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Biotechnology Separation Systems Industry Market 2019 Industry Growth, Competitive Analysis, Future Prospects And Forecast 2025 – Latest Herald

Posted: May 2, 2020 at 11:46 am

A detailed research study on the Biotechnology Separation Systems Industry Market was recently published by UpMarketResearch. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. The report puts together a concise analysis of the growth factors influencing the current business scenario across various regions. Significant information pertaining to the industry analysis size, share, application, and statistics are summed in the report in order to present an ensemble prediction. Additionally, this report encompasses an accurate competitive analysis of major market players and their strategies during the projection timeline.

The latest report on the Biotechnology Separation Systems Industry Market consists of an analysis of this industry and its segments. As per the report, the market is estimated to gain significant returns and register substantial y-o-y growth during the forecast period.

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According to the report, the study offers details regarding the valuable estimations of the market such as market size, sales capacity, and profit projections. The report documents factors such as drivers, restraints, and opportunities that impacts the remuneration of this market.

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Contact Info UpMarketResearchName Alex MathewsEmail [emailprotected]Organization UpMarketResearchAddress 500 East E Street, Ontario, CA 91764, United States.

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Biotechnology Separation Systems Industry Market 2019 Industry Growth, Competitive Analysis, Future Prospects And Forecast 2025 - Latest Herald

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Analysts Mean recommendation for Vir Biotechnology, Inc. (VIR) was 3.20: Is this the key time? – The InvestChronicle

Posted: May 2, 2020 at 11:46 am

Lets start up with the current stock price of Vir Biotechnology, Inc. (VIR), which is $31.41 to be very precise. The Stock rose vividly during the last session to $33.45 after opening rate of $33.1 while the lowest price it went was recorded $30.5 before closing at $32.72.

Price records that include history of low and high prices in the period of 52 weeks can tell a lot about the stocks existing status and the future performance. Presently, Vir Biotechnology, Inc. shares are logging -58.13% during the 52-week period from high price, and 169.57% higher than the lowest price point for the same timeframe. The stocks price range for the 52-week period managed to maintain the performance between $11.65 and $75.00.

The companys shares, operating in the sector of healthcare managed to top a trading volume set approximately around 498248 for the day, which was evidently lower, when compared to the average daily volumes of the shares.

When it comes to the year-to-date metrics, the Vir Biotechnology, Inc. (VIR) recorded performance in the market was 160.20%, having the revenues showcasing 53.54% on a quarterly basis in comparison with the same period year before. At the time of this writing, the total market value of the company is set at 3.47B, as it employees total of 229 workers.

During the last month, 3 analysts gave the Vir Biotechnology, Inc. a BUY rating, 0 of the polled analysts branded the stock as an OVERWEIGHT, 1 analysts were recommending to HOLD this stock, 1 of them gave the stock UNDERWEIGHT rating, and 0 of the polled analysts provided SELL rating.

According to the data provided on Barchart.com, the moving average of the company in the 100-day period was set at 25.10, with a change in the price was noted +18.22. In a similar fashion, Vir Biotechnology, Inc. posted a movement of +133.93% for the period of last 100 days, recording 821,416 in trading volumes.

Total Debt to Equity Ratio (D/E) can also provide valuable insight into the companys financial health and market status. The debt to equity ratio can be calculated by dividing the present total liabilities of a company by shareholders equity. Debt to Equity thus makes a valuable metrics that describes the debt, company is using in order to support assets, correlating with the value of shareholders equity. The total Debt to Equity ratio for VIR is recording 0.00 at the time of this writing. In addition, long term Debt to Equity ratio is set at 0.00.

Raw Stochastic average of Vir Biotechnology, Inc. in the period of last 50 days is set at 26.69%. The result represents downgrade in oppose to Raw Stochastic average for the period of the last 20 days, recording 36.79%. In the last 20 days, the companys Stochastic %K was 42.39% and its Stochastic %D was recorded 42.40%.

