Propulsion of Malignant Mesothelioma Pipeline as Novel and Extensive Therapies Enter the Treatment Domain, Anticipates DelveInsight – Yahoo Finance

Malignant Mesothelioma is a rare growth of mesothelial cells strongly associated with asbestos exposure. Major pipeline molecules include durvalumab, pembrolizumab, tremelimumab, nintedanib, ADI-PEG 20, and MesoPher. Additionally, the development of novel therapies is going to introduce advanced treatment options.

Las Vegas, USA, Oct. 13, 2021 (GLOBE NEWSWIRE) -- Propulsion of Malignant Mesothelioma Pipeline as Novel and Extensive Therapies Enter the Treatment Domain, Anticipates DelveInsight

Malignant Mesothelioma is a rare growth of mesothelial cells strongly associated with asbestos exposure. Major pipeline molecules include durvalumab, pembrolizumab, tremelimumab, nintedanib, ADI-PEG 20, and MesoPher. Additionally, the development of novel therapies is going to introduce advanced treatment options.

DelveInsights Malignant Mesothelioma Pipeline Insight 2021 report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, key companies working to advance the pipeline space, and future growth potential of the Malignant Mesothelioma pipeline domain.

Some of the crucial points taken from the Malignant Mesothelioma Pipeline report:

DelveInsights Malignant Mesothelioma Pipeline analysis depicts the space with 25+ active players working to develop 25+ pipeline therapies.

Major pharmaceutical companies that are developing potential drug candidates to improve the Malignant Mesothelioma treatment scenario include Momotaro-Gene, Polaris Group, Amphera, Vivace Therapeutics, MedImmune, TCR2 Therapeutics, Atara Biotherapeutics, Inhibrx, Eisai, Targovax, Merck & Co, Bayer HealthCare, SELLAS Life Sciences Group, CanBas, FKD Therapies, Virttu Biologics, MolMed, Ys Therapeutics, LIPAC Oncology, TCR2 Therapeutics, Hutchison Medipharma Limited, Clovis Oncology, Sanofi, Merck & Co., PharmaMar, Targovax and many others.

Key Malignant Mesothelioma pipeline therapies such as rAd-IFN, Pembrolizumab, ADI-PEG 20, MesoPher, MTG201, HMPL-453, SAR444245, Rucaparib, TC 210, iCasp9M28z T-cell, INBRX-109, VT3989, LEITP-1009, YS110, Gavo-cel, iCasp9M28z T-cell, Lurbinectedin, ONCOS-102 and others are under investigation in different phases of clinical trials.

Targovax initiated a randomized, phase I/II clinical trial combining ONCOS-102 with Pem-Cis in 31 patients, indicating that ONCOS-102 can activate the immune system and increase tumour infiltrating T-cells into Malignant Pleural Mesothelioma.

Sellas Life Sciences Group is evaluating Galinpepimut-S (GPS) for the treatment of Malignant Mesothelioma. It is an immunotherapy that targets the Wilms Tumor 1 (WT1) protein which is present and over-expressed in an array of hematologic malignancies and solid tumors.

LIPAC is developing a new Liposomal Enhanced IntraThoracic Paclitaxel (LEITP) for the treatment of Malignant Pleural Mesothelioma utilizing the LiPax technology. Preclinical studies with LEITP-1009 are underway.

In July 2021, PharmaMar announced that the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA) has given its positive opinion for Orphan Drug Designation to Zepzelca (lurbinectedin) for the treatment of Malignant Mesothelioma.

UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase.

Momotaro-Gene is evaluating MTG201, a novel investigational gene therapy with unique dual mechanisms of action capable of addressing a range of cancers. A Phase II clinical trial is being conducted at the Baylor College of Medicine in Houston, Texas.

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The Malignant Mesothelioma pipeline report lays down detailed profiles of the pipeline assets, inactive and dormant assets, comparative analysis of clinical and non-clinical stage Malignant Mesothelioma products, comprehensive assessment of driving and restraining factors, along with the opportunities and risks in the Malignant Mesothelioma pipeline landscape.

Malignant Mesothelioma Overview

Malignant Mesothelioma is a rare, incurable, asbestos-related cancer. It mainly affects the lining of the lung and chest cavity (pleura) or lining of the abdomen (peritoneum). In rare cases, mesothelioma tumors can grow in the linings of the heart (pericardium) or testes (tunica vaginalis).

There are 4 types of mesothelioma, each affecting a different area in the body. The four types are pleural mesothelioma, peritoneal mesothelioma, pericardial mesothelioma, and testicular mesothelioma.

Explore more about Malignant Mesothelioma pipeline therapeutics assessment @ Malignant Mesothelioma Pipeline Assessment

Malignant Mesothelioma Pipeline Drugs

Drug

Company

Phase

MoA

RoA

rAd-IFN

Trizell Ltd

III

IFNA2B expression stimulants

NA

Pembrolizumab

Merck & Co

III

Programmed cell death-1 receptor antagonists

Intravenous

ADI-PEG 20

Polaris Pharmaceuticals

II/III

Arginine deiminase replacements

Intramuscular

MesoPher

Amphera

II/III

Immunostimulant

Intradermal

MTG201

Momotaro-Gene

II

DKK3 expression modulators

Intratumoural

HMPL-453

Hutchison Medipharma Limited

II

Type 1, 2, 3 1 fibroblast growth factor receptor antagonists

Oral

SAR444245

Sanofi

II

Interleukin-2 replacements

Intravenous

Rucaparib

Clovis Oncology

II

Poly(ADP-ribose) polymerase 1, 2, 3 inhibitors

Oral

TC 210

TCR2 Therapeutics

I/II

Immunologic cytotoxicity; T lymphocyte replacements

NA

iCasp9M28z T-cell

Bellicum Pharmaceuticals

I/II

Immunologic cytotoxicity; Programmed cell death-1 receptor antagonists; T lymphocyte replacements

NA

INBRX-109

Inhibrx

I

TRAIL receptor 2 agonists

Parenteral

VT3989

Vivace Therapeutics

I

Transcription factor inhibitors

Oral

LEITP-1009

LIPAC Oncology

Preclinical

Proto-oncogene protein c-bcl-2 inhibitors

NA

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Malignant Mesothelioma Therapeutics Assessment

The Malignant Mesothelioma Pipeline report proffers an integral view of the Malignant Mesothelioma emerging novel therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, and Mechanism of Action.

By Product Type

Mono

Combination

Mono/Combination

By Stage

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Propulsion of Malignant Mesothelioma Pipeline as Novel and Extensive Therapies Enter the Treatment Domain, Anticipates DelveInsight - Yahoo Finance