The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus – Nature.com

Atkinson, M. A., Eisenbarth, G. S. & Michels, A. W. Type 1 diabetes. Lancet 383, 6982 (2014).

Article PubMed Google Scholar

Roep, B. O. The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure. Diabetologia 46, 305321 (2003).

Article CAS PubMed Google Scholar

Pociot, F. & Lernmark, . Genetic risk factors for type 1 diabetes. Lancet 387, 23312339 (2016).

Article CAS PubMed Google Scholar

Moltchanova, E. V., Schreier, N., Lammi, N. & Karvonen, M. Seasonal variation of diagnosis of type 1 diabetes mellitus in children worldwide. Diabet. Med. 26, 673678 (2009).

Article CAS PubMed Google Scholar

Patterson, C. et al. Seasonal variation in month of diagnosis in children with type 1 diabetes registered in 23 European centers during 19892008: little short-term influence of sunshine hours or average temperature. Pediatr. Diabetes 16, 573580 (2015).

Article CAS PubMed Google Scholar

Sderstrm, U., Aman, J. & Hjern, A. Being born in Sweden increases the risk for type 1 diabetes a study of migration of children to Sweden as a natural experiment. Acta Paediatr. 101, 7377 (2012).

Article PubMed Google Scholar

Wang, Z., Xie, Z., Lu, Q., Chang, C. & Zhou, Z. Beyond genetics: what causes type 1 diabetes. Clin. Rev. Allerg. Immunol. 52, 273286 (2017).

Article CAS Google Scholar

Olmos, P. et al. The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins. Diabetologia 31, 747750 (1988).

Article CAS PubMed Google Scholar

Peng, H. & Hagopian, W. Environmental factors in the development of type 1 diabetes. Rev. Endocr. Metab. Disord. 7, 149162 (2007).

Article Google Scholar

Patelarou, E. et al. Current evidence on the associations of breastfeeding, infant formula, and cows milk introduction with type 1 diabetes mellitus: a systematic review. Nutr. Rev. 70, 509519 (2012).

Article PubMed Google Scholar

Stene, L. C. & Gale, E. A. M. The prenatal environment and type 1 diabetes. Diabetologia 56, 18881897 (2013).

Article CAS PubMed Google Scholar

van der Werf, N., Kroese, F. G. M., Rozing, J. & Hillebrands, J.-L. Viral infections as potential triggers of type 1 diabetes. Diabetes Metab. Res. Rev. 23, 169183 (2007).

Article PubMed Google Scholar

Nekoua, M. P., Alidjinou, E. K. & Hober, D. Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus. Nat. Rev. Endocrinol. 18, 503516 (2022). This Review highlights evidence that persistent Coxsackievirus B infection triggers or accelerates islet autoimmunity and T1DM in susceptible individuals.

Article CAS PubMed PubMed Central Google Scholar

Soltesz, G., Patterson, C. & Dahlquist, G.; EURODIAB Study Group. Worldwide childhood type 1 diabetes incidence what can we learn from epidemiology? Pediatr. Diabetes 8, 614 (2007).

Article PubMed Google Scholar

Hober, D. & Sauter, P. Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat. Rev. Endocrinol. 6, 279289 (2010). The interplay between enterovirus infection with -cells, the immune system and host genes in the pathogenesis of T1DM is discussed.

Article PubMed Google Scholar

Lnnrot, M. et al. Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia 60, 19311940 (2017). A prospective study of 8,676 newborn babies reporting that viral respiratory infections are associated with an increased risk of islet autoimmunity.

Article PubMed PubMed Central Google Scholar

Rasmussen, T., Wits, E., Tapia, G., Stene, L. C. & Rnningen, K. S. Self-reported lower respiratory tract infections and development of islet autoimmunity in children with the type 1 diabetes high-risk HLA genotype: the MIDIA study. Diabetes Metab. Res. Rev. 27, 834837 (2011).

Article CAS PubMed Google Scholar

Beyerlein, A., Wehweck, F., Ziegler, A.-G. & Pflueger, M. Respiratory infections in early life and the development of islet autoimmunity in children at increased type 1 diabetes risk: evidence from the BABYDIET study. JAMA Pediatr. 167, 800807 (2013).

