New York, March 3 (IANS): A gene mutation could curtail sperm production and lead to early loss of fertility in men, says a study.
The study determined that loss of the gene that makes the protein TAF4b in male mice results in the premature exhaustion of their fertility.
The researchers noted that the process of sperm generation in mice may have direct applications to a similar loss of fertility in men.
"What is fascinating about these mice is they can reproduce," said senior study author Richard Freiman from Brown University in the US.
"Mice can usually reproduce until they are two years old, but these mice can only reproduce until they are four months old," said Freiman.
What the team discovered is that the loss of the gene that makes the protein TAF4b causes a deficit in the number of progenitor cells at an embryonic stage of a male mouse's reproductive development.
Lacking those important precursor cells means that the mice struggle to develop a robust stem cell infrastructure to sustain sperm production for the long term.
The affected mice are fertile at first, but quickly deplete the limited sperm supply that they can generate, the researchers pointed out.
TAF4b is a protein that affects how genes are regulated and transcribed, and its absence has profound impact on the reproductive system.
In previous work, Freiman's research group has shown that female mice without TAF4b are totally infertile and that their ovaries age prematurely.
See more here:
Faulty gene may cut short male fertility
- Botox could be used as new treatment for stomach cancer, experts say [Last Updated On: August 22nd, 2014] [Originally Added On: August 22nd, 2014]
- Botox Injections Could Be Used To Treat Stomach Cancer, Experts Say [Last Updated On: August 22nd, 2014] [Originally Added On: August 22nd, 2014]
- Botox 'could be used to treat stomach cancer' [Last Updated On: August 22nd, 2014] [Originally Added On: August 22nd, 2014]
- New York Stem Cell | Regenerative Disk Therapy for Spine NY [Last Updated On: August 22nd, 2014] [Originally Added On: August 22nd, 2014]
- Stem Cell Research in New York State | NYSTEM [Last Updated On: August 22nd, 2014] [Originally Added On: August 22nd, 2014]
- NYU researchers ID process producing neuronal diversity in fruit flies' visual system [Last Updated On: August 29th, 2014] [Originally Added On: August 29th, 2014]
- Novogen Announces Presentation at Rodman & Renshaw 16th Annual Healthcare Conference [Last Updated On: September 4th, 2014] [Originally Added On: September 4th, 2014]
- Stem Cells - The New York Times [Last Updated On: September 4th, 2014] [Originally Added On: September 4th, 2014]
- Donate blood and join in on the fight against cancer [Last Updated On: September 6th, 2014] [Originally Added On: September 6th, 2014]
- New Drug Study Offers Promise of Brain Cell Regeneration for Alzheimers Patients [Last Updated On: September 11th, 2014] [Originally Added On: September 11th, 2014]
- TiGenix: TiGenix to participate or present at key conferences in the second half of 2014 [Last Updated On: September 16th, 2014] [Originally Added On: September 16th, 2014]
- New Treatment May Prevent Diabetes After Pancreatitis Surgery [Last Updated On: September 22nd, 2014] [Originally Added On: September 22nd, 2014]
- Americord Backs Another Cord Blood Clinical Trial [Last Updated On: September 25th, 2014] [Originally Added On: September 25th, 2014]
- Harvard makes diabetes breakthrough [Last Updated On: October 13th, 2014] [Originally Added On: October 13th, 2014]
- Analysis of the Global Stem Cell Market [Last Updated On: October 13th, 2014] [Originally Added On: October 13th, 2014]
- Cell Discovery Challenges Dogma on How Fetus Develops; Holds Insights for Liver Cancer and Regeneration [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- Scientists at New York Stem Cell Foundation, Columbia U ... [Last Updated On: October 29th, 2014] [Originally Added On: October 29th, 2014]
- New York Stem Cell [Last Updated On: November 11th, 2014] [Originally Added On: November 11th, 2014]
- Mount Sinai Researchers Awarded $1 Million Grant to Find New Stem Cell Therapies for Vision Recovery [Last Updated On: November 20th, 2014] [Originally Added On: November 20th, 2014]
- Stranger Donates Stem Cells In Hopes Of Curing New York Woman With Leukemia [Last Updated On: November 28th, 2014] [Originally Added On: November 28th, 2014]
