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CAR-T cell therapy Market for Non-Hodgkin Lymphoma is expected to touch USD 2796.2 Million by 2030 – MENAFN.COM

Posted: April 24, 2020 at 7:45 pm

(MENAFN - GetNews) The CAR T-Cell Therapy for Non-Hodgkin's lymphoma (NHL) market report provides current treatment practices, emerging therapies, CAR T-Cell Therapy for Non-Hodgkin's lymphoma market share of the individual therapies, current and forecasted CAR T-Cell Therapy for Non-Hodgkin's lymphoma market size from 2017 to 2030 segmented by US and EU markets.

DelveInsight's CAR T-Cell Therapy for Non-Hodgkin's lymphoma (NHL) - Market Insights and Market Forecast-2030 ' report delivers an in-depth understanding of the CAR T-Cell Therapy for Non-Hodgkin's lymphoma (NHL) and market trends in the 6MM, i.e., the United States and EU5 (Germany, Spain, Italy, France and the United Kingdom).

CAR-T cell therapy market for NHL

The CAR T-Cell Therapy for Non-Hodgkin's lymphoma (NHL) market report provides current treatment practices, emerging therapies, CAR T-Cell Therapy for Non-Hodgkin's lymphoma market share of the individual therapies, current and forecasted CAR T-Cell Therapy for Non-Hodgkin's lymphoma market size from 2017 to 2030 segmented by US and EU markets. The Report also covers current CAR T-Cell Therapy for Non-Hodgkin's lymphoma treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market.

Marketed Therapies in CAR-T cell therapy market for NHL

Chemotherapies, radiation therapies and immunotherapies are either used in combination or alone, depending upon the severity, success rate, age and several other factors. However, CAR-T cell therapy promises one-time treatment and cancer-free life. The available therapeutics treatment options in CAR T-Cell Therapy market for Non-Hodgkin lymphoma aim to kill the leukemia cells in the blood and bone marrow.

The approval of Yescarta was proved to be the light of the day for the group of cancer patients who were left with a few other options, and those with certain types of lymphoma that had not responded to previous treatments.

Emerging Therapies in CAR-T cell therapy market for NHL

This section focusses on the rate of uptake of the potential CAR T-Cell Therapies recently launched in the Non-Hodgkin's lymphoma market or expected to get launched in the market during the study period 20172030. The analysis covers Non-Hodgkin's lymphoma market uptake by CAR T-Cell Therapies; patient uptake by therapies; and sales of each therapy.

The approval of the novel CAR-T cell therapy attracted many pharma investors and pharma companies, highlighting the bright scope of CAR-T cell therapies in oncology.

Several companies, including Celgene , and Gilead , are working to fuel the CAR-T cell therapy market for Non-Hodgkin lymphoma. The expected launch of Lisocabtagene maraleucel (also known as JCAR017) of Celgene 's, (a BMS company) and KTE-X19 by Gilead will significantly drive the NHL market in the near future.

The report covers the detailed information of collaborations, acquisition and merger, licensing and patent details for Non-Hodgkin's lymphoma (NHL) emerging CAR T-Cell Therapies.

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CAR-T cell therapy market for NHL: Forecast

As per DelveInsight, the CAR T-Cell Therapy Market size for Non-Hodgkin lymphoma in the 6MM (the US, EU5 (the UK, Germany, France, Italy and Spain)) is expected to be USD 2796.2 Million by 2030.

Among the EU-5 countries, Germany, Italy and France are observed to be among top holders of the largest CAR T-Cell Therapy market share for Non-Hodgkin lymphoma followed by UK and Spain.

