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Living with COVID-19 – The Phuket News

Posted: March 28, 2020 at 6:44 am

There is nowhere you can go in Phuket without the COVID-19 coronavirus determining every aspect of your life, other than staying at home hoping not to become infected. Here is a reality check on what COVID-19 means in Phuket.

Dr Thomas Lodi is a wellness expert who has been practicing medicine for over 30 years. He now heads The LifeCo wellness centre located between Nai Thon and Nai Yang beaches, just south of Phuket International Airport.

For the first 10 years of his medical career, Dr Lodi worked in conventional settings as an internal medicine specialist, urgent care physician and as an intensivist in ICU and CCU departments of various hospitals throughout the US.

Subsequently, Dr Lodi continued his search for more effective and less toxic therapies by training with alternative health experts in Japan, Europe, Mexico and the US. He is licensed as a Homeopathic Medical Doctor MD (H) in Arizona and as an Allopathic Medical Doctor in the State of New York.

In 2018, Dr Lodi was featured in the acclaimed docu-series The Truth about Cancer and recently hosted seminars at the H.E.A.T Anti-Aging conference in Bangkok. He is the Founder and Medical Director of Integrative Oncology and Internal Medicine at An Oasis of Healing Center in Arizona. He is also the Founder and Chief Medical Consultant for the Institute of Integrative Oncology, Singapore and Director of Integrative Oncology and Integrative Medicine at The Lifeco Wellness Center, Phuket.

Here we ask Dr Lodi the simple, but most pressing, questions about living with the threat of COVID-19 in Phuket.

What are the real dangers of COVID-19, the best we know right now?

Respiratory failure and cytokine storm (excessive immune responses that damage lungs). The two cell types to which this virus attaches are mucus cells and cilia cells in the lungs. These cells together keep the lungs clean mucus is secreted to trap particulate matter and the cilia beat rhythmically outward towards the mouth like a conveyor belt. With these cells non-functional, the lungs will accumulate everything from microorganisms, waste products, toxins from the environment and so on. Also, the immune system gets turned on full blast and causes system wide inflammation.

Who is primarily at risk?

The elderly over 65 and those with chronic illnesses and compromised immune systems.

What are the symptoms and how bad are they for most people?

The symptoms are a dry cough, shortness of breath, aches and pains, weakness, no appetite and, of course, fever.

Most people will not know they have it: 81% of cases symptoms are mild (lungs); 14% become severely ill; 4.7% become critically ill; and the fatality rate is 3.4 %. Of course these figures may change as we learn more about the virus.

How is COVID-19 contracted?

Fifty percent of infections are hand to face (mouth, nose, eyes). Also, the virus can be airborne in droplets from sneezing and coughing.

Phuket seems to be the only place where people who come into frequent contact with strangers are the only ones wearing face masks. Everyday people going about their daily lives do not. Should people wear face masks? Who should? Why?

If you are not sick or around people, there is no need to wear a mask. Here are the WHO recommendations:

If you are being self-isolated due to one of the following circumstances:

You have travelled from high risk areas within the past 14 days; or

You have been in close contact with a confirmed case of coronavirus;

then, you should use a surgical mask in the following circumstances:

You need to leave your home for any reason and be in public areas;

You are visiting a medical facility; or

You have symptoms and other people are present in the same room as you.

N95 masks filter out about 95% of all liquid or airborne particles.

People have expressed sincere concern about the fingerprint-scanning device at Immigration at the airport. Should people be concerned about this? What should people do about this, if anything?

They have hand sanitiser bottles next to the fingerprinting device. Use it twice: once before and once after.

People have also expressed their opinion that the normal everyday temperature in Phuket and elsewhere in Thailand has helped to prevent the spread of COVID-19 in the country. One senior health official has even said he expects COVID-19 to disappear as Thailand enters its annual hot season. Is there any merit in this understanding?

Not enough is known about this variant of coronavirus because it is new. The standard coronavirus that causes upper respiratory illnesses remains intact in cold weather and dies quickly at 58C.

Are the precautions the Thai government is taking to prevent the spread of COVID-19 reasonable? Or is it lacking? Or even an overreaction? Or a bit of both? Any there any examples that highlight your opinion on this?

The Thai government will do what all governments are doing Each government has had an initial different response, but now that the pandemic is without doubt, all governments will be requiring the same regarding social distancing and quarantines.

Now that COVID-19 has already reached around the world, do you believe travel bans should still be in place? Should people still travel?

Traveling makes no sense now since most countries are locked down, and it is safer not to travel at this point to keep the virus contained.

What can people do to help protect themselves against being infected with COVID-19?

Viruses are not really alive so they cannot be killed. Ultimately, it is our immune systems that develop an adaptive response to recognise any cell infected with the virus and eliminate it. Everything we that we need to do to avoid becoming ill must be geared towards strengthening our immunesystems.

Sleep early and at least seven hours.

Eat no more than two healthy meals per day with 18 hours between your last and first meals. During the window of time when the body is not digesting food, it has time to focus much more energy to the immune system.

Eat plant-based, whole foods rather than processed foods.

Eat at least 70% of your food uncooked and organic.

Meditate at least twice per day.

Vitamin C not only can treat active infection but can protect from getting infected. Vitamin C actually prevents viruses from entering cells. Take from eight to 15 grammes per day orally, depending on bowel tolerance, body size and stress levels

Vitamin A: 30,000-50,000 units per day with food until vitamin A levels in the blood are over 300 iu/dL

Vitamin D: 30,000 iu/day to keep levels in blood above 70, which contributes to enhancing immune response.

Zinc: 90mg per day

Selenium: 400ug per day.

Magnesium: 1,000mg per day. Best used as a transdermal spray applied directly to the body

Green tea: drink several cups of fresh-brewed green tea per day.

Keep your bowels clean with probiotic enemas and colon hydrotherapy and healthy food. Up to 60% of the immune system exists in the gut.

What else should people know about COVID-19 that has not been given enough attention in the media?

If it is not covered in the media, we probably should not discuss it.

In summary, how should people go about their daily lives now that COVID-19 has spread around the world and is now part of our daily lives?

For now, hang out with friends and family and avoid crowds and follow the rules above. Most will not get sick from this virus but you do not want to be the one who spreads it to someone who does not have the health you have and may become critically ill or die.