Article PubMed Google Scholar

Mustonen, N. et al. Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk. Pediatr. Diabetes 19, 293299 (2018).

Article CAS PubMed Google Scholar

Lee, H.-Y., Lu, C.-L., Chen, H.-F., Su, H.-F. & Li, C.-Y. Perinatal and childhood risk factors for early-onset type 1 diabetes: a population-based case-control study in Taiwan. Eur. J. Public Health 25, 10241029 (2015).

Article PubMed Google Scholar

Ruiz, P. L. D. et al. Pandemic influenza and subsequent risk of type 1 diabetes: a nationwide cohort study. Diabetologia 61, 19962004 (2018).

Article PubMed PubMed Central Google Scholar

Kordonouri, O. et al. Infections in the first year of life and development of beta cell autoimmunity and clinical type 1 diabetes in high-risk individuals: the TRIGR cohort. Diabetologia 65, 20982107 (2022).

Article CAS PubMed PubMed Central Google Scholar

Beyerlein, A., Donnachie, E., Jergens, S. & Ziegler, A.-G. Infections in early life and development of type 1 diabetes. JAMA 315, 18991901 (2016).

Article PubMed Google Scholar

Wu, R. et al. Respiratory infections and type 1 diabetes: potential roles in pathogenesis. Rev. Med. Virol. 33, e2429 (2023).

Article CAS PubMed PubMed Central Google Scholar

Ho, D. et al. Identifying the lungs as a susceptible site for allele-specific regulatory changes associated with type 1 diabetes risk. Commun. Biol. 4, 1072 (2021).

Article CAS PubMed PubMed Central Google Scholar

Kim, D. et al. The architecture of SARS-CoV-2 transcriptome. Cell 181, 914921 (2020).

Article CAS PubMed PubMed Central Google Scholar

Liu, Y.-C., Kuo, R.-L. & Shih, S.-R. COVID-19: the first documented coronavirus pandemic in history. Biomed. J. 43, 328333 (2020).

Article PubMed PubMed Central Google Scholar

Liu, J. et al. SARS-CoV-2 cell tropism and multiorgan infection. Cell Discov. 7, 17 (2021).

Article CAS PubMed PubMed Central Google Scholar

Unsworth, R. et al. New-onset type 1 diabetes in children during COVID-19: multicenter regional findings in the U.K. Diabetes Care 43, e170e171 (2020).

Article CAS PubMed Google Scholar

Kamrath, C. et al. Incidence of type 1 diabetes in children and adolescents during the COVID-19 pandemic in Germany: results from the DPV registry. Diabetes Care 45, 17621771 (2022).

Article CAS PubMed Google Scholar

Gesuita, R. et al. Trends and cyclic variation in the incidence of childhood type 1 diabetes in two Italian regions over 33 years and during the COVID-19 pandemic. Diabetes Obes. Metab. 25, 16981703 (2023).

Article CAS PubMed Google Scholar

Rabbone, I. et al. Has COVID-19 delayed the diagnosis and worsened the presentation of type 1 diabetes in children? Diabetes Care 43, 28702872 (2020).

Article CAS PubMed Google Scholar

Rahmati, M. et al. The global impact of COVID19 pandemic on the incidence of pediatric newonset type 1 diabetes and ketoacidosis: a systematic review and metaanalysis. J. Med. Virol. 94, 51125127 (2022).

Article CAS PubMed PubMed Central Google Scholar

DSouza, D. et al. Incidence of diabetes in children and adolescents during the COVID-19 pandemic: a systematic review and meta-analysis. JAMA Netw. Open 6, e2321281 (2023).

Article PubMed PubMed Central Google Scholar

Ruiz, P. L. D. et al. SARS-CoV-2 infection and subsequent risk of type 1 diabetes in 1.2 million children [abstract 233]. EASD 2022. https://www.easd.org/media-centre/home.html#!resources/sars-cov-2-infection-and-subsequent-risk-of-type-1-diabetes-in-1-2-million-children-3e68c8b2-dde1-43aa-8d75-af7356502994 (2022).