Know more about the scenario of CAR-T Market for NHL

Scope of the Report

Table of Contents

1 Key Insights

2 Executive Summary

3 CAR T-Cell Therapy for NHL Market Overview at a Glance

4 CAR T-Cell Therapy: Background and Overview

5 Treatment Algorithm, Current Treatment, and Medical Practices

6 Unmet Needs

7 Key Endpoints of NHL Treatment

8 Marketed CAR T-Cell Therapies for NHL

8.2 KYMRIAH: NOVARTIS

8.3 YESCARTA: Kite Pharma (Gilead Sciences)

9 Emerging CAR T-Cell Therapies for NHL

9.1.1 KTE-X19: Gilead Sciences

9.1.2 JCAR017: Celgene Corporation (a BMS company)

10 CAR T-Cell Therapy for NHL: Six Major Market Analysis

11 Attribute analysis

12 6MM: Market Outlook

13 CAR T-Cell Therapy for NHL Clinical Trials in 6MM

14 KOL Views CAR T-Cell Therapy for NHL

15 Market Drivers

16 Market Barriers

17 Appendix

18 DelveInsight Capabilities

19 Disclaimer

About DelveInsight

DelveInsight is a premier Business Consulting and Market Research firm focused exclusively on the life science segment. With a wide array of smart end-to-end solutions, the firm helps the global Pharmaceutical and Bio-Tech companies formulate prudent business decisions for better growth in the market.

Media Contact Company Name: DelveInsight Business Research LLP Contact Person: Vinita Rakheja Email: Send Email Phone: 9193216187 Address: 304 S. Jones Blvd #2432 Country: United States Website: http://www.delveinsight.com/

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CAR-T cell therapy Market for Non-Hodgkin Lymphoma is expected to touch USD 2796.2 Million by 2030 - MENAFN.COM

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Global CAR T-Cell Therapy for Multiple Myeloma Market (impact of COVID-19) 2020-2026 Juno Therapeutics, Kite Pharma, Novartis, Collectis – NJ MMA News

Posted: April 24, 2020 at 7:45 pm

Heres recently issued report on the Global CAR T-Cell Therapy for Multiple Myeloma Market that allows you to offer a brief analysis of the market size, demand, supply chain, distribution channels, futuristic trends, market growth elements and so on. It offers a comprehensive analysis of assorted business aspects like global CAR T-Cell Therapy for Multiple Myeloma market trends, recent technological advancements, market shares, size and new innovations. What is more, this analytical knowledge has been compiled through knowledge searching techniques like primary and secondary analysis for CAR T-Cell Therapy for Multiple Myeloma industry. Moreover, an professional team of researchers throws lightweight on numerous static additionally as dynamic aspects of the worldwide CAR T-Cell Therapy for Multiple Myeloma market.

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Geographically, the worldwide CAR T-Cell Therapy for Multiple Myeloma market has been analyzed in numerous regions like North America, geographical region, geographical region, Asia-Pacific, Africa, Europe and Asian nation. The worldwide CAR T-Cell Therapy for Multiple Myeloma market region is dominating this market among the forthcoming future. Worldwide CAR T-Cell Therapy for Multiple Myeloma market is that the skilled and correct study of assorted business views like key players, key geographies, divers, restraints, opportunities and challenges. This global analysis report has been mass on the concept of assorted market segments and sub-segments associated with the worldwide market.

Global CAR T-Cell Therapy for Multiple Myeloma market competition by prime manufacturers, with CAR T-Cell Therapy for Multiple Myeloma sales volume, value (USD/Unit), revenue (Million USD) and market share for each manufacturer. The report provides an in-depth analysis of the worldwide CAR T-Cell Therapy for Multiple Myeloma Market progressing to cut back time to plug for products and services, cut back operational value, improve accuracy and operational performance. Besides this, the report elaborates crucial aspects such as fresh product establishment, greater expenditure in R&D and increasing demand in the manufacturing differentiable growth opportunities in the CAR T-Cell Therapy for Multiple Myeloma Market globally.

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The complete profile of the manufacturers are mentioned. And so the capability, production, price, revenue, cost, gross, margin of profit, sales volume, sales revenue, consumption, rate of growth, import and export, future strategies and therefore the technological developments that they are creating are also enclosed among the report. The historical knowledge and forecast knowledge from 2020 to 2026.

Leading companies reviewed in the CAR T-Cell Therapy for Multiple Myeloma report are:

Juno TherapeuticsKite PharmaNovartisCollectis

The CAR T-Cell Therapy for Multiple Myeloma Market report is segmented into following categories:

The product segment of the report offers product market information such as demand, supply and market value of the product.

