Regenerative Medicine Workshop, Part 21 – Research Horizons

The Regenerative Medicine Workshop at Hilton Head began its third decade with a long and diverse lineup of researchers who presented their latest work on a spacious range of topics, from DNA barcoded technology to strategies to reverse tissue degeneration in rotator cuff injuries.

In other words, the usual dizzying array of up-to-the-minute research from some of the worlds leading scientists and engineers.

But if there was a topical theme to last weeks 21st annual workshop (March 1-4), it was immunology.

The Hilton Head summit has always been a place where you can learn about the great, late breaking innovations in regenerative medicine, says Ned Waller, professor in the Emory University School of Medicine, and a researcher with the Petit Institute for Bioengineering and Bioscience at Georgia Tech. What striking this year is, half the talks are about immunology.

And that suits Waller just fine. He is director of the Division of Stem Cell Transplantation and Immunotherapy at the Winship Cancer Institute of Emory, where he also directs the Bone Marrow and Stem Cell Transplant Center. And his research presentation at Hilton Head was entitled, Another Arrow in the Anti-cancer Quiver: VIP Immunotherapy.

Waller also is one of three co-directors of the Regenerative Engineering and Medicine (REM) research center, a consortium of research institutes in Georgia: Emory, Georgia Tech, and the University of Georgia. REM is one of four organizing partners of the workshop, the others being the Stem Cell and Regenerative Medicine Center at the University of Wisconsin, the Mayo Clinics Center for Regenerative Medicine, and the McGowan Institute for Regenerative Medicine at the University of Pittsburgh.

Accordingly, faculty, post-doctoral, and student researchers from those institutions were well represented. But the workshop also drew researchers from across the spectrum and the planet. Among the speakers were Ronald Germain from the National Institutes of Health, and Molly Stevens from Imperial College in London. Rolando Gittens, who earned his Ph.D. in bioengineering at Georgia Tech in 2012 and is now a research scientist at the Institute for Scientific Research and High Technology Services of Panama.

There were also deep-dive presentations from researchers based at Duke, Harvard, Tufts, and Yale universities, among others, and Jeff Hubbell, the Nerem Lecturer from the University of Chicago (who delivered a talk on Biomolecular Engineering in Regenerative Medicine and Immunotherapies).

Steve Stice, as co-director of the REM from the University of Georgia (UGA), the newest member of the consortium, appreciated the geographic range of work that was presented.

One of the nice things this years is that UGA and other institutions are well represented, says Stice, professor and director of the Regenerative Bioscience Center at UGA and a Petit Institute researcher. So its not just Emory and Georgia Tech, its also Mayo, and Wisconsin, and Pittsburgh, and weve brought in speakers from all over. Its really grown and become a highly recommended event in the regenerative medicine community.

Trainees postdocs, grad students, and at least one undergraduate had a chance to present their work, also. First there was the rapid fire presentations (5 minutes) on Thursday afternoon, then a research poster competition that night, featuring 65 different projects on display.

The winning poster came from Daniel Hachim, a grad student at the University of Pittsburgh, whose project is entitled, Unveiling Macrophage Populations and Mechanisms Driving the Better Remodeling Outcomes Associated with Shifting Phenotype in the Host Response Against Biomaterials.

Cheryl San Emeterio, a Ph.D. student at Georgia Tech, has presented posters the last three years at this event, but this was her first rapid fire presentation.

I thought it was flattering and inspiring, to talk among so many distinguished scientists here, says San Emeterio, who does her research in the lab of Ed Botchwey, associate professor in the Wallace H. Coulter Department of Biomedical Engineering (a joint department of Emory and Georgia Tech).

Its great to get my work out there on this scale, and I hope that people are interested and want to discuss it further. And maybe we can form some sort of productive collaboration, adds San Emeterio, whose research is entitled, Age-dependent immune Dysregulation during Repair of Volumetric Muscle Injury.

Standing near her poster for most of the evening was Madeline Smerchansky, a Petit Undergraduate Scholar from Georgia Tech attending her first Hilton Head conference. She saw the opportunity as something of an investment.

This is practice for the future, says Smerchansky, a third-year student.

At least one researcher during the four-day workshop offered a glimpse into the future from a perspective that did not include biomolecular science or immunology. Aaron Levine offered his insights , but not the usual stuff based in biomolecular science or bioengineering. Aaron Levine, associate professor in the School of Public Policy at Georgia Tech and a Petit Institute researcher, delivered a presentation called, Regenerative Medicine in a Time of Policy Uncertainty.

We havent seen a lot of clear signals yet with how the policy environment is going to play out from the current presidential administration, says Levine, who focused his Friday morning talk on, among other things, potential policy drivers for regenerative medicine, such as the 21st Century Cures Act (will it be implemented by this administration, and if so, how much of it?), and the appointment of a commissioner for the Food and Drug Administration (FDA).

The future of the Cures Act may be largely dependent on who the next FDA commissioner is, noted to Arnie Caplan, of Case Western University, during Levines post-talk Q&A session.

Later that evening, it was Caplans turn to take center stage, with Chris Evans of the Mayo Clinic.

They were the main event, you might say. With a backdrop of Caplan and Evans as photo-enhanced boxers, the mood was light for their Friday night debate, entitled, MSCs are Not Stem Cells. Or, as Nerem put it, is an MSC a mesenchymal stem cells, a medical signaling cell, or a mediocre scientific concept.

By all accounts, they verbally fought to a draw. But who knows. Maybe there will be a rematch in 2018, when the Regenerative Medicine Workshop will return to Hilton Head (March 21-24).

CONTACT:

Jerry Grillo Communications Officer II Parker H. Petit Institute for Bioengineering and Bioscience

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Regenerative Medicine Workshop, Part 21 - Research Horizons