Lets take a glance in the erstwhile performances of Vir Biotechnology, Inc., multiple moving trends are noted. Year-to-date Price performance of the companys stock appears to be pessimistic, given the fact the metric is recording 160.20%. The shares increased approximately by 1.71% in the 7-day charts and went up by 7.10% in the period of the last 30 days. Common stock shares were driven by 53.54% during last recorded quarter.

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Analysts Mean recommendation for Vir Biotechnology, Inc. (VIR) was 3.20: Is this the key time? - The InvestChronicle

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Vir Biotechnology Inc. [VIR] The Fundamentals are a good enough reason to be bullish on VIR – The Dwinnex

Posted: May 2, 2020 at 11:46 am

Vir Biotechnology Inc. [NASDAQ: VIR] stock went down by -8.01% or -2.62 points down from its previous closing price of 32.72. The stock reached $30.10 during the last trading session. During the course of the last 5 trading session in the week, VIR share price went up during 2 out of 5 days, that way gaining 0.07% in the period of the last 7 days.

VIR had two major price movements with the latest trading session as the price jumped to a high of $33.45, at one point touching $30.04. The latest high is set lower that the high price recorded in the period of the last 52 weeks, set at -59.87%. The 52-week high currently stands at 75.00 distance from the present share price, after the recent low of 11.65.

Stock market traders frequently keep their eyes on what Wall Street experts as it relates to a potential investment. For Vir Biotechnology Inc. [VIR], the most recent analyst consensus recommendation available since its latest financial results for the quarter ending in 12/30/2019. On average, stock market experts give VIR an Hold rating. The average 12-month price forecast for this stock is $30.10, with the high estimate being $42.00, the low estimate being $20.00 and the median estimate amounting to $33.00. This is compared to its latest closing price of $32.72.

Wall Street analysts provide their ratings on a scale of 1 to 5, and the current average score for Vir Biotechnology Inc. [VIR] is sitting at 3.00. This is compared to 1 month ago, when its average rating was 3.00.

Keep your eyes peeled for the soon-to-be-published financial results of this company, which are expected to be made public on 06/03/2020.

This companys Return on Total Capital is -61.54, and its Return on Invested Capital has reached -62.97.

Turning to investigate this organizations capital structure, Vir Biotechnology Inc. [VIR] has generated a Total Debt to Total Equity ratio of 0.27. Similarly, its Total Debt to Total Capital is 0.27, while its Total Debt to Total Assets stands at 0.22. Looking toward the future, this publicly-traded companys Long-Term Debt to Equity is 0.21, and its Long-Term Debt to Total Capital is 0.21.

What about valuation? This companys Enterprise Value to EBITDA is -18.23. The Enterprise Value to Sales for this firm is now 374.73, and its Total Debt to Enterprise Value stands at 0.00. Vir Biotechnology Inc. [VIR] has a Price to Book Ratio of 3.19.

Vir Biotechnology Inc. [VIR] has 106.03M shares outstanding, amounting to a total market cap of 3.19B. Its stock price has been found in the range of 11.65 to 75.00. At its current price, it has moved down by -59.87% from its 52-week high, and it has moved up 158.36% from its 52-week low.

This stocks Relative Strength Index (RSI) is at 43.52. This RSI score is good, suggesting this stock is neither overbought or oversold.

Shares of Vir Biotechnology Inc. [VIR], on the whole, present investors with both positive and negative signals. Wall Street analysts have mixed reviews when it comes to the 12-month price outlook, and this companys financials show a combination of strengths and weaknesses. Based on the price performance, this investment is somewhat risky while presenting reasonable potential for ROI.

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Is Aravive Inc (ARAV) a Winner or a Loser in the Biotechnology Industry? – InvestorsObserver

Posted: May 2, 2020 at 11:46 am

A rating of 99 puts Aravive Inc (ARAV) near the top of the Biotechnology industry according to InvestorsObserver. Aravive Inc's score of 99 means it scores higher than 99% of stocks in the industry. Aravive Inc also received an overall rating of 88, putting it above 88% of all stocks. Biotechnology is ranked 10 out of the 148 industries.