The application of product in terms of USD value is represented in numerical and graphical format for all the major regional markets.The CAR T-Cell Therapy for Multiple Myeloma market report is segmented into Type by following categories;MonotherapyCombination Therapy

The CAR T-Cell Therapy for Multiple Myeloma market report is segmented into Application by following categories;Multiple MyelomaRefractory or Relapsed Multiple Myeloma

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The report provides substantial knowledge relating to the market share that every one in every of these firms presently garner across this business, in tandem with the market share that they are expected to amass by the highest of the forecast period. Also, the report elaborates on details regarding the products manufactured by every of these companies, that may facilitate new entrants and outstanding stakeholders work on their competition and strategy portfolios. To not mention, their decision-making method is vulnerable to get easier on account of the actual fact that the CAR T-Cell Therapy for Multiple Myeloma System market report additionally enumerates a gist of the products value trends and so the profit margins of each firm among the industry.

This will enable the readers to focus on CAR T-Cell Therapy for Multiple Myeloma market product specifications, current competitive manufacturers in CAR T-Cell Therapy for Multiple Myeloma market and also the market revenue with gain. Worldwide Industry Analyze CAR T-Cell Therapy for Multiple Myeloma Market by competitive manufacturers, regions and applications of CAR T-Cell Therapy for Multiple Myeloma market, forecast up to 2026. This report analyses the scope of CAR T-Cell Therapy for Multiple Myeloma market. This will be achieved by CAR T-Cell Therapy for Multiple Myeloma previous historical information, analysing qualitative insights info, demonstrable projections regarding global CAR T-Cell Therapy for Multiple Myeloma market size.

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Global CAR T-Cell Therapy for Multiple Myeloma Market (impact of COVID-19) 2020-2026 Juno Therapeutics, Kite Pharma, Novartis, Collectis - NJ MMA News

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CAR T Cell Therapy Market Size, Share 2020 Global Industry, Share, Emerging Trends, Growth Boosted By Demand and Advanced Technology till 2027 -…

Posted: April 24, 2020 at 7:45 pm

CAR T Cell Therapy Market Research Report 2020, is mostly driven by the improved taking on of CAR T Cell Therapy across small and medium-sized enterprises. Worldwide CAR T Cell Therapy Market quantifying the talk on those players at the interval. The report figures the limits and strong points of the players. To begin with the CAR T Cell Therapy Market report which covers market characteristics, industry structure and comitative landscape, the problems, desire concepts, along with business strategies market effectiveness.

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About CAR T Cell Therapy Market Report

This research report categorizes the global CAR T Cell Therapy Market by players/brands, region, type and application. This report also studies the global market status, competition landscape, Market share, growth rate, future trends, market drivers, opportunities and challenges, sales channels, distributors and Porters Five Forces Analysis.

Market Competition by Top Key Players/Manufacturers:

Novartis International AG, Kite Pharma, Inc. (Gilead Sciences, Inc.), Juno Therapeutics (Celgene Corporation), Bluebird Bio, Inc. (Celgene Corporation), Sorrento Therapeutics Inc., Mustang Bio, Inc., Aurora Biopharma Inc., Legend Biotech (Genscript Biotech Corporation), Pfizer, Inc., CARsgen Therapeutics, Ltd., and others.

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CAR T Cell Therapy Market Dynamics in the world mainly, the worldwide 2020-2026 CAR T Cell Therapy Market is analyzed across major global regions. CMI also provides customized specific regional and country-level reports for the following areas:

Major Highlights of the CAR T Cell Therapy Market Report:

CAR T Cell Therapy Market Overview, Market shares and strategies of key players, Sales Market Forecast, Manufacturing Analysis of CAR T Cell Therapy, Market Driving Factor Analysis of CAR T Cell Therapy, Market Competition Status by Major Manufacturers, Upstream and Downstream Market Analysis of CAR T Cell Therapy, and Cost and Gross Margin Analysis of CAR T Cell Therapy.

Why This Report is Useful? It helps:

1. The report will include the qualitative and quantitative analysis with CAR T Cell Therapy Market estimation and compound annual growth rate (CAGR) between 2020 and 20262. Assess the CAR T Cell Therapy production processes, major issues, and solutions to mitigate the development risk.3. Comprehensive analysis of market dynamics including factors and opportunities of the global CAR T Cell Therapy Market will be provided in the report4. Insights from this report will allow marketers and management authorities of companies to make informed decisions with respect to their future product launch, technology upgrades, market expansion, and marketing tactics.

Ask For Discount Before Purchasing This Business Report : https://www.coherentmarketinsights.com/insight/request-discount/102

Further in the report, the CAR T Cell Therapy market is examined for Sales, Revenue, Price and Gross Margin. These points are analyzed for companies, types, and regions. In continuation with this data, the sale price is for various types, applications and regions are also included. The CAR T Cell Therapy industry consumption for major regions is given. Additionally, type wise and application wise figures are also provided in this report.

