Stavropoulos DJ, Merico D, Jobling R, Bowdin S, Monfared N, Thiruvahindrapuram B, et al. Whole-genome sequencing expands diagnostic utility and improves clinical management in paediatric medicine. NPJ Genom Med. 2016;1:19.
Article Google Scholar
Lionel AC, Costain G, Monfared N, Walker S, Reuter MS, Hosseini SM, et al. Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test. Genet Med. 2018;20:43543.
CAS Article Google Scholar
Clark MM, Stark Z, Farnaes L, Tan TY, White SM, Dimmock D, et al. Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases. npj Genom Med. 2018;3:16.
Article Google Scholar
Lynch F, Nisselle A, Gaff CL, McClaren B. Rapid acute care genomics: challenges and opportunities for genetic counselors. J Gen Couns. 2021;30:3041.
Article Google Scholar
Gyngell C, Newson AJ, Wilkinson D, Stark Z, Savulescu J. Rapid challenges: ethics and genomic neonatal intensive care. Pediatrics. 2019;143:S14S21.
Article Google Scholar
Bowdin S, Gilbert A, Bedoukian E, Carew C, Adam MP, Belmont J, et al. Recommendations for the integration of genomics into clinical practice. Genet Med. 2016;18:1075.
CAS Article Google Scholar
Australian Genomics Health Alliance Acute Care Flagship. Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system. JAMA. 2020;323:250311.
Article Google Scholar
French CE, Delon I, Dolling H, Sanchis-Juan A, Shamardina O, Mgy K, et al. Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children. Intens Care Med. 2019;45:62736.
CAS Article Google Scholar
Farnaes L, Hildreth A, Sweeney NM, Clark MM, Chowdhury S, Nahas S, et al. Rapid whole-genome sequencing decreases infant morbidity and cost of hospitalization. Genom Med. 2018;3:10.
Article Google Scholar
Stark Z, Lunke S, Brett GR, Tan NB, Stapleton R, Kumble S, et al. Meeting the challenges of implementing rapid genomic testing in acute pediatric care. Genet Med. 2018;20:155463.
Article Google Scholar
Petrikin JE, Cakici JA, Clark MM, Willig LK, Sweeney NM, Farrow EG, et al. The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants. NPJ Genom Med. 2018;3:6.
Article Google Scholar
Dimmock D, Caylor S, Waldman B, Benson W, Ashburner C, Carmichael JL, et al. Project Baby Bear: Rapid precision care incorporating rWGS in 5 California childrens hospitals demonstrates improved clinical outcomes and reduced costs of care. Am J Hum Genet. 2021;108:12318.
CAS Article Google Scholar
Kingsmore SF, Cakici JA, Clark MM, Gaughran M, Feddock M, Batalov S, et al. A randomized, controlled trial of the analytic and diagnostic performance of singleton and trio, rapid genome and exome sequencing in ill infants. Am J Hum Genet. 2019;105:71933.
CAS Article Google Scholar
Gubbels CS, VanNoy GE, Madden JA, Copenheaver D, Yang S, Wojcik MH, et al. Prospective, phenotype-driven selection of critically ill neonates for rapid exome sequencing is associated with high diagnostic yield. Genet Med. 2020;22:73644.
Article Google Scholar
Mestek-Boukhibar L, Clement E, Jones WD, Drury S, Ocaka L, Gagunashvili A, et al. Rapid Paediatric Sequencing (RaPS): Comprehensive real-life workflow for rapid diagnosis of critically ill children. J Med Genet. 2018;55:7218.
CAS Article Google Scholar
Elliott AM. Genetic counseling and genome sequencing in pediatric rare disease. Cold Spring Harbor Pers Med. 2019;10:a036632.
Chung CC, Leung GK, Mak CC, Fung JL, Lee M, Pei SL, et al. Rapid whole-exome sequencing facilitates precision medicine in paediatric rare disease patients and reduces healthcare costs. Lancet Regional Health West Pac. 2020;1:100001.
Article Google Scholar
Wang H, Lu Y, Dong X, Lu G, Cheng G, Qian Y, et al. Optimized trio genome sequencing (OTGS) as a first-tier genetic test in critically ill infants: practice in China. Hum Genet. 2020;139:47382.
CAS Article Google Scholar
van Diemen CC, Kerstjens-Frederikse WS, Bergman KA, de Koning TJ, Sikkema-Raddatz B, van der Velde JK, et al. Rapid targeted genomics in critically ill newborns. Pediatrics. 2017;140:e20162854.
Article Google Scholar
migiel R, Biela M, Szmyd K, Boch M, Szmida E, Skiba P, et al. Rapid whole-exome sequencing as a diagnostic tool in a neonatal/pediatric intensive care unit. J Clin Med. 2020;9:2220.