- "Breakthrough" drug tested for Hodgkin lymphoma [Last Updated On: December 9th, 2014] [Originally Added On: December 9th, 2014]
- Hodgkin Lymphoma Treatment Shows Promise in Small Trial [Last Updated On: December 9th, 2014] [Originally Added On: December 9th, 2014]
- "Breakthrough" drug shows promise for Hodgkin lymphoma [Last Updated On: December 9th, 2014] [Originally Added On: December 9th, 2014]
- Human primordial cells created in the lab [Last Updated On: December 24th, 2014] [Originally Added On: December 24th, 2014]
- BrainStorm Announces Final Analysis of Phase 2a ALS Study Showing Nearly All Subjects Experienced Clinical Benefit ... [Last Updated On: January 5th, 2015] [Originally Added On: January 5th, 2015]
- Major grant rewards Roswell Park for innovative research into immunotherapy [Last Updated On: January 16th, 2015] [Originally Added On: January 16th, 2015]
- IntelliCell BioSciences Announces Collaboration to Develop Closed Processing System for Cell Therapy Manufacturing [Last Updated On: January 21st, 2015] [Originally Added On: January 21st, 2015]
- Girl aged just EIGHT helps scientist dad make cancer breakthrough after chat round dinner table [Last Updated On: January 29th, 2015] [Originally Added On: January 29th, 2015]
- Master Switch Found to Stop Tumor Cell Growth by Inducing Dormancy [Last Updated On: January 31st, 2015] [Originally Added On: January 31st, 2015]
- Mount Sinai Health System Names Director of Newly Established Ronald M. Loeb Center for Alzheimer's Disease [Last Updated On: February 19th, 2015] [Originally Added On: February 19th, 2015]
- New York City Pain Specialists Introduce New Treatment for Knee Pain; First Physicians in Northeast to Offer iovera ... [Last Updated On: February 23rd, 2015] [Originally Added On: February 23rd, 2015]
- Study affirms role of specialized protein in assuring normal cell development [Last Updated On: February 27th, 2015] [Originally Added On: February 27th, 2015]
- Asterias Biotherapeutics to Ring Opening Bell at New York Stock Exchange [Last Updated On: March 8th, 2015] [Originally Added On: March 8th, 2015]
- New York Blood Center's New Mobile App Helps Save Lives On the Go [Last Updated On: March 8th, 2015] [Originally Added On: March 8th, 2015]
- New ALS gene and signaling pathways identified [Last Updated On: March 10th, 2015] [Originally Added On: March 10th, 2015]
- Stanley Center at the Broad Institute and NYSCF partner to study psychiatric diseases [Last Updated On: March 10th, 2015] [Originally Added On: March 10th, 2015]
- Key mechanism identified in tumor-cell proliferation in pediatric bone cancers [Last Updated On: April 2nd, 2015] [Originally Added On: April 2nd, 2015]
- Key Mechanism Identified In Pediatric Bone Cancers That Allows Proliferation Of Tumor-Forming Stem Cells [Last Updated On: April 2nd, 2015] [Originally Added On: April 2nd, 2015]
- Research in the News: Tiny hair follicle offers big clues about the life and death of stem cells [Last Updated On: April 7th, 2015] [Originally Added On: April 7th, 2015]
- New York State Stem Cell Science Consortia | Memorial ... [Last Updated On: April 18th, 2015] [Originally Added On: April 18th, 2015]
- Stem Cell Rejuvenation New York - Norman Rowe MD [Last Updated On: May 4th, 2015] [Originally Added On: May 4th, 2015]
- New York Stem Cell Treatment Center [Last Updated On: July 2nd, 2015] [Originally Added On: July 2nd, 2015]
- Center for Stem Cell Biology | Memorial Sloan Kettering ... [Last Updated On: September 29th, 2016] [Originally Added On: September 29th, 2016]
- Stem Cell Therapy New York City | Regenerative Medicine ... [Last Updated On: November 29th, 2016] [Originally Added On: November 29th, 2016]
- These Scientists Have a Plan To Cheat Death. Will It Work? - NBCNews.com [Last Updated On: July 6th, 2017] [Originally Added On: July 6th, 2017]
- Sex For Reproduction May Be Obsolete Within 30 Years Thanks To New Technology, Professor Predicts - Medical Daily [Last Updated On: July 6th, 2017] [Originally Added On: July 6th, 2017]
- A New Method for Making Stem Cells - Live Science [Last Updated On: July 6th, 2017] [Originally Added On: July 6th, 2017]