Kendall, E. K., Olaker, V. R., Kaelber, D. C., Xu, R. & Davis, P. B. Association of SARS-CoV-2 infection with new-onset type 1 diabetes among pediatric patients from 2020 to 2021. JAMA Netw. Open 5, e2233014 (2022).

Article PubMed PubMed Central Google Scholar

Qeadan, F. et al. The associations between COVID-19 diagnosis, type 1 diabetes, and the risk of diabetic ketoacidosis: a nationwide cohort from the US using the Cerner Real-World Data. PLoS One 17, e0266809 (2022).

Article CAS PubMed PubMed Central Google Scholar

Lugar, M. et al. SARS-CoV-2 infection and development of islet autoimmunity in early childhood. JAMA 330, 11511160 (2023).

Article CAS PubMed PubMed Central Google Scholar

McKeigue, P. M. et al. Relation of incident type 1 diabetes to recent COVID-19 infection: cohort study using e-health record linkage in Scotland. Diabetes Care 46, 921928 (2023).

Article PubMed Google Scholar

Noorzae, R., Junker, T. G., Hviid, A. P., Wohlfahrt, J. & Olsen, S. F. Risk of type 1 diabetes in children is not increased after SARS-CoV-2 infection: a nationwide prospective study in Denmark. Diabetes Care 46, 12611264 (2023).

Article PubMed Google Scholar

Messaaoui, A., Hajselova, L. & Tenoutasse, S. Anti-SARS-CoV-2 antibodies in new-onset type 1 diabetes in children during pandemic in Belgium. J. Pediatr. Endocrinol. Metab. 34, 13191322 (2021).

Article CAS PubMed Google Scholar

Jia, X. et al. Prevalence of SARS-CoV-2 antibodies in children and adults with type 1 diabetes. Diabetes Technol. Ther. 23, 517521 (2021).

Article CAS PubMed PubMed Central Google Scholar

Rewers, M. et al. SARS-CoV-2 infections and presymptomatic type 1 diabetes autoimmunity in children and adolescents from Colorado, USA, and Bavaria, Germany. JAMA 328, 12521255 (2022).

Article CAS PubMed PubMed Central Google Scholar

Krischer, J. P. et al. SARS-CoV-2 no increased islet autoimmunity or type 1 diabetes in teens. N. Engl. J. Med. 389, 474475 (2023).

Article CAS PubMed PubMed Central Google Scholar

Pietropaolo, M., Hotez, P. & Giannoukakis, N. Incidence of an insulin-requiring hyperglycemic syndrome in SARS-CoV-2-infected young individuals: is it type 1 diabetes? Diabetes 71, 26562663 (2022).

Article CAS PubMed PubMed Central Google Scholar

Rahmati, M. et al. New-onset type 1 diabetes in children and adolescents as postacute sequelae of SARS-CoV-2 infection: a systematic review and meta-analysis of cohort studies. J. Med. Virol. 95, e28833 (2023).

Article CAS PubMed Google Scholar

Kamrath, C., Eckert, A. J., Holl, R. W. & Rosenbauer, J. Impact of the COVID-19 pandemic on children and adolescents with new-onset type 1 diabetes. Pediatr. Diabetes 2023, e7660985 (2023). This meta-analysis, including 40 studies carried out worldwide, reports an increased incidence of T1DM during the COVID-19 pandemic as well as an increased risk of T1DM following SARS-CoV-2 infection.

Article Google Scholar

Zhang, T. et al. Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis. BMC Med. 20, 444 (2022).

Article CAS PubMed PubMed Central Google Scholar

Lai, H. et al. Risk of incident diabetes after COVID-19 infection: a systematic review and meta-analysis. Metabolism 137, 155330 (2022).

Article CAS PubMed PubMed Central Google Scholar

Rubino, F. et al. New-onset diabetes in covid-19. N. Engl. J. Med. 383, 789790 (2020).

Article PubMed Google Scholar

Eslami, N. et al. SARS-CoV-2: receptor and co-receptor tropism probability. Curr. Microbiol. 79, 133 (2022).

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