Dr Lodi and the team at The LifeCo Wellness Center located near Phuket International Airport have created basic and comprehensive immune boosting packages which are certainly appreciated at this time. Learn more at http://www.thelifeco.com/en/viral-infection-prevention-program/

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Living with COVID-19 - The Phuket News

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COVID-19: Tips for mindfulness and coping with anxiety – The Union Leader

Posted: March 28, 2020 at 6:44 am

Amid ever-changing information around the COVID-19 pandemic, many people are experiencing heightened stress and anxiety.

Anxiety is not right, and it is not wrong. It is just part of the human experience, says Kristin Lothman, a mind-body counselor with Mayo Clinics Department of Integrative Medicine and Health.

Healthy anxiety calls us into action to be safe, to take care of the people that we love and to arrive at the present moment experience with resilience.

There are many strategies to manage anxiety, Lothman says. I recommend developing a self-care practice. Elements of that could include journaling, exercise, yoga, meditation and prayer.

Another way to cope with anxiety is to practice mindfulness, Lothman says.

Mindfulness is about paying attention on purpose to the present moment. And I believe mindfulness is a powerful tool we can use right now.

Lothman adds that mindfulness is about focus and awareness. The best way I can connect is to not be distracted, to bepresent, to engage in eye contact, she says.

To calm the body and mind, Lothman suggests a guided meditation _ a practice of relaxed concentration where you follow the instructions of a narrator related to breathing and imagery. Breathing exercises are also valuable, especially for younger children.

You might practice these three or four times a day. Maybe not the entire meditation but even if you can get in 10 breaths that may be enough to notice a shift in your inner experience, Lothman says.

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An Integrative And Functional Doc Explains Her Philosophy On Health And Wellness! – LatestLY

Posted: March 28, 2020 at 6:44 am

Dr Bindiya Gandhi (Photo Credits: File Image)

Dr Bindiya Gandhi is double boarded by the American Board

Family Medicine as well as the American Board of Integrative and

Holistic Physicians, Shes also a certified yoga instructor and reiki master lets ask her few questions!

1.)Why did you choose to be a functional medicine doctor?

I am very passionate about medicine and helping people but I

knew there was more to medicine than conventional medicine that is when I learned about integrative & functional medicine. I

wanted to be able to provide other alternatives to patients and dig deeper than just prescribe medications. Also dealing with my own

personal medical issues over the year pushed me into this newer world of medicine.

2.) How is your practice different than other doctors?

I spend more time with patients. My job is to get to the root cause of medical problems. I don't just prescribe medication. I take a dynamic approach and incorporate nutrition, exercise, meditation, spirituality, energy medicine, herbs, supplements and more so patients can get the optimal results.

3.) Have you had any major failures? How did you recoverand learn from it?

Sometimes I feel like a failure as a business owner. Starting my

own business from scratch has been hard but I remind myself

why I am doing what I"m doing and I continue to push through and break all the boundaries for my patients and for the greater

purpose. I have had to make a lot of sacrifices and put in a lot of

work into my practice and I know as long as I continue to pursue

my passion and mission from the goodness of my heart, all will

work out!

4.) What are your major achievements?

That's a great question, I would honestly say to this day my two beautiful healthy babies are my greatest achievements. There was a time when I didn't even think I could pregnant and that I could even be a mother. So being a mother to two beautiful healthy girls makes me proud and grateful.

5.) What is your philosophy on health?

I absolutely love educating my patients. Not only do I spend a lot

of time educating them about their symptoms, conditions as well

as treatment plans, but I love empowering them and inspiring

them to do better so they can be healthier and in turn, fulfil their

lifes mission and purpose.

IG: @DrBindiyaMD

WEBSITE: DrBindiyaMD.com

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Riding the Rough C’s – National Pain Report

Posted: March 28, 2020 at 6:44 am

My first C, 38 years of Complex Regional Pain Syndrome, braced me with the gift of resilience. But I guess no one can be prepared for my second C, Cancer and one of the toughest prognoses at that, triple-negative breast cancer.

After spending half a year learning, reading, talking and thinking about whether treatment made sense with CRPS, I started a high-dose regimen of my third C, the dreaded (a well-earned adjective) Chemotherapy. Im just starting week ten of fighting for my life.

Because my lot tends to read like Ahab battling the great white whale, OF COURSE that wasnt enough! While staying in a friends beach-front condo to take a weeks break from treatment due to severe pain, all hell broke loose not only in my world, but the whole damn world. Welcome, C #4, COVID-19.

Cynthia Toussaint

Im not much of a complainer, but going through chemo therapy with high-impact pain, a severely compromised immune system and a pandemic is, pardon my French, the sh*ts. In fact, during last weeks visit with my integrative doctor, he expressed deep concern that if I catch even a cold, I will likely end up with pneumonia in an over-crowded hospital with limited supplies and staff.

Already my weekly chemo infusions are much more difficult post-pandemic. Before I go in, I have mandatory screenings with the clinic staff about any symptoms John and I may be feeling and anyone weve come in contact with. When we get to the hospital, him pushing me in my wheelchair, we hit a barricade of fatigued masked and gloved healthcare professionals who are dead set on keeping the virus out. After more interviewing and temperatures taken, we finally get through the treatment doors. Johns only allowed to join me (so far!) due to being my pain caregiver.

When I hit the chemo chair, my nurse is unable to mask me per usual due to the expected supply shortage. I couldnt help myself last week when I asked Scarlett if she was comfortable doing her work and she replied, Honestly, Cynthia, I dont want to be here. Its too unsafe. Then she said, But cancer is so aggressive, at least I get to help the people who are worst off. That really shook me.

When I had the pre-infusion check in with my oncologist, he urged me not to miss another treatment as they dont know day-to-day whether the clinics going to shut down. Seriously, I may have to start this treatment all over again? And, if so, when and where? This whole thing is surreal.

Oh, and last week an old familiar pain friend dropped in more barbarous than ever. Good God, Ive never been so constipated in my life as opioids have nothing on chemo for plugging the pipes. After straining for two days and nights and almost passing out on the throne, John begged me to go to the ER. Any other time, but not now. Certain a hospital visit would deliver the virus, I lay awake on my side crying through that miserable night.

The next morning my oncologist prescribed lactulose, assuring me it would quickly do the trick. Ten hours and two doses (complimented with suppositories) later, I experienced my most painful movement ever. Vacillating between wanting to vomit and near fainting, I had a woman in pain friend on speakerphone (remember, six feet apart!) comforting me and John pleading to push. I felt like I gave birth.

