Category Archives: Utah Stem Cells

Appointment Adds World Class Expertise in Neuro-Cellular Interactions and functions

SALT LAKE CITY, UT--(Marketwired - Aug 7, 2017) - Q Therapeutics, Inc., developer of clinical-stage cell therapies for central nervous system (CNS) disease and injury, announced the appointment of Tom Parks, Ph.D. as an independent member to the Company's Board of Directors.In addition, Dr. Parks has agreed to serve on the Board's Nominating and Governance Committee; and will be joined on the Committee by current independent directors, Peter Barton Hutt, Peter Grebow, and Hunter Jackson.

Dr. Parks brings to Q Therapeutics more than 30 years experience in life science research and its translation into therapeutic products. As a faculty member in the Department of Neurobiology & Anatomy at the University of Utah School of Medicine from 1978, he conducted a long-term NIH-funded research program on development of the central auditory nervous system and served as chair of that department from 1992-2007. He was a co-founder of NPS Pharmaceuticals, Inc. and served on its board from 1986-2006. From 2008-2016, Dr. Parks was Vice President for Research and President of the Research Foundation for the University of Utah. He currently serves on the boards of Navigen Pharmaceuticals Inc., SentrX Animal Care Inc., and ConusRx Inc. He is a Fellow of the National Academy of Inventors and a recipient of the Utah Governor's Medal for Science and Technology. Dr. Parks earned a Bachelor of Science degree in Biology from the University of California at Irvine, a Ph.D. in Psychobiology from Yale University, and completed postdoctoral work at the University of Virginia School of Medicine.

"We are very pleased to welcome Dr. Parks to our Board of Directors. He brings tremendous expertise in the field of central nervous system development and the conditions leading to establishment of functional connections between neurons. We expect that Dr. Parks will prove of immeasurable value to Q Therapeutics as we continue to advance our first product, Q-Cells, through clinical development as well as development of our second generation induced pluripotent cell (iPSC) products," stated Steven Borst, President and Chief Executive Officer of Q Therapeutics.

About Q Therapeutics, Inc. -- Headquartered in Salt Lake City, Q Therapeutics is a clinical-stage company developing adult stem cell therapies to treat debilitating central nervous system (CNS) disease and injury. The Company's first therapeutic product candidate, Q-Cells, is intended to restore or preserve normal CNS activity by supplying essential nerve cell functions. Q-Cells may be suitable to treat a range of CNS disorders, including demyelinating conditions such as multiple sclerosis (MS), transverse myelitis , cerebral palsy and stroke, as well as other neurodegenerative diseases and injuries such as Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease), Huntington's disease, spinal cord injury, traumatic brain injury, and Alzheimer's disease.Q Therapeutics' initial clinical targets are TM and ALS, with INDs in both indications now allowed to proceed by the FDA. The Company's proprietary product pipeline also includes neural cell products derived from induced pluripotent stem cells (iPSC). For more information, see http://www.qthera.com.

Cautionary Statement Regarding Forward Looking Information -- This news release may contain forward-looking statements made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such forward-looking statements in this press release regarding potential applications of Q Therapeutics' technologies constitute forward-looking statements that involve risks and uncertainties, including, without limitation, risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of its intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors that could affect results and other risks and uncertainties are detailed from time to time in Q Therapeutics' periodic reports.

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Q Therapeutics Expands Board of Directors With Appointment of Dr. Tom Parks as Independent Member - Marketwired (press release)

There are some fancy tools out there for repairing skin, from 3D bioprinting, scaffolds and matrices to spray guns that rain stem cells directly onto a wound. Doctors in Brazil are even experimenting with sterilized Tilapia fish skin as a novel dressing for burns.

Creativity is nice, but that alone wont save patients battling through the most critical hours of their lives. Denver Lough, an M.D./Ph.D., saw this first hand while working at the Johns Hopkins Plastic and Reconstructive Surgery Program. Nothing was truly getting the job done.

Name one regenerative medicine product or company thats out there that actually truly regenerates anything, Lough challenged in a recent phone interview. Not, we grow keratinocytes, or we can turn a cell into an osteogenic lineage but really; does this grow full thickness tissue? Theres really not one out there and theres certainly not one thats being used clinically right now for skin regeneration.

Now CEO and CSO of PolarityTE, Lough believes the fundamental approach to tissue regeneration is taught wrong. And thats why, after all these years, skin healing remains imperfect.