In this study, the years considered to estimate the market size of 2020-2026 CAR T Cell Therapy Market are as follows:History Year: 2015-2017Base Year: 2017Estimated Year: 2020Forecast Year 2020 to 2026

About Coherent Market Insights:

Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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Cell Therapy Technologies Market: Global Outlook and Forecast 2020-2025 – Surfacing Magazine

Posted: April 24, 2020 at 7:45 pm

ThisGlobalCell Therapy TechnologiesMarketprovides a detailed analysis of theCell Therapy Technologiesmarket based on segmentation such as applications, and geography and forecasts the market for 2020 to 2025. The globalCell Therapy Technologiesmarket is extremely fragmented. The report analyzes the markets competitive landscape and offers information on several field services manufacturers rivaling in the industry. Additionally, thisCell Therapy Technologiesmarket analysis report suggests strategies companies can follow and recommends key areas they should focus on, to make the most of upcoming growth opportunities.

DOWNLOAD FREE SAMPLE REPORT:https://www.fiormarkets.com/report-detail/376050/request-sample

Market Description:

To help clients improve their revenue shares in the market, this research report provides an analysis of theCell Therapy Technologiesmarkets competitive landscape and offers information on the products offered by various leading companies. Although the market share of this segment will decrease, it will continue to dominate the market throughout the forecast years. The market is in the growth phase, as well as the competition is expected to become less intense by the end of the forecast period. It also covers accurate predictions on upcoming trends and changes in consumer behavior and the growth of the industry across the key regions.

TheCell Therapy Technologiesmarket segmentation is based on the regions:North America, Europe, Asia Pacific, South America, and the Middle East and Africa. These regions will witness an increase in their market share and remain the market leader for the forecast period.

It has a detailed analysis of the major industry players to provide insights into their services, business overviews, agreements, key strategies, partnerships, new service launches, and expansions, collaborations and the competitive landscape associated with theCell Therapy Technologiesmarket. The analysis contains the key industry players:Beckman Coulter, Becton, Dickinson and Company, GE Healthcare, Lonza, Merck KGaA, Miltenyi Biotec, STEMCELL Technologies, Inc., Terumo BCT, and Thermo Fisher Scientific, PHARMICELL Co. Ltd, ANTEROGEN.CO.LTD., Novartis AG, GlaxoSmithKline plc, CELGENE CORPORATION, Bone Therapeutics, Cell Therapies, Celyad, Regen BioPharma, Cellular Therapeutics Ltd, TxCell, Advancells and others.

BROWSE COMPLETE REPORT AND TABLE OF CONTENTS :https://www.fiormarkets.com/report/global-cell-therapy-technologies-market-by-product-consumables-376050.html

Exploring the Growth Structure of The Market:

The report contains detailed information on factors that will accelerate the growth of the market during the forecast period from 2020-2025 along with the CAGR of the market during the forecast period. However, comprehensive details on factors will challenge the growth of companies rivaling in the market. It consists of a precise estimation of the globalCell Therapy Technologiesmarket size and its contribution to the parent market as well as a thorough analysis of the markets competitive landscape and detailed information on several vendors.

It comprehensively segments theCell Therapy Technologiesmarket and provides the closest approximations of the revenue numbers for the overall market and its sub segments across major regions. It would help stakeholders understand their competitors better and gain more insights to enhance their positions in theCell Therapy Technologiesmarket. The competitive landscape section includes a competitor ecosystem, new service developments, partnerships, and acquisitions. It would help stakeholders understand the pulse of the market and provide information on the key market drivers, restraints, challenges, and opportunities.

Contact Us:Mark StoneSales ManagerPhone: (201) 465-4211Email:sales@fiormarkets.comWeb:www.fiormarkets.com

View More Information onCell Therapy TechnologiesMarket :https://www.marketwatch.com/press-release/global-cell-therapy-technologies-market-2020-includes-attractiveness-and-raw-material-analysis-and-competitor-position-grid-analysis-to-2025-2020-04-21

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Mogrify and Sangamo in license agreement for ‘off-the-shelf’ CAR-Treg – BioPharma-Reporter.com

Posted: April 24, 2020 at 7:45 pm

The two partners have entered into a collaboration and exclusive license agreement to use Mogrifys proprietary induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) to develop allogeneic cell therapies.

