A Phase I Study of FT819 CAR T-Cell Therapy in People with B-Cell Cancers – On Cancer – Memorial Sloan Kettering

Full TitleA Phase I Study of FT819 in Subjects with B-cell MalignanciesPurpose

The purpose of this study is to find the best way to give the investigational therapy FT819 safely in patients with B-cell lymphoma (BCL), chronic lymphocytic leukemia (CLL), or B-cell acute lymphocytic leukemia (B-ALL) that came back or continued to grow despite prior treatment.

FT819 is a cellular immunotherapy made in a laboratory starting with white blood cells (called T cells) that come from a healthy donor. The donated T cells are genetically modified to help them identify and kill cancer cells. A protein called chimeric antigen receptor (CAR) is added to the FT819 cells. CAR recognizes a protein called CD19 which is found on B-cell cancer cells. FT819 binds to B-cell cancer cells that contain CD19 and kills them. This CAR T-cell therapy is given intravenously (by vein).

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

For more information about this study and to inquire about eligibility, please contact Dr. Jae Park at 646-608-3743.

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A Phase I Study of FT819 CAR T-Cell Therapy in People with B-Cell Cancers - On Cancer - Memorial Sloan Kettering