Article Google Scholar
Frankel LA, Pereira S, McGuire AL. Potential psychosocial risks of sequencing newborns. Pediatrics. 2016;137:S249.
Brett GR, Martyn M, Lynch F, de Silva MG, Ayres S, Gallacher L, et al. Parental experiences of ultrarapid genomic testing for their critically unwell infants and children. Genet Med. 2020;22:197685.
Article Google Scholar
Lynch F, Nisselle A, Stark Z, Gaff CL, McClaren B. Parents experiences of decision making for rapid genomic sequencing in intensive care. EJHG. 2021;29:180410.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inf. 2009;42:37781.
Article Google Scholar
Varni JW, Sherman SA, Burwinkle TM, Dickinson PE, Dixon P. The PedsQL family impact module: preliminary reliability and validity. Health Qual Life Out. 2004;2:16.
Article Google Scholar
Marteau TM, Bekker H. The development of a six-item short-form of the state scale of the Spielberger StateTrait Anxiety Inventory (STAI). Brit J Clin Psych. 1992;31:3016.
CAS Article Google Scholar
DowneWamboldt B. Content analysis: method, applications, and issues. Health Care Women Int. 1992;13:31321.
Article Google Scholar
Pai AL, Greenley RN, Lewandowski A, Drotar D, Youngstrom E, Peterson CC. A meta-analytic review of the influence of pediatric cancer on parent and family functioning. J Fam Psych. 2007;21:407.
Article Google Scholar
McClellan CB, Cohen LL. Family functioning in children with chronic illness compared with healthy controls: a critical review. J Ped. 2007;150:2213.
Article Google Scholar
Hill M, Hammond J, Lewis C, Mellis R, Clement E, Chitty LS. Delivering genome sequencing for rapid genetic diagnosis in critically ill children: parent and professional views, experiences and challenges. EJHG. 2020;28:152940.
Article Google Scholar
Pereira S, Smith HS, Frankel LA, Christensen KD, Islam R, Robinson JO, et al. Psychosocial effect of newborn genomic sequencing on families in the BabySeq Project: A randomized clinical trial. JAMA Pediatrics. 2021;175:113241.
Article Google Scholar
Ashtiani S, Makela N, Carrion P, Austin J. Parents experiences of receiving their childs genetic diagnosis: a qualitative study to inform clinical genetics practice. Am J Med Genet. 2014;164A:1496502.
Article Google Scholar
Cakici JA, Dimmock DP, Caylor SA, Gaughran M, Clarke C, Triplett C, et al. A prospective study of parental perceptions of rapid whole-genome and -exome sequencing among seriously ill infants. Am J Hum Genet. 2020;107:95362.
CAS Article Google Scholar
Ayres S, Gallacher L, Stark Z, Brett GR. Genetic counseling in pediatric acute care: reflections on ultrarapid genomic diagnoses in neonates. J Gen Couns. 2019;28:27382.
Article Google Scholar
Diamonstein CJ. Factors complicating the informed consent process for whole exome sequencing in neonatal and pediatic intensive care units. J Gen Couns. 2019;28:25662.
Article Google Scholar
See the original post here:
'Diagnostic shock': the impact of results from ultrarapid genomic sequencing of critically unwell children on aspects of family functioning | European...
- Seattle Genetics Reports Fourth Quarter and Year 2011 Financial Results [Last Updated On: February 13th, 2012] [Originally Added On: February 13th, 2012]
- Seattle Genetics Loss Narrows; But Stock Down - Update [Last Updated On: February 14th, 2012] [Originally Added On: February 14th, 2012]
- Seattle Genetics Highlights Updated Survival Data from ADCETRIS® Pivotal Trial in Patients with Relapsed or Refractory ... [Last Updated On: June 15th, 2012] [Originally Added On: June 15th, 2012]
- A Growth-Free Quarter -- and That's OK [Last Updated On: August 11th, 2012] [Originally Added On: August 11th, 2012]
- Seattle Genetics and Millennium Complete Enrollment in Phase III AETHERA Trial of ADCETRIS® for Post-Transplant ... [Last Updated On: September 25th, 2012] [Originally Added On: September 25th, 2012]
- ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research [Last Updated On: October 4th, 2012] [Originally Added On: October 4th, 2012]
- FAQ-4 of 19: What Chance That Stem Cells Will Help Me When I Get Stem Cell Therapy - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- FAQ-4 of 19: What Is My Chance of Success With Stem Cells in Stem Cell Therapy - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- FAQ-3 of 19 -How Do Stem Cells Work in Stem Cell Therapy? - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- Stem Cell Therapy for osteoarthritis Cosmetic Surgery Thailand Review - Urban Beauty Thailand - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- [RMS] C-Class Stem Cell Processing Center (SPC) - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- FAQ-4 19- What Chances for Stem Cell Success When I Get Stem Cell Therapy? - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- FAQ-4 19- What Chance Stem Cells Can Help Me After Stem Cell Therapy? - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- Is stem cell therapy really effective? - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- STEM CELL THERAPY cure HIV patient - Video [Last Updated On: November 1st, 2012] [Originally Added On: November 1st, 2012]
