headline on the piece read, “The Connector Who Wired up a Regional
Innovation Economy.”
At the time of his death at the age of
63, Roth was CEO of Connect, a nonprofit organization that supported
technology and innovation and one that he was credited with reviving.
Bigelow also wrote,
63, Roth was CEO of Connect, a nonprofit organization that supported
technology and innovation and one that he was credited with reviving.
Bigelow also wrote,
“Once California voters approved a
2004 ballot proposition that authorized the issuance of $3 billion in
grants for stem cell R&D, (Mary) Walshok (associate vice
chancellor for public programs at UC San Diego) said Roth also played
a key role in bringing together UCSD, Scripps, Salk, and
Sanford-Burnham to create the Sanford Consortium for Regenerative
Medicine. In fact, Walshok doubts whether anyone but Duane Roth could
have brought the four major research centers together.”
Another speaker at the memorial
services Friday attended by about 1,000 persons was Bill Walton, the
former UCLA and NBA great, who grew up in San Diego.
services Friday attended by about 1,000 persons was Bill Walton, the
former UCLA and NBA great, who grew up in San Diego.
Bigelow wrote,
“Walton, the NBA Hall of Famer who
has led San Diego Sports Innovators as a division of Connect since
2010, said Roth became a business mentor to him. In his comments
Friday afternoon, Walton said Roth inspired him to be a better
person, and he counted Roth among the people who had the biggest
influence on his life—a list that included his own father, UCLA
coach John Wooden, sportscaster Chick Hearn, author David Halberstam,
and Jerry Garcia of the Grateful Dead.”
Bigelow described Roth as an ecumenical
and pragmatic advocate for innovation who could work with persons who
did not always agree with him on all issues. He was a conservative
and active Republican, but his co-vice chair at at the stem cell
agency, Art Torres, former chairman of the state Democratic Party, on
more than one occasion has lauded Roth's ability to work together.
and pragmatic advocate for innovation who could work with persons who
did not always agree with him on all issues. He was a conservative
and active Republican, but his co-vice chair at at the stem cell
agency, Art Torres, former chairman of the state Democratic Party, on
more than one occasion has lauded Roth's ability to work together.
Bigelow wrote about similar remarks
Friday by Don Rosenberg, an executive vice president and general
counsel at Qualcomm.
Friday by Don Rosenberg, an executive vice president and general
counsel at Qualcomm.
“'Duane and I were as different as
two people can be,' Rosenberg said during his eulogy at the Church of
the Immaculata. 'Duane was born in Iowa, baptized in the Mennonite
church, a Republican. And me, raised in Brooklyn, Jewish, a Democrat.
We quickly learned we had more in common. We were kindred spirits. We
liked the same things: Bikes, biking, cars, and people.'”
Posted in Stem Cells, Stem Cell Therapy
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Stem Cell Agency’s Duane Roth Eulogized at Memorial Services
Posted: August 18, 2013 at 3:01 am
An estimated 1,000 persons attended
services last week for Duane Roth, co-vice chairman of the California
stem cell agency, who died at the age of 63 following a bicycle
accident.
services last week for Duane Roth, co-vice chairman of the California
stem cell agency, who died at the age of 63 following a bicycle
accident.
The San Diego U-T reported,
“A Who’s
Who of San Diego’s technology, business and civic community
gathered Friday to bid farewell to Duane Roth.
The biotech entrepreneur, community leader and director of Connect
died last weekend of injuries sustained in a cycling accident.
“Among
attendees were Gayle and former Gov. Pete
Wilson, who had just celebrated his upcoming 80th birthday
with former colleagues and friends in Sacramento, county
Supervisor Ron Roberts, former
Assemblyman Nathan Fletcher, Chamber
head Jerry Sanders, Preuss School
benefactors Peggy and Peter
Preuss, SDG&E CEO Jessie Knight,
and many biotech and high-tech leaders. These included Irwin
Jacobs, Ted Waitt and Denny
Sanford.”
