#AACR17: Study Explores Best Time to Give CAR T Cell Therapy – Memorial Sloan Kettering Cancer Center (blog)

Summary

For patients with leukemia who relapse after chemotherapy, treatment options have traditionally been limited. At MSK, an experimental immunotherapy called CAR T therapy has expandedoptions for these patients. New research data presented at this years annual meeting of the American Association for Cancer Research (AACR) suggest that patients do better on the therapy when they are treated at the time of minimal residual disease.

Highlights

Like many patients who come to Memorial Sloan Kettering, Glen Blum, 31, had already received treatment at another hospital for a cancer that was proving stubbornly hard to beat.

His saga began several years ago, when lingering back pain led to a blood test, a biopsy, and eventually a diagnosis of acute lymphoblastic leukemia, or ALL. This aggressive cancer, which grows in the bone marrow, had already damaged several of his vertebrae. He received conventional treatment with both chemotherapy and radiation, which helped for a while. But as is often the case with ALL, the cancer came roaring back. And when it did, it was resistant to further treatment with conventional drugs.

Thats when Mr. Blums doctor recommended that he enroll in a clinical trial of an experimental immunotherapy treatment at MSK. The goal of that treatment, called chimeric antigen receptor (CAR) T cell therapy, would be to shrink his cancer down to a point where he would be eligible for a potentially life-saving bone marrow transplant.

The way they explained itto me is that the treatment would get my own immune cells to see the cancer cells as foreign and eliminate them, says Mr. Blum, who lives in East Harlem in New York City. Then the bone marrow transplant was a secondary step so that I wouldnt grow more cancer cells.

The treatment would get my own immune cells to see the cancer cells as foreign and eliminate them.

Historically, a bone marrow transplant is often a leukemia patients last, best hope for a cure once initial therapy has failed. But the procedure is not without significant risks. To receive new bone marrow, patients must first have their existing bone marrow destroyed with high-dose chemotherapy or radiation. Because the bone marrow is what produces blood cells including the white blood cells that make up the immune system patients are vulnerable to infections while the new bone marrow grows. There is also the risk that immune cells from the donor marrow will start to attack the bodys healthy cells, a dangerous complication called graft-versus-host disease.

But what if it were possible for patients to receive CAR T cell therapy earlier, before a relapse? Would outcomes for these patients be better? And might they be able to forgo a bone marrow transplant altogether?

On April 3, at the AACR annual meeting, MSK physician-scientist Jae Park presented research that speaks directly to these questions. Dr. Park and his colleagues took a retrospective look at all adult patients with relapsed or refractory ALL treated with CAR T cells at MSK 51 patients in all. They wanted to understand who benefits the most from this experimental treatment. For example, does the amount of leukemia a person has at the time of CAR T therapy influence how long that person remains free of disease or how severe the side effects are?

To get at these questions, the team divided those 51 patients into two groups: those with minimal residual disease (MRD, defined as less than 5% of cancer cells in the bone marrow at the time of CAR therapy) and those with obvious morphologic disease (MD, defined as 5% or greater cancer cells in the bone marrow). They then performed statistical analyses on the two groups to determine whether they differed in terms of length of survival and severity of side effects.

What they found was that, indeed, there was a significant difference in outcomes between the two groups. Although both groups initially experienced deep regressions leading to a high rate of complete responses, patients in the MRD group lived longerand hadless toxicity compared with those in the MD group. (After an average of 18 months of follow-up, most of the MRD patients werestill alive and free of disease, while the MD patients had a median survival of 17 months; the rate of a life-threatening side effect called cytokine release syndrome was 5% for MRD patients versus 42% for MD patients.)

According to Dr. Park, the results of this study provide strong support for administering CAR T cell therapy soon after initial chemotherapy, when a patient has minimal residual disease, rather than waiting until a patient relapses. The data from this study, he says, indicate that the CAR T cell therapy is likely to be both more effective and less toxic in the earlier setting. A prospective study to test this hypothesis is currently being planned.

Our ultimate goal is to cure the disease with as little therapy as possible and with the minimum of toxicity.

Another suggestive finding though one that needs to be interpreted with caution, given the small sample size was that receiving a BMT after the CAR T therapy did not seem to improve outcomes in either group of patients. This raises the possibility that CAR T therapy might serve as a final or destination therapy, rather than as a bridge to transplant as it is typically used.

Our ultimate goal is to cure the disease with as little therapy as possible and with the minimum of toxicity, Dr. Park says. A bone marrow transplant is currently the only proven curative treatment for patients with relapsed or refractory ALL. But at the same time, its a pretty toxic therapy, and carries a mortality rate anywhere from 15% to 25%. So if we could use CAR T cell therapy to treat the disease while sparing at least some patients the risks of transplant, that would be a big improvement.

Glen Blum and his fiance, Ashley

For Mr. Blum, there was never really a question that he would go for the transplant, though he admits there was a point after the CAR T cell therapy when he considered his options.

Hearing that your cancer is at zero feels like a victory, he said. It feels like, Oh great, Im done.But then when I thought about all I went through to get to that point all the rounds of chemo and radiation, the hospital stays, the experimental treatment to not go the last mile just didnt feel right.

Yet Mr. Blums experience with bone marrow transplantation indicates why doctors are eager get to a point at which they can safely avoid it. About a month after the transplant, he got an infection that led to a severe case of pneumonia.

I was in the ICU, and honestly, it was a really scary time, Mr. Blum says. The doctorstold my mother not to leave the hospital. They were worried I might not make it.

According to Dr. Park, the decision to recommend a BMT or not becomes a question of weighing different factors, including the number of previous treatments, the characteristics of the disease, the risks of the transplant, the risk of relapse, and the age of the patient.

These are the practical conversations were having with patients every day, he says. And while Im not suggesting by any means that weve answered the question definitively, this study raises the possibility that at least for some patients CAR therapy could be an end point.

In May, it will be one year since Mr. Blum had his bone marrow transplant. Though he still has some back pain, he says he is feeling much better. Hes since gotten engaged, and he and his fiance, Ashley, are planning a trip to Jamaica in June assuming doctors give him the all-clear before then.

He says he has no regrets about the treatment he received, despite the difficulties. He always felt very well cared for at MSK.

That hospital is a piece of heaven, Mr. Blum says. Everyone there, including Dr. Park, has a heart three times the size of normal.

Link:
#AACR17: Study Explores Best Time to Give CAR T Cell Therapy - Memorial Sloan Kettering Cancer Center (blog)