Biotechs working in this field have zoomed in on individual cells, he said, working to culture and manipulate stem cells or to find the right recipe for growth factors that can guide differentiation. Thats not how biology works, Lough contests.

[Biology] works through cells interacting with each other, having gradients, having interfaces, having polarity. A cell needs to know what way is up, what way is down, he said.When you pull a single cell out of a tissue and try to command it to go down a pathway, you negate all of those factors.

The cells need to know what pathways their neighbors are expressing.

Put another way:Its like taking you in the middle of the night, out of your bed, taking off your clothes, cutting off parts of your arms and legs, pushing you through a screen door and throwing you out in the middle of the ocean and saying act like you, conduct yourself like you, Lough said earnestly.

PolarityTE will relocate you, your family, and your house. Its first product, for skin regeneration, starts with just a small piece of healthy skin taken from a patient with extensive burns. The sample is shipped to the companys facility in Salt Lake City, Utah, where it is processed into a paste to cover the wound. The paste contains so-called Minimally Polarized Functional Units (MPFUs) that instinctively organize and propagate to help heal a wound. The turnaround time is just 24-48 hours and the use of the patients own tissue obviates the risk of immune rejection.

With this new take on an old skin graft approach, PolarityTE aims to capture the diversity of the tissue ecosystem, with epidermal, dermal, and hypodermal cells, fibroblasts, hair follicles even the structural organization and blood vessel integration seen in the natural skin.

Of note, the technology pays special attention to the edges of the wound where the real healing occurs, its not a single cell that jumps between the margins, Lough said.

Its still early days, but the path-to-market is fast for an autologous (self) tissue transplant. FDA doesnt even require human trials for its regulatory clearance. To that end, the company recently announced the successful grafting of regenerated full-thickness, organized skin and hair follicles in third-degree burn wounds in pigs. The team is now looking ahead to a first-in-human trial in the third-quarter of 2017 and a possible roll out of the product early next year.

It would be a mistake, however, to place PolarityTE in the bucket of skin grafts only. Lough hopes the technology can go much further, to regenerate and restore bone, muscle, fascia, cartilage, and nerve tissues.

Photo: VolodymyrV, Getty Images

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Reinventing tissue regeneration, one layer at a time - MedCity News

William Cimikoski, MD Medical Director of Utah Stem Cells, is a Medical Toxicologist that specializes in Stem Cell Joint Regeneration, Bioidentical Hormone Replacement Therapy, Medical Aesthetics, and Medial Weight Loss. With seven years of medical Residency and Fellowship specialty training, he is a foremost authority featured on HealthLine TV and ABCs Good 4 Utah.

Dr. Cimikoski was born and raised in Fairfield County, CT, in the suburbs of Manhattan. As a youth, he excelled in several contact sports, including hockey, lacrosse, and soccer. By the time he was 17-years-old he had suffered frequent sports related knee injuries (on both knees) and underwent numerous surgeries, ultimately culminating in major reconstructive knee surgery during his senior year in high school. This essentially ended his participation in competitive contact sports and he started to pursue his other passions in non-contact sports, including skiing and windsurfing. This is what brought him to the beautiful mountains of Utah where he could delight to his hearts content in the plentiful powdery snow.

He is a Medical Toxicologist who has completed seven years of specialty residency and fellowship training. He received his medical training at Brown University, where he did his Internship, followed by his Emergency Medicine Residency at Georgia Health Sciences University and Albany Medical Center. He also completed a Critical Care Fellowship in Medical Toxicology at Penn State University. To indulge his vice of windsurfing, he took a several year hiatus from the rat race and rigors of Emergency Medicine to work as a Ships Physician for Carnival Cruise Lines. While working for Carnival in 2004, he met his beautiful wife, Sarah (from Brazil), and they decided to settle in Utah in 2009 to start a family. They now have three young children under the age of five, two boys and a girl.

Dr. Cimikoski is keenly aware of the perils associated with osteoarthritis and orthopedic injuries, due to his own experiences and interest related to these debilitating processes. He is an exceptionally accomplished fitness and nutrition expert. This, coupled with his Medical Toxicology background, makes him uniquely qualified to provide the very best health care, and optimize his patients potential through the use of Bioidentical Hormones, Stem Cell Joint Regeneration, Medical Aesthetics, and Medical Weight Loss Management. He is pleased and eager to offer these cutting edge services with Utah Stem Cells, a new concept in medical healthcare wellness.

