Stem cell technology is moving at a rapid pace at the Massachusetts General Hospital and the Harvard Stem Cell Institute. The Cardiovascular Research Center's Stem Cell Biology + Therapy Program is now developing master cardiovascular stem cells that have genetic mutations that lead to important forms of heart disease. By utilizing these stem cells as model systems, it should be possible to identify the molecular pathways that drive heart disease, and to develop specific, targeted therapy for rare and common forms of heart disease, by directly screening for both genes and drugs that can block the onset of the disease at a cellular level. At the same time, the group is studying the potential of master cardiovascular stem cells for regeneration of heart muscle and other important heart tissues, including the formation of coronary arterial blood vessels. New programs in fat and skeletal muscle stem cells have recently been added, in close collaboration with the Harvard Stem Cell Institute.
Principal Investigators: Caroline Burns, PhD Chad Cowan, PhD Ibrahim Domian, MD, PhD
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Stem Cell Therapy, Stem Cell Biology at Mass General Hospital
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