Searching for the best stocks to invest in can be difficult. There are thousands of options and it can be confusing on what actually constitutes a great value. Investors Observer allows you to choose from eight unique metrics to view the top industries and the best performing stocks in that industry. A score of 88 would rank higher than 88 percent of all stocks.

Our proprietary scoring system captures technical factors, fundamental analysis and the opinions of analysts on Wall Street. This makes InvestorsObservers overall rating a great way to get started, regardless of your investing style. Percentile-ranked scores are also easy to understand. A score of 100 is the top and a 0 is the bottom. Theres no need to try to remember what is good for a bunch of complicated ratios, just pay attention to which numbers are the highest.

Aravive Inc (ARAV) stock is trading at $13.92 as of 10:58 AM on Monday, Apr 27, an increase of $0.22, or 1.61% from the previous closing price of $13.70. The stock has traded between $13.35 and $14.24 so far today. Volume today is below average. So far 102,204 shares have traded compared to average volume of 204,303 shares.

To see InvestorsObserver's Sentiment Score for Aravive Inc click here.

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Is Aravive Inc (ARAV) a Winner or a Loser in the Biotechnology Industry? - InvestorsObserver

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Gritstone Oncology Announces the Appointment of Dr. Elaine V. Jones as Chair of the Board of Directors – GlobeNewswire

Posted: May 2, 2020 at 11:46 am

EMERYVILLE, Calif., May 01, 2020 (GLOBE NEWSWIRE) -- Gritstone Oncology, Inc. (Nasdaq: GRTS), a clinical-stage biotechnology company developing the next generation of cancer immunotherapies to fight multiple cancer types, today announced the appointment of Elaine V. Jones, Ph.D., as chair of the board of directors.

Elaine has been a very strong addition to our board, as reflected in the unanimous vote to appoint her to the position of board chair, said Andrew Allen, M.D., Ph.D., co-founder, president and chief executive officer of Gritstone Oncology. She has made significant contributions towards advancing our current programs, including our existing cancer neoantigen-based immunotherapies and bispecific antibodies, as well as in our evaluation of additional portfolio expansion opportunities. Her scientific and business acumen, as well as her extensive experience in shaping innovative biotechs, will be invaluable to Gritstone as we pioneer entirely novel classes of products based on our deep understanding of T cells and T cell targets.

Dr. Jones was most recently vice president, worldwide business development and senior partner at Pfizer Ventures, the corporate venture capital arm of Pfizer Inc. During her tenure from 2008 to 2019, Dr. Jones was responsible for managing biotechnology and healthcare investments for Pfizer, as well as serving on the board of directors for several biotechnology companies. Prior to this, Dr. Jones held the position of general partner at EuclidSR Partners, a venture firm specializing in private investment in both private and public equity within the health sciences, healthcare, biopharmaceutical sectors. Dr. Jones began her investing career in 1999 at S.R. One, the corporate investment fund of GlaxoSmithKline. During her venture career, she served on the boards of more than 20 early to mid-stage biotechnology, therapeutic and pharmaceutical companies. Previously, Dr. Jones was the director of scientific licensing at SmithKline Beecham and a research scientist in the research and development division of SmithKline Beecham Pharmaceuticals. She received a B.S. in biology from Juniata College and a Ph.D. in microbiology from the University of Pittsburgh.

Dr. Jones added, It has been a pleasure to serve on the board of directors for Gritstone, a company that had the vision to become a leader in neoantigen and tumor antigen discovery and is now administering pioneering immunotherapies utilizing these T cell targets in cancer patients. I am honored to be appointed as chair and look forward to working closely with the board and Gritstones leadership team to continue the companys positive momentum in our pursuit of bringing novel cancer treatments to patients.