Last evening whilst detailing this saga on the phone with my psychologist, I pieced together the BM culprit. You probably guessed it, the usual suspect western medicine caused my suffering. Heres the low down. My oncologist told me, time and again, to take my anti-nausea meds and I finally caved three weeks ago. Shortly after starting that med, I noticed my urine turned bright yellow. Now I see that signaled dehydration which, as we know, leads to constipation. Then get this; when I asked my oncologist what the side-effects are for lactulose, he said, There arent any. Well, lo and behold, nausea is the #1 side effect for this high-octane laxative.

Again, western medicine has set me up to be as miserable as possible. If I continue to follow my oncologists advice, Id be on a side-effect loop until the end of time (which, ironically, may be just around the corner.) Instead, I called my integrative doctor, and am going to go with a sensible constipation-busting regimen of magnesium and lots of daily dark green leafy veggies. Hello!!

On the good news front, my level 10 lower body agony has been easing. As you may recall from my last post, I was wrangling with my integrative center for weekly acupuncture to control my CRPS pain along with chemo-induced myalgia and neuropathy. My saint-of-a-doctor there put his foot down with the front desk, and is now treating me every week, come hell or high water. The pain let-up is achingly slow, but its no longer getting worse. Another massive help is that a friend is heating her outdoor pool for me to get my heavenly, healing laps in. I continue to find angels among these roiling Cs.

Curiously, the only familiar part of this ever churning epic is the self-isolation. Ive been socially cut off for the past four decades, so being separated from others is par for the course. I can imagine this is a real bear for the uninitiated and am grateful that in times of crisis we with life-altering chronic illnesses are generally miles ahead of the curve.

These high Cs are especially rough, but so far I find them navigable with a port-in-the-storm always within reach. We women in pain are paradoxically prepared for a crisis with endlessly mended sails to keep adrift. A rogue wave may hit us broadside, but instead of capsizing, we remain unsinkable.

Despite these unprecedented times, ladies, continue to set out for the horizon and never look back.

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Letter to the President on Containing the Coronavirus Pandemic – Modern Ghana

Posted: March 28, 2020 at 6:44 am

On March 18, 2020, I watched live via You Tube on how Doctors from China, who served on the front lines in the fight against coronavirus pandemic, share their experience of traditional Chinese medicine (TCM) with U.S. experts via a conference call. TCM has been proven effective in the treatment of an increasing number of COVID-19 cases in China, showing that the ancient system of healing plays a complementary role to western medicine in fighting the infection.

WHO chief said Wuhan provides hope to the world that even the most severe situation of COVID-19 can be turned around. Yang Xiao, a doctor working in the intensive care unit (ICU) of Zhongnan Hospital of Wuhan University, believes that the diagnosis and treatment scheme of COVID-19 plays an important role in the battle. China has updated the diagnosis and treatment scheme six times from Jan. 16 to March 4 based on its accumulating treatment experience. As an effective guide for the medical staff fighting against COVID-19, the scheme contributes to a continuous decline in mortality from the virus.

"Every word in the scheme was written with great caution, which showed a responsibility for the patients' lives," said Yang." The scheme plays a guiding role, especially for hospitals in some counties and cities in central China's Hubei Province."

About 20,000 boxes of the instant TCM mixture, which has proved effective in combating COVID-19 in Wuhan, Hubei province, reached the Netherlands on Tuesday. [Photo provided to chinadaily.com.cn]

China experience in COVID-19 fight

Three kinds of experience are crucial in the country's battle against the virus, said Zhang Boli, an academician of the Chinese Academy of Engineering.

In Hubei, TCM treatment has been given to 90.6 percent of COVID-19 patients.

Clinical observation showed that the TCM has proven to be effective in the treatment of over 90 percent of all confirmed COVID-19 cases on the Chinese mainland, said Yu Yanhong, Party chief of the National Administration of Traditional Chinese Medicine, at a press conference in Wuhan.

In Hubei, TCM treatment has been given to 90.6 percent of COVID-19 patients.

Medical workers massage patients' acupuncture points at the Wuhan pulmonary hospital in Wuhan. Photo: Xinhua

While many scientists are skeptical about its benefits, traditional medicine has official support and has been endorsed by President Xi Jinping. It has been credited with curing tens of thousands of patients during the outbreak and is also being promoted beyond Chinas borders, as an alternative medical solution and a source of national pride.

One of the treatments being used is ephedra, which has been used to treat respiratory complaints since the 13th century, and a special soup in which it is mixed with poria, blackberry lily, apricot kernel and gypsum can help alleviate symptoms, according to official guidelines from the Chinese National Health Commission. The use of Chinese medicine has been supported by the national medical authorities during most recent pandemics, including the H1N1 flu outbreak in 2009 and H7N9 in 2013.

Chinese medicine mostly worked on the human immune system and could not replace invasive forms of treatment such as life support. Chinese health authorities have published a series of figures trying to prove the efficacy of Chinese medicine. Official figures showed that more than 50,000 recovered Covid-19 patients have been prescribed Chinese medicine in their treatment.

According to Hubeis provincial health commission, Chinese medicine has been used on 91.91 per cent of the patients as of mid-March. In the makeshift hospitals built temporarily to treat patients with mild symptoms, between 94 and 99 per cent of people were given Chinese medicine. For instance, Artemisinin is a globally recognized remedy for malaria derived from sweet wormwood, a plant used in TCM. Tu Youyou, the Chinese scientist who turned to ancient Chinese medical texts to find artemisinin, was awarded the Nobel Prize for Medicine in 2015.

The studies:

In a clinical trial of 102 patients with mild symptoms in Wuhan, patients with combined treatments compared with the control group of patients receiving only Western medicine, Yu said. Their recovery rate was 33% higher, she added. In another study of more serious cases, patients receiving combined treatments also left hospital sooner than the control group and had greater levels of oxygen in their blood and a higher lymphocyte count -- an important indicators of the health of recovering patients, according to Yu.

In another study by Wang et al 2020, titled Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment published in the journal BioScience Trends Advance Publication. The authors report the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra ), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection. They concluded that results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia

In another study by Zhang et al 2020, titled In silicons screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus published in the Journal of Integrative Medicine. The authors concluded that Chinese herbal remedies classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds.

