Hormone Replacement Therapy in Dogs – WagWalking

Diagnosis of USMI is typically based on signalment (breed, age, sex), history, and lack of other causes of incontinence found during physical examination. Most commonly USMI is seen in spayed dogs of medium to large size. Certain breeds are predisposed to this condition including Boxers, Doberman Pinschers, English Springer Spaniels, German Shepherds, Irish Setters, Old English Sheepdogs, Rottweilers, and Weimaraners. Other factors that predispose to this condition include docked tail and obesity.

The gold standard diagnostic test is a urethral pressure profile. For this test a urinary catheter is placed in an awake or lightly sedated dog and removed at a constant rate while warm sterile water is infused. The pressure generated in the urethra is then measured. This is a 15-30 minute procedure that requires no anesthesia.

Once a diagnosis is made, your veterinarian will prescribe your dog the necessary medicines to treat USMI: Estrogen (DES) and/or Phenylpropanolamine (PPA), an alpha-1 adrenergic agonist. DES is prescribed as a daily pill and then slowly tapered to a low dose maintenance schedule. PPA may be used in addition to DES and will also be tapered to a maintenance schedule from a three time per day dose.

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Hormone Replacement Therapy in Dogs - WagWalking