Compared with White people, those who are Black have higher cardiovascular risk when early-onset type 2 diabetes (T2D) develops, according to the results of a study published in Diabetes Care.
Studies have shown an increase in the incidence of early-onset T2D diagnosis and a greater risk for T2D among Black people when compared with White people, but the evaluation of ethnicity-specific temporal trends of early-onset T2D diagnosis and the impact of comorbidities at the time of diagnosis had not yet been conducted.
To investigate and compare the trends in early-onset T2D diagnosis of Black and White people as well as the trends of various risk factors at the time of T2D diagnosis, data from 606,440 individuals aged 18 to 70 years who were diagnosed with T2D between 2000 and 2018 were analyzed. Atherosclerotic cardiovascular disease (ASCVD) was defined by the presence of a clinical diagnosis of ischemic heart disease.
Over the past 2 decades, the rate of T2D diagnosis among Black patients within the age groups 18 to 39 and 40 to49 years has consistently been higher than that of their White counterparts (P <.01). The proportion of both Black and White patients diagnosed with T2D before 50 years of age increased significantly from 2012 to 2018 (P <.05).
Black patients had significantly higher mean hemoglobin A1c (HbA1c) than White patients across all age groups. Although no difference was seen in other age groups, Black patients 18 to 39 years of age had significantly higher body mass index (BMI) than their White counterparts (P =.02).
MACE-3 refers to 3-point major adverse cardiovascular events heart failure, myocardial infarction, or stroke. Black patients had a significantly higher risk for MACE-3 compared with White patients across all age groups, with the youngest age group having the highest relative risk (hazard ratio [HR], 1.63; 95% CI, 1.42-1.88) and the lowest relative risk observed in the oldest age group (HR, 1.11; 95% CI, 1.06-1.15).
Taken as a whole, the results of this study illustrated the increasing burden of early-onset T2D and the increased risk of MACE-3 for Black patients. Understanding the trends in diagnosis of early-onset T2D and the differences in the prevalence of related comorbidities among people of different ethnicities may improve healthcare practitioners ability to detect and manage this disease.
Limitations of this study include the use of electronic medical records, which may have resulted in errors in data collection due to condition coding, and the fact that the database did not link directly to hospitalized data.
Future investigation into potential explanations for the differences between ethnicities observed in this study are warranted.
Reference
Dibato JE, Montvida O, Zaccardi F, et al. Association of cardiometabolic multimorbidity and depression with cardiovascular events in early-onset adult type 2 diabetes: a multiethnic study in the US. Published online November 11, 2020. Diabetes Care. doi: 10.2337/dc20-2045
- TRANSPLANT VIEWS: Stem cell therapy used for diabetic patients [Last Updated On: June 23rd, 2011] [Originally Added On: June 23rd, 2011]
- Diabetes - Video [Last Updated On: November 29th, 2011] [Originally Added On: November 29th, 2011]
- Stem Cell Treatment vs Diet For Diabetes - Video [Last Updated On: January 12th, 2012] [Originally Added On: January 12th, 2012]
- Orgenesis' Sarah Ferber, Ph.D on Using a Diabetes Patient's Own Liver Cells as a Novel Source of Insulin [Last Updated On: June 15th, 2012] [Originally Added On: June 15th, 2012]
- Diabetes drug may kill cancer stem cells, study says [Last Updated On: June 20th, 2012] [Originally Added On: June 20th, 2012]
- Diabetes reversed in mice using stem cells [Last Updated On: June 28th, 2012] [Originally Added On: June 28th, 2012]
- Diabetes Reversed In Mice Thanks To Stem Cell Transplant [Last Updated On: June 28th, 2012] [Originally Added On: June 28th, 2012]
- Diabetes Reversal In Mice Via Stem Cells [Last Updated On: June 28th, 2012] [Originally Added On: June 28th, 2012]
- Diabetes drug makes brain cells grow [Last Updated On: July 6th, 2012] [Originally Added On: July 6th, 2012]
- Diabetes drug helps brain growth, makes mice smarter [Last Updated On: July 6th, 2012] [Originally Added On: July 6th, 2012]
- Diabetes study hit by lack of funds [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Stem Cells Lupus Testimony Stem Alive - Video [Last Updated On: November 20th, 2012] [Originally Added On: November 20th, 2012]
