Identical twins are a scientific enigma: No one knows why a fertilized human egg will sometimes split into two genetically identical embryosbut new research suggests that epigenetics have something to do with it.
Epigenetics is the study of how genes turn on or off depending on a persons behaviors and environment. Geneticists know that fraternal twins run in families, which suggests something in our DNA makes some people more likely to birth fraternal twins than others. But since identical twins happen more randomly, theres likely no genetic component.
To investigate whether epigenetics play a role in identical twin development, an international team of researchers analyzed the genomes of more than 6,000 individuals around the world, including identical twins, fraternal twins, and non-twin family members. They looked at 450,000 sites across their DNA to identify patterns of epigenetic differences, and found that identical twins had the same signature DNA tags at 834 points. This pattern was so consistent that an algorithm the team designed to look for those markers can reliably identify whether someone is an identical twin with up to 80 percent accuracy. The findings were published in Nature Communications.
You could think about these chemical epigenetic tags on DNA as molecular scars, said Baylor College of Medicine epigeneticist Robert Waterland to Science News. Waterland was not involved in the study, but he thinks its likely that the epigenetic markers are byproducts of the twin-splitting process.
[Related: These Australian twins are the second semi-identical pair ever reported]
That said, more work needs to be done. While it is possible that the DNA tags are a result of identical twinning, another theory is that it plays some role in causing it.
Why and how identical twins exist is really a mystery in developmental biology, senior author and biological psychologist at Vrije Universiteit Amsterdam, Dorret Boomsma, told Livescience.
About 12 percent of all human pregnancies begin as multiple pregnancies, but less than 2 percent actually yield birthed twins. The remaining 98 percent result in a vanishing twin, when one twin is miscarried and reabsorbed, according to a 1990 report in the International Journal of Fertility and Sterility. Sometimes that twin appears in an ultrasound before vanishing, but other times parents have no idea that they ever carried multiple embryos.
Analyzing peoples epigenomes and looking at their DNA tags could show whether or not someone had a vanished twin, which opens up a lot of avenues of inquiry, said Nancy Segal, a developmental psychologist at California State University at Fullerton who was not involved in the study, to Science News.
Identical twins are more likely to experience conditions like spina bifida, Beckwith-Wiedemann syndrome, and even left-handedness. Perhaps non-twins with these conditions stem from actually being an unknown identical twin, Segal said.
To properly determine whether the epigenetic changes are a cause or effect of an egg splitting in two will require experimenting with embryos and stem cells in the lab, and observing how development changes under different conditions, according to Deakin University twin researcher Jeffrey Craig in an interview with Science. But for now, the true confirmed cause of identical twinship is yet unknown.
More:
Epigenetics could reveal if you had a 'vanishing twin' - Popular Science
- Epigenetics: A New Bridge between Nutrition and Health [Last Updated On: August 23rd, 2014] [Originally Added On: August 23rd, 2014]
- Epigenetics - Definition and More from the Free Merriam ... [Last Updated On: August 29th, 2014] [Originally Added On: August 29th, 2014]
- NOVA | Epigenetics - PBS [Last Updated On: September 1st, 2014] [Originally Added On: September 1st, 2014]