About Gritstone OncologyGritstone Oncology (Nasdaq: GRTS), a clinical-stage biotechnology company, is developing the next generation of cancer immunotherapies to fight multiple cancer types. Gritstone develops its products by leveraging two key pillarsfirst, a proprietary machine learning-based platform, Gritstone EDGETM, which is designed to predict, from a routine tumor biopsy, the tumor-specific neoantigens (TSNA) that are presented on a patients tumor cells; and second, the ability to develop and manufacture potent immunotherapies utilizing patients TSNA to potentially drive the patients immune system to specifically attack and destroy tumors. The companys off the shelf shared neoantigen-based immunotherapy, SLATE, and its individualized neoantigen-based immunotherapy, GRANITE, are being evaluated in Phase 1 clinical studies. Novel tumor-specific antigens can also provide targets for bispecific antibody (BiSAb) therapeutics for solid tumors, and Gritstones BiSAb program is currently in lead optimization. For more information, please visit gritstoneoncology.com.

Gritstone Forward-Looking StatementsThis press release contains forward-looking statements, including, but not limited to, statements related to the potential of Gritstones therapeutic programs. Such forward-looking statements involve substantial risks and uncertainties that could cause Gritstones research and clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including Gritstones programs early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Gritstones ability to successfully establish, protect and defend its intellectual property and other matters that could affect the sufficiency of existing cash to fund operations. Gritstone undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of the company in general, see Gritstones most recent Annual Report on Form 10-K filed on March 11, 2020 and any current and periodic reports filed with the Securities and Exchange Commission.

ContactsMedia:Dan Budwick1AB(973) 271-6085dan@1abmedia.com

Investors:Alexandra SantosWheelhouse Life Science Advisors(510) 871-6161asantos@wheelhouselsa.com

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Gritstone Oncology Announces the Appointment of Dr. Elaine V. Jones as Chair of the Board of Directors - GlobeNewswire

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Erika Hersch-Green Wins CAREER Award for Biodiversity Research – Michigan Tech News

Posted: May 2, 2020 at 11:45 am

Increasing amounts of nitrogen and phosphorus in terrestrial ecosystems lead to decreasing biodiversity, not only among plant species, but in herbivores and pollinators as well.

Globally, ecosystems change as the climate does, responding to shifts in temperature and the availability of water and nutrients such as nitrogen and phosphorus. These shifts affect plant community productivity and diversity. However, in general we know very little about how these changes happen.

Erika Hersch-Green, evolutionary biologist and assistant professor of biological sciences at Michigan Technological University, has received a National Science Foundation CAREER award to investigate how increased nitrogen and phosphorus availability across different temperature and water regimes alters the primary productivity of some plants, while reducing the growth of others. Hersch-Green will examine how the amounts of nutrients available to plants determine which plants thrive or wither due to their specific genome attributes.

For evolutionary biologists, one of the main goals is to match the genotype of organisms to what they look like their phenotype, Hersch-Green said. Historically, evolutionary biologists have focused on how natural selection for protein function or genetic drift has shaped evolutionary landscapes, as well as the mapping of genotype to phenotype. My research is taking a slightly different perspective, looking at how molecular attributes of organisms interact to reduce the material cost of building genomes. I am examining whether natural selection operates to reduce the cost to a plant species of building genomes, rather than how natural selection acts on proteins, which is a novel approach.

Hersch-Green is conducting her research across several grassland sites distributed across North America, focusing on two common North American grassland plants: fireweed and goldenrod.

Hersch-Greens research examines how nutrients affect plants that vary in their genome size. Genomes are made up of nucleic acids and cells, which cost plants a significant amount of nitrogen and phosphorus to build. And, some of these plants are polyploids with varying numbers of chromosomes which, in turn, affects genome size.

The cost of building genomes and a nutrient environment influence physiological tradeoffs of primary processes like photosynthesis and growth versus secondary tradeoffs like defense compounds, Hersch-Green said. My research takes a multifaceted approach. Im combining molecular cytological [chromosomal] and physiological phylogenetic [appearance] approaches.

Hersch-Green will examine mechanistic tradeoffs in 10 Nutrient Network consortium sites distributed across the American West Coast and Midwest, including a new site at Michigan Techs Ford Center and Research Forest featuring gardens planted in particular arrangements to test particular mechanisms. The sites vary in climate zones, temperature and available moisture.

