Grayson authorizes more than $1 million for ongoing and new equine research in 2022 – EQUUS Magazine

The board of directors of Grayson-Jockey Club Research Foundation has announced that it has authorized expenditure of $1,661,180 to fund15 new projects and 10 continuing projects at 16 universities as well as three career development awards. The 2022 slate of research brings Graysons totals since 1983 to more than $32.1 million to underwrite 412 projectsat 45 universities.

Grayson aims to support projects that address a wide range of equine health issues, and this diversity can be seen in our approved projects this year, said Jamie Haydon, president of the foundation. We are not able to fund these research projects and career development awards without the generosity of our donors, and we are grateful to them for recognizing the importance of equine veterinary research.

Below is an alphabetical list by school of the new projects:

Persistence of Antimicrobial Resistance in Horse FarmsLaura Huber,Auburn University

This project will determine the effect of antimicrobial pressure on multidrug resistant Rhodococcus equi. persistence in the soil of horse breeding farms in a 5-year period.

Evaluating extracellular vesicles from equine fetally-derived mesenchymal stem cells as an endometritis therapeuticFiona Hollinshead,Colorado State University

This project will beevaluating extracellular vesicles from equine fetally-derived mesenchymal stem cells as an endometritis therapeutic.

Development of a Palmar Osteochondral Disease ModelChris Kawcak,Colorado State University

The goal of this proposal is to develop an experimental model of palmar osteochondral disease in horses to better study disease progression and facilitate development of improved treatment strategies.

Development of a Vectored Vaccine to Equine Rotavirus AMariano Carossino, Louisiana State University

A novel viral vectored vaccine against equine rotavirus A (G3 and G14), the leading cause of foal diarrhea, will be designed and evaluated in mares and a neonatal mouse model as proof-of-concept.

Novel Strangles Vaccine Using CD40-Targeted DeliveryLuc Berghman,Texas A&M University

This project will be targeting bacterial components ofStreptococcus equispp. equito the horses immune surveillance cells (the APCs) that will result in a fast and strong immune response that will protect against strangles.

Trained Immunity in FoalsAngela Bordin, Texas A&M University

This project will study how giving oral live bacteria protects foals against infection byRhodococcus equi, the cause of severe and debilitating pneumonia in foals, for future development of a vaccine.

Immunogenicity in Foals of an mRNA Vaccine for R. EquiNoah Cohen, Texas A&M University

This study proposes to develop an mRNA vaccine delivered by inhalation to protect foals against pneumonia caused byRhodococcus equi.

Does Antibiotic Treatment Change the Microbial ResistomePaul Morley, Texas A&M University

This research will compare four antibiotic treatments to these protocols that can be selected to treat bacterial infections while also lessening the risks for promoting antibiotic resistance.

Immunomodulation and Exosomes to Enhance Tendon HealingSushmitha Durgam,The Ohio State University

This studyaims to characterize M1 and M2 macrophage-derived inflammatory factors and assess their impact on superficial digital flexor tendon tenocyte activities while examining the potential of extracellular vesicles/exosomes to enhance tendon healing.

Pharmacokinetics of Oral Mycophenolate Mofetil in HorsesGwendolen Lorch,The Ohio State University

This proposal will evaluate the pharmacokinetics of orally administered mycophenolate mofetil as a safe, effective, and inexpensive immunosuppressant drug for management of equine immune-mediated disease.

Equine Placentitis: New Approaches to an Old ProblemPouya Dini,University of California, Davis

The goal of this study is to identify pathogens involved in placentitis and investigate their interaction with the placenta using bioinformatics and in vitro studies to develop better diagnostic and treatment methods.

Motion of the Proximal Sesamoid Bones on Uneven FootingSusan Stover,University of California, Davis

This study proposes to determine how hoof conformation, shoeing, and uneven racetrack surfaces could contribute to fetlock breakdowns.

Influence of Vitamin D and Cortisol inR. Equi InfectionKelsey Hart,University of Georgia

This study will investigate how blood levels of cortisol and vitamin D are related to the development and progression ofRhodococcus equipneumonia in foals after natural exposure.

Fentanyl Matrix Patches in HorsesRachel Reed,University of Georgia

This study aims to show that fentanyl administered via patches placed on the skin is well-absorbed and represents a promising means of providing clinically relevant continuous pain relief to horses.

Sirolimus for the Control of Insulin DysregulationAndrew Van Eps,University of Pennsylvania

This study will evaluate the drug sirolimus (a potent suppressor of insulin production) for the treatment of insulin dysregulation (the most important cause of laminitis) in horses.

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Grayson authorizes more than $1 million for ongoing and new equine research in 2022 - EQUUS Magazine