Category Archives: Stem Cells

How to work in stem cells - growth drivers
http://www.12hourmba.com 12 Hour MBA in Stem Cells - How to work in stem cells Big ideas and fundamentals for pharmaceutical companies, biotechs, CROs, CMOs, advisors and suppliers Understand stem cells from bench to bedside Discover where the money is made with stem cells Understand risk and project management techniques for stem cells Explore practices for stem cell product commercialisation Learn about regulations, the government and the impact they can have Consider the ethics of stem cells Discover what the future holds for stem cells Visit our website http://www.12hourmba.com Subscribe http://www.youtube.com Follow us on twitter: http://www.twitter.com Read our blog: blogs.terrapinn.comFrom:MBATrainingCompanyViews:0 0ratingsTime:02:00More inEducation

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How to work in stem cells - growth drivers - Video

How to work in stem cells - ethical debate on cloning
http://www.12hourmba.com 12 Hour MBA in Stem Cells - How to work in stem cells Big ideas and fundamentals for pharmaceutical companies, biotechs, CROs, CMOs, advisors and suppliers Understand stem cells from bench to bedside Discover where the money is made with stem cells Understand risk and project management techniques for stem cells Explore practices for stem cell product commercialisation Learn about regulations, the government and the impact they can have Consider the ethics of stem cells Discover what the future holds for stem cells Visit our website http://www.12hourmba.com Subscribe http://www.youtube.com Follow us on twitter: http://www.twitter.com Read our blog: blogs.terrapinn.comFrom:MBATrainingCompanyViews:0 0ratingsTime:02:11More inEducation

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How to work in stem cells - ethical debate on cloning - Video

Clinical implantation of chondrotissue® with concomitant surgical procedures
This treatment video (by courtesy of Dr. Harold Vanderschmidt) includes partial resection of the lateral meniscus, ACL reconstruction with BTB graft, and the implantation of chondrotissue®. For this purpose the cartilage defect was debrided up to the subchondral bone and then microfractured to allow the migration of mesenchymal stem cells into the scaffold. After measuring the defect size with a sterile template, the rehydrated chondrotissue® was cut to fit the defect size, was implanted through a transpatellar portal and was fixed with fibrin glue.From:BioTissueAGViews:4 0ratingsTime:00:55More inPeople Blogs

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Clinical implantation of chondrotissue® with concomitant surgical procedures - Video

Injectable Sponges for Stem Cells and More (Brainstorm Ep117)
Shirts and Stuff http://www.zazzle.com Follow us on Twitter twitter.com Like us on Facebook http://www.facebook.com Medical News tinyurl.com Technology News tinyurl.com Chemistry News tinyurl.com Hosted by http://www.youtube.com Contributors http://www.facebook.com - Raychelle and Monica http://www.facebook.comFrom:qdragon1337Views:68 17ratingsTime:05:00More inScience Technology

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Injectable Sponges for Stem Cells and More (Brainstorm Ep117) - Video

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

Verastem, Inc., (VSTM) a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that researchers at the Broad Institute have published a study utilizing the cancer stem cell screening assay exclusively licensed to Verastem to identify novel chemicals that preferentially kill cancer stem cells.

Published in the Journal of Biomolecular Screening, researchers at the Broad Institute of Harvard University and the Massachusetts Institute of Technology utilized the screen originally developed in the laboratories of Verastem scientific cofounders Robert Weinberg, Ph.D. and Eric Lander, Ph.D. Due to the difficulty in propagating cancer stem cells outside of the tumor environment, the researchers created unique cancer stem cell-like cells and used phenotypic high-throughput screening to evaluate 300,718 compounds for their ability to preferentially kill cancer stem cells. The screen identified 2,244 hits and further characterized selective compounds.

This study demonstrates the power of the cancer stem cell screening technology that was developed by our founders and underpins our research at Verastem, said Jonathan Pachter, Ph.D., Verastem Vice President and Head of Research. To date, innovation in cancer therapy has been limited by a myopic focus only on targeting bulk tumor cells with little regard for resistant cancer stem cell populations. Verastem is harnessing the power of cancer stem cell-directed screens to identify novel drugs that have the ability to kill the cellular components of the tumor that resist current therapies and drive tumor recurrence.

The top three chemical series described in the current study are exclusively licensed to Verastem and are part of a portfolio of drugs being advanced for the treatment of a broad range of cancer indications.

Verastem has built a pipeline of novel chemical series that have demonstrated the unique ability to kill cancer stem cells and plans to enter into multiple clinical studies, including a potential registration study in mesothelioma, over the next 12 months.

The article is titled Phenotypic High-Throughput Screening Elucidates Target Pathway in Breast Cancer Stem-Like Cells. View the complete text of the study at http://bit.ly/WfDzSB

About Verastem, Inc.

Verastem, Inc. (VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cells are an underlying cause of tumor recurrence and metastasis. Verastem is developing small molecule inhibitors of signaling pathways that are critical to cancer stem cell survival and proliferation: FAK, PI3K/mTOR and Wnt. For more information, please visit http://www.verastem.com.

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Verastem’s Screening Technology Highlighted in New Study in the Journal of Biomolecular Screening that Identifies ...

Tim Roy Jr. Walking
Tim Roy Jr. (WheelChair Warrior) walking after receiving Stem Cells Treatments and Physical Therapy Sessions. Making progress from a life time of commitment!From:RollingThunderBoxerViews:0 0ratingsTime:01:19More inPeople Blogs

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Tim Roy Jr. Walking - Video

LAFAYETTE -- In the land inhabited by Dr. Deepak Srivastava, miracles begin in petri dishes.