Using fireweed and goldenrod, Hersch-Green will look specifically at tradeoffs in size between the plants genome their total genetic code and their transcriptome the parts of the genome transcribed into RNA molecules. RNA codes, decodes, regulates and expresses genes. Hersch-Green will use different nutrient environments with different cytotypes of each plant to measure certain functional traits. By combining data from multiple plants, the creatures that pollinate plants or eat the plants (known as consumer community assemblages), and time series phylogenetic modeling and experiments Hersch-Green hopes to gain insights into the roles of material costs and genome size in biodiversity patterns.

Her work provides a system-level understanding of how eutrophication the increasingly dense growth of particular plants at the expense of other species brought on by increasing nutrient inputs are affecting individual organisms and multi-species communities by looking at their interactions. Ultimately, this research will generate genomic tools for other species as well.

Every CAREER award features an education component. Hersch-Greens approach features multiple methods to enhance scientific literacy for middle schoolers, high schoolers and undergraduates. At Hersch-Greens Ford Center site, she is working with a STEM educator to formulate different science communication and botany modules based on photosynthesis research conducted by Hersch-Green and graduate students in her lab. She is also collaborating with Erin Smith, director of the Humanities Digital Media Zone and faculty advisor to Cin/Optic Communication and Media Enterprise students, to create a series of educational modules.

The goal of any CAREER award is to effect change beyond the field of study through novel research and education. Hersch-Greens research, through two prairie plants, examines how community diversity, from plant to pollinator to herbivore, is changing and in broad terms, how that affects biodiversity.

Michigan Technological University is a public research university, home to more than 7,000 students from 54 countries. Founded in 1885, the University offers more than 120 undergraduate and graduate degree programs in science and technology, engineering, forestry, business and economics, health professions, humanities, mathematics, and social sciences. Our campus in Michigans Upper Peninsula overlooks the Keweenaw Waterway and is just a few miles from Lake Superior.

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Science Becomes A Dividing Issue In Year Of Election And Pandemic – Michigan Radio

Posted: May 2, 2020 at 11:45 am

It now seems apparent that COVID-19 will dominate American life for months to come, quite possibly through the national election in November.

That means the disease, and efforts to respond to it, will likewise dominate the 2020 campaign and make it largely about something it has never been about before.

That something is science.

It is hard to think of a time when hard science biology, virology, epidemiology has been so much the core of our political conflict. Issues from evolution to stem cells to vaccination have long been a part of our political conversation, but not at the forefront of presidential elections.

This virus crisis has largely taken over the political conversation. Americans are all learning new, polysyllabic vocabulary and complex truths about threats they cannot see.

And that is likely to bring out all of the culture's ambivalence about science.

Trust in science

Last summer, a Pew Research Center survey found that 86% of Americans expressed "a fair amount or a great deal of faith" that scientists act in their best interests.

But the survey's co-author told NPR, "It tends to be kind of soft support." In fact, only 48% were willing to say that medical doctors "make fair and accurate research statements and recommendations all or most of the time." And only 32% were willing to say as much for "medical research scientists."

A YouGov poll in April 2017 found an even less sanguine attitude, as reported in Scientific American. That measure found only 35% of Americans had "a lot of confidence" in scientists. A plurality (45%) had "a little," while those with "none at all" had grown substantially since YouGov polled the same question in 2013.

Little wonder then that political figures such as Texas Lt. Gov. Dan Patrick, a Republican, and media personalities such as Fox News' Tucker Carlson pounce on the difference between various projections of deaths from COVID-19.

They interpret lower death totals (thus far) as evidence that the threat was overblown, even though public health experts consider it proof that shutdowns and social distancing are working and note that the threat is not over.

Rejecting expertise

Scientific experts, like experts in general, have fared poorly in the populist atmosphere of the past decade in Europe and the United States.

"Voters say they reject expertise because experts, whom they think of as indistinguishable from governing elites, have failed them," writes Tom Nichols, a professor of national security affairs at the U.S. Naval War College.