Sangamo Therapeutics plans to utilize the stem cells with its zinc finger protein (ZFP) technology to create gene-engineered chimeric antigen receptor regulatory T cell (CAR-Treg) technology.

In return for the license to use Mogrifys technology, Sangamo will pay an upfront fee and will be eligible to receive further additional milestone payments. A spokesperson was unable to reveal any further details on the financials.

Mogrifys technology allows iPSCs and ESCs to be transformed using transcriptions factors or small molecules into any human cell type.

In the example of this agreement, Mogrify will be responsible for the discovery and optimization of iPSCs or ESCs to regulatory T cells, which can be transformed into novel off-the-shell allogeneic CAR-Treg cell therapy candidates.

Mogrify states that this method of production potentially makes therapies more cost-effective.

A spokesperson told BioPharma-Reporter why this is: The use of optimized transcription factor combinations helps to drive the change of the cells transcriptome and can, therefore, increase the efficiency (yield) and speed of conversion.

This means more of the target cells can be made quicker and from a smaller amount of starting material. This includes both the source cell population and other necessary materials, such as culture media, which are costly.

Jason Fontenot, head of cell therapy at Sangamo, stated that access to Mogrifys technology diversifies the companys options for developing CAR-Treg cell therapies.

In 2018, Sangamo acquired TxCell to gain the latters own CAR-Treg technology.

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Autologous Cell Therapy Market Analysis by Size, Share, Top Key Manufacturers, Demand Overview, Regional Outlook And Growth Forecast to 2026 – Cole of…

Posted: April 24, 2020 at 7:45 pm

Regeneus

Global Autologous Cell Therapy Market Segmentation

This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.

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Global Autologous Cell Therapy Market Regions and Countries Level Analysis

The regional analysis is a very complete part of this report. This segmentation highlights Autologous Cell Therapy sales at regional and national levels. This data provides a detailed and accurate analysis of volume by country and an analysis of market size by region of the world market.

The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia and the United States Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The chapter on the competitive landscape of the global market report contains important information on market participants such as business overview, total sales (financial data), market potential, global presence, Autologous Cell Therapy sales and earnings, market share, prices, production locations and facilities, products offered and applied strategies. This study provides Autologous Cell Therapy sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.

Why choose us:

We offer state of the art critical reports with accurate information about the future of the market.

Our reports have been evaluated by some industry experts in the market, which makes them beneficial for the company to maximize their return on investment.

We provide a full graphical representation of information, strategic recommendations and analysis tool results to provide a sophisticated landscape and highlight key market players. This detailed market assessment will help the company increase its efficiency.

The dynamics of supply and demand shown in the report offer a 360-degree view of the market.

Our report helps readers decipher the current and future constraints of the Autologous Cell Therapy market and formulate optimal business strategies to maximize market growth.

Have Any Query? Ask Our Expert @ https://www.marketresearchintellect.com/need-customization/?rid=175172&utm_source=COD&utm_medium=888

Table of Contents:

Study Coverage: It includes study objectives, years considered for the research study, growth rate and Autologous Cell Therapy market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Autologous Cell Therapy market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Autologous Cell Therapy Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage and more. These reports deliver an in-depth study of the market with industry analysis, market value for regions and countries and trends that are pertinent to the industry.

Contact Us:

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Market Research Intellect

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Tel: +1-650-781-4080

Tags: Autologous Cell Therapy Market Size, Autologous Cell Therapy Market Growth, Autologous Cell Therapy Market Forecast, Autologous Cell Therapy Market Analysis

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What Factors Influence Hematological Recovery in Patients Who Receive CAR-T Therapies? – Cancer Therapy Advisor

Posted: April 24, 2020 at 7:45 pm

A few weeks afterreceiving chimeric antigen receptor (CAR) T-cell (CAR-T) therapy, many patientsexperience prolonged reductions in blood cell counts, possibly making them morevulnerable to infections.

Two recent studies characterized the extent and duration of postCAR-T cytopenia among patients receiving CAR-T therapy for hematological malignancies with 1 study offering insights on some of the possible factors that may influence hematological count recovery.