- Seattle Genetics Announces ADCETRIS® Receives European Commission Conditional Marketing Authorization [Last Updated On: November 6th, 2012] [Originally Added On: November 6th, 2012]
- Seattle Genetics Highlights ADCETRIS® (Brentuximab Vedotin) Data in Relapsed Hodgkin Lymphoma and Other CD30-Positive ... [Last Updated On: December 13th, 2012] [Originally Added On: December 13th, 2012]
- Seattle Genetics Highlights Data Presentations from Genentech ADC Collaborator Programs at ASH Annual Meeting [Last Updated On: December 16th, 2012] [Originally Added On: December 16th, 2012]
- Seattle Genetics Highlights Next Generation Antibody-Drug Conjugate SGN-CD33A at ASH Annual Meeting [Last Updated On: December 16th, 2012] [Originally Added On: December 16th, 2012]
- Clinical Data from NewLink Genetics' HyperAcute Prostate Cancer Immunotherapy Published in Journal of Immunotherapy [Last Updated On: December 16th, 2012] [Originally Added On: December 16th, 2012]
- Seattle Genetics Announces Data from Investigator-Sponsored Trials of ADCETRIS® (Brentuximab Vedotin) in Cutaneous T ... [Last Updated On: December 16th, 2012] [Originally Added On: December 16th, 2012]
- Seattle Genetics Reports Data from Phase I Trial of ADCETRIS® (Brentuximab Vedotin) in Front-line Hodgkin Lymphoma at ... [Last Updated On: December 16th, 2012] [Originally Added On: December 16th, 2012]
- Seattle Genetics to test possible new Adcetris use [Last Updated On: December 16th, 2012] [Originally Added On: December 16th, 2012]
- Myriad Genetics to Present at the 2013 J.P. Morgan Annual Healthcare Conference [Last Updated On: December 18th, 2012] [Originally Added On: December 18th, 2012]
- Data From SGEN on Cancer Candidate [Last Updated On: January 30th, 2013] [Originally Added On: January 30th, 2013]
- Health Canada Approves ADCETRIS® (Brentuximab Vedotin) for the Treatment of Relapsed or Refractory Hodgkin Lymphoma ... [Last Updated On: February 2nd, 2013] [Originally Added On: February 2nd, 2013]
- Canada Approves Seattle Genetics' Adcetris [Last Updated On: February 5th, 2013] [Originally Added On: February 5th, 2013]
- Canada Approves Seattle Genetics' Adcetris - Analyst Blog [Last Updated On: February 5th, 2013] [Originally Added On: February 5th, 2013]
- ADC Data from Seattle Genetics [Last Updated On: April 11th, 2013] [Originally Added On: April 11th, 2013]
- Genetics of alcoholism research [Last Updated On: April 16th, 2013] [Originally Added On: April 16th, 2013]
- Genetics Policy Institute and univerCELLmarket to co-publish 360 – the Free Newsletter Covering Stem Cells and ... [Last Updated On: April 29th, 2013] [Originally Added On: April 29th, 2013]
- Genetics Policy Institute and univerCELLmarket to co-publish 360 – the Free Newsletter Covering Stem Cells and ... [Last Updated On: May 2nd, 2013] [Originally Added On: May 2nd, 2013]
- Genetics Policy Institute Opens Washington, D.C. Office [Last Updated On: May 7th, 2013] [Originally Added On: May 7th, 2013]
- Seattle Genetics Announces Initiation of Phase 1/2 Trial of ADCETRIS® (Brentuximab Vedotin) in Combination with ... [Last Updated On: June 11th, 2013] [Originally Added On: June 11th, 2013]
- Seattle Genetics Announces Initiation of Phase 1/2 Trial of ADCETRIS® (Brentuximab Vedotin) in Combination with ... [Last Updated On: June 17th, 2013] [Originally Added On: June 17th, 2013]
- Takeda and Seattle Genetics Highlight Post-Hoc Analysis Examining Progression-free Survival with ADCETRIS® ... [Last Updated On: June 19th, 2013] [Originally Added On: June 19th, 2013]
- Seattle Genetics Highlights ADCETRIS® (Brentuximab Vedotin) Clinical Data at International Conference on Malignant ... [Last Updated On: June 22nd, 2013] [Originally Added On: June 22nd, 2013]
- SGEN/Astellas to Co-Develop Another ADC [Last Updated On: June 30th, 2013] [Originally Added On: June 30th, 2013]
- Life Stem Genetics is Pleased to Announce That It Has Completed the First $500,000 Private Placement of the Recently ... [Last Updated On: October 22nd, 2013] [Originally Added On: October 22nd, 2013]
- Life Stem Genetics Strengthens Its Executive Advisory Board by Adding MBAs Matthew Sullivan and Shahab Bakhtyar [Last Updated On: October 29th, 2013] [Originally Added On: October 29th, 2013]
- Seattle Genetics, Inc. Posts Record Adcetris Sales [Last Updated On: October 31st, 2014] [Originally Added On: October 31st, 2014]
- Inbreeding - Wikipedia, the free encyclopedia [Last Updated On: May 9th, 2015] [Originally Added On: May 9th, 2015]