Chang et al 2020 study titled An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease published in the journal The American Journal of Chinese Medicine. According to the study authors: In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. They had this to say : We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. We have also reviewed the clinical evidence generated from SARS and H1N1 management with hypothesized mechanisms and latest in silico findings to identify candidate Chinese medicines for the consideration of possible trials and management. Given the paucity of strongly evidence-based regimens, the available data suggest that Chinese medicine could be considered as an adjunctive therapeutic option in the management of COVID-19

Yang et al 2020, study also titled Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective published in the journal International Journal of Biological Sciences the authors also supported the fact that at the top of these conventional therapies, greater than 85% of SARS-CoV-2 infected patients in China are receiving Traditional Chinese Medicine (TCM) treatment.

Ling CQ, 2020 study titled Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2) published in the Journal of Integrative Medicine also asserted that in 2003, patients with severe acute respiratory syndrome (SARS) who were treated with TCM benefited from shorter hospitalization, decrease in steroid-related side effects, and improvement of symptoms

Some TCM Formulas used

Three formulas and three medicines have proved to be effective in treating the infection, according to the State Administration of Traditional Chinese Medicine. Here is a list of them.

1. Jinhua Qinggan granule

The Jinhua Qinggan granule was developed during the 2009 H1N1 influenza pandemic. It consists of 12 herbal components including honeysuckle, mint and licorice and can remove heat from the body and detoxify lungs. It has a curative effect in treating patients with mild and moderate symptoms and can also improve the recovery rate of lymphocytes and white blood cells as well as lower the rate of worsening conditions.

A comparative experiment showed patients who took Jinhua Qinggan granule tested negative for coronavirus 2.5 days earlier than a group that did not take it. The group treated with the granule also took eight days to show improvement, while the other group took 10.3 days.

2. Lianhua Qingwen capsule/granule

Lianhua Qingwen medicine is a very common TCM used for the treatment of cold and flu. Composed of 13 herbal components, it has a curative effect in patients with mild symptoms and helps to relieve fever, cough and fatigue. It can also help prevent the disease from worsening.

3. Xuebijing injection

This injection was developed and marketed during the SARS epidemic in 2003. It consists of five herbal extracts, and its main function is to detoxify and remove blood stasis. It is typically used to treat sepsis. It is effective in suppressing systemic inflammatory response syndrome induced by infection in the treatment of severe and critically ill patients, as well as repairing impaired organ function. Initial clinical studies have shown the injection, combined with Western medicine, can increase the rate of hospital discharge and reduce the rate of disease deterioration. Basic research has also found it has a certain antiviral effect in vitro that can significantly inhibit inflammatory factors induced by novel coronavirus. A comparative experiment of 710 cases jointly conducted by over 30 hospitals showed the injection, combined with regular treatment, can reduce the mortality rate of severe patients by 8.8 percent and shorten intensive care unit hospitalization by four days.

4. Lung Cleansing and Detoxifying decoction

The lung cleansing and detoxifying decoction is derived from several classic recipes in a TCM book known in English as Treatise on Cold Damage Diseases (Shang Han Za Bing Lun), which was written by doctor Zhang Zhongjing some time before 220 AD. It has 21 herbal components and is mainly effective in improving symptoms of fever, cough and fatigue as well as lung conditions in severe patients, as shown by CT scans. Studies have proved the decoction can regulate multiple cell signaling pathwaysas cells communicate with each other by receiving and processing chemical signals in response to environmental changesto inhibit virus replication. Huang Luqi, president of the China Academy of Chinese Medical Sciences, said 1,264 patients in 10 provinces received the decoction and 1,214 have recovered, accounting for 96.1 percent, and no cases worsening.

5. Huashi Baidu formula

Huashi Baidu formula is a core recipe developed by the national TCM team from the China Academy of Chinese Medical Sciences. Made up of 14 herbal components, the formula is based on the recommendations of the early national diagnosis and treatment plan as well as the experiences from clinical practice at Wuhan Jinyintan Hospital.

Its main use is to detoxify, remove dampness and heat from the body and relieve cough to achieve an inner-body balance. It can be used to treat patients with mild, moderate and severe conditions. This prescription has a comprehensive treatment effect during different stages of novel coronavirus pneumonia. It can significantly shorten the length of hospital stays and improve clinical symptoms and lung conditions, as shown by CT scans and other examinations. Studies on guinea pigs found the formula can reduce lung viral load by 30 percent.

6. Xuanfei Baidu granule

Xuanfei Baidu granule, with 13 herbal components, originates from several classic TCM recipes. It can detoxify the lungs and clear dampness and heat, and is used for treating patients with mild and moderate symptoms. Research has shown the prescription can shorten the time it takes for clinical symptoms to vanish and for temperatures to return to normal. It can also effectively prevent patients with mild and moderate symptoms from deteriorating. -China Daily/ANN

Mr. President, I believe it is time to support the traditional Medicine industry and this is the right time to show your support. You could also invite these practitioners and appeal to them to find remedies to complement the conventional efforts by the Medical industry. This COVID-19 fight is not one sided approach; but needs an integrative approach to handle it. Traditional Medicine Practitioners and their centers are more in number than conventional centers and they also need training in testing in their various centers. In fact, they are the first line health workers patients visit before going to the conventional centers, so any efforts to do away with them could be suicidal in your efforts to deal with the pandemic.

Hibiscus Tea could bring hope

Mr. Prez, Traditional Medicine could support people under quarantine in Ghana. For instance, a well know hibiscus Tea has been proven effective in flu management and could also be incorporated as part of the integrative approach in the disease management for those affected by the disease. We can produce hibiscus Tea in large quantities to support the efforts. In a recent 2019 study by Takeda et al titled Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism published in the journal Food and Environmental Virology.

The authors analyzed the antiviral activity of hibiscus (Hibiscus sabdariffa L.) tea extract against human IAV and evaluated its potential as a novel anti-IAV drug and a safe inactivating agent for whole inactivated vaccine. The in vitro study revealed that the pH of hibiscus tea extract is acidic, and its rapid and potent antiviral activity relied largely on the acidic pH. However, hibiscus tea extract and protocatechuic acid, one of the major components of the extract, showed not only potent acid-dependent antiviral activity but also weak low-pH-independent activity. The low-pH-independent activity did not affect the conformation of immunodominant hemagglutinin protein. Although this low-pH-independent activity is very limited, it may be suitable for the application to medication and vaccination because this activity is not affected by the neutral blood environment and does not lose antigenicity of hemagglutinin. Further study of the low-pH-independent antiviral mechanism and attempts to enhance the antiviral activity may establish a novel anti-IAV therapy and vaccination strategy.