- Epigenetics - Simple English Wikipedia, the free encyclopedia [Last Updated On: May 13th, 2015] [Originally Added On: May 13th, 2015]
- Epigenetics - PBS Video [Last Updated On: September 8th, 2015] [Originally Added On: September 8th, 2015]
- Epigenetics | Tocris Bioscience [Last Updated On: September 28th, 2015] [Originally Added On: September 28th, 2015]
- Epigenetics Research Technologies [Last Updated On: September 28th, 2015] [Originally Added On: September 28th, 2015]
- Epigenetics | The S File -- Pregnancy [Last Updated On: September 28th, 2015] [Originally Added On: September 28th, 2015]
- Epigenetics - Wikipedia, the free encyclopedia [Last Updated On: September 30th, 2015] [Originally Added On: September 30th, 2015]
- Epigenetics: Fundamentals | What is Epigenetics? [Last Updated On: October 1st, 2015] [Originally Added On: October 1st, 2015]
- Behavioral epigenetics - Wikipedia, the free encyclopedia [Last Updated On: October 5th, 2015] [Originally Added On: October 5th, 2015]
- Biomedical Sciences Graduate Program | Epigenetics [Last Updated On: October 6th, 2015] [Originally Added On: October 6th, 2015]
- Epigenetics and the Human Brain - Learn Genetics [Last Updated On: October 7th, 2015] [Originally Added On: October 7th, 2015]
- Bruce Lipton - Epigenetics - YouTube [Last Updated On: October 12th, 2015] [Originally Added On: October 12th, 2015]
- Wiring the Brain: The Trouble with Epigenetics (Part 1) [Last Updated On: October 19th, 2015] [Originally Added On: October 19th, 2015]
- Epigenetics: Current Research and Emerging Trends | Book [Last Updated On: October 19th, 2015] [Originally Added On: October 19th, 2015]
- Epigenetics: How Environment Shapes Our Genes [Last Updated On: October 25th, 2015] [Originally Added On: October 25th, 2015]
- Insights From Identical Twins [Last Updated On: October 29th, 2015] [Originally Added On: October 29th, 2015]
- What is Epigenetics? - Zymo Research [Last Updated On: October 30th, 2015] [Originally Added On: October 30th, 2015]
- Learn Genetics - Epigenetics [Last Updated On: August 8th, 2016] [Originally Added On: August 8th, 2016]
- Epigenetics & Inheritance [Last Updated On: September 24th, 2016] [Originally Added On: September 24th, 2016]
- NOVA - Official Website | Epigenetics [Last Updated On: September 24th, 2016] [Originally Added On: September 24th, 2016]
- epigenetics | Britannica.com [Last Updated On: September 29th, 2016] [Originally Added On: September 29th, 2016]
- Epigenetics - Wikipedia [Last Updated On: October 20th, 2016] [Originally Added On: October 20th, 2016]
- Epigenetics simply ingenious [Last Updated On: October 28th, 2016] [Originally Added On: October 28th, 2016]
- Behavioral epigenetics - Wikipedia [Last Updated On: October 30th, 2016] [Originally Added On: October 30th, 2016]
- Breakthroughs in Epigenetics - The New Yorker [Last Updated On: November 16th, 2016] [Originally Added On: November 16th, 2016]
- A Super Brief and Basic Explanation of Epigenetics for Total ... [Last Updated On: November 23rd, 2016] [Originally Added On: November 23rd, 2016]
- Evolution's Third Rail Transgenerational Epigenetics Can Have a Profound Impact - Discovery Institute [Last Updated On: August 2nd, 2017] [Originally Added On: August 2nd, 2017]
- Epigenetics Around the Web: Should farmers use vinegar, instead of genetically engineered solutions, to protect ... - Genetic Literacy Project [Last Updated On: August 8th, 2017] [Originally Added On: August 8th, 2017]
- Mutation in prostate tumors shown to change epigenetic identity, the ... - Medical Xpress [Last Updated On: August 8th, 2017] [Originally Added On: August 8th, 2017]
- Using Epigenetics to Combat a Terrible Neglected Tropical Disease - WhatIsEpigenetics.com [Last Updated On: August 8th, 2017] [Originally Added On: August 8th, 2017]