Posted in Stem Cells, Stem Cell Therapy
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Stem Cell Agency's Duane Roth Eulogized at Memorial Services
Posted: August 18, 2013 at 3:01 am
An estimated 1,000 persons attended
services last week for Duane Roth, co-vice chairman of the California
stem cell agency, who died at the age of 63 following a bicycle
accident.
services last week for Duane Roth, co-vice chairman of the California
stem cell agency, who died at the age of 63 following a bicycle
accident.
The San Diego U-T reported,
“A Who’s
Who of San Diego’s technology, business and civic community
gathered Friday to bid farewell to Duane Roth.
The biotech entrepreneur, community leader and director of Connect
died last weekend of injuries sustained in a cycling accident.
“Among
attendees were Gayle and former Gov. Pete
Wilson, who had just celebrated his upcoming 80th birthday
with former colleagues and friends in Sacramento, county
Supervisor Ron Roberts, former
Assemblyman Nathan Fletcher, Chamber
head Jerry Sanders, Preuss School
benefactors Peggy and Peter
Preuss, SDG&E CEO Jessie Knight,
and many biotech and high-tech leaders. These included Irwin
Jacobs, Ted Waitt and Denny
Sanford.”
Posted in Stem Cells, Stem Cell Therapy
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‘Paradigm Shift’ — Researchers as Patient Advocates?
Posted: August 18, 2013 at 3:01 am
It is not easy for a stem cell
scientist to break into “print” in that bastion of American
capitalism, Forbes magazine. Much less one from that perceived
antithesis of free enterprise, Reed College.
scientist to break into “print” in that bastion of American
capitalism, Forbes magazine. Much less one from that perceived
antithesis of free enterprise, Reed College.
But researcher Paul Knoepfler of UC
Davis has done just that.
Davis has done just that.
John Farrell of Forbes wrote about Knoepfler on
Friday in the wake of the announcement Knoepfler will be honored with
a “national advocacy” award by the Genetics Policy Institute.
Friday in the wake of the announcement Knoepfler will be honored with
a “national advocacy” award by the Genetics Policy Institute.
 |
| Paul Knoepfler -- Advocate for a "new ethos" UC Davis photo |
Knoepfler, who received a degree in
English literature from Reed in 1989, is being recognized for his
activities as a stem cell blogger since 2009.
English literature from Reed in 1989, is being recognized for his
activities as a stem cell blogger since 2009.
Farrell quoted Knoepfler as saying in
an email,
an email,
“With many stumbles, face plants,
land mines, and even a few threats of litigation and career
retaliation along the way for the last three and half a years, I
turned my crazy idea into a reality.”
Farrell continued,
“But it was only possible,
(Knoepfler) added, with guidance from many patient advocates and
bloggers in other fields who generously helped him learn the ropes of
blogging.
“'I see this award as a validation of
the notion that advocacy by scientists has become a valued part of
the stem cell field,' he said.
“'My hope is to catalyze a continuing
paradigm shift whereby stem cell scientists and biomedical scientists
more generally have a new ethos that not just accepts, but also
deeply values advocacy.'”
Posted in Stem Cells, Stem Cell Therapy
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'Paradigm Shift' — Researchers as Patient Advocates?
Posted: August 18, 2013 at 3:01 am
It is not easy for a stem cell
scientist to break into “print” in that bastion of American
capitalism, Forbes magazine. Much less one from that perceived
antithesis of free enterprise, Reed College.
scientist to break into “print” in that bastion of American
capitalism, Forbes magazine. Much less one from that perceived
antithesis of free enterprise, Reed College.
But researcher Paul Knoepfler of UC
Davis has done just that.
Davis has done just that.
John Farrell of Forbes wrote about Knoepfler on
Friday in the wake of the announcement Knoepfler will be honored with
a “national advocacy” award by the Genetics Policy Institute.
Friday in the wake of the announcement Knoepfler will be honored with
a “national advocacy” award by the Genetics Policy Institute.
|
| Paul Knoepfler -- Advocate for a "new ethos" UC Davis photo |
Knoepfler, who received a degree in
English literature from Reed in 1989, is being recognized for his
activities as a stem cell blogger since 2009.
English literature from Reed in 1989, is being recognized for his
activities as a stem cell blogger since 2009.