Whats important to know is that by day 90, mostpatients recover, noted UroosaIbrahim, MD, stemcell transplantation and cellular therapy fellow at the Tisch Cancer Instituteof the Icahn School of Medicine at Mount Sinai,New York, who coauthored 1 of the studies. Were supporting them for [approximately]3 months [with treatment], but then theyll recover, which is good to know.

One study by MemorialSloan Kettering Cancer Center (MSKCC) researchers followed 83 adult patientswho received CAR-T therapy: 40 patients received 1 of 2 Food and DrugAdministration (FDA)-approved therapies, axicabtageneciloleucel (axi-cel; Yescarta) ortisagenlecleucel (tisa-cel; Kymriah), to treat relapsed/refractory B-cell lymphoma.

The remainder comprised 37 patients with relapsed/refractory B-cell acute lymphoblastic leukemia who were currently enrolled in a clinical trial in which they received an experimental CAR-T therapy where cells express the 19-28z CAR construct (ClinicalTrials.gov Identifier: NCT01044069), and 6 multiple myeloma patients who received a different experimental CAR-T construct that targets the B-cell maturation antigen (BCMA) (ClinicalTrials.gov Identifier: NCT03070327). The findings were presented at the annual Transplantation and Cellular Therapy Meetings of ASCT and CIBMTR in February 2020.1

By 1 month, theresearchers observed that 24% of patients experienced a complete recovery ofhemoglobin, platelets, absolute neutrophil count, and white blood cell counts recovery being defined as reaching safe levels, and without requiringtransfusions or treatment with growth factors.

Recovery of hemoglobinwas noted in 61% of patients, platelets in 51% of patients, absolute neutrophilcount in 33% of patients, and white blood cell count in 28% of patients.Examining 41 patients at 3 months, those figures were 93%, 90%, 81%, and 59%,respectively, and overall, 56% saw a complete blood count recovery.

The results werebroadly consistent with recent research by Dr Ibrahim and Keren Osman, MD,associate professor and director of medicine at the Icahn School of Medicine atMount Sinai and director of cellular therapy service in the bone marrow andstem cell transplantation program at the schools Tisch Cancer Institute. Thatstudy comprised 50 patients 41 with multiple myeloma and 9 with diffuse largeB-cell lymphoma who received either axicabtagene ciloleucel, or 1 of 2 experimentalanti-BCMA CAR-T therapies, bb2121 or bb21217.

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Cell Therapy And Tissue Engineering Market Analysis by Size, Share, Top Key Manufacturers, Demand Overview, Regional Outlook And Growth Forecast to…

Posted: April 24, 2020 at 7:45 pm

RoslinCT

Global Cell Therapy And Tissue Engineering Market Segmentation

This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.

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Global Cell Therapy And Tissue Engineering Market Regions and Countries Level Analysis

The regional analysis is a very complete part of this report. This segmentation highlights Cell Therapy And Tissue Engineering sales at regional and national levels. This data provides a detailed and accurate analysis of volume by country and an analysis of market size by region of the world market.

The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia and the United States Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The chapter on the competitive landscape of the global market report contains important information on market participants such as business overview, total sales (financial data), market potential, global presence, Cell Therapy And Tissue Engineering sales and earnings, market share, prices, production locations and facilities, products offered and applied strategies. This study provides Cell Therapy And Tissue Engineering sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.

Why choose us:

We offer state of the art critical reports with accurate information about the future of the market.

Our reports have been evaluated by some industry experts in the market, which makes them beneficial for the company to maximize their return on investment.

We provide a full graphical representation of information, strategic recommendations and analysis tool results to provide a sophisticated landscape and highlight key market players. This detailed market assessment will help the company increase its efficiency.

The dynamics of supply and demand shown in the report offer a 360-degree view of the market.

Our report helps readers decipher the current and future constraints of the Cell Therapy And Tissue Engineering market and formulate optimal business strategies to maximize market growth.

Have Any Query? Ask Our Expert @ https://www.marketresearchintellect.com/need-customization/?rid=170580&utm_source=COD&utm_medium=888

Table of Contents:

Study Coverage: It includes study objectives, years considered for the research study, growth rate and Cell Therapy And Tissue Engineering market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Cell Therapy And Tissue Engineering market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Cell Therapy And Tissue Engineering Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage and more. These reports deliver an in-depth study of the market with industry analysis, market value for regions and countries and trends that are pertinent to the industry.

