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Human Induced Pluripotent Stem Cell-Derived Cortical Neurons Integrate in Stroke-Injured Cortex and Improve Functional Recovery At two months after transplantation into a stroke-damaged rat cortex, cortically fated cells showed less proliferation and more efficient conversion to mature neurons with morphological and immunohistochemical characteristics of a cortical phenotype and higher axonal projection density as compared with non-fated cells. [Brain] Abstract| Press Release

Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration Genetic disruption of the plasminogen activator inhibitor-1 (PAI-1) gene, or pharmacological inhibition of PAI-1 activity, significantly improved the myeloablation-related mortality and promoted rapid hematopoietic recovery after hematopoietic stem cell transplantation through the induction of hematopoiesis-promoting factors. [Stem Cells] Abstract

WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony Forming Cells Researchers investigated the effects of WKYMVm, a selective formyl peptide receptor 2 agonist isolated by screening synthetic peptide libraries, on homing ability of endothelial colony forming cells and vascular regeneration of ischemic tissues. [Stem Cells] Abstract

TRIM5? Variations Influence Transduction Efficiency with Lentiviral Vectors in Both Human and Rhesus CD34+ Cells In Vitro and In Vivo Investigators examined whether TRIM5? could account for variations in transduction efficiency using both an established rhesus gene therapy model and human CD34+ cell culture. Evaluation of TRIM5? genotypes (Mamu-1, -2, -3, -4, -5, and TrimCyp) in 16 rhesus macaques that were transplanted with transduced CD34+ cells showed a significant correlation between TRIM5? Mamu-4 and high gene marking in both lymphocytes and granulocytes six months after transplantation. [Mol Ther] Abstract

Stem Cells Derived from Tooth Periodontal Ligament Enhance Functional Angiogenesis by Endothelial CellsIn comparison to mesenchymal stem cells and stem cells derived from tooth pulp tissues, researchers determined if periodontal ligament of teeth stem cells (PDLSCs) released soluble pro-angiogenic factors with the capacity to induce vessel formation by endothelial cells (ECs). Next, the ability of PDLSCs to modulate angiogenesis was examined through their co-transplantation with ECs in subcutaneous sites of immunocompromised mice. [Tissue Eng Part A] Abstract

Transplantation of Insulin-Secreting Cells Differentiated from Human Adipose Tissue-Derived Stem Cells into Type 2 Diabetes Mice Investigators evaluated the efficacy of cell therapy using insulin-secreting cells differentiated from human eyelid adipose tissue-derived stem cells into type 2 diabetes mice. [Biochem Biophys Res Commun] Abstract

Mesenchymal Stem Cells and Endothelial Progenitor Cells Stimulate Bone Regeneration and Mineral DensityResearchers quantified extra-cortical bone augmentation and tissue mineral density following co-transplantation of peripheral blood derived endothelial progenitor cells and bone marrow derived mesenchymal stem cells by micro computed tomography. [J Periodontol] Abstract

Improved Preparation of Acellular Nerve Scaffold and Application of PKH26 Fluorescent Labeling Combined with In Vivo Fluorescent Imaging System in Nerve Tissue Engineering Scientists prepared a novel acellular nerve scaffold by the technique of hypotonic buffer combined with freeze-drying, and used PKH26 fluorescent labeling combined with an in vivo fluorescent imaging system to evaluate the biological behavior of tissue-engineered nerves in vitro and in vivo. [Neurosci Lett] Abstract

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo Researchers found that genetically decreasing mammalian target of rapamycin complex 1 (mTORC1) activity in neonatal neural stem cells prevented their differentiation, resulting in reduced lineage expansion and aborted neuron production. [Cell Rep] Abstract| Graphical Abstract | Press Release

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