Farrell quoted Knoepfler as saying in
an email,
an email,
“With many stumbles, face plants,
land mines, and even a few threats of litigation and career
retaliation along the way for the last three and half a years, I
turned my crazy idea into a reality.”
Farrell continued,
“But it was only possible,
(Knoepfler) added, with guidance from many patient advocates and
bloggers in other fields who generously helped him learn the ropes of
blogging.
“'I see this award as a validation of
the notion that advocacy by scientists has become a valued part of
the stem cell field,' he said.
“'My hope is to catalyze a continuing
paradigm shift whereby stem cell scientists and biomedical scientists
more generally have a new ethos that not just accepts, but also
deeply values advocacy.'”
Posted in Stem Cells, Stem Cell Therapy
Comments Off on 'Paradigm Shift' — Researchers as Patient Advocates?
CTO001RSL Stem cells therapy for breast cancer treatment – Video
Posted: August 16, 2013 at 11:44 pm
CTO001RSL Stem cells therapy for breast cancer treatment
http://www.scientificanimations.com/ This 3D medical animation demonstrates the use of autologus stem cells for the treatment of breast cancer. Breast cancer...
By: Scientific Animations
See the rest here:
CTO001RSL Stem cells therapy for breast cancer treatment - Video
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Developmental on-switch: Substances that convert body cells back into stem cells initially activate all genes in the …
Posted: August 16, 2013 at 11:44 pm
Aug. 16, 2013 Substances that convert body cells back into stem cells initially activate all genes in the embryo.
Freiburg researchers have demonstrated for the first time why the molecular cocktail responsible for generating stem cells works. Sox2 and Oct4 are proteins whose effect on cells resembles that of an eraser: They remove all of the cell's previous experiences and transform it into a so-called pluripotent stem cell. Like cells in the embryo, this stem cell can then develop into all forms of tissue. The discoverers of this reprogramming technique received the Nobel Prize in Physiology or Medicine in 2012. However, until now scientists did not understand precisely why these proteins can reprogram cells and what function they have in the embryo.
A team from the Department of Developmental Biology and the Cluster of Excellence BIOSS Centre for Biological Signalling Studies, led by Dr. Daria Onichtchouk and Prof. Dr. Wolfgang Driever, has discovered that the Oct4 protein in the zebrafish embryo, which is initially provided by the mother, is responsible for switching on the embryo's genes for the first time, thus initiating the animal's independent development. Young embryonic cells can develop into all tissues and cell types found in the body, just like cultures of the so-called pluripotent stem cells. These multi-talented cells are the focus of much attention in biomedical research because experts hope to use them to regenerate damaged organs without having to resort to embryonic stem cells.
In an article published in the journal Science, the Freiburg scientists explain that the zebrafish Pou5f1 protein, which is very similar to the human Oct4 protein, serves as the main starting signal for embryonic development. Pou5f1 awakens the genes after the resting period following fertilization. In all animals, development is initially controlled by proteins from the mother in the egg cell; the genes of the embryo are not activated until some time later. In the zebrafish, for instance, this process is triggered as soon as the embryo has a thousand cells. This "zygotic gene activation" reprograms the cells of the embryo: Specialized, rapidly dividing cells that do not create any new gene products become stem cells. These embryo stem cells can form all cell types -- like pluripotent stem cells. In the case of so-called mesodermal cells, which can form blood or muscles, the scientists demonstrate how the Pou5f1 protein sets off the cascade of gene products that create muscle, blood, or bone cells from the embryonic cells. This regulatory network is very similar to that of the pluripotent stem cells.
Researchers have been able to generate pluripotent stem cells for several years now, but have found it difficult to convert them into stable cell types with sufficient reliability -- if stem cells are unstable, they can become cancerous. Using the regulatory network discovered in the zebrafish, developmental biologists can now study how particular cell types in the body are created from stem cells and what makes them stable. Scientists require reliable processes for forming stable tissue before it can be used for applications in medicine.
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Developmental on-switch: Substances that convert body cells back into stem cells initially activate all genes in the ...
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Heart’s own stem cells could help treat cardiac failure
Posted: August 16, 2013 at 11:44 pm
Washington, August 16 (ANI): Researchers have highlighted, for the first time, the natural regenerative capacity of a group of stem cells that reside in the heart.