Contact Us:

Mr. Steven Fernandes

Market Research Intellect

New Jersey ( USA )

Tel: +1-650-781-4080

Tags: Cell Therapy And Tissue Engineering Market Size, Cell Therapy And Tissue Engineering Market Growth, Cell Therapy And Tissue Engineering Market Forecast, Cell Therapy And Tissue Engineering Market Analysis

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A Tribute to Max Randell, Gene Therapy Pioneer – PLoS Blogs

Posted: April 24, 2020 at 7:43 pm

I awoke on Monday morning to the sad news that Max Randell had passed away on April 18. He would have been 23 on October 9.

Maxie wasnt expected to live past the age of 8, or even much past toddlerhood, according to some doctors. But gene therapy, and his incredible family, had something to say about that. COVID-19 didnt claim him his body just tired of fighting.

Max Randells legacy is one of hope, to the rare disease community whose family members step up to participate in the clinical trials that lead to treatments. In this time of the pandemic, attention has, understandably, turned somewhat away from the many people who live with medical limitations all the time. Ill explore that story next week.

A Devastating Diagnosis

Max was diagnosed at 4 months of age with Canavan disease, an inherited neuromuscular disease that never touched his mind nor his ability to communicate with his eyes, even though his body increasingly limited what he could do. Fewer than a thousand people in the US have the condition.

Canavan disease is an enzyme deficiency that melts away the myelin that insulates brain neurons. Gene therapy provides working copies of the affected gene, ASPA.

Babies with Canavan disease are limp and listless. Most never speak, walk, or even turn over. Yet their facial expressions and responses indicate an uncanny awareness. A child laughs when his dad makes a fart-like noise; a little girl flutters her fingers as if they are on a keyboard when a friend plays piano. Theyre smart.

Today, with excellent speech, occupational, and physical therapy and earlier diagnosis, people with Canavan disease can live into their teens or twenties. Those with mild mutations live even longer.

Maxs passing is a tragedy, but he taught researchers about gene therapy to the brain. And that may help others.

Gene Therapy for Canavan

Max had his first gene therapy at 11 months of age and a second a few years later, after slight backsliding when clinical trials halted in the wake of the death of Jesse Gelsingerin a gene therapy trial for a different disease.

Ive written about Maxs journey through many editions of my human genetics textbook, in my book ongene therapy, and in several DNA Science posts, listed at the end.

Ive had the honor to attend two of Maxs birthday parties, which celebrate Canavan kids and the organization that his family founded, Canavan Research Illinois. At one party I brought along birthday cards that students whod read my gene therapy book made for him. And his grandma Peggy, who emailed me of his passing this past Monday, showed me how Max communicated with eyeblinks of differing duration and direction.

Heres what his mom Ilyce wrote about one yearly gathering:

This year will be the 20th Annual Canavan Charity Ball. Each year as I plan this event Im faced with the undeniable reality that theres a chance Maxie wont be here by the time the day rolls around. With each passing year this fear grows stronger and it becomes increasingly difficult to put into print that our annual event is in honor of Maxies birthday. Ive been talking to Maxie a lot lately about his life. He feels happy, strong, loved, content, productive, and fulfilled and he is looking forward to his upcoming 21st birthday. Im excited to celebrate this incredible milestone.

Maxs parents and brother Alex have had the unusual experience of time, of being able to watch their loved one as the years unfolded following gene therapy. They were able to see more subtle improvements than can the parents whose children have more recently had gene therapy to treat a brain disease. Parents watch and wait and hope that language will return, or that a child will become more mobile or less hyperactive, depending on the treated condition. The changes may be subtle, or slow, or restricted and thats what Max taught the world.

For him, the viruses that ferried the healing genes into his brain seem to have gathered at his visual system. His parents noticed improvements in the short term, just before his first birthday, as well as long term.

Within two to three weeks, he started tracking with his eyes, and he got glasses. He became more verbal and his motor skills improved. His vision is still so good that his ophthalmologist only sees him once a year, like any other kid with glasses. She calls him Miracle Max, Ilyce told me in 2010.

In 2016 I heard from Ilyce again:

I wanted to give you an update on Maxie. Hes going to be 19 on October 9th. He graduated from high school in June and is beginning a work program on Monday. Its been very exciting to watch him grow into a young man!