- Common diabetes drug could fight ovarian cancer [Last Updated On: December 4th, 2012] [Originally Added On: December 4th, 2012]
- Diabetes distresses bone marrow stem cells by damaging their microenvironment [Last Updated On: February 1st, 2013] [Originally Added On: February 1st, 2013]
- Mike Maldonado uses exercise to fight Diabetes and Cancer - Video [Last Updated On: February 22nd, 2013] [Originally Added On: February 22nd, 2013]
- Diabetes : Deep-sea diving tank combined with stem cells to treat condition [Last Updated On: March 12th, 2013] [Originally Added On: March 12th, 2013]
- Diabetes team finds new hormone that could transform care [Last Updated On: April 25th, 2013] [Originally Added On: April 25th, 2013]
- Hormone Shows Potential as Diabetes Treatment in Mice [Last Updated On: April 27th, 2013] [Originally Added On: April 27th, 2013]
- Potential Diabetes Breakthrough - Video [Last Updated On: April 28th, 2013] [Originally Added On: April 28th, 2013]
- Stem Cell Therapy Cures Type 1 Diabetes in Mice [Last Updated On: June 7th, 2013] [Originally Added On: June 7th, 2013]
- John Chick: Giving diabetes the boot [Last Updated On: August 22nd, 2013] [Originally Added On: August 22nd, 2013]
- Scientists Create Personalized Stem Cells, Raising Hopes for Diabetes Cure [Last Updated On: April 28th, 2014] [Originally Added On: April 28th, 2014]
- Stem Cells from a Diabetes Patient [Last Updated On: April 28th, 2014] [Originally Added On: April 28th, 2014]
- Gut Cells May Be Coaxed to Make Insulin for People With Type 1 Diabetes [Last Updated On: July 1st, 2014] [Originally Added On: July 1st, 2014]
- Diabetes tipo 2 Podra ser reversible? [Last Updated On: July 31st, 2014] [Originally Added On: July 31st, 2014]
- James Shapiro: "Cutting Edge Islet and Stem Cell Transplant Therapies in the Clinic for Diabetes" - Video [Last Updated On: August 4th, 2014] [Originally Added On: August 4th, 2014]
- Cure for Type 1 diabetes imminent after Harvard stem-cell breakthrough [Last Updated On: October 9th, 2014] [Originally Added On: October 9th, 2014]
- New diabetes breakthrough 'bigger than the discovery of insulin' [Last Updated On: October 11th, 2014] [Originally Added On: October 11th, 2014]
- A cure for diabetes and awful jokes [Last Updated On: October 12th, 2014] [Originally Added On: October 12th, 2014]
- Stem Cell Success Raises Hopes of Type 1 Diabetes Cure [Last Updated On: October 12th, 2014] [Originally Added On: October 12th, 2014]
- Major step toward diabetes cure - Video [Last Updated On: October 12th, 2014] [Originally Added On: October 12th, 2014]
- Did Scientists Just Cure Type 1 Diabetes? - Video [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- Muscle relaxant may treat rare form of diabetes, scientists find [Last Updated On: November 26th, 2014] [Originally Added On: November 26th, 2014]
- TESTIMONI LAMININE - Ginjal Diabetes dan Komplikasi - Video [Last Updated On: December 3rd, 2014] [Originally Added On: December 3rd, 2014]
- Laminine - Seminar Diabetes - Video [Last Updated On: December 5th, 2014] [Originally Added On: December 5th, 2014]
- Stem cells show promise for reversing type 2 diabetes [Last Updated On: March 19th, 2015] [Originally Added On: March 19th, 2015]
- Vitamin D prevents diabetes and clogged arteries in mice [Last Updated On: March 19th, 2015] [Originally Added On: March 19th, 2015]
- stemtech testimonial diabetes www afastemcell com - Video [Last Updated On: April 29th, 2015] [Originally Added On: April 29th, 2015]
- Afastemcell - testimoni penderita diabetes - Video [Last Updated On: April 29th, 2015] [Originally Added On: April 29th, 2015]
- Diabetes.net Welcome to the Original Diabetes Network [Last Updated On: May 9th, 2015] [Originally Added On: May 9th, 2015]
- Diabetes mellitus [Last Updated On: May 30th, 2015] [Originally Added On: May 30th, 2015]
- Type 2 Diabetes: Everything You Need to Know [Last Updated On: August 6th, 2015] [Originally Added On: August 6th, 2015]
- Diabetes Mellitus Center - Washington, DC - MedicineNet [Last Updated On: August 21st, 2015] [Originally Added On: August 21st, 2015]
- Washington, DC - American Diabetes Association [Last Updated On: August 21st, 2015] [Originally Added On: August 21st, 2015]