According to the new study these cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack that leads to heart failure.
The study shows that if the stem cells are eliminated, the heart is unable to repair after damage. If the cardiac stem cells are replaced the heart repairs itself, leading to complete cellular, anatomical and functional heart recovery, with the heart returning to normal and pumping at a regular rate.
Also, if the cardiac stem cells are removed and re-injected, they naturally 'home' to and repair the damaged heart, a discovery that could lead to less-invasive treatments and even early prevention of heart failure in the future.
The study had set out to establish the role of cardiac stem cells (eCSCs) by first removing the cells from the hearts of rodents with heart failure. This stopped regeneration and recovery of the heart, demonstrating the intrinsic regenerative capacity of these cells for repairing the heart in response to heart failure.
Current treatments for heart failures are aimed at treating the underlying causes, such as coronary heart disease, heart attack and blood pressure through lifestyle changes, medicines and in severe cases, surgery.
These treatments are sometimes successful in preventing or delaying heart failure. However, once heart failure develops the only curative treatment is heart transplantation.
By revealing this robust homing mechanism, which causes cardiac stem cells to home to and repair the heart's damaged muscle, the findings could lead to less invasive treatments or even preventative measures aimed at maintaining or increasing the activity of the heart's own cardiac stem cells.
Dr Georgina Ellison, the first author of the paper and Professor Bernardo Nadal-Ginard, the study's corresponding author, both from the Centre of Human and Aerospace Physiological Sciences and the Centre for Stem Cells and Regenerative Medicine at King's, said that in a healthy heart the quantity of cardiac stem cells is sufficient to repair muscle tissue in the heart.
They said that however, in damaged hearts many of these cells cannot multiply or produce new muscle tissue. In these cases it could be possible to replace the damaged cardiac stem cells or add new ones by growing them in the laboratory and administering them intravenously.
Read more:
Heart's own stem cells could help treat cardiac failure
Posted in Stem Cells
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Heart's own stem cells could help treat cardiac failure
Posted: August 16, 2013 at 11:44 pm
Washington, August 16 (ANI): Researchers have highlighted, for the first time, the natural regenerative capacity of a group of stem cells that reside in the heart.
According to the new study these cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack that leads to heart failure.
The study shows that if the stem cells are eliminated, the heart is unable to repair after damage. If the cardiac stem cells are replaced the heart repairs itself, leading to complete cellular, anatomical and functional heart recovery, with the heart returning to normal and pumping at a regular rate.
Also, if the cardiac stem cells are removed and re-injected, they naturally 'home' to and repair the damaged heart, a discovery that could lead to less-invasive treatments and even early prevention of heart failure in the future.
The study had set out to establish the role of cardiac stem cells (eCSCs) by first removing the cells from the hearts of rodents with heart failure. This stopped regeneration and recovery of the heart, demonstrating the intrinsic regenerative capacity of these cells for repairing the heart in response to heart failure.
Current treatments for heart failures are aimed at treating the underlying causes, such as coronary heart disease, heart attack and blood pressure through lifestyle changes, medicines and in severe cases, surgery.
These treatments are sometimes successful in preventing or delaying heart failure. However, once heart failure develops the only curative treatment is heart transplantation.
By revealing this robust homing mechanism, which causes cardiac stem cells to home to and repair the heart's damaged muscle, the findings could lead to less invasive treatments or even preventative measures aimed at maintaining or increasing the activity of the heart's own cardiac stem cells.
Dr Georgina Ellison, the first author of the paper and Professor Bernardo Nadal-Ginard, the study's corresponding author, both from the Centre of Human and Aerospace Physiological Sciences and the Centre for Stem Cells and Regenerative Medicine at King's, said that in a healthy heart the quantity of cardiac stem cells is sufficient to repair muscle tissue in the heart.
They said that however, in damaged hearts many of these cells cannot multiply or produce new muscle tissue. In these cases it could be possible to replace the damaged cardiac stem cells or add new ones by growing them in the laboratory and administering them intravenously.
Read more:
Heart's own stem cells could help treat cardiac failure
Posted in Stem Cells
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