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Stem Cell Therapy for Knees- Advanced Techniques

Specialties

We specialize in Stem Cell Joint Pain Treatment, Bioidentical Hormones for men and women, Stem Cell Aesthetics and Medical Weight Loss.

Established in 2015.

Utah Stem Cells was founded for the purpose of developing a new and exciting concept in a medical wellness center. Utilizing the latest advancements in stem cell technology, all of our services are specifically designed to enhance the quality of your life. We focus entirely on treatments that will help you feel stronger, with pain free joints, better mood, and a more beautiful appearance. You will look great and feel even better.

Dr. Bill Cimikoski, Medical Director of Utah Stem Cells, is a Medical Toxicologist that specializes in Stem Cell Joint Regeneration-a foremost authority featured on HealthLine TV and ABC's Good 4 Utah. Assisted by experienced and trained nurses and physician assistants, Dr Bill offers the treatments that can benefit you the most, while making sure that from a toxicology perspective won't hurt in the long term.

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Utah Stem Cells - Sports Medicine - 7430 Creek Rd, Sandy ...

ResearchNov 08, 2016 Unmasking a Silent Killer: A Culprit Behind Polycystic Kidney Disease kidney disease

Published in October in Cell as part of a study led by scientists at the University of Utah School of Medicine, the structure reveals how specific mistakes in PKD2 triggers polycystic kidney disease, the most common inherited kidney disorder.... Read More

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients. For the first time, they have corrected the mutation in a proportion of stem cells that is high enough to produce a substantial benefit in sickle cell patients.... Read More

University of Utah researchers have found that the structure of an insulin molecule produced by predatory cone snails may be an improvement over current fast-acting therapeutic insulin. The finding suggests that the cone snail insulin, produced by the snails to stun their prey, could begin working in as few as five minutes, compared with 15 minutes for the fastest-acting insulin currently available. ... Read More

University of Utah biochemist Danny Chou, Ph.D., is one of four researchers worldwide to receive a grant from the Juvenile Diabetes Research Foundation (JDRF) and the pharmaceutical company Sanofi US Services Inc. to develop glucose-responsive insulin to help millions of people with Type 1 diabetes (T1D) maintain proper blood glucose levels. ... Read More

One of the most fundamental challenges that a cell faces is how to bring membranes that are far apart, close together. New research in Science shows how cellular machinery, called ESCRT (Endosomal Sorting Complexes Required for Transport), accomplishes this essential task. ... Read More

Jared Rutter, Ph.D., is one of only 26 to receive prestigious Honor ... Read More

Distinguished professor of biochemistry receives one of science's highest honors ... Read More

Program honors 15 researchers nationwide with funds to support their work... Read More

By looking at the ends of double-stranded RNA, Dicer enzyme tells difference ... Read More

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Biochemistry - | University of Utah

The University of Utah School of Medicine combines excellence in teaching, research, and clinical expertise to train tomorrow's physicians for the rapidly changing world of medicine. With a faculty of more than 1,000 physicians and researchers and 23 clinical and basic-science departments, the School of Medicine trains the majority of Utah physicians, offering an MD degree, physician assistant training, residency, fellowship specialty training, and degrees in public health or research.

The School of Medicine also is widely recognized for interdisciplinary research in the genetics of disease, cancer, biomedical informatics, infectious diseases, and other areas of leading-edge medicine.

Interested in learning more?Browse our student's page for information on our range of programs, eligibility, and how to apply.

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On Dec. 1-2, national experts in genetics, medicine, law, big data and other will fields gather for Frontiers in Precision Medicine II: Cancer, Big Data and the Public, a unique precision medicine symposium at the University of Utah S.J. Quinney College of Law. The symposium, sponsored by the Us Colleges of Law, School of Medicine and Huntsman Cancer Institute, addresses topics in law, ethics, and science as precision medicine is gaining more attention nationwide from health care systems, practitioners, researchers, insurers and federal agencies. ... Read More

Published in October in Cell as part of a study led by scientists at the University of Utah School of Medicine, the structure reveals how specific mistakes in PKD2 triggers polycystic kidney disease, the most common inherited kidney disorder.... Read More