Nichols published a book in 2017 called The Death of Expertise: The Campaign Against Established Knowledge and Why It Matters. Summing up his argument for Politico, Nichols observed that Americans have always had a healthy skepticism about "eggheads" of various kinds.

He says that skepticism renewed itself in the "social and political traumas" of the 1960s and 1970s. But since then, he argues, "Globalization and technological advances have created a gulf between people with enough knowledge and education to cope with these changes and people who feel threatened and left behind in the new world of the 21st century."

Lacking "scientific merit"

The plain fact is that for many, science is a source of wisdom but by no means the only one. There can be a "balancing" of science with religious teaching or humanistic ethics or what people may regard as their own common sense.

That is why so many Americans may identify with President Trump's overeagerness about potential drug therapies for COVID-19 that have worked on other diseases.

Trump's hopefulness for the antimalarial hydroxychloroquine, for example, was apparently not shared by one of the administration's own leading vaccine scientists, Richard Bright. Bright tried to limit broad use of the drug because its application lacked "scientific merit." As a result, he says, he was removed as director of the Biomedical Advanced Research and Development Authority.

In a statement released by his attorneys last week, Bright sounded the alarm: "To combat this deadly virus, science, not politics or cronyism, has to lead the way."

Also this past week, the president stood at the podium of the White House briefing room and cast doubt on the survival of the coronavirus in the fall. He then deferred to his top scientific adviser on the question.

"We will have the virus in the fall," said Dr. Anthony Fauci of the National Institutes of Health.

Trump also insisted the head of the Centers for Disease Control and Prevention had been misquoted about the difficulties of managing COVID-19 in the fall. Dr. Robert Redfield took the lectern to say he had not been misquoted.

But all this was prelude to the Thursday night stunner, when the president extended his embrace of "game-changer" therapy ideas to raising the question of whether injecting a disinfectant (which can kill the coronavirus on a surface) into a person could kill the virus (in reality, doing so would be toxic).

This prompted such immediate blowback from scientists, hospital personnel and even the makers of Lysol that the president later insisted he had made the comment sarcastically. And the next evening's briefing was cut off at just 22 minutes, with the president taking no questions.

A long-term struggle

The crisis is spreading through the body politic even as it spreads through the human population. It will stress both in myriad ways. Americans' conflicted relationship with science will play a role in how they deal with that stress.

For the moment, most are accepting the scientific approach of social distancing in service of a greater good. But there are rejections of stay-at-home orders in street protests and in some statehouses.

Saturday night, Trump repeated a line used to argue for reopening the country sooner rather than later: "Remember, the Cure can't be worse than the problem itself." He added, "Be careful, be safe, use common sense!"

The struggle has been joined, and it will likely outlast both this one campaign season and this one pandemic.

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Science Becomes A Dividing Issue In Year Of Election And Pandemic - Michigan Radio

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Freezing Life: The Current Trends in Cryopreservation – Technology Networks

Posted: May 2, 2020 at 11:43 am

Cryopreservation has become an indispensable step in the daily routine of scientific research as well as in a number of medical applications, ranging from assisted reproduction and transplantations to cell-based therapies and biomarker identification. It is hardly possible to picture todays scientific and medical advancements without this technique.The successful development and implementation of all the therapeutic and scientific discoveries involving cryopreservation relies on the correct and safe translation of the method from the laboratory to the clinical and manufacturing scale.

With the need to correctly use this technique, more research is focusing on optimizing cryopreservation methods and investigating what the long-term effects and consequences are on the physiology of the cryopreserved material.