Also a 2016 study by High antiviral effects of hibiscus tea extract on the H5 subtypes of low and highly pathogenic avian influenza viruses and published Journal Veterinary Medicine Science.

The authors screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, lavender tea, rose tea and oak tea) against the H5N1 HPAIV in vitro. Among the tested extracts, only the hibiscus extract and its fractionated extract (frHibis) highly and rapidly reduced the titers of all H5 HPAIVs and low pathogenic AIVs (LPAIVs) used in the pre-treatment tests of Madin-Darby canine kidney (MDCK) cells that were inoculated with a mixture of the virus and the extract. Immunogold electron microscopy showed that anti-H5 monoclonal antibodies could not bind to the deformed H5 virus particles pretreated with frHibis. In post-treatment tests of MDCK cells cultured in the presence of frHibis after infection with H5N1 HPAIV, the frHibis inhibited viral replication and the expression of viral antigens and genes. Among the plants tested, hibiscus showed the most prominent antiviral effects against both H5 HPAIV and LPAIV.

Mr. President, taking into conclusion the possibility that hibiscus extract might prevent and treat life-threatening viral infection is all the more encouraging; especially considering that it is also known to have a very high threshold of safety. While the researchers did not speculate too deeply on the mechanism of action behind the observed ant-viral activity of hibiscus, noting only the possibility that its anthnocyanin pigment could be responsible, they suggested further studies should be conducted to identify the effectiveness components contained in hibiscus and to elucidate potential anti-viral mechanism in more detail.

They concluded:

"Our preliminary study showed that, in addition to the H5 subtype, hibiscus inactivated seven other subtypes (data not shown), whereas P. sidoides extracts inactivated human influenza viruses (H1N1 and H3N2) but not H5N1 HPAIV . Thus, hibiscus may be a promising candidate as a potent anti-influenza drug, irrespective of subtype".

Mr. Prez, this is the right time to involve practitioners of Traditional and Alternative medicine and Conventional Medicine Practitioners together to work as an integrative team to deal with the disease. Most of them knows their stuff very well and they may help in the fights against the pandemic. If China had done it, we surely can!

Thank You and God bless our home land Ghana!

The author is a distinguished researcher, practitioner and an honorary Professor of Naturopathic and Holistic Medicine-Vinnytsia State Pedagogical University, Ukraine, President of Nyarkotey Collge of Holistic Medicine and currently LLB Law/MBA student. He is the formulator of FDA approved Mens Formula for Prostate Health & Immune booster, Womens Formula for general wellness Nyarkotey Hibiscus Tea for Cardiovascular Health & wellness. Can be contacted by 0241083423/0541234556.

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Letter to the President on Containing the Coronavirus Pandemic - Modern Ghana

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Can antibody therapy help fight COVID-19? – Livemint

Posted: March 28, 2020 at 6:44 am

NEW DELHI: With a long road ahead for vaccines and drugs, scientists are now exploring age-old technique of passive antibody therapy as potential treatment for COVID-19, which has infected over 5 lakh people across the world and killed at least 24,000.

Antibodies are protein molecules released by the body when a foreign substance (like for instance, virus) enters the system. These molecules bind to the foreign substance and neutralize it. Simply put, they are the weapon used by the immune system to fight new infections.

In case of COVID-19, over 1.22 lakh people, including a large young population, infected with the disease have recovered globally. Now, some molecular laboratories and diagnostic companies in countries worst hit by the pandemic -- China and US-- are racing to develop effective tests which can detect and assess these antibodies in the blood of patients who have recovered from the illness and also analyse if the antibody laden plasma of these recovered persons can be infused in patients at early stage of the disease.

It is an age-old technique, a classical way of dealing with infections being used since early 19th century. When a patient is at an early stage of infection, he makes antibody after 5-7 days, but by then he/she gets sicker and its becomes difficult to fight the infection. Basically, your natural antibodies are coming too late to protect you. In this technique, antibody-laden serum from a previously recovered patient can be infused in a patient at an early stage, to prevent the progression of the disease," explains noted virologist T. Jacob John, who retired as Professor of virology from Christian Medical College (CMC), Vellore.

The data is scarce and inconsistent about how effective the technique is against COVID-19 and concerns over any immunological reaction. Some clinical trials are underway, but it is too early to speak about its accuracy, experts said, but added that it may have potential".

While it is too early for India to experiment the approach, scientists in the country are looking at experiments with hope.

Such approach can be tested when the number of infections is very high, like for instance in China or US (where it has crossed 80,000). We are also looking at it, but currently we are not at the stage, where we have sufficient number of people who have recovered from this catastrophic illness. But clearly that is an area which is being keenly observed," said noted scientist Dr Anurag Aggarwal who heads the CSIR- Institute of Genomics and Integrative Biology (IGIB), Delhi.

As on Friday, India recorded as many as 724 cases of COVID-19, out of which around 67 have recovered.

The US Food and Drug Administration (FDA) has already classified it as an investigational new drug under an emergency approval system and clinical trials have begun. China too has been experimenting with the approach since early days of the outbreak, with modest success.

New York has announced its plan to use the therapy as part of its strategy to fight COVID-19 last week. If it succeeds, it may use it for their front-line health workers who may have been exposed to the virus.

A general principle of passive antibody therapy is that it is more effective when used for prophylaxis than for treatment of disease. When used for therapy, antibody is most effective when administered shortly after the onset of symptoms," says the study published in the Journal of Clinical Medicine.

The intervention was also adopted during the 1918 HINI influenza outbreak. A large case study conducted on 1,700 patients who received blood serum from survivors showed low mortality. It also showed some modest results in the 20092010 H1N1 influenza virus. Its efficacy for the new coronavirus remains under investigation.

So far there have been no approved drug or vaccines for COVID-19.

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Non-Profit Offers Free Stem Cell Therapy to Veterans – Pain News Network

Posted: March 28, 2020 at 6:43 am

By A. Rahman Ford, PNN Columnist

No group is more worthy of the revolutionary benefits of stem cell therapy than Americas military veterans. While the U.S. Department of Veterans Affairs (VA) thinks the field is in its infancy and much more research is needed before stem cells are offered as treatment, brave practitioners are stepping forward to help veterans NOW.