Researchers from the University of Utah studying Drosophila fruit flies have found that in flies, providing a common dietary supplement prevents death caused by Pngl deficiency, the fly analog of the human genetic disorderN-Glycanase 1 (NGLY1) deficiency. Findings were reported at the American Society of Human Genetics (ASHG) 2016 Annual Meeting in Vancouver, B.C. ... Read More

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients. For the first time, they have corrected the mutation in a proportion of stem cells that is high enough to produce a substantial benefit in sickle cell patients.... Read More

Researchers at the University of Utah School of Medicine and ARUP Laboratories in Salt Lake City unravel the mystery behind a rare Zika-related death in an adult, and unconventional transmission to a second patient in a correspondence published online on September 28 in the New England Journal of Medicine. Details point to an unusually high concentration of virus in the first patients blood as being responsible for his death. The phenomenon may also explain how the second patient may have contracted the virus through casual contact with the primary patient, the first such documented case. ... Read More

Jody Rosenblatt, Ph.D., a cell biologist at Huntsman Cancer Institute and an associate professor of oncological sciences at the University of Utah has been selected as a Howard Hughes Medical Institute (HHMI) Faculty Scholar, HHMI announced today. The award provides $1 million to fund her research over the course of five years.... Read More

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medicine.utah.edu - University of Utah School of Medicine

The article shows the first example of capture beads having more than one capture sequence, expanding the ability to study genetic variation and differences in gene expression profiles between cell populations.

Undergraduate and graduate women are invited to a monthly gathering to hear stories from successful women in STEM. Career advice and mentorship served with tea, coffee, hot chocolate, and treats!

The new hybrid device combines the best of biofuel cells and supercapacitors to harness energy-dense, abundant glucose.

In a study in ACS Infectious Diseases, the Burrows group used G-quadruplexes as genetic landmarks to compare Zika with other related viruses and suggest a possible drug target.

Two tenure-track positions in the areas of Synthetic Organic Chemistry, Chemical Biology, Bioanalytical and/or Biophysical Chemistry are available.

The Advanced Chemical Biology Lab (CHEM 5750) is a course-based undergraduate research experience - a CURE" - giving students real training in a research lab.

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Home - Department of Chemistry - The University of Utah

Are you confused about all the different types of stem cells? Read on to learn where different types of stem cells come from, what their potential is for use in therapy, and why some types of stem cells are shrouded in controversy.

Researchers are working on new ways to use stem cells to cure diseases and heal injuries. Learn more about unlocking stem cell potential.

Somatic stem cells (also called adult stem cells) exist naturally in the body. They are important for growth, healing, and replacing cells that are lost through daily wear and tear.

Stem cells from the blood and bone marrow are routinely used as a treatment for blood-related diseases. However, under natural circumstances somatic stem cells can become only a subset of related cell types. Bone marrow stem cells, for example, differentiate primarily into blood cells. This partial differentiation can be an advantage when you want to produce blood cells; but it is a disadvantage if you're interested in producing an unrelated cell type.

Most types of somatic stem cells are present in low abundance and are difficult to isolate and grow in culture. Isolation of some types could cause considerable tissue or organ damage, as in the heart or brain. Somatic stem cells can be transplanted from donor to patient, but without drugs that suppress the immune system, a patient's immune system will recognize transplanted cells as foreign and attack them.

Therapy involving somatic stem cells is not controversial; however, it is subject to the same ethical considerations that apply to all medical procedures.

Embryonic stem (ES) cells are formed as a normal part of embryonic development. They can be isolated from an early embryo and grown in a dish.

ES cells have the potential to become any type of cell in the body, making them a promising source of cells for treating many diseases.

Without drugs that suppress the immune system, a patient's immune system will recognize transplanted cells as foreign and attack them.

When scientists isolate human embryonic stem (hES) cells in the lab, they destroy an embryo. The ethical and legal implications of this have made some reluctant to support research involving hES cells. In recent years, some researchers have focused their efforts on creating stem cells that don't require the destruction of embryos.

Learn more about the controversy behind embryonic stem cells and why new stem-cell technologies may bring it to an end. The Stem Cell Debate: Is It Over?

Induced pluripotent stem (iPS) cells are created artificially in the lab by "reprogramming" a patient's own cells. iPS cells can be made from readily available cells including fat, skin, and fibroblasts (cells that produce connective tissue).

