Elevated FGF23 Linked to Mortality in Type 2 Diabetes – Renal and Urology News

Elevated levels of fibroblastgrowth factor 23 (FGF23) are associated with increased risks for a majoradverse cardiovascular event (MACE) and death in patients with type 2 diabetesand normal to mildly impaired kidney function, according to new study findings publishedin Diabetes Care.

Martin H. de Borst, MD, PhD,of the University of Groningen in the Netherlands, and colleagues analyzedplasma c-terminal FGF23 levels in 310 patient with type 2 diabetes (mean age 62years; 58% men) with an estimated glomerular filtration rate (eGFR) of 60mL/min/1.73 m2 or higher from the Diabetes and Lifestyle CohortTwente (DIALECT). During 5.8 years of follow-up, 47 patients experienced a MACEand 28 patients died. Each doubling of FGF23 was significantly associated with a1.7- and 2.8-fold increased risk for MACE and all-cause mortality, respectively,in adjusted analyses.

In a subset of patients witheGFR of 90 mL/min/1.73 m2 or higher, each doubling of FGF23 was significantlyassociated with a 3.3-fold higher risk for all-cause mortality in adjustedanalyses. Theassociation with MACE was attenuated, likely due to underpowering, according tothe investigators.

The researchers adjusted Cox regression models for a range of confounders including age, sex, body mass index, C-reactive protein, triglycerides, medications (for diabetes, hypertension, and cholesterol), urinary phosphate, urea excretion, plasma albumin, and urinary albumin-to-creatinine ratio.

High FGF23 level has beenconsistently associated with cardiovascular morbidity and mortality in patientswith chronic kidney disease, Dr de Borst and his colleagues noted. The new observationaldata extend previous research.

Our data provide a rationalefor future studies on the specific role of FGF23 in patients with type 2 diabetesand normal kidney function.

Reference

Yeung SMH, Binnenmars SH, Gant CM, etal. Fibroblast growth factor 23 and mortality in patients with type 2 diabetesand normal or mildly impaired kidney function [published online September 5,2019]. Diabetes Care. doi:10.2337/dc19-0528

View original post here:
Elevated FGF23 Linked to Mortality in Type 2 Diabetes - Renal and Urology News