Dr. Joseph Kanan and his staff at the Tullahoma Chiropractic Center are providing free stem cell therapy for veterans who suffer from chronic pain. Kanan in partnership with Veterans in Pain recently performed his first pro bono procedure on a veteran named Ryan, who has severe hip pain. Stem cell injections into Ryans hip, which are not covered by insurance, normally would have cost $6,500. Ryan got them for free.

I think veterans do a lot for our country and there are very few doctors that are performing medical procedures like this, Kanan told The Tullahoma News. We were very glad to be able to do this for him.

Kanan says his Tennessee clinic performs stem cell therapy for veterans twice a month and has had good results so far. One patient was able to avoid a knee replacement and reported consistent improvement one year after the procedure. Patients can expect to experience 10 percent improvement every month for 10 months.

Veterans in Pain is a non-profit that connects military veterans with civilian physicians who provide free regenerative medicine treatments for chronic pain. VIP has provided $250,000 worth of services since 2019.

VIP founder and president Micaela Bensko is herself a stem cell therapy recipient. She spent years in a wheelchair after an accident in her driveway left her with severe spine damage that led to arachnoiditis, a chronic inflammation of spinal nerves. A friend suggested stem cell therapy, which inspired Bensko to establish VIP as a resource for veterans.

Veterans in Pain connects each veteran with a volunteer physician in their area. If one cannot be located, the cost of transportation and accommodations are covered for treatments, as they were for Ryan. Veterans associated with VIP visit schools, organizations and corporations sharing their story of recovery. Most of VIPs funding is provided by small individual donations, grants and grassroots fundraising.

According to the National Institutes of Health, nearly two-thirds of veterans report having chronic pain, with about 9% having severe pain. Chronic pain among veterans is closely associated with mental health conditions such as depression, anxiety, poor sleep and substance abuse disorders. Many veterans suffer from more than one condition.

Because of red tape and a shortage of pain management specialists at the VA, many veterans suffering from chronic pain are left devoid of proper diagnosis and treatment, causing many to self-medicate or search for answers on their own.Chronic pain can lead to substance abuse, a common and growing trend among veterans. A 2017 study found that 30% of military suicides were preceded by alcohol or drug abuse.

The dire plight of military veterans suffering from chronic pain is yet another compelling reason for the FDA to loosen its regulation of stem cell therapy. Our heroes are counting on it.

A. Rahman Ford, PhD, is a lawyer and research professional. He is a graduate of Rutgers University and the Howard University School of Law, where he served as Editor-in-Chief of the Howard Law Journal. Rahman lives with chronic inflammation in his digestive tract and is unable to eat solid food. He has received stem cell treatmentin China.

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Indy Q&A: Cortez Masto wants government to take greater charge of mask, glove supply chain – The Nevada Independent

Posted: March 28, 2020 at 6:41 am

Democratic Sen. Catherine Cortez Masto said major manufacturers attribute a shortage of masks and gloves for front-line health care workers in part to a lack of government leadership in the supply chain, and shes calling on the president to involve the government in manufacturing the scarce goods.

Cortez Masto made her comments in an interview with The Nevada Independent on Thursday, the day after she voted in favor of a $2.2 trillion emergency aid package aimed at relieving the economic fallout from the bill.

The House is expected to vote Friday on the bill that will include massive amounts of financial aid to large companies and small businesses, as well as hundreds of dollars for most individual Americans. Its the third bill in a series of coronavirus response legislation that included a measure to promote the development of a vaccine, and a bill to provide free COVID-19 testing and paid sick leave.

Read on for highlights of the interview, which also included the senators reaction to speculation that she could be a vice presidential nominee for Joe Biden.

Some large businesses will get help through the stimulus bills to try to keep people on their payroll. Do you think casinos are going to apply for funding and which ones?

I dont know which casinos will apply for the funding or whether they will. But I will say this I have been on the phone with our hospitality industry, from our gamers to the small businesses, to the workers, to organized labor, to restaurant owners.

At the end of the day when it comes to our hospitality industry in Nevada, we are all in this together. Theres 450,000 jobs statewide that this industry employs, 450,000 people. And its from individuals who actually work within the casinos and those who benefit because they have a small business that works with the casinos, from our dry cleaners to our florists to small restaurants.

So the goal here, for me and the whole entire delegation as we work together on this package was to make sure we were taking care of everyone in our industry.

So theres a combination of things within the package that will, at the end of the day, make sure that everybody has some form of liquidity. Cause thats what its about. We are asking people, rightfully so, to shelter in place, to stem the spread of the coronavirus. And because of that, they are potentially losing out on wages, salaries, and health care benefits.

And so the goal here is to make them liquid, put money in their pocket now, help their businesses, those small businesses so that they give them the liquidity they need, so that when this crisis is over, we can open our doors and our economic recovery can kind of spring back that much quicker.

Is there anything you would like to see in any forthcoming legislation coming out of Congress?

Once we get it signed by the president, we get the money out, we will have a better understanding [of] what else we need to do. I am already hearing from our governor, from other governors, from hospitality, from our health care workers that more needs to be done and we are prepared to do that.

So yes, I think there is going to be a fourth package thats going to be necessary, but I think we need to wait to get this one out, get the money out there and see where, where else we can be helpful.

One of the biggest concerns right now is that health care professionals say they dont have the masks and the gloves and the personal protective equipment they need. What can you do as a senator to help address this problem?

What this package does is put more money in there to make sure that our hospitals, not only in our urban, but our rural areas, can keep their doors open and then pay for the personal protective equipment for health care workers, including the testing supplies that are so necessary. So theres money in there for that.

The other thing though that needs to be done, and this is why so many of my colleagues and I have talked and sent letters that it is time for this president to really rely on I know hes invoked the Defense Production Act but he hasnt done anything about it.

He hasnt set it in motion. My concern is there is no one at the national level that is managing the supply and demand of this medical equipment that we need right now. Our governors competing with other governors, on the private market for this equipment. And we need to now manage this at a national level to make sure that the supplies are getting to the states and those local communities and to the hospitals where it is needed.

Jacky Rosen and I were on two conference calls. We wanted to reach out to the manufacturers to find out what were the barriers, whats going on here. So we had separate conference calls, one with Cardinal Health and the other with Medline, who produces a lot of these supplies.

And the one thing that we came away from is theyre getting misinformation. Theyre hearing at the federal level from Health and Human Services and FEMA. Theyre hearing different things and nobody is coordinating one area one person taking control and command to coordinate with everyone. And so that is part of the problem.

