Category Archives: Stem Cells

Stem Cells And Their Potential For Clinical Application
ll4.me Stem Cells And Their Potential For Clinical Application EAN/ISBN : 9781402064692 Publisher(s): Springer Netherlands Format: ePub/PDF Author(s): Bilko, Nadja M. - Fehse, Boris - Ostertag, Wolfram EAN/ISBN : 9781402064692 Publisher(s): Springer Netherlands Format: ePub/PDF Author(s): Bilko, Nadja M. - Fehse, Boris - Ostertag, WolframFrom:meghannumbers9854Views:0 0ratingsTime:00:14More inPeople Blogs

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Morning Live
Morning live discussion on stem cellsFrom:gretastoreViews:0 0ratingsTime:08:02More inEducation

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A small study suggests that stem cells from a stranger may be as good as a patient's own in undoing the damage after a heart attack has weakened the heart's ability to pump blood.

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A small study suggests that stem cells from a stranger may be as good as a patient's own in undoing the damage after a heart attack has weakened the heart's ability to pump blood. The study hints at the possibility that stem cells could be banked, much like blood is banked, to deal with a medical emergency in this case, heart attack.

The findings on the study of a kind of stem cell called mesenchymal cells were presented at the annual meeting of the American Heart Association this week and published online in the Journal of the American Medical Association.

"We believe the basic message of the study is that this procedure is safe and that future, larger studies are warranted," lead author Dr. Joshua Hare, director of the Interdisciplinary Stem Cell Institute at the University of Miami, told reporters at a national briefing.

The researchers studied patients following heart-attacked-caused ischemic cardiomyopathy, the most common cause of heart failure. According to the Texas Heart Institute, it occurs when the heart suffers a temporary blood shortage, resulting in loss or weakening of heart muscle tissue and reduction in its ability to pump blood.

Whether a donor's cells will work as well is important, because it can take up to two months to grow millions of cells needed for transplant and there's no time in the immediate wake of a heart attack, Stephanie Dimmeler, molecular cardiology section chief at University of Frankfurt in Germany, told U.S. News and World Reports' HealthDay. Dimmeler was not involved in the study.

For the study, researchers looked at 30 patients from Miami who had enlarged hearts that had been damaged by an earlier heart attack. Half received their own mesenchymal stem cells, while the other half received the same kind of cell, but from young, healthy donors. The heart patients each received 20 million, 100 million or 200 million stem cells into 10 scarred left ventricular sites. The researchers then followed their cases for 13 months.

Mesenchymal stem cells are taken from bone marrow and lack a feature on their surface that triggers an immune response called rejection, Hare told the Associated Press. They are multipotent cells that can change to become a number of different types of cells, including bone, muscle, ligament, cartilage, fat and tendon, according to mesenchymalcells.org, which is dedicated to providing information about that particular type of cell. The heart is a muscle tasked with pumping blood throughout the body.

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Study says stem cells — even a stranger's — may repair heart attack damage

Hare has had three heart attacks, one in 1993, a second in 1996 (when his heart stopped for 18 seconds) and the most-recent in August of 2012.

For people like Hare, with attack-damaged heart tissue, it might seem there are no medical options left.

But researchers at Mayo Clinic in Rochester have undertaken urgent efforts to change that.

The research study Hare joined is placebo-controlled.That means some study participants will get their own stem cells back and others will get a substitute. Researchers will be able to compared patients receiving the treatment with those receiving nothing.

The goal is to determine if stem cells derived from their own bodies can repair damaged heart muscle and whether that treatment produces better patient outcomes than standard therapy.

"They take bone marrow out of your hips, both hips, and then they send it to a lab and then it comes back," Hare said. "And this time they injected it into the vessel where I had my last heart attack."

The process of donating the marrow so stem cells could be separated out by a company in New Jersey, he said, was free of trauma.

"That was nothing," he said.

He takes a positive-mental-attitude approach to the concept that he may or may not have received an infusion of his own stem cells to heal his heart.

"Even if I didn't have the real stem cells, it hopefully would help somebody else," he said.

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Hope for the future

Exercise doesnt only help keep those unwanted inches off -- it also jump-starts stem cells in the heart, promoting tissue restoration for those who have previously suffered heart attacks.

The Telegraph reports that breaking sweat with a simple 30-minute exercise may partially repair damage caused by heart conditions in adults. Researchers from Liverpool John Moores University did laboratory tests and found that exercise can wake up around 60 percent of dormant heart stem cells and increase cardiomyocites, which are cells that form the cardiac muscle.

"The exercise is increasing the growth factors which are activating the stem cells to go on and repair the heart, and this is the first time that this potential has been shown. We hope it might be even more effective in damaged hearts because you have got more reason to replace the large amount of cells that are lost," lead author Dr. Georgina Ellison shares.

Athough more research is needed to fully understand how to harness the power of these newly-activated stem cells, it pays to get up and get moving. There are many light and moderate exercises out there that can be done without straining the body. If you have a heart condition and you're seeking to stay fit and healthy, ask your doctor or trainer for physical activities that suit your specific situation.

(Photo by daveynin via Flickr Creative Commons)

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Exercise May Boost Stem Cells and Repair Heart Damage

Regenerative Nephrology
ll4.me Regenerative Nephrology Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.* Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings foracademic, medical and pharma researchers. * Experts in the renal stem ...From:lorraineknouse326Views:0 0ratingsTime:00:12More inPeople Blogs

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Fibroblast Growth Factor FGF Stem Cells YouTube
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Current Medication after Stem Cells
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Current Medication after Stem Cells - Video

Dr. Tommy Mitchell Stem Cells Cloning Immanuel Baptist Church Highland, CA. November 5, 2012
At 44:00 Min he accidentally says "Is using Adult Stem Cells Wrong? Yes. He should have said Embryonic Stem Cells. ; ) Dr. Tommy Mitchell Lecture on Stem Cells Cloning at Immanuel Baptist Church Highland, CA. November 5, 2012 Dr. Mitchell graduated with a BA with highest honors from the University of Tennessee, Knoxville, in 1980, with a major in Cell Biology and a minor in Biochemistry. For his superior scholarship during his undergraduate study, he was elected to Phi Beta Kappa Society (the oldest and one of the most-respected honor societies in America). Dr. Mitchell subsequently attended Vanderbilt University School of Medicine in Nashville, where he received his medical degree in 1984. Dr. Mitchell completed his residency at Vanderbilt University Affiliated Hospitals in 1987. He is Board Certified in Internal Medicine. In 1991, he was elected a *Fellow of the American College of Physicians (FACP). Tommy had a thriving medical practice in his hometown of Gallatin, Tennessee, for 20 years, but, in late 2006, he withdrew from medical practice to pursue creation ministry full time.From:MClover420Views:0 0ratingsTime:01:00:01More inEducation

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Stem Cells - Rough Draft
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