- Epigenetics 2017 | Epigenetics | Epigenetics Conference | CME ... [Last Updated On: August 8th, 2017] [Originally Added On: August 8th, 2017]
- Epigenetics and Cancer 2017 | Epigenetics Conferences ... [Last Updated On: August 8th, 2017] [Originally Added On: August 8th, 2017]
- A Super Brief and Basic Explanation of Epigenetics for ... [Last Updated On: August 14th, 2017] [Originally Added On: August 14th, 2017]
- Epigenetics: How Your Mind Can Reprogram Your Genes [Last Updated On: August 14th, 2017] [Originally Added On: August 14th, 2017]
- Cambridge Epigenetix and NuGEN Technologies Sign Agreement ... - Technology Networks [Last Updated On: August 19th, 2017] [Originally Added On: August 19th, 2017]
- 'Magical' Mushroom Could Fight off Cancer with Epigenetics - WhatIsEpigenetics.com [Last Updated On: August 19th, 2017] [Originally Added On: August 19th, 2017]
- More Than Just Genes: How Environment, Lifestyle, and Stress Impact ADHD - ADDitude [Last Updated On: August 19th, 2017] [Originally Added On: August 19th, 2017]
- SECOND OPINION | Your life is leaving genetic scars that might show up in your child's genes - CBC.ca [Last Updated On: August 19th, 2017] [Originally Added On: August 19th, 2017]
- Epigenetics? - What is Epigenetics? - Epigenome NOE [Last Updated On: August 19th, 2017] [Originally Added On: August 19th, 2017]
- Pregnant Moms' Exposure to Pollution May Epigenetically Increase Child's Asthma Susceptibility - WhatIsEpigenetics.com [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- Cool talk alert: Epigenetics and what genes can't tell us - Technical.ly Brooklyn [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- Global Epigenetics Market - Analysis, Technologies & Forecasts to 2021 - Increasing Use of Epigenetics as a Tool to ... - PR Newswire (press... [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- Artificial Catalysts For Epigenetics Without Enzymes - Asian Scientist Magazine [Last Updated On: August 28th, 2017] [Originally Added On: August 28th, 2017]
- Global Epigenetics Market - Top Trends, Drivers, and Forecasts by Technavio - Business Wire (press release) [Last Updated On: September 3rd, 2017] [Originally Added On: September 3rd, 2017]
- Epigenetics: Fundamentals, History, and Examples | What is ... [Last Updated On: July 9th, 2018] [Originally Added On: July 9th, 2018]
- Epigenetics: DNA Methylation, Chromatin Modification ... [Last Updated On: August 1st, 2018] [Originally Added On: August 1st, 2018]
- Epigenetics | Abcam [Last Updated On: August 1st, 2018] [Originally Added On: August 1st, 2018]
- Epigenetics Research | Icahn School of Medicine [Last Updated On: September 9th, 2018] [Originally Added On: September 9th, 2018]
- Epigenetics 1st Edition - amazon.com [Last Updated On: September 17th, 2018] [Originally Added On: September 17th, 2018]
- Epigenetics - Alex Jones [Last Updated On: January 2nd, 2019] [Originally Added On: January 2nd, 2019]
- 2019 Epigenetics Conference GRC [Last Updated On: January 13th, 2019] [Originally Added On: January 13th, 2019]
- Epigenetics | Spectrum | Autism Research News [Last Updated On: January 13th, 2019] [Originally Added On: January 13th, 2019]
- DNA Methylation | What is Epigenetics? [Last Updated On: February 13th, 2019] [Originally Added On: February 13th, 2019]
- What is epigenetics? - Genetics Home Reference - NIH [Last Updated On: March 14th, 2019] [Originally Added On: March 14th, 2019]
- Epigenetics: Will It Change the Way We Treat Disease? - Dr. Axe [Last Updated On: March 30th, 2019] [Originally Added On: March 30th, 2019]
- What is Epigenetics? The Answer to the Nature vs. Nurture ... [Last Updated On: May 20th, 2019] [Originally Added On: May 20th, 2019]
- Epigenetics - National Institute of Environmental Health ... [Last Updated On: May 20th, 2019] [Originally Added On: May 20th, 2019]