What I am hearing from these manufacturers that are producing some of these is they want somebody at the federal level to take control to start managing all of the supplies because that is why we are seeing, unfortunately, price gouging going on.

What would be the next step to have someone in charge of this manufacturing situation?

The president needs to say, as he invoked the Defense Production Act, now he needs to set it in motion and he needs to have one agency, whether its HHS, FEMA, whoever it is, take control of not only that supply and demand of the, this medical equipment nationally but the production of it, to understand what those barriers are cause some of the barriers are.

Some of the products or the chemicals we need are not even in the United States. Theyre in another country. We know the test kits alone need a reagent and were low on that reagent. Well, some of that reagent comes from Maine, but some of it comes from out of the country. And so we need somebody at the federal level that is managing all of that and taking control.

Sen. Harry Reid has asked Joe Biden if he could have you as his running mate. Would you consider being a potential running mate for Joe Biden?

I am so honored to have my name even out there and thought of in that way. But I will tell you right now, I am focused on my job here in the United States Senate. I am honored every single day that I get to work on behalf of the state that I was born and raised in and all the people and businesses that live there.

And really, my focus now is just getting us through this crisis and doing what I can at a federal level to make sure that we have the resources we need in our state and individuals have the health care that they need.

What is your office doing to try to meet the needs of Nevadans without health insurance, including undocumented people?

What I want people to know, first of all, is if they have any questions about anything thats going on, whatever their needs are, to reach out to my office. We have case workers that are bilingual, speak Spanish. We are here to help them and work, get them the resources they need or help them through this process.

I will say in this particular package that weve passed, theres a couple of things I want people to know. The package includes $1.3 billion to cover testing costs at community health clinics. And I know those community health clinics in our state serve patients regardless of their immigration status.

So I would tell anyone that if they feel the symptoms or they didnt feel well because, and theyre having the symptoms of coronavirus, to go to one of those community health clinics. The other thing they need to know is if they seek that assistance, it will not be counted against them as part of their public charge analysis.

We were able to, to work with the federal government to make sure that anybody seeking attention and medical needs or assistance because of this virus, will, this will not be used against them. We want people to come forward and we want them to get the healthcare that they need.

A couple of other things. Theres unemployment benefits that we expanded in this package. Anyone who has a valid work authorization during both the time that they were employed and the time they were unemployed can apply for these benefits. This includes both DACA and TPS beneficiaries.

The only thing that, I think, this bill has a shortcoming in is on the direct payments that go to individuals and families. Only those with valid Social Security numbers qualify for the one time payment.

We published an article about fears among ICE detainees that they could be vulnerable to catching coronavirus in these detention centers. What can be done about this situation?

So what we have done at the federal level is I was part of a letter along with my colleagues that we sent it to ICE demanding what type of action they are going to take to prevent the spread of the coronavirus in their detention facilities. And Im waiting. Many of us are waiting for that response.

Theres other ways that we can release them into the community without having to detain them.

We have so many new technologies now and things that we can do to work with them and their attorneys to help them out.

And I think thats what we should be focused on. You know, many, many folks in ICE right now, theyre not violent criminals. And what Im seeing and hearing is that some of them are even put in cells with violent criminals. Theyre not. And so we have to, if were really gonna stem the spread of this virus, then we have to focus on every population.

The Supreme Court is expected to rule in June on the legality of DACA. What can be done for our DACA population that was already concerned about this, and that stress has been compounded by the coronavirus?

I think at this point in time, my concern is that this administration, even though he has said that if he wins this litigation and I mean this president, as the one who brought this litigation forward if he wins, hes not gonna do anything to harm our Dreamers.

I dont trust him and I dont think anybody should in this case, because weve seen what hes done with our immigrant populations. pitting them against one another, calling them horrific names and instilling fear in our community. What it requires us right now is to continue to fight to protect this community.

But at the same time, Ill be honest with you, it means that we have to all come out and vote and elect individuals who are going to stand up for everyone in this country. We are a nation of immigrants Most of us come from immigrants whove come to this country for a better life, and I think that is the beauty of the United States, and thats worth fighting for.

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Indy Q&A: Cortez Masto wants government to take greater charge of mask, glove supply chain - The Nevada Independent

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Old human cells rejuvenated with stem cell technology – Stanford Medical Center Report

Posted: March 26, 2020 at 8:44 pm

During this process the cells not only shed any memories of their previous identities, but they revert to a younger state. They accomplish this transformation by wiping their DNA clean of the molecular tags that not only differentiate, say, a skin cell from a heart muscle cell, but of other tags that accumulate as a cell ages.

Recently researchers have begun to wonder whether exposing the adult cells to Yamanaka proteins for days rather than weeks could trigger this youthful reversion without inducing full-on pluripotency. In fact, researchers at the Salk Institute for Biological Studies found in 2016 that briefly expressing the four Yamanaka factors in mice with a form of premature aging extended the animals life span by about 20%. But it wasnt clear whether this approach would work in humans.

Sarkar and Sebastiano wondered whether old human cells would respond in a similar fashion, and whether the response would be limited to just a few cell types or generalizable for many tissues. They devised a way to use genetic material called messenger RNA to temporarily express six reprogramming factors the four Yamanaka factors plus two additional proteins in human skin and blood vessel cells. Messenger RNA rapidly degrades in cells, allowing the researchers to tightly control the duration of the signal.

The researchers then compared the gene-expression patterns of treated cells and control cells, both obtained from elderly adults, with those of untreated cells from younger people. They found that cells from elderly people exhibited signs of aging reversal after just four days of exposure to the reprogramming factors. Whereas untreated elderly cells expressed higher levels of genes associated with known aging pathways, treated elderly cells more closely resembled younger cells in their patterns of gene expression.

When the researchers studied the patterns of aging-associated chemical tags called methyl groups, which serve as an indicator of a cells chronological age, they found that the treated cells appeared to be about 1 to 3 years younger on average than untreated cells from elderly people, with peaks of 3 years (in skin cells) and 7 years (in cells that line blood vessels).

Next they compared several hallmarks of aging including how cells sense nutrients, metabolize compounds to create energy and dispose of cellular trash among cells from young people, treated cells from old people and untreated cells from old people.

We saw a dramatic rejuvenation across all hallmarks but one in all the cell types tested, Sebastiano said. But our last and most important experiment was done on muscle stem cells. Although they are naturally endowed with the ability to self-renew, this capacity wanes with age. We wondered, Can we also rejuvenate stem cells and have a long-term effect?