Max had an appointment with his ophthalmologist this week and his vision continues to improve. His doctor said that the gene is still active in his brain because his optic nerve shows absolutely no signs of degeneration and looks the same each year. I wish we could have been able to express the gene throughout more of his brain, but I am grateful for the treatments because of the progress hes made.

Even though gene therapy wasnt a cure for Max, the things we are experiencing definitely give me a lot of hope that once the delivery system is perfected, I can see a potential cure for Canavan disease in the future. Just knowing that the gene is still there 15 years later gives me confidence that a one-time gene transfer would actually work!

Maxs gene therapy circa 2002 targeted less than 1% of brain cells, with fewer viral vectors than are used to deliver healing genes in todays clinical trials. But it looks like some of the vectors may have made their way beyond the optic nerves, judging by the interest in math he had in high school and his critical thinking skills.

A Choice of Gene-Based Therapies

When the Randell family decided to pursue gene therapy, it was pretty much the only game in town. Thats changed.

Only two gene therapies have been approvedin the U.S. But a search at clinicaltrials.gov yielded 602 entriesdeploying the technology. The list still rounds up the usual suspects of years past mostly immune deficiencies, eye disorders, or blood conditions, with a few inborn errors of metabolism.

But one clinical trial mentions the gene-editing tool CRISPR, which can replace a mutant gene, not just add working copies as classical gene therapy does. TheCRISPRtrial is an experiment on stem cells removed from patients with Kabuki syndrome, which affects many body systems.

Spinal muscular atrophy now has two FDA-approved treatments, one an antisense therapy (Spinraza) that silences a mutation and the other (Zolgensma) a gene therapy that infuses copies of the functioning gene. Without treatment, the destruction of motor neurons in the spinal cord is usually lethal by age two.

In 2018, FDA approved the first drug based on RNA interference (RNAi), yet another biotechnology. It silences gene expression, which is at the RNA rather than the DNA level of the other approaches. Onpattro treats the tingling, tickling, and burning sensations from the rare condition hereditary transthyretin-mediated amyloidosis.

When I wrote my book on gene therapy in 2012, the technology was pretty much the only choice of research to pursue besides protein-based therapies like enzyme replacement. Now families raising funds for treatments for single-gene diseases can add antisense, RNAi, and CRISPR gene editing to the list of possibilities.

In any battle, a diversity of weapons ups the odds of defeating the enemy.

RIP Max Randell.

DNA Science posts:

Fighting Canavan: Honoring Rare Disease Week

A Brothers Love Fights Genetic Disease

Gene Therapy for Canavan Disease: Maxs Story

Celebrating the Moms of Gene Therapy

To support research:Canavan Research Illinois

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A Tribute to Max Randell, Gene Therapy Pioneer - PLoS Blogs

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Merck KGaA to spend $110M on new gene therapy facility in California – BioPharma Dive

Posted: April 24, 2020 at 7:43 pm

Dive Brief:

Merck KGaA, like other contract manufacturers such as Lonza, is betting the next big wave of demand will be for complex production of gene therapies and other products such as viral vaccines and immunotherapies. The gene therapy market will grow to about $10 billion by 2026 from $1 billion in 2018, the company said, citing estimates from Biotech Forecasts.

"Viral vector manufacturing has transitioned from a niche industry to the cornerstone of the future of biopharmaceuticals," said Udit Batra, head of Merck KGaA'slife science business, in a statement.

The German company has been on a spending spree in recent years, announcing plans to invest 1 billion euros in its global headquarters in Darmstadt, more than $400 million in two sites in Switzerland,and $70 million in a research and development hub expansion in Billerica, Massachusetts.

Carlsbad is already home to a Merck KGaA facility that has been involved in gene therapy since 1997, about the time that researchers beginning studying the potential for such treatments in people. At present, the site has 16 modular viral bulk manufacturing clean room suites and two fill/finish suites, Merck KGaA said.

With the new facility, the Carlsbad location will have 27 suites used in different parts of the manufacturing process and will support production at the 1000-liter scale using single-use equipment, Merck KGaA said.

The company also has a manufacturing facility in Glasgow that produces intermediates and final products for gene therapy and viral vaccines.

Merck KGaA, established in 1688, is majority owned by descendants of the original founder and had sales of 16.2 billion euros last year. The U.S. pharmaceutical giant Merck was once a subsidiary but is no longer associated with its German namesake.

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Merck KGaA to spend $110M on new gene therapy facility in California - BioPharma Dive

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