- Is sex addiction rooted in the unregulated production of oxytocin? - Earth.com [Last Updated On: September 30th, 2019] [Originally Added On: September 30th, 2019]
- This is Hollywood's deadliest action star - We Are The Mighty [Last Updated On: October 9th, 2019] [Originally Added On: October 9th, 2019]
- Challenges in Developing Therapeutics for Addiction and Pain - Clinical Pain Advisor [Last Updated On: October 9th, 2019] [Originally Added On: October 9th, 2019]
- Global Epigenetics Market In-Depth Research Report Enabled with Respective Tables and Figures By Industry Experts - Sound On Sound Fest [Last Updated On: October 9th, 2019] [Originally Added On: October 9th, 2019]
- 'Easily misunderstood': 4 things to know about epigenetics, including the fact that most changes are not passed on to offspring - Genetic Literacy... [Last Updated On: October 9th, 2019] [Originally Added On: October 9th, 2019]
- Unlocking the archive - Chromatrap ChIP from Formula Fixed Paraffin Embedded (FFPE) Tissue - Labmate Online [Last Updated On: November 9th, 2019] [Originally Added On: November 9th, 2019]
- The Affair Showrunner Sarah Treem Explains Why That Ending Felt Like The Right Thing to Do - Vulture [Last Updated On: November 9th, 2019] [Originally Added On: November 9th, 2019]
- Unlikely gathering of scientists generates extraordinary research team to create the fat free cell - MSUToday [Last Updated On: November 9th, 2019] [Originally Added On: November 9th, 2019]
- Study: Maternal Interaction May Influence the Epigenetics of Baby's Social Development - University of Virginia [Last Updated On: November 9th, 2019] [Originally Added On: November 9th, 2019]
- Nurture vs Nature: Epigenetics, IVF and the Donor Egg - Parentology [Last Updated On: November 15th, 2019] [Originally Added On: November 15th, 2019]
- For $500, This Company Will Tell You How Well You're Aging - Outside [Last Updated On: November 15th, 2019] [Originally Added On: November 15th, 2019]
- Global Epigenetics Market CAGR, Share and Growth Rate, and Forecast (2013-2023) of the Industry Major Players. - Montana Ledger [Last Updated On: November 20th, 2019] [Originally Added On: November 20th, 2019]
- Reprogramming ant 'soldiers' - Penn: Office of University Communications [Last Updated On: November 20th, 2019] [Originally Added On: November 20th, 2019]
- Get to the core with epigenetics - Deccan Herald [Last Updated On: November 20th, 2019] [Originally Added On: November 20th, 2019]
- Calculate Your Dog's Age With This New, Improved Formula - Smithsonian.com [Last Updated On: November 20th, 2019] [Originally Added On: November 20th, 2019]
- Researchers discover why youre skipping the gym for Netflix and sleep - The CEO Magazine [Last Updated On: December 9th, 2019] [Originally Added On: December 9th, 2019]
- Global Epigenetics Market Growth 2019-2025 Abcam, Novartis, Roche, Active Motif, Inc., Agilent Technologies, Inc. - Exclusive Industry Reports [Last Updated On: December 9th, 2019] [Originally Added On: December 9th, 2019]
- STORM Therapeutics' Collaborator Awarded ASH-BSH Abstract Achievement Award at the 61st ASH Annual Meeting & Exposition - PR Newswire UK [Last Updated On: December 9th, 2019] [Originally Added On: December 9th, 2019]
- 'Couch potato' mice reveal that epigenetics affects urge to exercise - BioNews [Last Updated On: December 9th, 2019] [Originally Added On: December 9th, 2019]
- Epigenetics Market Size Analysis, Application Analysis, Regional Outlook, Competitive Strategies and Forecasts, 2019 To 2025 - The Market Stats News [Last Updated On: December 15th, 2019] [Originally Added On: December 15th, 2019]
- Global Epigenetics Market | 2018-2023 Growth Analysis, Business Opportunities, Sales, Revenue, Gross Margin, Advance Technology and Application... [Last Updated On: December 15th, 2019] [Originally Added On: December 15th, 2019]