When the researchers transplanted old mouse muscle stem cells that had been treated back into elderly mice, the animals regained the muscle strength of younger mice, they found.

Finally, the researchers isolated cells from the cartilage of people with and without osteoarthritis. They found that the temporary exposure of the osteoarthritic cells to the reprogramming factors reduced the secretion of inflammatory molecules and improved the cells ability to divide and function.

The researchers are now optimizing the panel of reprogramming proteins needed to rejuvenate human cells and are exploring the possibility of treating cells or tissues without removing them from the body.

Although much more work needs to be done, we are hopeful that we may one day have the opportunity to reboot entire tissues, Sebastiano said. But first we want to make sure that this is rigorously tested in the lab and found to be safe.

Other Stanford co-authors are former postdoctoral scholar Marco Quarta, PhD; postdoctoral scholar Shravani Mukherjee, PhD; graduate student Alex Colville; research assistants Patrick Paine, Linda Doan and Christopher Tran; Constance Chu, MD, professor of orthopaedic surgery; Stanley Qi, PhD, assistant professor of bioengineering and of chemical and systems biology; and Nidhi Bhutani, PhD, associate professor of orthopaedic surgery.

Researchers from the Veterans Affairs Palo Alto Health Care System, the University of California-Los Angeles and the Molecular Medicine Research Institute in Sunnyvale, California, also contributed to the study.

The research was supported by the National Institutes of Health (grants R01 AR070865, R01 AR070864, P01 AG036695, R01 AG23806, R01 AG057433 and R01 AG047820), the Glenn Foundation for Medical Research, the American Federation for Aging Research and the Department of Veterans Affairs.

Sarkar, Quarta and Sebastiano are co-founders of the startup Turn Biotechnologies, a company that is applying the technology described in the paper to treat aging-associated conditions. Rando is a member of the scientific advisory board.

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Study offers potential breakthrough in the war on antibiotic-resistant superbugs – Yahoo Finance

Posted: March 26, 2020 at 8:44 pm

A study published in STEM CELLS Translational Medicine, by researchers at The Baker Institute for Animal Health, at Cornell's College of Veterinary Medicine, demonstrates for the first time that mesenchymal stromal cells (MSCs) are an effective weapon against bacteria in biofilm.

DURHAM, N.C., March 26, 2020 /PRNewswire-PRWeb/ -- Researchers have potentially made a breakthrough in the war on antibiotic-resistant superbugs including MRSA, which kills an estimated 20,000 people in the United States alone each year with a new discovery whose details are published today in STEM CELLS Translational Medicine. The study, by researchers at The Baker Institute for Animal Health, at Cornell's College of Veterinary Medicine, demonstrates for the first time that mesenchymal stromal cells (MSCs) are an effective weapon against bacteria in biofilm.

Biofilms are thin, slimy films made up of bacteria that can attach to skin wounds, teeth and other surfaces, creating the opportunity for infections to flourish. These highly structured cellular communities offer bacteria shelter from harmful factors, helping them resist antibiotics, mutate rapidly and evade the immune system.

"MSCs help kill the bacteria through the secretion of enzymes, called proteases, that break the peptide bonds of proteins and cause biofilm to destabilize. This in turn increases the effectiveness of antibiotics that previously weren't working, as the bacteria are no longer being protected by the biofilm," explained Gerlinde R. Van de Walle, DVM, Ph.D., who led the study along with Charlotte Marx, DVM, Ph.D.

Other recent studies, including one by the Cornell team, have shown that MSCs can inhibit the growth of bacteria associated with chronic infections by secreting antimicrobial peptides. "But these studies were conducted primarily on planktonic bacteria, which are individually floating bacteria cells. Thus, information on the effects on biofilms was largely lacking," Dr. Marx said.

The current study explores how MSC secretome, delivered as conditioned medium, performs against various wound-related bacterial pathogens. It also looks at the mechanisms that affect bacterial biofilms. The experiments were performed in vitro, using equine MSC. "We use equine MSC in our work since the horse represents a physiologically relevant model for human wound healing and offers a readily translatable model for MSC therapies in humans," Dr. Van de Walle explained.

The researchers began by showing that equine MSC secretome inhibits the growth of four types of planktonic bacteria that commonly colonize skin wounds. Encouraged by the results, they next sought to determine the effect of the MSC secretome on these same bacterial strains in biofilms, which is the predominant way bacteria invade wounds. They looked at how the MSCs affected biofilm formation, then repeated the experiments on biofilms that were already established. Finally, they turned their attention to the bacteria strain responsible for MRSA.

Dr. Marx reported the results. "Our salient findings," she said, "were that factors secreted by equine MSC impaired both planktonic and biofilms including MRSA as well as disrupted mature biofilms generated by these bacteria. Importantly, we found that these effects resulted from a protease-dependent mechanism."

Dr. Van de Walle added, "We also found that MSC-secreted factors allowed previously ineffective antibiotic treatments to become more effective at reducing bacterial survival. In light of the rise of antibiotic-resistant bacterial strains as an increasing global health threat, our findings provide the rationale for using the MSC secretome as a complementary treatment for bacterial infections."

"Outcomes from this study highlight for the first time that the secretome from mesenchymal stem cells significantly reduces the formation of bacterial infections, including the antibiotic resistant MRSA," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. "Antibiotic resistance has long been a concern and this research highlights some promising new tactics."

###

The full article, "The mesenchymal stromal cell (MSC) secretome impairs methicillin-resistant S. aureus (MRSA) biofilms via cysteine protease activity in the equine model," can be accessed at https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/sctm.19-0333.

Story continues

About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), co-published by AlphaMed Press and Wiley, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. SCTM is the official journal partner of Regenerative Medicine Foundation.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS (http://www.StemCells.com), celebrating its 38th year, is the world's first journal devoted to this fast paced field of research. The Oncologist (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 25th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scholarly journals, combined with our digital learning, assessment and certification solutions, help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our stakeholders. The company's website can be accessed at http://www.wiley.com.

About Regenerative Medicine Foundation (RMF): The non-profit Regenerative Medicine Foundation fosters strategic collaborations to accelerate the development of regenerative medicine to improve health and deliver cures. RMF pursues its mission by producing its flagship World Stem Cell Summit, honouring leaders through the Stem Cell and Regenerative Medicine Action Awards, and promoting educational initiatives.

SOURCE STEM CELLS

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