Comparison of Coronary Heart Disease and Stroke in Association with Di | DMSO – Dove Medical Press

Guang-Ran Yang,1 Dongmei Li,2 Lin Li3

1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, Peoples Republic of China; 2Clinical and Translational Science Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA; 3Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing 100730, Peoples Republic of China

Correspondence: Guang-Ran Yang Email gr.yang@ccmu.edu.cn

Objective: Diabetic retinopathy (DR) was reported to have higher prevalence of coronary heart disease (CHD) and stroke compared with people without DR. However, whether DR had similar effects on CHD and stroke in US adults with diabetes was not well known. This study was to compare the association between DR, CHD and stroke in US adults with diabetes using the 2015 Behavioral Risk Factor Surveillance System (BRFSS).Methods: Respondents with diabetes aged over 18 years and undergone a fundus examination over the past 2 years were included in this study. DR, CHD and stroke were self-reported. A weighted hierarchical logistic regression was used to examine the association of DR with CHD and stroke.Results: A total of 21,049 respondents with diabetes aged over 18 years having undergone a fundus examination over the past 2 years were included in the analysis. There were 4690 people reported having CHD, accounting for the weighted prevalence 22.1%. The weighted prevalence of stroke was 9.6%. There was 28.3% of CHD people who had DR which was higher than that in people without CHD. Differences in weighted frequency distributions of gender, age category (over 45 years or not), current smoking, hypercholesterolemia, hypertension and insulin treatment were significantly different between the CHD and without CHD groups (p< 0.001). Similar results were found in people with stroke. Logistic analysis showed that DR was related to CHD and stroke (crude OR =1.876, 2.263, respectively, p all < 0.001). After adjusting other variables, these associations persisted (Adjusted OR=1.632 (95% CI=1.625 1.639), 1.846 (95% CI=1.836 1.856), respectively, p all< 0.001).Conclusion: The BRFSS 2015 data indicated that DR was not only associated with CHD but also associated with stroke in US adults with diabetes, independently of other risk factor. DR might be more strongly associated with stroke than with CHD.

Keywords: diabetes, diabetic retinopathy, coronary heart disease, stroke, risk factor

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Comparison of Coronary Heart Disease and Stroke in Association with Di | DMSO - Dove Medical Press