- Do Stem Cells have the ability to reverse aging process? - Fox Weekly [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- Chop Off This Worm's Head and It Can Still Detect Light - New York Times [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- Researchers find how to reprogramme cells in immune system - India.com [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- Good cellular neighbors combat incipient cancers - Medical Xpress - Medical Xpress [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- Scientists Repair Gene in Human Embryos for First Time - NBC New York [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- Scientists Successfully Slow Aging in Mice Using Stem Cells - Futurism [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- Gene Editing for 'Designer Babies'? Highly Unlikely, Scientists Say - New York Times [Last Updated On: August 5th, 2017] [Originally Added On: August 5th, 2017]
- Penn Engineers Identify Protein Implicated in 3-D Epigenetics of Brain Development - Penn Current [Last Updated On: August 5th, 2017] [Originally Added On: August 5th, 2017]
- Gene therapy via skin may treat diabetes, obesity - Economic Times [Last Updated On: August 5th, 2017] [Originally Added On: August 5th, 2017]
- How New York Post readers helped save a toddler's life - New York Post [Last Updated On: August 7th, 2017] [Originally Added On: August 7th, 2017]
- Blood Donations needed pre and post Labor Day Holiday! - TAPinto.net [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- 'Mini-organs' help personalize treatments for cystic fibrosis patients - New York Post [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- Are stems cells really the fountain of youth? - Star2.com - Star2.com [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- The organoid architect - Science Magazine [Last Updated On: August 27th, 2017] [Originally Added On: August 27th, 2017]
- 5. Hematopoietic Stem Cells | stemcells.nih.gov [Last Updated On: September 19th, 2017] [Originally Added On: September 19th, 2017]
- Are Stem Cells the Future of Hip Replacement? | Plancher ... [Last Updated On: October 18th, 2017] [Originally Added On: October 18th, 2017]
- Stem Cell Transplant - New York - Park Avenue Stem Cell ... [Last Updated On: August 9th, 2018] [Originally Added On: August 9th, 2018]
- Stem Cell Therapy New York | NYC Stem Cells | (212) 262-2412 [Last Updated On: September 5th, 2018] [Originally Added On: September 5th, 2018]
- Stem Cell Therapy for Heart Disease | Stem Cell Therapy in ... [Last Updated On: December 26th, 2018] [Originally Added On: December 26th, 2018]
- Stem Cell Therapy | New York - Park Avenue Stem Cell [Last Updated On: January 8th, 2019] [Originally Added On: January 8th, 2019]
- Stem Cell Investigator Awards - New York Stem Cell Foundation [Last Updated On: January 23rd, 2019] [Originally Added On: January 23rd, 2019]
- Stem Cells New York | Stem Cell Recovery | Oral Surgery [Last Updated On: February 18th, 2019] [Originally Added On: February 18th, 2019]
- NYC Stem Cells Treatment Institute - Call Us (646) 480-1259 [Last Updated On: February 18th, 2019] [Originally Added On: February 18th, 2019]
- Rethink Stem Cells? Science Already Has - The New York Times [Last Updated On: February 22nd, 2019] [Originally Added On: February 22nd, 2019]
- Stem Cell Therapy Doctor in New York, NYC Dr. Reyfman [Last Updated On: February 25th, 2019] [Originally Added On: February 25th, 2019]
- Neuroscience Investigator Awards - New York Stem Cell ... [Last Updated On: March 8th, 2019] [Originally Added On: March 8th, 2019]
- Banking Menstrual Stem Cells | What are Menstrual Stem ... [Last Updated On: April 15th, 2019] [Originally Added On: April 15th, 2019]
- Stem Cell Therapy in New York | National Stem Cell Centers [Last Updated On: April 17th, 2019] [Originally Added On: April 17th, 2019]
- Stem cells for tendinopathy - Dr. Marc Darrow is a Stem ... [Last Updated On: April 20th, 2019] [Originally Added On: April 20th, 2019]
- Stem Cell Therapy New York | Stem Cell Treatment ... [Last Updated On: April 28th, 2019] [Originally Added On: April 28th, 2019]
- Attorney General James Announces Lawsuit Against New York ... [Last Updated On: April 28th, 2019] [Originally Added On: April 28th, 2019]
- In Mice and Men, Prostate Drug Reportedly Treats Parkinson's Disease? - Alzforum [Last Updated On: September 21st, 2019] [Originally Added On: September 21st, 2019]
- A Horse Births a Zebra - Louisville.com [Last Updated On: September 21st, 2019] [Originally Added On: September 21st, 2019]