An important part of cell therapy research is focused on adult stem cells (ASCs). ASCs can be derived from different sources such as peripheral blood, bone marrow or adipose tissue and display strong promises because of their capacity to differentiate into any cell type of the human body.In recent work3, the team of Michael Pepper at the Institute for Cellular and Molecular Medicine in Pretoria, South Africa, explored the effects of cryopreservation on the differentiation ability of adipose tissue-derived stem cells (ADSCs). After analyzing gene expression of key adipogenic genes and the degree of differentiating cells, characterized with high levels of CD36 and intracellular lipid droplets, the scientists reported that slow freeze cryopreservation of cells shortly after their isolation causes no alterations on their ability to differentiate. Pepper is convinced of the necessity to perform such analysis when cryopreserving important cell pools: It is critical to do a post-thaw analysis of cell function to determine how the cryopreservation may have affected the cells.His team is analyzing the effects of cryopreservation on other cell types largely used in cell-based therapies such as hematological stem cells and peripheral blood mononuclear cells (PBMCs). Although they didnt observe major alterations in terms of immunophenotyping or the post-thaw proliferation of the cells, Pepper expresses his concern that more subtle characteristics might be affected.

Correct cryopreservation of cells intended for therapeutic use is crucial. This is very important particularly as cells may persist for a long time in the recipient. This area of cell therapy research definitely requires more attention, Pepper says. Moreover, his words reflect on the need to evaluate not only the direct post-thaw recovery, but to look deeper into the late-onset effects cryopreservation might have and ensure that transplanted cells have preserved their therapeutic properties.

In contrast to slow freezing, vitrification relies on the fast freezing of the material by putting it in high concentration of cryoprotectant and in contact with liquid nitrogen. This method allows the direct transition of water from liquid to solid state without crystal formation. The highly concentrated cryoprotectant prevents ice formation and therefore there is no need for slow cooling.

Although vitrification has a great potential, there are a couple of parameters that are a point of concern. The quick and drastic freeze is possible thanks to the high concentration of cryoprotectant, but the latter is also associated with higher toxicity. In some cases, an additional limitation is the direct contact of the sample with liquid nitrogen which is a predisposition for viral or bacterial contamination.The team of Christiani Amorim at the Institute for Experimental and Clinical Research in Louvain, Belgium, is approaching the challenges of vitrification in the context of ovarian auto-transplantation. Ovarian auto-transplantation consists of preserving a piece of ovarian tissue with active follicles from the pre-therapeutic ovary of a cancer patient, as chemotherapy often has damaging effects on the reproductive organs. This tissue sample will be conserved and auto-transplanted onto the patients ovary when she has recovered and wishes to become pregnant.In their recent research4, the authors used stepped vitrification, in which the concentration of the cryoprotectant is gradually increased while simultaneously temperature decreases. This avoids ice crystal formation and also prevents cryoprotectant toxicity.Although stepped vitrification has previously given good results in bovine ovarian tissue5, this was not the case for human ovarian tissue. The scientists didnt detect normal follicles following thawing and linked this to high cryoprotectant toxicity. Indeed, they observed all signs of dimethyl sulfoxide (DMSO)-related cell membrane damage: significant organelle damage, cell membrane disintegration and apoptosis. These observations imply on the variability of outcomes that the method could give when applied to the same type of tissue but from a different organism.Amorim is positive about the future of their method and recognizes the need for further research on the topic: I can see a great potential in the stepped vitrification approach, but I also believe that there is a lot we still need to learn before thinking about using it as method of choice for human ovarian tissue cryopreservation. The high cryoprotectant concentration that should be applied in this approach is my first concern. () Our study clearly showed that 50% DMSO is too high, so we need to try lower concentrations or combine it with other cryoprotectants.

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Five HMS Faculty Elected to National Academy of Sciences – Harvard Medical School

Posted: May 2, 2020 at 11:43 am

Five scientists have been elected to the National Academy of Sciences in recognition of their distinguished and continuing achievements in original research. They are among 120 members and 26 international members elected.

The newly elected members from HMS are:

Joel Habener, professor of medicine and chief of the laboratory of molecular endocrinology at Massachusetts General Hospital

Judy Lieberman, professor of pediatrics and chair of cellular and molecular medicine at Boston Children's Hospital

Margaret Livingstone, the Takeda Professor of Neurobiology in the Blavatnik Institute

Olivier Pourqui, the Frank Burr Mallory Professor of Pathology at Brigham and Women's Hospital and professor of genetics in the Blavatnik Institute

Suzanne Walker, professor of microbiology in the Blavatnik Institute

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Other Harvard faculty elected this year include: Dennis Gaitsgory, professor of mathematics, Michael Kremer, the Gates Professor of Developing Societies in the Department of Economics and Wilfried Schmid, professor of mathematics.

