DALLAS, Aug. 29, 2022 (GLOBE NEWSWIRE) -- Gradalis Inc. announced a peer-reviewed publication today in the Nature portfolio journal, Communications Medicine, in which several biomarkers were evaluated for their potential to predict survival following Vigil® (Gemogenovatucel-T) treatment. The publication entitled “ENTPD1 as a Predictive Marker of Treatment Response to Gemogenovatucel-T as Maintenance Therapy in Newly Diagnosed Ovarian Cancer,” features results from VITAL, a Phase 2b randomized, double-blind, placebo-controlled trial of Vigil in patients with newly diagnosed ovarian cancer. The analysis indicates that pretreatment expression levels of the ENTPD1 gene may be a significant predictor of overall survival (OS) and recurrence-free survival (RFS) following Vigil therapy. Vigil is a novel, personalized cellular immunotherapy platform that is designed to decloak the full repertoire of a patient’s tumor antigens, reactivate the immune system, and summon key effector cells to deliver a durable clinical response. In VITAL, Vigil showed a positive trend in RFS in the overall population and a significant improvement in RFS and OS in newly diagnosed ovarian cancer patients with BRCAwt and HRP molecular profiles. This finding may allow for a more refined targeting of patients who will benefit from Vigil therapy.
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Gradalis Announces Publication in Nature Communications Medicine Identifying Survival Predicting Biomarker in Patients with Ovarian Cancer Treated...
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