Mouse iPS cells can become any cell in the body (or even a whole mouse). Although more analysis is needed, the same appears to be true for human iPS cells, making them a promising source of cells for treating many diseases. Importantly, since iPS cells can be made from a patient's own cells, there is no danger that their immune system will reject them.

iPS cells are much less expensive to create than ES cells generated through therapeutic cloning (another type of patient-specific stem cell; see below). However, because the "reprogramming" process introduces genetic modifications, the safety of using iPS cells in patients is uncertain.

Therapy involving iPS cells is subject to the same ethical considerations that apply to all medical procedures.

Therapeutic cloning is a method for creating patient-specific embryonic stem (ES) cells.

Therapeutic cloning can, in theory, generate ES cells with the potential to become any type of cell in the body. In addition, since these cells are made from a patient's own DNA, there is no danger of rejection by the immune system.

In 2013, for the first time, a group of researchers used therapeutic cloning to make ES cells. The donor nucleus came from a child with a rare genetic disorder. However, the cloning process remains time consuming, inefficient, and expensive.

Therapeutic cloning brings up considerable ethical considerations. It involves creating a clone of a human being and destroying the cloned embryo, and it requires a human egg donor.

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Genetic Science Learning Center. (2014, July 10) Stem Cell Quick Reference. Retrieved November 18, 2016, from http://learn.genetics.utah.edu/content/stemcells/quickref/

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Stem Cell Quick Reference [Internet]. Salt Lake City (UT): Genetic Science Learning Center; 2014 [cited 2016 Nov 18] Available from http://learn.genetics.utah.edu/content/stemcells/quickref/

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Genetic Science Learning Center. "Stem Cell Quick Reference." Learn.Genetics.July 10, 2014. Accessed November 18, 2016. http://learn.genetics.utah.edu/content/stemcells/quickref/.

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Stem Cell Quick Reference - Learn Genetics

Current treatments for the painful and debilitating effects of arthritis or joint pain rely on early intervention with synthetic drugs and, in severe cases, surgery.

The human body is composed of more than 200 cell types. Each of these cells in the body is designated to perform a particular function. For e.g. its the pancreatic cells that ensure you pancreas are functioning properly. But there are some other cells in human body, which are different. These cells are called stem cells. These cells not only demonstrate their capacity to generate more stem cells but also help in making different cell types. For over a decade the adult stem cells have been used therapeutically for treating certain cancer as well as rare blood diseases.

Medical practitioners often call stem cell therapy a gift of science. So is the therapy scientifically proven type of regenerative medicine? Yes, it is! There is a considerable amount of excitement about this therapy. Stem cell has the potential to revolutionize the concept of healthcare. There is lot medical practitioners are doing with the stem cells. Diseases such as strokes and diabetes will be soon treated by the therapy. Two other areas where the therapy has worked wonders include bone and blood cancer treatment and injuries to the joint.

Next stem cell product that is making headway into the healthcare industry is for burn and wound healing. Doctors are also planning on injecting the stem cells into to brain of a patient with cerebral palsy to help enhance the function as well as restore the brain tissue. Another major field is where medical practitioners are combining 3D bio printing with stem cell regenerative medicine.

Amniotic stem cell therapy has been acknowledged in the medical history across the world as a biggest discovery in natural healing. The stem cells are first injected into the patients injured area. They then metamorphosize into different cells, when often depends upon the instructions provided by a human body. So they may become a tissue cells, bone cells or other kind. This is what medical practitioners believe is so unique about their growth. Huge number of cells injected into the patients body will help in healing the injuries at an accelerated pace. Best results are seen in neuropathy, knee pain and osteoarthritis.

Fat, cortisone and other medicines offer temporary cure. But stem cells have the capability to restore the regenerative tissue and bone back to their original condition. One of the prime components here is the high uronic acid that is known to lubricate your joints and tendons, easing pain and restoring your mobility.

The injections used in treating patients with joint problems contain naturally developing anti-inflammatory agents that actually stimulates tissue repair. Besides, there have been no cases of patient rejection recorded so far. Over 10,000 injections have been used on patients without any cases of adverse side effects. So if you want to avoid expensive and painful surgery and dependency on prescriptive medication access our Amniotic stem cell therapy and bid adieu to your pain.

*Disclaimer: These statements have not been evaluated by the FDA

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Amniotic Stem Cell Therapy in Salt Lake City, Park City Utah

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Curriculum Index - University of Utah