The National Academy of Sciences is a nonprofit institution that was established under a congressional charter signed by President Abraham Lincoln in 1863. It recognizes achievement in science by election to membership, andwith the National Academy of Engineering and the National Academy of Medicineprovides science, engineering, and health policy advice to the federal government and other organizations. The National Academy of Sciences charter commits the Academy to provide scientific advice to the government whenever called upon by any government department. The NAS is committed to furthering science in America, and its members are active contributors to the international scientific community.

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Five HMS Faculty Elected to National Academy of Sciences - Harvard Medical School

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Missouri Indian American Professor Develops Disinfecting Tunnel to Kill Viral Infections Using Silver Nano-particles – India West

Posted: May 2, 2020 at 11:43 am

An Indian American professor has developed the technology behind the Nanolife Disinfectant Tunnel, which successfully uses silver nano-particles to kill off viral infections.

Kattesh Katti, professor of radiology and director of the Institute of Green Nanotechnology at the University of Columbia in Missouri, told India-West the technology has been tested successfully on COVID-related viruses. Currently, the 8-foot-long tunnel has been deployed at three locations in Chennai, including the Tirumala Tirupati Temple, where thousands of devotees worship each day.

Indias Prime Minister Narendra Modi has placed an order for more tunnels, according to Katti, which are distributed in India through the company Nanolife.

Katti discovered the effectiveness of silver nano-particles in killing off viruses 20 years ago, and commercialized the technology via a hand sanitizer that uses no alcohol or chemicals. The technology was also being used as a cleaning agent in Indian hospitals, he said.

Then the COVID-19 pandemic hit; Katti and the team at Nanolife re-purposed their technology to address the global crisis, which has killed more than 214,000 people around the world, and infected more than three million people.

India, currently on a nationwide quarantine ordered by Modi in March, has a relatively low rate of infection and death from COVID-19: the country had reported 937 deaths and approximately 30,000 infections as of April 28.

But the countrys overcrowded conditions which make required social distancing difficult could drastically raise the number of deaths from the virus, predict Indian epidemiologists.

A country like India really needs more resources, Katti told India-West. The very high population density makes the pandemic significantly more dangerous, he said.

Unlike other disinfecting tunnels currently used in India and some other countries, Nanolifes disinfectant tunnel uses no harmful chemicals, which could be toxic. The technology is based simply on silver nano-particles, water and a proprietary herb that keeps the particles intact, said Katti, adding that the product is used in very low concentrations in the tunnels.

Prof. Jagat Ram of the Postgraduate Institute of Medical Education and Research, Chandigarh, and Prof. JS Thakur, chairman, Covid-19 Prevention Committee at PGI, have questioned the efficacy of disinfecting tunnels, stating that they provide people with a false sense of security. But the tunnels to which they were referring to use sodium hypochlorite, which is known to have several serious side effects. Nanolifes tunnels have no side effects, according to Katti.

The Government of India has banned the export of COVID-related technology, citing the huge need within the country for such products. Thus, for the moment, the Nanolife Disinfectant Tunnel is limited to deployment in India, but Katti is aiming to eventually bring the device to the U.S.

The Dharwad native said he envisions the Nanolife Disinfectant Tunnel in front of railway stations, airports, office buildings, and other large gathering places. Demand far outweighs production capability at the moment, he told India-West.

According to his bio, green nanotechnology is at the focal point of Katti's approach to pursuing research in nanotechnology and molecular medicine as he strongly believes in the total elimination of toxic chemicals in the production of engineered nanoparticles.

He uses phytochemicals occurring naturally within plants and herbs for nano constructs in a variety of applications.

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Missouri Indian American Professor Develops Disinfecting Tunnel to Kill Viral Infections Using Silver Nano-particles - India West

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