- Type 1 Diabetes: Causes, Tests, Symptoms and Treatments [Last Updated On: August 23rd, 2015] [Originally Added On: August 23rd, 2015]
- Type 2 Diabetes: Causes, Symptoms, Prevention, and More [Last Updated On: August 26th, 2015] [Originally Added On: August 26th, 2015]
- Diabetes mellitus - Wikipedia, the free encyclopedia [Last Updated On: August 27th, 2015] [Originally Added On: August 27th, 2015]
- Diabetes | Overview [Last Updated On: August 31st, 2015] [Originally Added On: August 31st, 2015]
- Virginia Diabetes and Endocrinology [Last Updated On: September 7th, 2015] [Originally Added On: September 7th, 2015]
- About Diabetes - American Heart Association [Last Updated On: September 8th, 2015] [Originally Added On: September 8th, 2015]
- Diabetes [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- NIHSeniorHealth: Diabetes - What is Diabetes? [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- Diabetes Symptoms: Common Symptoms of Diabetes [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- Type 2 Diabetes Condition Center - Health.com [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- Diabetes - Symptoms, Diagnosis, Treatment of Diabetes - NY ... [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- Raleigh North Carolina Office of the American Diabetes ... [Last Updated On: September 12th, 2015] [Originally Added On: September 12th, 2015]
- Louisiana Office of the American Diabetes Association [Last Updated On: September 21st, 2015] [Originally Added On: September 21st, 2015]
- Diabetes Basics - What is Diabetes? - Lifeclinic [Last Updated On: October 3rd, 2015] [Originally Added On: October 3rd, 2015]
- Kentucky: Cabinet for Health and Family Services - Diabetes [Last Updated On: October 3rd, 2015] [Originally Added On: October 3rd, 2015]
- Albuquerque-Santa Fe, New Mexico American Diabetes [Last Updated On: October 7th, 2015] [Originally Added On: October 7th, 2015]
- Chicago Illinois Office of the American Diabetes Association [Last Updated On: October 16th, 2015] [Originally Added On: October 16th, 2015]
- Wisconsin Diabetes Prevention and Control Program | Wisconsin ... [Last Updated On: October 25th, 2015] [Originally Added On: October 25th, 2015]
- Diabetes Basics [Last Updated On: July 25th, 2016] [Originally Added On: July 25th, 2016]
- Diabetes: Symptoms, Causes and Treatments - Health News [Last Updated On: July 25th, 2016] [Originally Added On: July 25th, 2016]
- What Can I Eat If I Have Diabetes [Last Updated On: August 1st, 2016] [Originally Added On: August 1st, 2016]
- JDRF Type 1 Diabetes Research Funding and Advocacy [Last Updated On: August 5th, 2016] [Originally Added On: August 5th, 2016]
- children with DIABETES Online Community [Last Updated On: August 5th, 2016] [Originally Added On: August 5th, 2016]
- WHO | Diabetes programme [Last Updated On: August 5th, 2016] [Originally Added On: August 5th, 2016]
- Bridgewater, New Jersey - American Diabetes Association [Last Updated On: August 14th, 2016] [Originally Added On: August 14th, 2016]
- Diabetes Prevention and Control - New Jersey [Last Updated On: August 17th, 2016] [Originally Added On: August 17th, 2016]
- NJDOH - Family Health services - New Jersey [Last Updated On: August 17th, 2016] [Originally Added On: August 17th, 2016]
- Diabetes Australia [Last Updated On: August 18th, 2016] [Originally Added On: August 18th, 2016]
- Diabetes Facts & Information | Joslin Diabetes Center [Last Updated On: August 23rd, 2016] [Originally Added On: August 23rd, 2016]
- Diabetes mellitus type 2 - Wikipedia, the free encyclopedia [Last Updated On: August 23rd, 2016] [Originally Added On: August 23rd, 2016]
- Diabetes - Better Health Channel [Last Updated On: August 23rd, 2016] [Originally Added On: August 23rd, 2016]
- Diabetes Symptoms: American Diabetes Association [Last Updated On: September 1st, 2016] [Originally Added On: September 1st, 2016]
- Types of Diabetes | NIDDK [Last Updated On: September 7th, 2016] [Originally Added On: September 7th, 2016]
- Diabetes mellitus - Wikipedia [Last Updated On: October 26th, 2016] [Originally Added On: October 26th, 2016]
- Diabetes May Be Warning Sign of Pancreatic Cancer - WebMD [Last Updated On: February 6th, 2017] [Originally Added On: February 6th, 2017]
- Roche won't sell diabetes businessit's looking for deals to boost it instead - FierceBiotech [Last Updated On: February 6th, 2017] [Originally Added On: February 6th, 2017]