One of those miracles resulted in an Oct. 8 announcement: Dr. Shinya Yamanaka, a researcher Srivastava originally hired in 1993 to study fat metabolism, had won the 2012 Nobel Prize in Medicine, sharing the honor with Dr. John Gurdon of the University Of Cambridge.

At a late October Lafayette Library and Learning Center Foundation Science Caf session, Srivastava -- senior investigator at the Gladstone Institute of Cardiovascular Disease in San Francisco -- explained the science behind Yamanaka's groundbreaking discovery, and how it might change how medicine looks in 10 years.

Building on Gurdon's own discovery that a modified egg cell can convert itself, Yamanaka found a way to take an adult skin cell and, by introducing four master genes, flip the switch to create what is now called an "induced pluripotent stem cell." These IPS cells, made from one's own body, outmaneuver the immune system's tendency toward rejection. Within three weeks of switch-flipping, IPS cells behave like embryonic cells and can be implanted.

"This is like science fiction; we never thought we'd be able to do this," Srivastava said as he brought up a video of thousands of skin cells, beating like a human heart in complete synchronicity.

Gladstone researchers have changed fibroblast cells (the most common cells of connective tissue in animals) into brain, blood

"Imagine 'personalized medicine,' where clinical trials in a dish -- instead of the toxicity of doing it in your body -- can lead to the discovery of new drugs," he suggested.

"What if we could take your skin cells and make new cells for your damaged heart? What if we could segregate the individuals who would have a bad side affect from a drug by testing their cells, not those of a mouse? What if we redeployed nature's own tool kit to make new heart cells?"

Srivastava described current post-heart attack cardiovascular treatment -- a rush to the hospital and delivery of medicine the doctor knows will help only seven out of 10 patients, and that will end the life of the one out of 10 who suffers an adverse reaction to it.

In cases where the heart is so damaged it must be replaced, a patient logjam is equally treacherous.

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'Flipping the switch:' Skin cells that provide benefits of stem cells

LOS ANGELES Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue.

The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.

Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.

The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare of the University of Miami.

The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that they grew large and flabby, unable to pump blood effectively.

Researchers advertised for people to supply marrow, which is removed using a needle into a hip bone. The cells were taken from the marrow and amplified for about a month

The cells were delivered through a tube pushed through a groin artery into the heart near the scarred area. Fifteen patients were given cells from their own marrow and 15 others, cells from strangers.

About a year later, scar tissue had been reduced by about one-third. Both groups had improvements in how far they could walk and in quality of life. There was no significant difference in one measure of how well their hearts were able to pump blood, but doctors hope these patients will continue to improve over time, or that refinements in treatment will lead to better results.

The big attraction is being able to use cells supplied by others, with no blood or tissue matching needed.

"You could have the cells ready to go in the blood bank so when the patient comes in for a therapy there's no delay," Hare said. "It's also cheaper to make the donor cells," and a single marrow donor can supply enough cells to treat as many as 10 people.

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Stem cells from strangers can repair hearts, study shows

cord blood bank | Collection of Cord Blood - Some Frequently Asked Questions
http://www.cordbloodrecommendation.com For a successful transplant, the process is relatively complex, but the basics of the process involve typing the blood. If you have a complicated birth, your doctor is obligated not to collect the material for donation. This blood would be sent to the company that you will have previously chosen for services. The collection process can be done by the bag method or with a syringe. Similar breakthroughs have been achieved by scientists throughout the world. Since children that come from the same mother and father share genetic material, this cord blood containing the stem cells can be used to treat all children in a family for these diseases, including leukemia and sickle cell anemia. The future uses of stem cells in medicine are very promising. But these are just some diseases from amongst the 70 diseases that can be cured by stem cell, and the list keeps on getting longer. It further saves you from the trouble of locating a matching donor when transplants are concerned. ""Stem cells can be found in multiple locations within our body. In spite of these plus points, the expensive procedure of blood cord cell donation and its preservation is dissuading parents from donating. It is indicated by the decline of muscle function, motor skills, and speech patterns. But how does one actually collect stem cells for cord blood banking? Well, the collection process for cord blood banking will actually take place right after the delivery of a baby ...From:BuscoFincaRaizcomarViews:0 0ratingsTime:01:31More inScience Technology

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cord blood bank | Collection of Cord Blood - Some Frequently Asked Questions - Video

umbilical cord stem cells | Cord Blood Banking - The Basic Facts About Cord Blood Banking
http://www.cordbloodrecommendation.com There are many children who die of diseases such as leukemia, because there is no cure except bone marrow transplant, for which there are a lot of problems with finding a genetic match. What happens to cord blood?These are great benefits, but sadly, the cord as well as the placenta usually just gets disposed of immediately after childbirth and delivery, casting aside any hopes of gaining something out of them. Those that choose a private blood bank consider this, in a sense, as similar to insurance: setting aside a perfect match of blood cells should their child, or immediate member of the family (if a matching blood type), should need a transfusion or bone marrow transplant in the future. The banking facility helps in making blood donation readily available for transplantation #39;s. Depending on where you live and what company you choose you can expect to find a range of five hundred to a thousand dollars. While many people have different opinions on the issues, even if you feel that you don #39;t want to have your baby #39;s blood stored at a local facility, you will find that you can donate it for free to many various causes. With people not fully understanding how important stem cells could be for us, everybody agrees that more research need to be done in order to help understand all that. g. ""Leukemia is a type of cancer that begins from those tissues in the body that form blood. SO if the cost of private donation is prohibitive for you and your ...From:myc0kyViews:0 0ratingsTime:01:31More inScience Technology

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umbilical cord stem cells | Cord Blood Banking - The Basic Facts About Cord Blood Banking - Video