- Genetics of Colorectal Cancer - National Cancer Institute [Last Updated On: July 16th, 2015] [Originally Added On: July 16th, 2015]
- Seattle Genetics: Advancing Antibody-Drug Conjugates for ... [Last Updated On: August 18th, 2015] [Originally Added On: August 18th, 2015]
- genetics | Britannica.com [Last Updated On: August 25th, 2015] [Originally Added On: August 25th, 2015]
- Genetics and Genetic Disorders and Diseases - WebMD [Last Updated On: September 2nd, 2015] [Originally Added On: September 2nd, 2015]
- Genetics - Biology [Last Updated On: September 2nd, 2015] [Originally Added On: September 2nd, 2015]
- Genetics: MedlinePlus Medical Encyclopedia [Last Updated On: September 2nd, 2015] [Originally Added On: September 2nd, 2015]
- Genetics of Skin Cancer - National Cancer Institute [Last Updated On: September 13th, 2015] [Originally Added On: September 13th, 2015]
- Genetics in Georgia | New Georgia Encyclopedia [Last Updated On: September 15th, 2015] [Originally Added On: September 15th, 2015]
- Faculty & Staff | Directory | Medical Partnership [Last Updated On: October 5th, 2015] [Originally Added On: October 5th, 2015]
- Genetics | Learn Science at Scitable [Last Updated On: October 12th, 2015] [Originally Added On: October 12th, 2015]
- Genetics - Wikipedia, the free encyclopedia [Last Updated On: October 15th, 2015] [Originally Added On: October 15th, 2015]
- Department of Genetics || University of Pennsylvania [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Genetics News - Genetics Science, Genetics Technology, Genetics [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Home > Genetics | Yale School of Medicine [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Ology Genetics - AMNH [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- About Genetics | Understanding Genetics [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Genetics | Article about genetics by The Free Dictionary [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Genetics - Simple English Wikipedia, the free encyclopedia [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Cell Size and Scale - Learn Genetics [Last Updated On: September 24th, 2016] [Originally Added On: September 24th, 2016]
- Genetics of Prostate Cancer (PDQ)Health Professional ... [Last Updated On: September 24th, 2016] [Originally Added On: September 24th, 2016]
- Genetics of Skin Cancer (PDQ)Health Professional Version ... [Last Updated On: September 24th, 2016] [Originally Added On: September 24th, 2016]
- Basic Genetics [Last Updated On: September 26th, 2016] [Originally Added On: September 26th, 2016]
- genetics facts, information, pictures | Encyclopedia.com ... [Last Updated On: October 20th, 2016] [Originally Added On: October 20th, 2016]
- Genetics - Wikipedia [Last Updated On: October 20th, 2016] [Originally Added On: October 20th, 2016]
- How culture, passion and genetics are fueling a Nigerian takeover of US sports - CBS sports.com (blog) [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- After vote, Accelerated Genetics slated to merge - La Crosse Tribune [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- Autism genetics, explained | Spectrum | Autism Research News - Spectrum [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- The problematics of genetics and the Aryan issue - The Hindu [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- North American genetics take centre stage in Wicklow - Agriland [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Genetics may lie at the heart of crop yield limitation - Phys.org - Phys.Org [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Research in genetics promises a long-term cure to diseases : Tony Mira, CEO at Ajuba International LLC - ETHealthworld.com [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- NewLink Genetics to Host Its Second Quarter 2017 Financial Results Conference Call on July 28, 2017 - GlobeNewswire (press release) [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Immunotherapy drug targets tumor's genetics instead of body part - Monroe Evening News [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Getting tumors tested for genetics is the latest theory to help drugs target cancer - The Denver Post [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Konica Minolta, With Eye on Health Care, Nears Deal for US Genetics Firm - New York Times [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Memphis Researchers Planning Big Upgrades to Online Genetics Database - Memphis Daily News [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Mosaic (genetics) - Simple English Wikipedia, the free ... [Last Updated On: July 10th, 2017] [Originally Added On: July 10th, 2017]
- Is There a Genetic Limit to Milk Production? - Dairy Herd Management [Last Updated On: July 11th, 2017] [Originally Added On: July 11th, 2017]